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Effects of Dexamethasone, clonidine, Tramadol and Nalbuphine on Fentanyl-Induced Hyperalgesia in Rats

Journal of Biosciences and Medicines 2021年第12期9卷 87-97页

作者： camila dos Santos Leite naira c.rreia c.sma pelógia Eliane Stevanato Marília Hidalgo Uchôas Marta Helena Rovani Pires Oscar césar Pires Laboratory of Immunopharmacology and Molecular Biology S&atilde o Francisco University Medical School Bragan&ccedil a Paulista Brazil Laboratory of cell and Molecular Tumor Biology and Bioactive compounds S&atilde o Francisco University Medical School Bragan&ccedil a Paulista Brazil Laboratory of Pharmacology and Physiology Medicine Department Taubaté University Taubaté Brazil Vera cruz Hospital Campinas Brazil

Opioids are drugs used to alleviate pain. However, studies have demonstrated that these drugs can cause an increase in pain sensitivity, which is called opioid-induced hyperalgesia. The objective of this study was to describe the effects of dexamethasone, clonidine, tramadol and nalbuphine on fentanyl-induced hyperalgesia in rats. After obtaining approval from the committee for the Ethical Use of Animals (cEUA), 36 male Wistar rats were divided into 6 groups: Group 1 (GcSSL) wherein the rats received 1 ml 0.9% saline solution in two injections;Group 2 (GFTSL), received fentanyl at a dose of 100 ug·kg-1 followed by 1 ml 0.9% saline solution via intraperitoneal;the remaining groups (3, 4, 5, 6) received fentanyl at a dose of 100 ug·kg-1 following doses via intraperitoneal: Group 3 (GFTDX), dexamethasone at a dose of 1.0 mg·kg-1;Group 4 (GFTcL), clonidine at a dose of 20 mg·kg-1;Group 5 (GFTTR), tramadol at a dose of 50 mg·kg-1, and Group 6 (GFTNB), nalbuphine at a dose of 5 mg·kg-1. Under general anestesia using isoflurane, the animals were submitted to a surgical incision. Hyperalgesia was evaluated by applying Von Frey filaments at 2 hours after the incision and on the 1st, 3rd and 5th days afterward. At 2 hours after the surgical procedure, there was lower intensity of pain in the fentanyl group (GFTSL) compared to the other groups, and on the fifth day there were no significant differences for pain intensity between groups. The results suggest the presence of fentanyl-induced hyperalgesia and efficacy in its reduction by dexamethasone, clonidine, tramadol and nalbuphine.

关键词： Hyperalgesia Fentanyl Dexamethasone clonidine Tramadol Nalbuphine Rats

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Effects of Ketoprofen, Ketamine, Lidocaine and Propofol on Fentanyl-Induced Hyperalgesia in Rats

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Journal of Biosciences and Medicines 2022年第7期10卷 53-63页

作者： camila dos Santos Leite naira c.rreia c.sma pelógia Eliane Stevanato Marília Hidalgo Uchôas Gabriela Apóstulo Silva Guilherme Apóstulo Silva carlos Augusto Pires Zerbini Marta Helena Rovani Pires Oscar césar Pires Laboratory of Immunopharmacology and Molecular Biology S&atilde o Francisco University Medical School Bragan&ccedil a Paulista Brazil Laboratory of cell and Molecular Tumor Biology and Bioactive compounds S&atilde o Francisco University Medical School Bragan&ccedil a Paulista Brazi Laboratory of Pharmacology and Physiology Medicine Department Taubaté University Taubaté Brazil Vera cruz Hospital Campinas Brazil

