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Experimental and numerical investigation to elucidate the fluid flow through packed beds with structured particle packings

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Particuology 2024年第6期89卷 218-237页

作者： Shirin patil Christian Gorges Joel Lòpez Bonilla Moritz Stelter Frank Beyrau Berend van Wachem Laboratory of Technical Thermodynamics Otto-von-Guericke-Universität MagdeburgUniversitätsplatz 239106 MagdeburgGermany Chair of Mechanical Process Engineering Otto-von-Guericke-Universität MagdeburgUniversitätsplatz 239106 MagdeburgGermany

The present paper presents an experimental and numerical investigation of the dispersion of the gaseous jet flow and co-flow for the simple unit cell(SUC)and body-centred cubic(BCC)configuration of particles in packed *** experimental setup is built in such a way that suitable and simplified boundary conditions are imposed for the corresponding numerical framework,so the simulations can be done under very similar conditions as the ***,a porous plate is used for the co-flow to achieve the uniform velocity and the fully developed flow is ensured for the jet *** SUC and BCC particle beds consist of 3d-printed spheres,and the non-isotropy near the walls is mostly eliminated by placing half-spheres at the channel *** flow velocities are analysed directly at the exit of the particle bed for both beds over 36 pores for the SUC configuration and 60 pores for the BCC configuration,for particle Reynolds numbers of 200,300,and *** particle image velocimetry is experimentally arranged in such a way that the velocities over the entire region at the exit of the packed bed are obtained *** numerical method consists of a state-of-the-art immersed boundary method with adaptive mesh *** paper presents the pore jet structure and velocity field exiting from each pore for the SUC and BCC packed particle *** numerical and experimental studies show a good agreement for the SUC configuration for all flow *** the BCC configuration,some differences can be observed in the pore jet flow structure between the simulations and the experiments,but the general flow velocity distribution shows a good overall *** axial velocity is generally higher for the pores located near the centre of the packed bed than for the pores near the *** addition,the axial velocities are observed to increase near the peripheral pores of the packed *** behaviour is predominant for the BCC configuration as compared to t

关键词： Uniform particle packing Packed bed reactor Stereo particle image velocimetry Immersed boundary method

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QFT preflter design for multivariable systems using interval constraint satisfaction technique

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控制理论与应用（英文版） 2013年第4期11卷 529-537页

作者： Mukesh d.patil P.S.V.NATARAJ department of Electronics Engineering Ramrao Adik Institute of Technology Systems and Control Engineering Indian Institute of Technology Bombay

In this paper, a computationally efficient method is proposed for automated design of the prefilters for multivariable systems. In quantitative feedback theory （QFT） method, proposed by Horowitz, the prefilter is designed to achieve the desired tracking specifications. In the proposed approach, we pose the prefilter design problem as an interval constraint satisfaction problem and solve it using the well-established interval constraint satisfaction techniques. The proposed method finds optimal values of the parameters of fixed structure prefilter within the initial search domain. An approach based on prefilter synthesis for single-input single-output is already developed. The purpose of this paper is to extend this approach to QFT prefilter design for general multivariable systems. To validate the above design approach, we applied the method to a laboratory setup of magnetic levitation system.

关键词： Interval constraint satisfaction technique Prefilter design Quantitative feedback theory

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Nanoemulsion containing a synergistic combination of curcumin and quercetin for nose-to-brain delivery:In vitro and in vivo studies

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Asian Pacific Journal of Tropical Biomedicine 2021年第11期11卷 510-518页

作者： Hitendra S Mahajan nayana d.patil r.3.patel institute of pharmaceutical education and research shirpurdist-dhule(m.s)india

