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Reference quality assembly of the 3.5-Gb genome of Capsicum annuum from a single linked-read library

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Horticulture Research 2018年第1期5卷 890-902页

作者： Amanda M.Hulse-Kemp Shamoni Maheshwari Kevin Stoffel Theresa A.Hill David Jaffe Stephen R.Williams neil Weisenfeld Srividya Ramakrishnan Vijay Kumar Preyas Shah michael C.Schatz Deanna M.Church Allen Van Deynze Department of Plant Sciences University of CaliforniaDavisCAUSA USDA-ARS Genomics and Bioinformatics Research Unit RaleighNCUSA Department of Crop and Soil Sciences North Carolina State UniversityRaleighNCUSA 10x Genomics Inc7068 Koll Center ParkwaySuite 401PleasantonCAUSA Department of Computer Science Johns Hopkins UniversityBaltimoreMDUSA

Linked-Read sequencing technology has recently been employed successfully for de novo assembly of human genomes,however,the utility of this technology for complex plant genomes is *** evaluated the technology for this purpose by sequencing the 3.5-gigabase(Gb)diploid pepper(Capsicum annuum)genome with a single Linked-Read *** genomes,including pepper,are characterized by long,highly similar repetitive ***,significant effort is used to ensure that the sequenced plant is highly homozygous and the resulting assembly is a haploid *** a phased assembly approach,we targeted a heterozygous F1 derived from a wide cross to assess the ability to derive both haplotypes and characterize a pungency gene with a large insertion/*** Supernova software generated a highly ordered,more contiguous sequence assembly than all currently available *** reference *** 83%of the final assembly was anchored and oriented using four publicly available de novo linkage maps.A comparison of the annotation of conserved eukaryotic genes indicated the completeness of *** validity of the phased assembly is further demonstrated with the complete recovery of both 2.5-Kb insertion/deletion haplotypes of the PUN1 locus in the F1 sample that represents pungent and nonpungent peppers,as well as nearly full recovery of the BUSCO2 gene set within each of the two *** most contiguous pepper genome assembly to date has been generated which demonstrates that Linked-Read library technology provides a tool to de novo assemble complex highly repetitive heterozygous plant *** technology can provide an opportunity to cost-effectively develop high-quality genome assemblies for other complex plants and compare structural and gene differences through accurate haplotype reconstruction.

关键词： Capsicum pepper insertion

Anatomic variations of the intra-hepatic biliary tree in the Caribbean:A systematic review

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World Journal of Gastrointestinal Endoscopy 2021年第6期13卷 170-183页

作者： Shamir O Cawich Alexander Sinanan Rahul R Deshpande michael T Gardner neil W Pearce Vijay Naraynsingh Department of Clinical Surgical Sciences University of the West IndiesSt Augustine 000000Trinidad and Tobago Department of Surgery Manchester Royal InfirmaryManchester M139WLUnited Kingdom Department of Anatomy University of the West IndiesKingston KIN7Jamaica Department of Surgery Southampton University NHS TrustSouthampton SO16DPSouthamptonUnited Kingdom

BACKGROUND In the classic descriptions of the human liver,the common hepatic duct forms at the confluence of left and right hepatic *** authors have documented variations in the intra-hepatic ductal system,but to the best of our knowledge there has been no report on bile duct variations in Caribbean *** To evaluate the variations in bile duct anatomy using magnetic resonance cholangiography(MRC)in unselected patients at a major hepatobiliary referral centre in the Eastern *** of the intra-hepatic biliary anatomy is important to optimize service delivery for any physician treating liver and biliary *** This study was carried out at a tertiary referral hospital for hepatobiliary diseases in the Eastern *** retrospectively evaluated magnetic resonance cholangiograms in 152 consecutive patients at this facility over a two-year period from April 1,2017 to March 31,*** consultant radiologists experienced in MRC interpretation reviewed all scans and described biliary anatomy according to the Huang’s classification.A systematic review of published studies was performed and relevant data were extracted in order to calculate the global prevalence of each biliary *** variants in our population were compared to the global *** There were 152 MRCs evaluated in this study in 86 males and 66 *** were 109(71.7%)persons with“classic”biliary anatomy(type A1)and variants were present in 43(28.3%)*** was no statistical relationship between the presence of anatomic variants and gender or *** encountered the following variants:29(19.1%)type A2,7(4.6%)type A3,6(3.95%)type A4,0 type A5 and a single variant(quadrification)that did not fit the classification *** to the global prevalence,our population had a significantly greater occurrence of A1 anatomy(71.7%vs 62.6%;P=0.0227)and A2 trifurcations(19.1%vs 11.5%;P=0.0069),but a significantly lower incidence of A3 varian