Opioid-induced hyperalgesia negatively affects physiological pain management and presents a complex causal mechanism, involving, pharmacodynamic and pharmacokinetic factors of interactions with receptors, opioid-independent ascending systems and with pro-nociceptive systems. After approval by the cEUA, 42 male Wistar rats were divided into 7 groups: In group 1 (GcSSL) the animals received 1 ml of 0.9% saline solution intraperitoneally (IP);in group 2 (GFTSL), they received fentanyl at a dose of 100 ug·kg-1 IP;in the remaining groups (3, 4, 5, 6 and 7) the animals received IP, fentanyl at a dose of 100 ug·kg-1 followed also by IP route of: group 3 (GFTKP) ketoprofen at a dose of 5 mg·kg-1;group 4 GFTKT), ketamine up to a dose of 10.0 mg·kg-1;group 5 (GFTLI), incisional lidocaine up to a dose of 10 mg·kg-1;group 6 (GFTLP), intraperitoneal lidocaine up to a dose of 10 mg·kg-1 and group 7 (GFTPP), propofol up to a dose of 60 mg·kg-1. Under general anesthesia, all animals with a plantar surgical incision. Hyperalgesia was evaluated by applying Von Frey filaments on the 2nd, 1st, 3rd and 5th days after treatment. In the 2nd hour and on the 5th day after the procedure, there was no hyperalgesia associated with the use of fentanyl, however, on the 1st and 3rd postoperative days there was hyperalgesia that was attenuated by ketoprofen, ketamine, lidocaine infiltrated in the incision and intraperitoneally, an effect not observed with the use of propofol. The results suggest fentanyl-induced hyperalgesia and the efficacy of ketoprofen, ketamine, incisional lidocaine and intraperitoneal lidocaine in reducing this effect.

关键词： Hyperalgesia Fentanyl Ketoprofen Ketamine Lidocaine Propofol Rats

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Incidence and histopathology of encysted progenetic metacercaria of clinostomum complanatum(Digenea:clinostomidae) in channa punctatus and its development in experimental host

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Asian Pacific Journal of Tropical Biomedicine 2012年第6期2卷 421-426页

作者： PA Ahammed Shareef sma Abidi Section of Parasitology Department of Zoology Aligarh Muslim University

Objective:To study the incidence of encysted progenetic metacercariae of clinostomum complanatum(c. complanatum) in channa punctatus(c. punctatus), associated histopathology and the experimental infection to laboratory chicken to obtain ovigerous adult ***:Live c. punctatus were brought from local fish market of Aligarh, India, dissected and examined on a monthly basis for the presence of c. complanatumcysts. For histochemistry, infected tissue sections with attached cysts were processed for haematoxylene and eosin staining. cysts were aseptically fed to 4 day old leghorn chicken to obtain adult worms. Mechanically excysted metacercaria and the ovigerous adult worms were stained in carmine to prepare permanent ***:One year survey for the infection of encysted progenetic metacercaria of ***. punctatusrevealed the prevalence, intensity and abundance of 24.7%, 2.27and 0.608, respectively. Histopathology showed heavy infiltration of immune cells at the site of cyst attachment and some tissue damage was also evident. Following feeding to experimental chicken, about 41.07% of the encysted metacercariae were able to excyst and migrate back to bucco-pharyngeal region where they tenaciously attached and fed on blood, and transformed into ovigerous adult worms from 62 hours onwards of post ***:The parasite is potentially pathogenic to the host, and the availability of a suitable intermediate host can be a contributing factor for the occurrence of c. complanatummetacercaria either in the excysted or encysted form, indicating loose host specificity and zoonotic potential.

关键词： clinostomum complanatum Encysted progenetic metacercaria channa punctatus Histopathology Experimental infection Ovigerous adult worm Incidence Host-parasite interaction Metacercarial transformation

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Hydrogen sulfide intervention in cystathionine-β-synthase mutant mouse helps restore ocular homeostasis

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International Journal of Ophthalmology(English edition) 2019年第5期12卷 754-764页

作者： Akash K.George Rubens P.Homme Avisek Majumder Anwesha Laha naira Metreveli Harpal S.SANDhu Suresh c.Tyagi Mahavir Singh Eye and Vision Science Laboratory University of Louisville School of Medicine Department of Physiology University of Louisville School of Medicine Department of Medicine UCSF Helen Diller Family Comprehensive Cancer CenterUniversity of California San Francisco Department of Ophthalmology and Visual Sciences Kentucky Lions Eye center University of Louisville School of Medicine

