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Vein of Galen aneurismal malformations-clinical characteristics,treatment and presentation: Three cases report

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World Journal of Clinical Cases 2019年第7期7卷 855-862页

作者： Peter Spazzapan Zoran milosevic Tomaz Velnar Department of Neurosurgery University Medical Centre Ljubljana Department of Radiology University Medical Centre Ljubljana

BACKGROUND The vein of Galen aneurismal malformations(VGAM) are rare arteriovenous malformations of the embryonic choroid plexus. They represent about 30% of paediatric neurovascular disorders and show diverse characteristics. The VGAM is constituted by a midline dilated venous structure that receives blood from abnormal macroscopic or microscopic arteriovenous shunting vessels. Two types of VGAM exist, the choroidal and the mural. The treatment represents a challenge with the therapeutic objective to preserve the normal brain development without creating new neurological *** SUMMARY We present three cases of VGAM in the early postnatal period and their treatment. All patents were treated with the endovascular technique, which was successful. According to our experience, the endovascular technique is a safe and efficient mode of VGAM *** The objective of treatment aims to child's normal neurological development. A proper selection of patients and a thorough diagnostic workup is of vital importance. When the endovascular treatment is performed, the primary aim is not a complete VGAM exclusion at one time, which could produce a sudden reversal of blood flow with consequent venous infarction and ischemia. The aim is therefore to occlude as much of the VGAM as needed to relieve the congestive cardiac failure, to gain time and to create the conditions for a normal maturation of the neurovascular system. With the use of endovascular techniques, which represent not only the first choice of treatment but also the only safe therapeutic modality, the natural history of VGAM and their risks may be avoided safely.

关键词： Vein of Galen Aneurismal malformation Children Treatment Case reports

Insights into hepatitis E virus epidemiology in Croatia

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World Journal of Gastroenterology 2022年第37期28卷 5494-5505页

作者： Pavle Jelicic Thomas Ferenc Anna Mrzljak Lorena Jemersic natasa Janev-Holcer Milan milosevic Maja Bogdanic Ljubo Barbic Branko Kolaric Vladimir Stevanovic Mateja Vujica Zeljka Jurekovic Jadranka Pavicic Saric Maja Vilibic Tatjana Vilibic-Cavlek Department of Environmental Health Croatian Institute of Public HealthZagreb 10000Croatia Department of Radiology Merkur University HospitalZagreb 10000Croatia Department of Gastroenterology and Hepatology University Hospital Center ZagrebZagreb 10000Croatia School of Medicine University of ZagrebZagreb 10000Croatia Department of Virology Croatian Veterinary InstituteZagreb 10000Croatia Department of Social Medicine and Epidemiology Faculty of Medicine University of RijekaRijeka 51000Croatia Department of Occupational and Environmental Health Andrija Stampar School of Public HealthZagreb 10000Croatia Department of Virology Croatian Institute of Public HealthZagreb 10000Croatia Department of Microbiology and Infectious Diseases with Clinic Faculty of Veterinary Medicine University of ZagrebZagreb 10000Croatia Department of Gerontology and Social Medicine Andrija Stampar Teaching Institute of Public HealthZagreb 10000Croatia Institute of Emergency Medicine of Krapina-Zagorje County Krapina 49000Croatia Department of Nephrology Merkur University HospitalZagreb 10000Croatia Department of Anesthesiology University Hospital MerkurZagreb 10000Croatia Department for Social Psychiatry Psychotherapy and PsychodiagnosticsUniversity Clinical Hospital Center“Sestre Milosrdnice”Zagreb 10000Croatia