Objective:To characterize a nanoemulsion containing a synergistic combination of curcumin(CUR)and quercetin(QUE)for brain targeting through the ***:The synergistic activity of the combination of two phytoconstituents,curcumin and quercetin(CUR-QUE)was determined at a 2:1 *** containing the synergistic combination were prepared using high-pressure homogenization *** formulation was characterized for globule size,drug content,thermodynamic stability,zeta potential measurement,and drug *** studies were performed using isolated nasal mucosa of ***,in vivo studies using allograft model were ***:CUR-QUE in a 2:1 ratio combination showed the lowest combination index values 0.99(combination indexd the growth of human glioblastoma U373 MG *** significant drug targeting efficiency percentage(178.25±2.86 for CUR and 170.54±6.11 for QUE)and nose to brain drug direct transport percentage(44.05±0.93 for CUR and 38.25±0.83 for QUE)of optimized nanoemulsion(F9)indicated effective central nervous system targeting via the intranasal *** vivo anticancer study using allograft model of nude mice demonstrated potential anticancer activity of the synergistic combination of CUR-QUE as compared to ***:This study demonstrates that synergistic combination of CUR-QUE was optimal for treatment of human ***,significant site-specific delivery to the brain was achieved by administering nanoemulsion through the *** study also reveals that intranasal delivery of nanoemulsion containing synergistic combination of CUR and QUE could be a promising strategy for brain tumor treatment.

关键词： Curcumin Quercetin Nanoemulsion Brain tumor Synergism

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Characterization of early maturing elite genotypes based on MTSI and MGIdI indexes: an illustration in upland cotton(Gossypium hirsutum L.)

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Journal of Cotton Research 2024年第3期 253-265页

作者： d S RAJ Supritha patil Rajesh S. patil Bhuvaneshwara R. NAYAK Spurthi N. PAWAR Kasu N. department of Genetics and Plant Breeding College of Agriculture University of Agricultural Sciences Agricultural Research Station department of Biotechnology College of Agriculture University of Agricultural Sciences department of Crop Physiology College of Agriculture University of Agricultural Sciences

Background Globally, the cultivation of cotton is constrained by its tendency for extended periods of growth. Early maturity plays a potential role in rainfed-based multiple cropping system especially in the current era of climate change. In the current study, a set of 20 diverse Gossypium hirsutum genotypes were evaluated in two crop seasons with three planting densities and assessed for 11 morphological traits related to early maturity. The study aimed to identify genotype(s) that mature rapidly and accomplish well under diverse environmental conditions based on the two robust multivariate techniques called multi-trait stability index(MTSI) and multi-trait genotype-ideotype distance index(MGIdI).Results MTSI analysis revealed that out of the 20 genotypes, three genotypes, viz., NNdC-30, A-2, and S-32 accomplished well in terms of early maturity traits in two seasons. Furthermore, three genotypes were selected using MGIdI method for each planting densities with a selection intensity of 15%. The strengths and weaknesses of the genotypes selected based on MGIdI method highlighted that the breeders could focus on developing early-maturing genotypes with specific traits such as days to first flower and boll opening. The selected genotypes exhibited positive genetic gains for traits related to earliness and a successful harvest during the first and second pickings. However, there were negative gains for traits related to flowering and boll *** The study identified three genotypes exhibiting early maturity and accomplished well under different planting densities. The multivariate methods(MTSI and MGIdI) serve as novel approaches for selecting desired genotypes in plant breeding programs, especially across various growing environments. These methods offer exclusive benefits and can easily construe and minimize multicollinearity issues.

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Trained through generations

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Cellular & Molecular Immunology 2022年第6期19卷 653-654页

作者： Neha d.patil Jonathan d.Turner Mahesh S.desai Jacques Zimmer department of Infection and Immunity Luxembourg Institute of HealthEsch-sur-AlzetteLuxembourg Odense Research Center for Anaphylaxis Department of Dermatology and Allergy CenterOdense University HospitalUniversity of Southern DenmarkOdenseDenmark

The first scientists to coin the term“trained immunity”were Mihai ***,Jessica Quintin,and Jos *** der Meer in a‘Perspective’article in 2011[2].With the publication of vast amounts of experimental data and follow-up reviews,the concept that the innate immune system can develop a memory function in parallel to the well-recognized adaptive memory,mediated by B and T lymphocytes,is largely accepted.