AIM: To investigate the applications of hydrogen sulfide(H2 S) in eye-specific ailments in ***: Heterozygous cystathionine-β-synthase(cBS+/-) and wild-type c57 BL/6 J(WT) mice fed with or without high methionine diet(HMD) were administered either phosphate buffered saline(PBS) or the slow-release H2 S donor: GYY4137. Several analyses were performed to study GYY4137 effects by examining retinal lysates for key protein expressions along with plasma glutamate and glutathione estimations. Intraocular pressure(IOP) was monitored during GYY4137 treatment; barium sulfate and bovine serum albumin conjugated fluorescein isothiocyanate(BSA-FITc) angiographies were performed for examining vasculature and its permeability post-treatment. Visionguided behavior was also tested employing novel object recognition test(NORT) and light-dark box test(LDBT) ***: cBS deficiency(cBS+/-) coupled with HMD led disruption of methionine/homocysteine(Hcy) metabolism leading to hyperhomocysteinemia(HHcy) in cBS+/-mice as reflected by increased Hcy, and s-adenosylhomocysteine hydrolase(SAHH) levels. Unlike cBS, cystathionine-γ lyase(cSE), methylenetetrahydrofolate reductase(MTHFR) levels which were reduced but compensated by GYY4137intervention. Heightened oxidative and endoplasmic reticulum(ER) stress responses were mitigated by GYY4137 effects along with enhanced glutathione(GSH) levels. Increased glutamate levels in cBS+/-strain were prominent than WT mice and these mice also exhibited higher IOP that was lowered by GYY4137 treatment. cBS deficiency also resulted in vision-guided behavioral impairment as revealed by NORT and LDBT findings. Interestingly, GYY4137 was able to improve cBS+/-mice behavior together with lowering their glutamate levels. Blood-retinal barrier(BRB) appeared compromised in cBS+/-with vessels' leakage that was mitigated in GYY4137 treated group. This corroborated the results for occludin(an integral plasma membrane protein of the cellular tight

关键词： blood-retinal barrier integrity endoplasmic reticulum stress glutamate cytotoxicity inflammation oxidative stress mice

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The Mg-carbonate-Fe interaction:Implication for the fate of subducted carbonates and formation of diamond in the lower mantle

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Geoscience Frontiers 2019年第4期10卷 1449-1458页

作者： naira S.Martirosyan Konstantin D. Litasov Sergey S. Lobanov Alexander F. Goncharov Anton Shatskiy Hiroaki Ohfuji Vitali Prakapenka Sobolev Institute of Geology and Mineralogy Russian Academy of ScienceKoptyuga ave.3Novosibirsk630090Russia Geophysical Laboratory Carnegie Institution for ScienceWashingtonDC20015USA Novosibirsk State University Pirogova st.2Novosibirsk630090Russia Geodynamic Research center Ehime UniversityMatsuyamaEhime790-8577Japan center for Advanced Radiation Sources University of ChicagoChicagoIL60637USA

The fate of subducted carbonates in the lower mantle and at the core-mantle boundary was modelled via experiments in the MgcO3-Fe^0 system at 70-150 GPa and 800-2600 Kin a laser-heated diamond anvil *** in situ synchrotro n X-ray diffraction and ex situ transmission electron microscopy we show that the reduction of Mg-carbonate can be exemplified by:6 MgcO3+19 Fe=8 FeO+10(Mg0.6Fe^0.4)O+Fe7 c3+3 *** presented results suggest that the interaction of carbonates with Fe^0 or Fe^0-bearing rocks can produce Fe-carbide and diamond,which can accumulate in the D"region,depending on its carbon to Fe *** to the sluggish kinetics of the transformation,diamond can remain metastable at the core-mantle boundary(cMB)unless it is in a direct contact with *** addition,it can be remobilized by redox melting accompanying the generation of mantle plumes.

关键词： Deep carbon cycle carbonate carbide High pressure Redox reaction

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Simultaneous enhancement of mechanical and shape memory properties by heat-treatment homogenization of Ti_(2)Ni precipitates in TiNi shape memory alloy fabricated by selective laser melting

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Journal of Materials Science & Technology 2022年第6期101卷 205-216页

作者： H.Z.Lu L.H.Liu c.Yang X.Luo c.H.Song Z.Wang J.Wang Y.D.Su Y.F.Ding L.c.Zhang Y.Y.Li National Engineering Research center of Near-net-shape Forming for Metallic Materials South China University of TechnologyGuangzhou 510640China Musculoskeletal Oncology Department Sun Yat-Sen University Cancer CenterGuangzhouGuangdong ProvinceChina Shenyang Aircraft Design and Research Institute Shenyang 110035China Guangdong Huayi Plumbing Fittings Industry co. Ltd.Kaiping 529321China School of Engineering Edith Cowan University270 Joondalup DriveJoondalupPerthWA 6027Australia