关键词： Liver Variant Biliary Duct Intra-hepatic Aberrant Trifurcation,Bifurcation

为IPTV技术解决DSL机顶盒的设计与部署难题

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电子产品世界 2006年第05S期13卷 46-46,48,50页

作者： michael VanBreda neil Quarmby 德州仪器

目前只有为数不多的几家运营商部署了集成的DSL调制解调器/IP机顶盒(STB),即目前通常所说的DSL STB设备.之所以涉足此领域的运营商不多,是因为这种技术要求从头进行产品设计与构建.OEM与ODM厂商目前尚未进入此市场,很可能是由于关键组... 详细信息

目前只有为数不多的几家运营商部署了集成的DSL调制解调器/IP机顶盒(STB),即目前通常所说的DSL STB设备.之所以涉足此领域的运营商不多,是因为这种技术要求从头进行产品设计与构建.OEM与ODM厂商目前尚未进入此市场,很可能是由于关键组件的集成相当困难,而且还面临其他设计方面的问题.目前,组件制造商正开始推出经全面设计、配备全套说明材料的开发板,其不仅具备所有接口,而且还能解决其他设计问题.通过简化DSLSTB的设计与构建,满足市场对视频带宽、服务质量(QoS)以及脉冲噪声保护(INP)等要求,上述开发板有助于大幅拓展DSL STB市场.

关键词：产品设计 IPTV DSL 机顶盒部署技术服务质量(QoS) 难题调制解调器全面设计

不同于上一辈的奢侈——新式的高档消费及其成因

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中国企业家 2002年第8期38卷 68-70页

作者： neil Fiske michael Silverstein 波士顿咨询公司芝加哥办公室副总裁兼芝加哥办公室领导人高级副总裁兼公司全球消费品市场专项的负责人

新式高档消费的供应商是真正的革新者及企业家,

关键词：消费成因分析消费者高档消费

On fundamental groups related to the Hirzebruch surface F_1

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Science China Mathematics 2008年第4期51卷 728-745页

作者： michael FRIEDMAN Mina TEICHER Department of Mathematics Bar-Ilan University

Given a projective surface and a generic projection to the plane,the braid monodromy factorization(and thus,the braid monodromy type)of the complement of its branch curve is one of the most important topological invariants,stable on *** this factorization,one can compute the fundamental group of the complement of the branch curve,either in C^2 or in CP^*** this article,we show that these groups,for the Hirzebruch surface F_1,(a,b),are *** is, they are an extension of a solvable group,which strengthen the conjecture on degeneratable surfaces.

关键词： Hirzebruch surfaces degeneration generic projection branch curve braid monodromy fundamental group classification of surfaces

不同于上一辈的奢侈——新式的高档消费及其成因

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中国企业家 2002年第8期 55-57页

作者： neil Fiske,michael Silverstein 波士顿咨询公司芝加哥办公室副总裁兼芝加哥办公室领导人高级副总裁兼公司全球消费品市场专项的负责人

新式高档消费的供应商是真正的革新者及企业家, 他们很多人都是行业局外人

关键词：高档消费革新者企业家销量消费者

Second quantization of a covariant relativistic spacetime string in Steuckelberg-Horwitz-Piron theory

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Frontiers of physics 2017年第3期12卷 187-196页