关键词： Jess immunity generation

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Organic bases as additives for steam-assisted gravity drainage

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Petroleum Science 2019年第6期16卷 1332-1343页

作者： Sean d.Brame Litan Li Biplab Mukherjee Pramod d.patil Stephanie Potisek Quoc P.Nguyen Petroleum and Geosystems Engineering department The University of Texas at Austin200 E.Dean KeetonAustinTX 78712USA The dow Chemical Company 230 Abner Jackson PkwyECB 2A183Lake JacksonTX 77566USA

Steam-assisted gravity drainage(SAGd)is a mature technology for bitumen recovery from oil ***,it is an energy-intensive process that requires large amounts of steam to heat and mobilize *** purpose of this work is to develop ways to enhance SAGd performance through the use of organic base *** research is approached from three focus areas that supplement and guide each other:characterization tests,sand-pack floods,and computational simulation.A number of key mechanisms for enhancing oil recovery were identified,high-temperature additive characterization tests were developed,and promising alkalis were tested in porous *** was employed to history-match sandpack flood production data,in order to demonstrate the effect of an additive on the oil–water relative *** on these results,it was concluded that oxygenated organic bases had the most potential for improving bitumen recovery through reducing the oil–water interfacial tension(IFT)by increasing the pH of the *** organic bases favorably modify the interfacial energies between the immiscible oil–water phases and enable them to flow easily through the porous media during ***-pack flood tests have successfully demonstrated a 10%–15%improvement in bitumen recovery,over baseline,in the presence of IFT-reducing *** results further showed that an IFT reduction had a positive impact on SAGd *** work demonstrates the potential of organic bases to improve not only SAGd,but other steam injection ***,a number of experimental methods were developed,tried,and tested during the course of this work.

关键词： Heavy oil Steam flood Low interfacial tension Wettability Enhanced oil recovery Organic bases

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Potential of herbal constituents as new natural leads against helminthiasis: A neglected tropical disease

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Asian Pacific Journal of Tropical Medicine 2019年第7期12卷 291-299页

作者： Kiran d.patil Shashikant B.Bagade Sanjay R.Sharma Ketan V.Hatware NMIMS School of Pharmacy and Technology Management

The WHO reports that billions of people and animals in tropical and subtropical regions are affected by helminthiasis as neglected tropical disease. It is predominant in underdeveloped areas;nevertheless, the increase in the number of travelers and migrants has made this infection more common. The current mass drug treatment produces severe side effects and many strains of helminths are resistant to them. None of the chemotherapeutic drugs meets the ideal requirements of anthelmintics, such as broad spectrum of activity, single dose cure, free from side effect and cost-effectiveness. Today, many researchers are screening the traditional herbal system in search of the anthelmintic herbal constituents which overcome all the problems of synthetic drugs. Several researchers proclaim anthelmintic activity of herbal medicines by using different experimental models. The present review demonstrates natural product drug discovery, outlining potential of herbal constituents from natural sources as natural leads against helminthiasis.

关键词： Neglected tropical diseases Herbal constituents Helminthiasis Herbal anthelmintics

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Pharmaceutical and nutraceutical potential of natural bioactive pigment:astaxanthin

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Natural Products and Bioprospecting 2022年第1期12卷 367-392页

作者： Apurva d.patil Pramod J.Kasabe Padma B.dandge department of Biochemistry Shivaji UniversityKolhapur 416004Maha-rashtraIndia School of Nanoscience and Biotechnology Shivaji UniversityKolhapurMaharashtraIndia

Astaxanthin(3,3′-dihydroxy-β,β-carotene-4,4′-dione)is an orange-red,lipophilic keto-carotenoid *** is majorly found in marine ecosystems particularly in aquatic animals such as salmon,shrimp,trout,krill,crayfish,and so *** is also synthesized in microalgae Heamatococcus pluvialis,Chlorococcum,Chlorella zofingiensis,red yeast Phaffia rhodozyma and bacterium Paracoccus *** aquatic and terrestrial creatures regarded as a primary and secondary sources of the astaxanthin producing and accumulating it through their metabolic ***-anthin is the powerful antioxidant,nutritional supplement as well as promising therapeutic compound,observed to have activities against different ravaging diseases and *** have reported remarkable bioactivities of astaxanthin against major non-communicable chronic diseases such as cardiovascular diseases,cancer,diabetes,neurodegenerative,and immune *** current review discusses some structural aspects of *** fur-ther elaborates its multiple potencies such as antioxidant,anti-inflammatory,anti-proliferative,anti-cancer,anti-obese,anti-diabetic,anti-ageing,anti-TB,anti-viral,anti-COVId 19,neuro-protective,nephro-protective,and fertility-enhanc-ing *** potencies make it a more precious entity in the preventions as well as treatments of prevalent systematic diseases and/or ***,the review is acknowledging and documenting its powerful bioactivities in relation with the pharmaceutical as well as nutraceutical applicability.