The excellent shape memory and mechanical properties of Ti Ni shape memory alloys(smas) fabricated using selective laser melting(SLM) are highly desirable for a wide range of critical applications. In this study, we examined the simultaneous enhancement of mechanical and shape memory properties using heat-treatment homogenization of Ti_(2)Ni precipitates in a Ti_(50.6)Ni_(49.4)sma fabricated using SLM. Specifically, because of the complete solution treatment, nanoscale spherical Ti_(2)Ni precipitates were homogeneously dispersed throughout the grain interior. Interestingly, the resultant sma exhibited an ultrahigh tensile strength of 880 ± 13 MPa, a large elongation of 22.4 ± 0.4%, and an excellent shape memory effect, with a recovery rate of > 98% and ultrahigh recoverable strain of 5.32% after ten loading–unloading cycles. These simultaneously enhanced properties are considerably superior than those of most previously reported Ti Ni smas fabricated using additive manufacturing. Fundamentally, the enhancement in tensile strength is ascribed to precipitation strengthening and work hardening, and the large plasticity is mainly attributed to the homogeneous nanoscale globular Ti_(2)Ni precipitates, which effectively impeded the rapid propagation of microcracks. Furthermore, the enhanced shape memory properties are derived from the suppression of dislocation movement and formation of retained stabilized martensite by the presence of high-density dislocations, nanoscale Ti_(2)Ni precipitates, and abundant interfaces. The obtained results provide insight into the enhancement of the two types of properties in Ti Ni smas and will accelerate the wider application of smas.

关键词： Shape memory alloy Selective laser melting Heat treatment Mechanical properties Shape memory properties

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Association of HbA1c Level with Lipid Ratio in Diabetic Patients

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Journal of Pharmacy and Pharmacology 2018年第8期6卷 796-799页

作者： Lizete Klavina Beate Ulmane Lāsma Milgrāve Gunta Tīcmene Rīga Stradins University Dzirciema street 16 Riga LV-1007 Latvia Family doctor's practice Department of Family Medicine Druvas doktorats Druva LV-3862 Latvia

Introduction： Diabetes mellitus is a common disease in the world and the number of diabetes patients is rapidly increasing. Dyslipidemia is one of the most risk factors for cardiovascular disease which is more prevalent among adults with diabetes than in the general population. Aim： To study the correlation of diabetes patients glycated hemoglobin （HbA1c） with lipid ratios. Materials and methods： Samples were collected from 101 diabetic patients （aged 19-86 years; male 51, female 50）. Retrospective study included data such as age, gender, type of diabetes, HbA1c, total cholesterol, LDL cholesterol and triglyceride from two family medicine doctor’s practices. According to the HbA1c level, the patients were divided into three groups, group A （HbA1c 〈 7%, n = 58）, group B （7% ≤ HbA1c 〈 10%, n = 37） and group c （HbA1c ≥ 10%, n = 6）. The correlations of HbA1c with lipid ratios were analyzed. Results： In the group A the mean HbA1c was 6.1 ± 0.5%, mean age-60.6 years, total cholesterol-4.7 mmol/L, LDL-2.8 mmol/L, triglycerides-1.6 mmol/L. In the group B the mean HbA1c was 7.7 ± 0.6%, mean age-64.0 years, total cholesterol-5.7 mmol/L, LDL-3.1 mmol/L, triglycerides-2.2 mmol/L and in the group c the mean HbA1c was 11.2 ± 1.0%, mean age-48.7 years, total cholesterol-4.9 mmol/L, LDL-2.7 mmol/L, triglycerides-1.7 mmol/L. conclusions： From all groups highest total cholesterol, LDL cholesterol, triglycerides were patients in the group B. In others two groups lipid profile changes were without any significant differences and there was no association with HbA1c.

关键词： Diabetes HbA1c total cholesterol LDL cholesterol triglycerides.