BACKGROUND Hepatitis E virus(HEV)is an emerging virus of global health *** seroprevalence rates differ greatly according to geographic region and population *** To analyze the seroprevalence of HEV in exposed(animal-related professions)and nonexposed populations,as well as solid organ and hematopoietic stem cell transplant *** Forestry workers(n=93),hunters(n=74),and veterinarians(n=151)represented the exposed *** general population(n=126)and pregnant women(n=118)constituted the control *** patients included liver transplant recipients(LTRs)(n=83),kidney transplant recipients(KTRs)(n=43),and hematopoietic stem cell transplant recipients(HSCRs)(n=39).HEV immunoglobulin G antibodies were detected using the enzyme-linked immunosorbent assay and confirmed by the immunoblot *** The HEV seroprevalence significantly differed between groups:Veterinarians 15.2%,hunters 14.9%,forestry workers 6.5%,general population 7.1%,and pregnant women 1.7%.In transplant patients,the seropositivity was highest in LTRs(19.3%),while in KTRs and HSCRs,the seroprevalence was similar to the general population(6.9%and 5.1%,respectively).A significant increase in seropositivity with age was observed from 2.9%in individuals less than 30 years to 23.5%in those older than 60 *** characteristics(sex,educational level,area of residence,and number of household members),eating habits(game meat,offal,and pork products consumption),and environmental and housing conditions(drinking water supply,type of water drainage/sewer,waste disposal,domestic animals)were not associated with HEV ***,individuals who reported a pet ownership were more often seropositive compared to those who did not have pet animals(12.5%vs 7.0%).CONCLUSION The results of this study showed that individuals in professional contact with animals and LTRs are at higher risk for HEV *** addition,age is a significant risk factor for HEV

关键词： Hepatitis E virus Seroprevalence Veterinarians Hunters Forestry workers Transplant patients Croatia

Laparoscopic liver resection: Current role and limitations

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World Journal of Gastrointestinal Oncology 2012年第8期4卷 187-192页

作者： Rouzbeh Mostaedi Zoran milosevic Ho-Seong Han Vijay P Khatri Department of Surgery University of California Davis Cancer Center University of CaliforniaDavis Medical Center Sacramento CA 95817 United States Clinic for Abdominal Endocrine and Transplantation Surgery Clinical Center Vojvodina21000 Novi Sad Serbia Department of Surgery Seoul National University Bundang Hospital Seoul National University College of Medicine300 Gumi-dong Bundang-gu Seongnam-si Gyeonggi-do 463-707 South Korea

Laparoscopic liver resection (LLR) for the treatment of benign and malignant liver lesions is often performed at specialized centers. Technological advances, such as laparoscopic ultrasonography and electrosurgical tools, have afforded surgeons simultaneous improvements in surgical technique. The utilization of minimally invasive techniques for liver resection has been reported to reduce operative time, decrease blood loss, and shorten length of hospital stay with equivalent postoperative mortality and morbidity rates compared to open liver resection (OLR). Non-anatomic liver resection and left lateral sectionectomy are now routinely performed laparoscopically at many institutions. Furthermore, major hepatic resections are performed by pure laparoscopy, hand-assisted technique, and the hybrid method. In addition, robotic surgery and single port surgery are revealing early promising results. The consensus recommendation for the treatment of benign liver disease and malignant lesions remains unchanged when considering a laparoscopic approach, except when comorbidities and anatomic limitations of the liver lesion preclude this technique. Disease free and survival rates after LLR for hepatocellular carcinoma and metastatic colon cancer correspond to OLR. Patient selection is a significant factor for these favorable outcomes. The limitations include LLR of superior and posterior liver lesions; however, adjustments in technique may now consider a laparoscopic approach as a viable option. As growing data continue to reveal the feasibility and efficacy of laparoscopic liver surgery, this skill is increasingly being adopted by hepatobiliary surgeons. Although the full scope of laparoscopic liver surgery remains infrequently used by many general surgeons, this technique will become a standard in the treatment of liver diseases as studies continue to show favorable outcomes.

关键词： Laparoscopic liver resection Laparoscopic hepatectomy Minimally invasive liver surgery Handassisted technique Hybrid technique

Preventing post-endoscopic retrograde cholangiopancreatography pancreatitis: What can be done?