关键词： Astaxanthin Nutritional supplement Therapeutic compound Chronic diseases Fertility enhancer

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decoding bovine coronavirus immune targets:an epitope informatics approach

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Animal diseases 2024年第2期4卷 138-153页

作者： Swati Rani Mehnaj Khatoon Jagadish Hiremath Kuralayanapalya Puttahonnappa Suresh Jayashree Anandakumar Nagendra Nath Barman Sheethal Manjunath Yamini Sri S Sharanagouda S.patil Spatial Epidemiology Lab ICAR-National Institute of Veterinary Epidemiology and Disease InformaticsYelahankaBengaluruKarnataka 560064India College of Veterinary Science Assam Agricultural UniversityGuwahatiAssam 785013India Yuvaraja’s College Mysuru University of MysuruMysuruKarnataka 570005India

Bovine coronavirus(BCoV)poses a significant threat to the global cattle industry,causing both respiratory and gastrointestinal infections in cattle *** necessitates the development of efficacious *** several inactivated and live BCoV vaccines exist,they are predominantly limited to *** immunization of adult cattle is imperative for BCoV infection control,as it curtails viral transmission to calves and ameliorates the impact of enteric and respiratory ailments across all age groups within the *** study presents an in silico methodology for devising a multiepitope vaccine targeting *** spike glycoprotein(S)and nucleocapsid(N)proteins,which are integral elements of the BCoV structure,play pivotal roles in the viral infection cycle and immune *** constructed a remarkably effective multiepitope vaccine candidate specifically designed to combat the BCoV *** immunoinformatics technology,B-cell and T-cell epitopes were predicted and linked together using linkers and adjuvants to efficiently trigger both cellular and humoral immune responses in *** in silico construct was characterized,and assessment of its physicochemical properties revealed the formation of a stable vaccine *** 3d modeling of the vaccine construct,molecular docking revealed a stable interaction with the bovine receptor ***,the viability of the vaccine’s high expression and simple purification was demonstrated by codon optimization and in silico cloning expression into the pET28a(+)*** applying immunoinformatics approaches,researchers aim to better understand the immune response to bovine coronavirus,discover potential targets for intervention,and facilitate the development of diagnostic tools and vaccines to mitigate the impact of this virus on cattle health and the livestock *** anticipate that the design will be useful as a preventive treatment for BCoV sickness in cattle,opening the door for furthe

关键词： Immunoinformatics Bovine coronavirus Multiepitope vaccine Molecular docking In silico cloning

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On-Line defect detection of Aluminum Coating Using Fiber Optic Sensor

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Photonic Sensors 2015年第1期5卷 72-78页

作者： Supriya S. patil A. d. SHALIGRAM department of Electronic Science Abasaheb Garware College Pune India department of Electronic Science University of Pune Pune India

Aluminum metallization using the sprayed coating for exhaust mild steel （MS） pipes of tractors is a standard practice for avoiding rusting. Patches of thin metal coats are prone to rusting and are thus considered as defects in the surface coating. This paper reports a novel configuration of the fiber optic sensor for on-line checking the aluminum metaUization uniformity and hence for defect detection. An optimally chosen high bright 440 nm BLUE LEd （light-emitting diode） launches light into a transmitting fiber inclined at the angle of 60° to the surface under inspection placed adequately. The reflected light is transported by a receiving fiber to a blue enhanced photo detector. The metallization thickness on the coated surface results in visually observable variation in the gray shades. The coated pipe is spirally inspected by a combination of linear and rotary motions. The sensor output is the signal conditioned and monitored with RISHUBH dAS. Experimental results show the good repeatability in the defect detection and coating non-uniformity measurement.

关键词： Fiber optic sensors on-line defect detection aluminum coating corrosion resistance color detection,exhaust pipes of vehicles

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