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H_(2)O_(2)-sensitive nanoscale coordination polymers for photoacoustic tumors imaging via in vivo chromogenic assay

Journal of Innovative Optical Health Sciences 2022年第5期15卷 1-12页

作者： Jiayue Zhao Fei Gong nailin yang Huali Lei Zhihui Han Yuqi yang Liang Cheng Jiangsu Key Laboratory for Carbon-Based Functional Materials and Devices Institute of FunctionalNano&Soft Materials(FUNSOM)Soochow University Suzhou 215123 JiangsuP.R.China Wuhan National Laboratory for Optoelectronics and School of Optical and Electronic Information Huazhong University of Science and Technology Wuhan 430074 P.R.China

Photoacoustic(PA)imaging with much deeper tissue penetration and better spatial resolution had been widely employed for the prevention and diagnosis of many *** this study,a new type of hydrogen peroxide(H_(2)O_(2)T-activated photoacoustic nanoprobe[Mn-AH nanoscale coordination polymer nanodots(NCPs)]was successfully synthesized by a simple one-step method in water phase containing 2,20-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid)(ABTS),horse radish peroxidase(HRP),and manganese ion(Mn^(2+).After modification by polyethylene glycol(PEG),Mn-AH NCPs exhibited excellent stability and biocompatibility for in vivo H_(2)O_(2)-responsive chromogenic assay with great speci¯city and *** the presence of H_(2)O_(2),colorless ABTS would be converted by HRP into the oxidized form with strong near-infrared(NIR)absorbance,enabling photoacoustic detection of endogenous H_(2)O_(2).Using H_(2)O_(2)-activated Mn-AH NCPs,we have successfully performed PA imaging and H_(2)O_(2)detection of subcutaneous murine colon CT26 tumor and deep-seated orthotopic bladder *** to the inherent Mn element existence inside the Mn-AH,this nanoprobe also serves as a good T1-weighted magnetic resonance imaging(MRI)contrast agent ***,after accomplishing its imaging functions,the Mn-AH NCPs could be cleared out from the body without any long-term toxicity,providing a new opportunity for cancer diagnosis and treatment.

关键词： Nanoscale coordination polymers(NCPs) PA imaging MRI H2O2 detection metabolic nanoprobes

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Biodegradable magnesium alloy with eddy thermal effect for effective and accurate magnetic hyperthermia ablation of tumors

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National Science Review 2021年第1期8卷 98-108页

作者： nailin yang Fei Gong Liang Cheng Huali Lei Wei Li Zongbin Sun Caifang Ni Zhanhui Wang Zhuang Liu Institute of Functional Nano & Soft Materials (FUNSOM) Jiangsu Key Laboratory for Carbon-Based Functional Materials and Devices Soochow University Department of Vascular Surgery and Interventional Radiology First Affiliated Hospital of Soochow University Luoyang Central Hospital affiliated to Zhengzhou University

Magnetic hyperthermia therapy (MHT) is able to ablate tumors using an alternating magnetic field (AMF)to heat up magnetocaloric agents (e.g. magnetic nanoparticles) administered into the tumors. For clinical applications, there is still a demand to find new magnetocaloric agents with strong AMF-induced heating performance and excellent biocompatibility. As a kind of biocompatible and biodegradable material,magnesium (Mg) and its alloys have been extensively used in the clinic as an implant metal. Herein, we discovered that the eddy thermal effect of the magnesium alloy (MgA) could be employed for MHT to effectively ablate tumors. Under low-field-intensity AMFs, Mg A rods could be rapidly heated, resulting in a temperature increase in nearby tissues. Such AMF-induced eddy thermal heating of MgA could not only be used to kill tumor cells in vitro, but also be employed for effective and accurate ablation of tumors in vivo. In addition to killing tumors in mice, we further demonstrated that VXtumors of much larger sizes growing in rabbits after implantation of Mg A rods could also be eliminated after exposure to an AMF, illustrating the ability of MgA-based MHT to kill large-sized tumors. Moreover, the implanted MgA rods showed excellent biocompatibility and～20%of their mass was degraded within three months. Our work thus discovered for the first time that non-magnetic biodegradable Mg A, an extensively used implant metal in clinic, could be used for effective magnetic thermal ablation of tumors under a low-field-intensity AMF. Such a strategy could be readily translated into clinical use.

