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Th17 involvement in nonalcoholic fatty liver disease progression to non-alcoholic steatohepatitis

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World Journal of Gastroenterology 2016年第41期22卷 9096-9103页

作者： Carla Melisa Chackelevicius Sabrina Eliana Gambaro Claudio Tiribelli natalia Rosso Italian Liver Foundation Area Science Park

The nonalcoholic fatty liver disease(NAFLD) is the hepatic manifestation of the metabolic syndrome. NAFLD encompasses a wide histological spectrum ranging from benign simple steatosis to non-alcoholic steatohepatitis(NASH). Sustained inflammation in the liver is critical in this process. Hepatic macrophages, including liver resident macropaghes(Kupffer cells), monocytes infiltrating the injured liver, as well as specific lymphocytes subsets play a pivotal role in the initiation and perpetuation of the inflammatory response, with a major deleterious impact on the progression of fatty liver to fibrosis. During the last years, Th17 cells have been involved in the development of inflammation not only in liver but also in other organs, such as adipose tissue or lung. Differentiation of a na?ve T cell into a Th17 cell leads to pro-inflammatory cytokine and chemokine production with subsequent myeloid cell recruitment to the inflamed tissue. Th17 response can be mitigated by T regulatory cells that secrete anti-inflammatory cytokines. Both T cell subsets need TGF-β for their differentiation and a characteristic plasticity in their phenotype may render them new therapeutic targets. In this review, we discuss the role of the Th17 pathway in NAFLD progression to NASH and to liver fibrosis analyzing different animal models of liver injury and human studies.

关键词： Th17 Interleukin-17 Nonalcoholic fatty liver disease Non-alcoholic steatohepatitis Inflammation

Clarifying sub-genomic positions of QTLs for flowering habit and fruit quality in U.S. strawberry (Fragaria×ananassa) breeding populations using pedigree-based QTL analysis

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Horticulture Research 2017年第1期4卷 85-93页

作者： Sujeet verma Jason D Zurn natalia Salinas Megan M Mathey Beatrice Denoyes James F Hancock Chad E Finn Nahla v Bassil vance M Whitaker IFAS/Department of Horticulture University of FloridaGulf Coast Research and Education Center14625 CR 672Wimauma33598FLUSA USDA-ARS National Clonal Germplasm Repository 33447 Peoria RoadCorvallis97333ORUSA Department of Horticulture Oregon State University4017 Agriculture and Life Sciences BuildingCorvallis97331ORUSA Department of Horticulture UMR 1332 Biologie du Fruit et PathologieINRAUniv.BordeauxVillenave d’OrnonF-33140France Michigan State University East Lansing48824MIUSA USDA-ARS HCRU3420 NW Orchard AvenueCorvallis97330ORUSA

The cultivated strawberry(Fragaria×ananassa)is consumed worldwide for its flavor and nutritional *** analysis of commercially important traits in strawberry are important for the development of breeding methods and tools for this *** several quantitative trait loci(QTL)have been previously detected for fruit quality and flowering traits using low-density genetic maps,clarity on the sub-genomic locations of these QTLs was *** discoveries in allo-octoploid strawberry genomics led to the development of the IStraw90 single-nucleotide polymorphism(SNP)array,enabling high-density genetic maps and finer resolution QTL *** this study,breeder-specified traits were evaluated in the Eastern(Michigan)and Western(Oregon)United States for a common set of breeding populations during 2 *** QTLs were validated for soluble solids content(SSC),fruit weight(FWT),pH and titratable acidity(TA)using a pedigree-based QTL analysis *** fruit quality,a QTL for SSC on linkage group(LG)6A,a QTL for FWT on LG 2BII,a QTL for pH on LG 4CII and two QTLs for TA on LGs 2A and 5B were *** addition,a large-effect QTL for flowering was detected at the distal end of LG 4A,coinciding with the FaPFRU *** haplotype analysis in the FaPFRU region indicated that the homozygous recessive genotype was highly predictive of seasonal *** probes in the FaPFRU region may help facilitate marker-assisted selection for this trait.

