Human immunodeficiency virus and hepatotropic viruses comorbidities as the inducers of liver injury progression
Human immunodeficiency virus and hepatotropic viruses comorbidities as the inducers of liver injury progression作者机构：Research Service Veterans Affairs Nebraska-Western Iowa Health Care System Department of Internal MedicineUniversity of Nebraska Medical Center Department of Pharmacology and Experimental Neuroscience University of Nebraska Medical Center
出 版 物：《World Journal of Gastroenterology》 (世界胃肠病学杂志（英文版）)
年 卷 期：2019年第25卷第4期
页 面：398-410页
核心收录：
基 金：National Institutes of Health No.NIAAAK01AA026864
主 题：Human immunodeficiency virus Hepatitis C virus Hepatitis B virus Fibrosis Stiffness Treatment
摘 要：Hepatotropic viruses induced hepatitis progresses much faster and causes more liver-related health problems in people co-infected with human immunodeficiency virus(HIV). Although treatment with antiretroviral therapy has extended the life expectancy of people with HIV, liver disease induced by hepatitis B virus(HBV) and hepatitis C virus(HCV) causes significant numbers of non-acquired immune deficiency syndrome(AIDS)-related deaths in coinfected patients. In recent years, new insights into the mechanisms of accelerated fibrosis and liver disease progression in HIV/HCV and HIV/HBV co-infections have been reported. In this paper, we review recent studies examining the natural history and pathogenesis of liver disease in HIV-HCV/HBV co-infection in the era of direct acting antivirals(DAA) and antiretroviral therapy(ART). We also review the novel therapeutics for management of HIV/HCV and HIV/HBV coinfected individuals.
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