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World Journal of Gastroenterology 2015年第4期21卷 1069-1080页

作者： Goran Hauser Marko milosevic Davor Stimac Enver Zerem Predrag Jovanovi? Ivana Blazevic Department of Internal Medicine Division of GastroenterologyClinical Hospital Centre Rijeka51000 RijekaCroatia Department of Anaesthesiology Clinical Hospital Centre Rijeka51000 RijekaCroatia Department of Gastroenterology University Clinical Center TuzlaTrnovac bb75000 TuzlaBosnia and Herzegovina Center for Emergency Medicine Clinical Hospital Centre Rijeka51000 RijekaCroatia

Post-endoscopic retrograde cholangiopancreatographypancreatitis(PEP) is the most common complication of endoscopic retrograde cholangiopancreatography. The incidence of post-endoscopic retrograde cholangiopancreatography(ERCP) pancreatitis varies substantially and is reported around 1%-10%, although there are some reports with an incidence of around 30%. Usually, PEP is a mild or moderate pancreatitis, but in some instances it can be severe and fatal. Generally, it is defined as the onset of new pancreatictype abdominal pain severe enough to require hospital admission or prolonged hospital stay with levels of serum amylase two to three times greater than normal, occurring 24 h after ERCP. Several methods have been adopted for preventing pancreatitis, such as pharmacological or endoscopic approaches. Regarding medical prevention, only non-steroidal anti-inflammatory drugs, namely diclofenac sodium and indomethacin, are recommended, but there are some other drugs which have some potential benefits in reducing the incidence of post-ERCP pancreatitis. Endoscopic preventive measures include cannulation(wire guided) and pancreatic stenting, while the adoption of the early pre-cut technique is still arguable. This review will attempt to present and discuss different ways of preventing post-ERCP pancreatitis.

关键词： Endoscopic retrograde cholangiopancreatography Pos

Problems in screening colorectal cancer in the elderly

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World Journal of Gastroenterology 2003年第10期9卷 2335-2337页

作者： DavidoviM.Mladen milosevic P.Dragoslav Zdravkovic Sanja Bojic Bozidar Djurica Snezana Center of Geriatric Medicine 11050 BeogradRifata Burdzevica 31Yugoslavia

AIM:To explore the problems in the screening of colorecta carcinoma in the elderly. METHODS:Three models of colorectal cancer prevention were examined:standard screening,active check-up of suspected cases and summons to have endoscopic check- up for previously diagnosed colorectal *** study was performed among three groups of elderly individuals: Group 1 (167 cases),hospitalized asymptomatic individuals without symptoms in large *** 2 (612 cases): old individuals at home for the aged,out of which 32 showed symptoms of colon disorders;Group 3 (44 cases):elderly people with diagnosed *** a result of 1788 rectosigmoidoscopies,we identified 61 individuals with polyps,out of which 44 patients were over 65 years old. However,only 9 of these 44 individuals agreed to have the endoscopy performed again. RESULTS:One cancer and 13 polyps were detected in Group 1,and two polyps in Group ***,it should be noted that only eleven individuals from Group 2 agreed to have the *** Group 3,there were no relapses of the polyps among the nine individuals who came back for the endoscopy. CONCLUSION:Poor understanding of the screening procedures is one of the greatest problems in early detection of the cancer in the ***,the cooperation is better with hospitalized patients,than with 'successfully old' persons.

关键词： Aged Aged, 80 and over Colonic Polyps control Colonoscopy Colorectal Neoplasms Humans Mass Screening Motivation Patient Acceptance of Health Care Patient Compliance

Sub-leading flow modes in PbPb collisions at (~sNN)^(1/2) = 2.76 TeV from the HYDJET++ model

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Chinese Physics C 2017年第7期41卷 42-51页

作者： P.Cirkovic D.Devetak M.Dordevic J.milosevic M.Stojanovic University of Belgrade and Institute of physics P.O. Box 68 11081 Belgrade Serbia University of Belgrade and Vinca Institute of Nuclear Sciences P.O. Box 522 11001 Belgrade Serbia University of Oslo Department of Physics Oslo Norway