关键词： breeding straw Fragaria

Liver as a target of human immunodeficiency virus infection

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World Journal of Gastroenterology 2018年第42期24卷 4728-4737页

Liver injury is a characteristic feature of human immunodeficiency virus(HIv) infection, which is the second most common cause of mortality in HIv-infected patients. Now it is recognized that liver plays a key role in HIv infection pathogenesis. Antiretroviral therapy(ART), which suppresses HIv infection in permissive immune cells, is less effective in hepatocytes, thereby making these cells a silent reservoir of HIv infection. In addition to direct hepatotoxic effects of HIv, certain ART treatment modalities provide hepatotoxic effects. The exact mechanisms of HIv-triggered chronic hepatitis progression are not elucidated, but the liver is adversely affected by HIv-infection and liver cells are prominently involved in HIv-elicited injury. These effects are potentiated by second hits like alcohol. Here, we will focus on the incidence of HIv, clinical evidence of HIvrelated liver damage, interactions between HIv and liver cells and the role of alcohol and co-infection with hepatotropic viruses in liver inflammation and fibrosis progression.

关键词： Liver cells Antiretroviral therapy Apoptosis Inflammation Fibrosis Immunodeficiency virus Alcohol

Magnetic field hyperactivity during the early Neoproterozoic: A paleomagnetic and cyclostratigraphic study of the Katav Formation, southern Urals, Russia

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Geoscience Frontiers 2023年第4期14卷 42-56页

作者： Inessa v.Golovanova Konstantin N.Danukalov Raushaniia Yu.Salmanova natalia M.Levashova Nikita P.Parfiriev Nina D.Sergeeva Joseph G.Meert Institute of Geology-Subdivision of the Ufa Federal Research Centre of the Russian Academy of Sciences(IG UFRC RAS) Russia Geological Institute Russian Academy of SciencesMoscowRussia Department of Earth and Planetary Sciences Neil Opdyke Paleomagnetic LaboratoryUniversity of FloridaGainesvilleFL 32611United States

We present a detailed magnetostratigraphic and cyclostratigraphic profile through the Riphean(Tonian)Katav Formation in the southern *** study confirms the primary nature of the magnetization in these *** cyclostratigraphic study identified several orbital periods including the 405 ka long *** allows us to quantify the reversal frequency in the Katav and our estimates range of 7–12 reversals per million *** on our study,we identify an interval of magnetic field reversal hyperactivity in the Neoproterozoic *** estimates for the Katav are contentious and range somewhere between 800 Ma and 900 Ma based on carbonate Pb-Pb ages and stable isotope *** paleomagnetic poles obtained in this study of the Katav(and overlying Inzer)Formation do not fit anywhere on the Baltica apparent polar wander path between 1100 Ma and 900 ***,they lie 90away from the 900 Ma segment of the *** tentatively estimate their age to be closer to 800 Ma and perhaps confirm a previously hypothesized pulse of rapid true polar wander between 825 Ma and 790 Ma.

关键词： Magnetostratigraphy Cyclostratigraphy Hyperactive reversal True polar wander Tonian

The characteristic pattern of multiple colored layers in coastal stratified lakes in the process of separation from the White Sea

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Journal of Oceanology and Limnology 2018年第6期36卷 1962-1977页

作者： Elena D.KRASNOvA Dmitry N.MATORIN Tatiana A.BELEvICH Ludmila E.EFIMOvA Anastasiia v.KHARCHEvA natalia M.KOKRYATSKAYA Galina N.LOSYUK Daria A.TODORENKO Dmitry A.vORONOv Svetlana v.PATSAEvA Biological Faculty of Lomonosov Moscow State University Leninskye Gory 1bld.12Moscow 119234Russia Faculty of Geography Lomonosov Moscow State University GSP-1 Leninskye Gory1Moscow 119991Russia Faculty of Physics Lomonosov Moscow State UniversityLeninskye Gory1Moscow 119991Russia N.Laverov Federal Center for Integrated Arctic Research Russian Academy of SciencesSevernoj Dviny Emb.23Arkhangelsk 163000Russia A.A.Kharkevich Institute for Information Transmission Problems Russian Academy of SciencesBolshoy Karetny Per.19bld.1Moscow 127051Russia A.N.Belozersky Institute of Physico-Chemical Biology Lomonosov Moscow State UniversityLeninskye Gory1Bld.40Moscow 119991Russia