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Machine learning guided automatic recognition of crystal boundaries in bainitic/martensitic alloy and relationship between boundary types and ductile-to-brittle transition behavior

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Journal of Materials Science & Technology 2021年第25期84卷 49-58页

作者： X.c.Li J.X.Zhao J.H.cong R.D.K.Misra X.M.Wang X.L.Wang c.J.Shang collaborative Innovation center of Steel Technology University of Science and Technology BeijingBeijing 100083China Department of Metallurgical Materials and Biomedical EngineeringUniversity of Texas at El Paso500 W.University AvenueEl PasoTX 79968USA

Gradient boosting decision tree(GBDT)machine learning(ML)method was adopted for the first time to automatically recognize and conduct quantitative statistical analysis of boundaries in bainitic microstructure using electron back-scatter diffraction(EBSD)*** spite of lack of large sets of EBSD data,we were successful in achieving the desired accuracy and accomplishing the objective of recognizing the *** with a low model accuracy ofcharacteristic features,the accuracy of the model was significantly enhanced to about 88%when the Euler angle was converted to overall misorientation angle(OMA)and specific misorientation angle(sma)and considered as important *** this model,the recall score of prior austenite grain(PAG)boundary was~93%,high angle packet boundary(OMA>40°)was~97%,and block boundary was~96%.The derived outcomes of ML were used to obtain insights into the ductile-to-brittle transition(DBTT)***,ML modeling approach suggested that DBTT was not determined by the density of high angle grain boundaries,but significantly influenced by the density of PAG and packet *** study underscores that ML has a great potential in detailed recognition of complex multi-hierarchical microstructure such as bainite and martensite and relates to material performance.

关键词： Machine learning Feature engineering Automatic recognition Lath structure crystallography

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Daily genetic profiling indicates JAK/STAT signaling promotes early hepatic stellate cell transdifferentiation

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World Journal of Gastroenterology 2010年第40期16卷 5047-5056页

作者： Ashley M Lakner cathy c Moore Alyssa A Gulledge Laura W Schrum Department of Biology University of North Carolina at Charlotte Digestive and Metabolic Disorders Laboratory Carolinas Medical Center

AIM: To identify signaling pathways and genes that initiate and commit hepatic stellate cells (HScs) to transdifferentiation. METHODS: Primary HScs were isolated from male Sprague-Dawley rats and cultured on plastic for 0-10 d. Gene expression was assessed daily (quiescent to day 10 culture-activation) by real time polymerase chain reaction and data clustered using AMADA software. The significance of JAK/STAT signaling to HSc transdifferentiation was determined by treating cells with a JAK2 inhibitor. RESULTS: Genetic cluster analyses, based on expression of these 21 genes, showed similar expression profiles on days 1-3, days 5 and 6, and days 7-10, while freshly isolated cells (day Q) and day 4 cells were genotypically distinct from any of the other days. Additionally, gene expression clustering revealed strong upregulation of interleukin-6, JAK2 and STAT3 mRNA in the early stages of activation. Inhibition of the JAK/STAT signaling pathway impeded the morphological transdifferentiation of HScs which correlated with decreased mRNA expression of several profibrotic genes including collagens, α-sma, PDGFR and TGFβR. cONcLUSION: These data demonstrate unique clustered genetic profiles during the daily progression of HSc transdifferentiation and that JAK/STAT signaling may be critical in the early stages of transdifferentiation.

关键词： cluster analysis Fibrosis Genetic profile Hepatic stellate cell Interleukin-6

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Experimental and Numerical Investigation of an End Plate connection with Using Long Shank sma Bolts

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Journal of Harbin Institute of Technology(New Series) 2015年第3期22卷 22-30页

作者： Hongwei Ma Yongbing Zhu Michael c.H.Yam Yang Wang School of civil Engineering and Transportation South China University of Technology State Key Laboratory of Subtropical Architecture Science South China University of Technology Department of Building and Real Estate The Hong Kong Polytechnic University

Superelastic shape memory alloys( smas) have the ability to recover their original shape after experiencing large strains. End-plate connection with using superelastic long shank sma bolts is proposed in this paper. By using strong beam-weak bolt cluster design methodology and special configurations to strength beam ends,a superelastic hinge is expected to form in column flange. To validate the mechanical behavior of the proposed beam-to-column connection,both quasi-static tests and numerical analysis are conducted with cyclic transverse loads applied on the beam ends. The results indicate the connection deformations concentrate on the long shank sma bolts upon loading and the bolt cluster rotates around the axis near beam flange. By using the super elastic effect,the sma bolts recover most elongations and the connection recovers to its original shape after experiencing 0. 02 rad interstorey drift angle. The connection shows obvious self-centering properties.

关键词： finite element connection shape memory alloy ductility self-centering

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