Nanoemulsion containing a synergistic combination of curcumin and quercetin for nose-to-brain delivery:In vitro and in vivo studies
作者机构：r.3.patel institute of pharmaceutical education and researchshirpurdist-dhule(m.s)india
出 版 物：《Asian Pacific Journal of Tropical Biomedicine》 (亚太热带生物医学杂志（英文版）)
年 卷 期：2021年第11卷第11期
页 面：510-518页
核心收录：
学科分类：1008[医学-中药学(可授医学、理学学位)] 1006[医学-中西医结合] 1002[医学-临床医学] 100602[医学-中西医结合临床] 10[医学]
主 题：Curcumin Quercetin Nanoemulsion Brain tumor Synergism
摘 要：Objective:To characterize a nanoemulsion containing a synergistic combination of curcumin(CUR)and quercetin(QUE)for brain targeting through the ***:The synergistic activity of the combination of two phytoconstituents,curcumin and quercetin(CUR-QUE)was determined at a 2:1 *** containing the synergistic combination were prepared using high-pressure homogenization *** formulation was characterized for globule size,drug content,thermodynamic stability,zeta potential measurement,and drug *** studies were performed using isolated nasal mucosa of ***,in vivo studies using allograft model were ***:CUR-QUE in a 2:1 ratio combination showed the lowest combination index values 0.99(combination index1)for treatment of human glioblastoma U373-MG *** combination inhibited the growth of human glioblastoma U373 MG *** significant drug targeting efficiency percentage(178.25±2.86 for CUR and 170.54±6.11 for QUE)and nose to brain drug direct transport percentage(44.05±0.93 for CUR and 38.25±0.83 for QUE)of optimized nanoemulsion(F9)indicated effective central nervous system targeting via the intranasal *** vivo anticancer study using allograft model of nude mice demonstrated potential anticancer activity of the synergistic combination of CUR-QUE as compared to ***:This study demonstrates that synergistic combination of CUR-QUE was optimal for treatment of human ***,significant site-specific delivery to the brain was achieved by administering nanoemulsion through the *** study also reveals that intranasal delivery of nanoemulsion containing synergistic combination of CUR and QUE could be a promising strategy for brain tumor treatment.
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