An unusual feature of the saline stratified lakes that were formed due to ongoing postglacial uplift on the White Sea coast is the presence of several differently colored thin layers in the zone with sharp gradients. Colored layers in five lakes at various stages of separation from the sea were investigated using optical microscopy, spectrophotometry, spectrofluorimetry, and photobiology. The upper greenish colored layer located in the aerobic strata of all lakes near the compensation depth of 1% light penetration contains green algae. In the chemocline, another layer, brightly green, red or pink, is dominated by mixotrophic flagellates. Despite the very low light intensities and the presence of H 2 S, active photosynthesis by these algae appears to be occurring, as indicated by high values of the maximum quantum yield of primary photochemistry, electron transport activity, photosynthetic activity of photosystem II, the fraction of active centers, and low values of heat dissipation. In the reduced zone of the chemocline, a dense green or brown suspension of anoxygenic phototrophs(green sulfur bacteria) is located.

关键词： algal blooms coastal lakes chemocline fluorescence kinetics Arctic White Sea

Atrial fibrillation among Russian men and women aged 55 years and older:prevalence,mortality,and associations with biomarkers in a population-based study

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Journal of Geriatric Cardiology 2020年第2期17卷 74-84页

作者： Maria A.Shkolnikova Dmitri A.Jdanov Rukizhat A.Ildarova natalia v.Shcherbakova Ekaterina B.Polyakova Evgeny N.Mikhaylov Svetlana A.Shalnova vladimir M.Shkolnikov veltischev Research and Clinical Institute for Pediatrics of the Pirogov Russian National Research Medical University MoscowRussian Federation Laboratory of Demographic Data Max Planck Institute for Demographic ResearchRostockGermany International Laboratory for Population and Health Research University Higher School of EconomicsMoscowRussian Federation Arrhythmia Department and Neuromodulation Laboratory Almazov National Medical Research CentreSaint-PetersburgRussian Federation National Research Center for Preventive Medicine MoscowRussian Federation

Objective To examine the prevalence of atrial fibrillation(AF),its impacts on cardiovascular disease(CvD)and all-cause mortality,and the associations between AF and inflammatory and serum biomarkers in a population-based sample of *** The study is a secondary analysis of data from the Stress,Aging and Health in Russia(SAHR)survey that includes information on 1800 individuals with an average age of 68.5 years at baseline,and on their subsequent mortality during 7.4 years on *** is detected by 12-lead electrocardiogram(ECG)and 24-hour Holter *** statistical analysis includes proportional hazard and logistic regression *** Of the 1732 participants with relevant Holter data,AF was detected in 100(74 by ECG and Holter,26 by Holter only).The prevalence of AF was 5.8%for men and 7.4%for *** fully adjusted model showed strongly elevated hazard of CvD and all-cause mortality in men and women with long non-self-limiting AF(LAF).LAF was found to be negatively associated with elevated total and lowdensity lipoprotein cholesterol and to be positively associated with elevated markers of inflammation in *** The study assessed for the first time the prevalence and the risks of death related to AF among older *** was shown to be a strong and independent predictor of CvD and all-cause *** is unlikely to contribute to the large excess male mortality in *** finding that one-quarter of AF cases were detected only by Holter monitoring demonstrates the usefulness of diagnostics with prolonged ECG registration.

关键词： Aging Atrial fibrillation Gender differences Holter monitoring Mortality Prevalence

Russian Collaborative Development of Reproduction Technologies for the Sustainable Management of Amphibian Biodiversity

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Asian Herpetological Research 2023年第1期14卷 103-115页

作者： victor K.UTESHEv Edith N.GAKHOvA Ludmila I.KRAMAROvA natalia v.SHISHOvA Svetlana A.KAUROvA Elena A.KIDOvA Artem A.KIDOv Robert K.BROWNE Institute of Cell Biophysics Russian Academy of SciencesPushchinoMoscow 142290Russia Institute of Theoretical and Experimental Biophysics Russian Academy of SciencesPushchinoMoscow 142290Russia Russian State Agrarian University-K.A.Timiryazev Agricultural Academy Moscow 127550Russia Sustainability America La Isla RoadCorozal DistrictBelize