Recent LHC results on the appearance of sub-leading flow modes in Pb Pb collisions at 2.76 TeV, related to initial-state fluctuations, are analyzed and interpreted within the HYDJET＋＋ model. Using the newly introduced Principal Component Analysis（PCA） method applied to two-particle azimuthal correlations extracted from the model calculations, the leading and sub-leading flow modes are studied as a function of the transverse momentum（p T） over a wide centrality range. The leading modes of the elliptic（v2^（1）） and triangular（v3^（1）） flow calculated with the HYDJET＋＋ model reproduce rather well the v2 {2} and v3 {2} coefficients measured experimentally using the two-particle correlations. Within the p T 3 Ge V/c range, where hydrodynamics dominates, the sub-leading flow effects are greatest at the highest p T of around 3 Ge V/c. The sub-leading elliptic flow mode（v2^（2））, which corresponds to the n = 2 harmonic, has a small non-zero value and slowly increases from central to peripheral collisions, while the sub-leading triangular flow mode（v3^（2））, which corresponds to the n = 3 harmonic, is even smaller and does not depend on centrality. For n= 2, the relative magnitude of the effect measured with respect to the leading flow mode shows a shallow minimum for semi-central collisions and increases for very central and for peripheral collisions. For the n= 3 case, there is no centrality dependence. The sub-leading flow mode results obtained from the HYDJET＋＋model are in rather good agreement with the experimental measurements of the CMS Collaboration.

关键词： hydrodynamics flow initial-state fluctuations principal component analysis HYDJET++

Microbiota and viral hepatitis:State of the art of a complex matter

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World Journal of Gastroenterology 2021年第33期27卷 5488-5501页

作者： Ivana milosevic Edda Russo Ankica Vujovic Aleksandra Barac Olja Stevanovic Stefano Gitto Amedeo Amedei Clinic for Infectious and Tropical Diseases Clinical Centre of Serbia Faculty of MedicineUniversity of BelgradeBelgrade 101801Serbia Department of Experimental and Clinical Medicine University of FlorenceFirenze 50100Italy

Changes in gut microbiota influence both the gut and liver,which are strictly connected by the so-called“gut-liver axis”.The gut microbiota acts as a major determinant of this relationship in the onset and clinical course of liver *** to the results of several studies,gut dysbiosis is linked to viral hepatitis,mainly hepatitis C virus and hepatitis B virus *** bacteriaderived metabolites and cellular components are key molecules that affect liver function and modulate the pathology of viral *** studies showed that the gut microbiota produces various molecules,such as peptidoglycans,lipopolysaccharides,DNA,lipoteichoic acid,indole-derivatives,bile acids,and trimethylamine,which are translocated to the liver and interact with liver immune cells causing pathological ***,the existence of crosstalk between the gut microbiota and the liver and its implications on host health and pathologic status are essential factors impacting the etiology and therapeutic *** mechanisms behind the pathogenic role of gut-derived components on the pathogenesis of viral hepatitis remain unclear and not *** this review,we discuss the current findings of research on the bidirectional relationship of the components of gut microbiota and the progression of liver diseases and viral hepatitis and vice ***,this paper highlights the current therapeutic and preventive strategies,such as fecal transplantation,used to restore the gut microbiota composition and so improve host health.

关键词： Gut microbiota Hepatitis B virus Hepatitis C virus Liver diseases,Fecal transplantation

Gut peptide changes in patients with obstructive jaundice undergoing biliary drainage:A prospective case control study

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World Journal of Clinical Cases 2022年第17期10卷 5551-5565页

作者： Tajana Pavic Stipe Pelajic Nina Blazevic Dominik Kralj Milan milosevic Ivana Mikolasevic Ivan Lerotic Davor Hrabar Department of Gastroenterology and Hepatology University Hospital Center Sestre MilosrdniceZagreb 10000Croatia Andrija Stampar School of Public Health WHO Collaborative Centre for Occupational Health University of ZagrebSchool of MedicineZagreb 10000Croatia Department of Gastroenterology University Hospital Center RijekaRijeka 51000Croatia