作者： michael Suleymanov Lawrence Horwitz Asher Yahalom Department of Physics Ariel University Ariel Israel Department of Electrical & Electronic Engineering Ariel University Ariel Israel School of Physics Tel Aviv University Ramat Aviv Israel Department of Physics Bar Ilan University Ramat Gan Israel

A relativistic 4D string is described in the framework of the covariant quantum theory first intro- duced by Stueckelberg [Helv. Phys. Acta 14, 588 （1941）], and further developed by Horwitz and Piron [Helv. Phys. Acta 46, 316 （1973）], and discussed at length in the book of Horwitz [Relativistic Quan- tum Mechanics, Springer （2015）]： We describe the space-time string using the solutions of relativistic harmonic oscillator [J. Math. Phys. 30, 66 （1989）]. We first study the problem of the discrete string, both classically and quantum mechanically, and then turn to a study of the continuum limit, which contains a basically new formalism for the quantization of an extended system. The mass and energy spectrum are derived. Some comparison is made with known string models.

关键词： second quantization spacetime string Steuckelberg-Horwitz-Piron theory

The Fundamental Group of the Complement of the Branch Curve of CP^1×T

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Acta Mathematica Sinica,English Series 2009年第9期25卷 1443-1458页

作者： Meirav AMRAM michael FRIEDMAN Mina TEICHER Department of Mathematics Bar-Ilan University

Denoting by T the complex projective torus, we can embed the surface CP^1 × T in CP^5. In this paper we compute the fundamental group of the complement of the branch curve of this surface. Since the embedding is not ＂ample enough＂, the embedded surface does not belong to the classes of surfaces where the fundamental group is virtually solvable： a property which holds for these groups for ＂ample enough＂ embeddings. On the other hand, as it is the first example of this computation for non simply-connected surfaces, the structure of this group （as shown in this paper） give rise to the extension of the conjecture regarding the structure of those fundamental groups of any surface.

关键词： fundamental group generic projection curves and singularities branch curve

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儿童青少年运动员的营养需要

体育科学 2001年第5期21卷 89-93页

作者： Oded bar-Or Susan barr michael Bergeron Ruth Carey Priscilla Clarkson Linda Houtkooper Anita Rivera-Brown Tom Rowland Suzanne Steen 艾华 Children's Exercise & Nutrition Center McMaster University School of Family & Nutritional Sciences University of British Columbia Department of Exercise Science University of Massachusetts Department of Nutritional Sciences University of Arizona Center for Sports Health and Exercise Sciences Albergue Olimpico and Dept. of Physical Medicine Rehabilitation and Sports Medicine University of Puerto Rico School of Medicine Pediatric Cardiology Baystate Medical Center Children's Hospital Graduate Division Dept. of Nutrition Education Immaculata College

1.儿童青少年运动员应该食用多样化的食物,其中,蛋白质应占膳食总能量的12%～15%,碳水化合物至少占55%,而脂肪至多占30%。日常生活中如何吃才能满足这些要求呢?膳食指南宝塔提供了一条可行之道。2.有些营养素对热爱运动的儿童青少年运... 详细信息

1.儿童青少年运动员应该食用多样化的食物,其中,蛋白质应占膳食总能量的12%～15%,碳水化合物至少占55%,而脂肪至多占30%。日常生活中如何吃才能满足这些要求呢?膳食指南宝塔提供了一条可行之道。2.有些营养素对热爱运动的儿童青少年运动员非常重要,要保证摄入充足,这些营养素是碳水化合物(包括纤维素)、维生素B_6、维生素D、铁、钙、镁、锌、铬。科学合理、包罗各类食物的平衡膳食,对青少年运动员最大程度地全面摄取各种营养素,满足生长发育和运动训练的需要,是非常必要的。3.鼓励儿童青少年运动员在运动训练前、中、后进行补液,以避免脱水的发生。4.如果膳食合理平衡,就没必要额外补充营养品。

关键词：运动员营养需要运动医学儿童青少年运动训练合理膳食生长发育