Reproduction technologies(RTs)can provide for the reliable reproduction of amphibians,as well as perpetuation of species genetic variation with the use of *** 1982,in anticipation of the biodiversity conservation crisis,major Russian institutions collaborated in a dynamic program to develop and implement RTs for the sustainable management of amphibian *** initial primary focus was the captive breeding of threatened Russian endemic anuran and caudate species,using RTs that varied from environmental manipulation to the use of exogenous gonadotropic hormones to stimulate *** species were mostly from Palearctic or cool mountain regions,but also included a wide range of species from warm *** early achievements included the successful cryopreservation of anuran spermatozoa and anuran diploid pluripotent cell nuclei,in order to store both the matrilineal and patrilineal genomes in biobanks,with their subsequent development to the blastula stage after implantation into enucleated *** the turn of the 21st Century,in support of the priorities of the Amphibian Conservation Action Plan(2007),we developed RTs for the refrigerated storage of testicular or urinary spermatozoa for days to weeks at 4℃,the cryopreservation of urinary spermatozoa using anovel cryoprotectant,the in vitro fertilisation of hormonally induced oocytes either fresh or after refrigerated ex situ or in situ storage,and the artificial insemination of salamanders with fresh *** this article,we describe previously unpublished techniques and techniques from obscure Russian sources.

关键词： artificial fertilisation assisted reproductive technologies(ART) cryopreservation gonadotropic hormones oocytes spermatozoa storage urinary spermatozoa

Seasonal Distribution of Manganese in the Soil-Water-Plant in the Zone of Burshtyn Thermal Power Station

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Journal of Physical Science and Application 2014年第5期4卷 317-322页

作者： Ivan v. Mazepa natalia v. Dovganich Maria A. Mazepa vasyl Stefanyk Precarpathian National University lvano-Frankivsk 76025 Ukraine

This study deals with the impact of Burshtyn thermal power station on the amount of manganese in soil, water and celandine tissue. The research of manganese amount and form in the system： water-plant is of great importance due to active influence of thermal power station on the chemical structure of the polluted area. The changes in the amount and form of manganese in soil, water and plant are interrelated and depend on the season, the distance from the polluter and morph-functional plant structure, the cleaning system possibilities of the industrial enterprise and some meteorological factors.

关键词： Soil water celandine gross and changeable manganese amount Burshtyn thermal power station.

A historical literature review of coronary microvascular obstruction and intra-myocardial hemorrhage as functional/structural phenomena

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The Journal of Biomedical Research 2023年第4期37卷 268-289页

作者： Leonid N.Maslov natalia v.Naryzhnaya Sergey v.Popov Alexandr v.Mukhomedzyanov Ivan A.Derkachev Boris K.Kurbatov Andrey v.Krylatov Feng Fu Jianming Pei vyacheslav v.Ryabov Evgenii v.vyshlov Svetlana v.Gusakova Alla A.Boshchenko Akpay Sarybaev Laboratory of Experimental Cardiology Cardiology Research InstituteTomsk National Research Medical Center of the Russian Academy of SciencesTomskTomsk Region 634012Russia Department of Physiology and Pathophysiology National Key Discipline of Cell BiologySchool of Basic Medicinethe Fourth Military Medical UniversityXi'anShaanxi 710032China Siberian State Medical University TomskTomsk Region 634050Russia National Center of Cardiology and Internal Medicine Bishkek 720040Kyrgyzstan.

The analysis of experimental data demonstrates that platelets and neutrophils are involved in the no-reflow phenomenon,also known as microvascular obstruction(MvO).However,studies performed in the isolated perfused hearts subjected to ischemia/reperfusion(I/R)do not suggest the involvement of microembolization and microthrombi in this *** intracoronary administration of alteplase has been found to have no effect on the occurrence of MvO in patients with acute myocardial ***,the major events preceding the appearance of MvO in coronary arteries are independent of microthrombi,platelets,and *** cells appear to be the target where ischemia can disrupt the endothelium-dependent vasodilation of coronary ***,reperfusion triggers more pronounced damage,possibly mediated by *** and intra-myocardial hemorrhage contribute to the adverse post-infarction myocardial ***,pharmacological agents used to treat MvO should prevent endothelial injury and induce relaxation of smooth *** conditioning protocols have been shown to prevent MvO,with L-type Ca2+channel blockers appearing the most effective in treating MvO.

关键词： heart ischemia reperfusion microvascular obstruction intra-myocardial hemorrhage