BACKGROUND Biliary obstruction is a relatively common condition that affects approximately 5 in 1000 people *** is very common in patients with biliary obstruction and since it is associated with significant morbidity and mortality,it is important to identify factors and mechanisms involved in its *** To determine the influence of obstructive jaundice on the hormones controlling appetite and nutritive *** This was a prospective case control study performed in a tertiary center in Zagreb,*** with biliary obstruction undergoing internal biliary drainage from September 2012 until August 2013 were *** excluding patients who developed procedure related complications or were lost in the follow-up,out of initial 73 patients,55 patients were included in the analysis,including 34 with benign and 21 with malignant ***,40 non-jaundiced controls were also ***,nutritional status,and serum ghrelin,cholecystokinin(CCK),interleukin 6(IL-6),and tumor necrosis factorα(TNF-α)were determined at admission,48 h and 28 d after internal biliary *** square test was used for categorical *** variables were analysed for normality by Kolmogorov-Smirnov test and relevant non-parametric(Mann-Whitney,Kruskal-Wallis,and Friedman)or parametric(t-test and analysis of variance)tests were *** Patients with obstructive jaundice were significantly malnourished compared to controls,regardless of disease *** ghrelin and CCK levels were significantly higher in patients with obstructive *** bilirubin concentrations were negatively correlated with ghrelin levels and positively correlated with TNF-α,but had no correlation with CCK *** internal biliary drainage,a significant improvement of nutritional status was observed although serum concentrations of ghrelin,IL-6,and TNF-α remained significantly elevated even 28 d after the *** level

关键词： Ghrelin Cholecystokinin Biliary obstruction Malnutrition

Subchronic Oral Cadmium Exposure Exerts both Stimulatory and Suppressive Effects on Pulmonary Inflammation/Immune Reactivity in Rats

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Biomedical and Environmental Sciences 2019年第7期32卷 508-519页

作者： KULAS Jelena NINKOV Marina TUCOVIC Dina POPOV Aleksandrov Aleksandra UKROPINA Mirela CAKIC milosevic Maja MUTIC Jelena KATARANOVSKI Milena MIKROV Ivana Immunotoxicology group Department of Ecology Institute for Biological Research 'Sinisa Stankovic ' University of Belgrade 142 Bulevar despota Stefana Belgrade 11000 Serbia Institute of Zoology Faculty of Biology University of Belgrade 16 Studentskitrg Belgrade 11000 Serbia Innovation center of the Faculty of Chemistry University of Belgrade 12-16 Studentskitrg 11000 Belgrade Serbia Institute of Physiology and Biochemistry Faculty of Biology University of Belgrade 16 Studentskitrg Belgrade 11000 Serbia

Objective The aim of this study is to investigate the effects of oral cadmium(Cd) ingestion on the pulmonary immune response. Methods Determination of Cd content in lungs and histopathological evaluation of the tissue was performed in rats following 30-day oral Cd administration(5 and 50 mg/L). Antioxidant enzyme defense(superoxide dismutase and catalase), cell infiltration, and production of tumor necrosis factor(TNF) and interferon(IFN)-γ, as well as the activity of myeloperoxidase(MPO), nitric oxide(NO), and various cytokines [interleukin(IL)-1β, IL-6, IL-10, and IL-17] were investigated. Results Cd caused tissue damage and cell infiltration in the lungs, and this damage was more pronounced at higher doses. Cd deposition resulted in lung inflammation characterized by a dose-dependent IL-1β increase in lung homogenates, increased TNF levels at both doses, and IL-6 stimulation at low doses with inhibition observed at higher doses. Cd exerted differential effects on lung leukocytes isolated by enzyme digestion, and these effects were characterized by a lack of change in the production of reactive oxygen and nitrogen species, an inhibition of IL-1β and TNF, and stimulation of MPO and IFN-γ. The higher capacity of Cd-exposed lung cells to respond to the opportunistic pathogen Staphylococcus epidermidis was demonstrated in vitro. Conclusion The potential of ingested Cd to exert both proinflammatory and immunosuppressive effects on pulmonary tissue inflammation and immune reactivity highlights the complex immunomodulatory actions of this metal.

关键词： Rats Oral cadmium administration Lungs Cytokine response