关键词： magnesium alloy eddy thermal effect alternating magnetic field hyperthermia tumor ablation biodegradation

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The combination of eddy thermal effect of biodegradable magnesium with immune checkpoint blockade shows enhanced efficacy against osteosarcoma

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Bioactive Materials 2023年第7期25卷 73-85页

作者： Jun Ge nailin yang Yuqi yang Hao Yu Xiaoyuan yang Yingjie Wang Tianyi Wang Shuning Cheng Yuanjie Wang Zhihui Han Yun Teng Jun Zou Huilin yang Liang Cheng Department of Orthopedic Surgery The First Affiliated Hospital of Soochow UniversitySuzhouJiangsuChina Institute of Functional Nano&Soft Materials(FUNSOM) Jiangsu Key Laboratory for Carbon-Based Functional Materials&DevicesSoochow UniversitySuzhouJiangsuChina Department of Neurosurgery The First Affiliated Hospital of Soochow UniversitySuzhouJiangsuChina

Osteosarcoma(OS)patients have a poor prognosis due to its high degree of heterogeneity and high rate of *** hyperthermia therapy(MHT)combined with immunotherapy is an effective strategy to treat solid and metastatic ***,we combined biodegradable magnesium(Mg)macroscale rods,which acted as an eddy thermo-magnetic agent under a low external alternating magnetic field,and immunotherapy to achieve a radical cure for *** eddy thermal effect(ETE)of the Mg rods(MgR)showed outstanding cytotoxic effects and enhanced the maturation of dendritic cells(DCs),and the mild MHT induced the immunogenic cell death(ICD)in the OS *** with immune checkpoint blockade(ICB)therapy,we obtained an excellent curative effect against OS,and a further evaluation demonstrated that the local MHT induced by the MgR increased T cells infiltration and the polarization of M1 ***,the biodegradable MgR also promoted bone *** work highlighted the uneven ETE mediated by the biodegradable MgR induced a comprehensive immunologic activation in the OS tumor microenvironment(TME),which would inspire the application of MHT for the effective treatment of OS.

关键词： Osteosarcoma Eddy thermal effect Magnesium rods(MgR) Osteosarcoma therapy Tumor microenvironment(TME) immunotherapy

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Hierarchical FeO_(χ)H_(y)@Ni_(3)B hybrid for efficient alkaline oxygen evolution at high current density

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Journal of Energy Chemistry 2024年第7期94卷 599-607页

作者： Fuxi Liu Qing Liang Zhenyu Li Meiqi Liu nailin Yue Zizhun Wang Xu Zou Wei Zhang Key Laboratory of Automobile Materials Ministry of Education School of Materials Science&EngineeringElectron Microscopy CenterInternational Center of Future ScienceJilin Provincial International Cooperation Key Laboratory of High-Efficiency Clean Energy MaterialsJilin UniversityChangchun 130012JilinChina

Electrocatalysts with high activity and long-term durability are vital toward large-scale hydrogen pro-duction from electrocatalytic water ***,the self-supported electrode(FeO_(χ)H_(y)@Ni_(3)B/NF)with hierarchical heterostructure was simply prepared by using Ni_(3)B chunks grown on nickel foam as sub-strate to in situ form vertical FeO_(χ)H_(y)*** hybrid shows efficient oxygen evolution reaction activity with overpotentials as low as 267 and 249 mV at 100 mA cm^(-2)in 1 M KOH solution and 30 wt%KOH solution,***,it also exhibits excellent catalytic stability,sustaining catalysis at 500 mA cm^(-2)in 1 M KOH solution for 200 h,and even for 200 h at 1000 mA cm^(-2)in 30 wt%KOH *** experimental results reveal that the FeO_(χ)H_(y)@Ni_(3)B/NF is endowed with superhydrophilic and superaerophobic surface properties,which not only provide more mass transport channels,as well as facilitated the diffusion of reaction intermediates and gas ***,it holds faster reaction kinetics,more accessible active sites and accelerated electron transfer rates due to strong synergistic interactions attheheterogeneous interface.

关键词： FeO_(χ)H_(y)@Ni_(3)B/NF hybrid Heterostructure Oxygen evolution reaction Electrocatalytic

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Tumor microenvironment-responsive contrast agents for specific cancer imaging:a narrative review

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Journal of Bio-X Research 2020年第4期3卷 144-156页

作者： Xianwen Wang Xiaoyan Zhong Huali Lei nailin yang Xiang Gao Liang Cheng Institute of Functional Nano&Soft Materials(FUNSOM) Jiangsu Key Laboratory for Carbon-based Functional Materials and Devices Department of Toxicology School of Public HealthJiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric DiseasesMedical College The Second Affiliated Hospital of Soochow University SuzhouJiangsu ProvinceChina

Molecular imaging is of great significance for early diagnosis and timely treatment of cancer and disease,as well as basic medical and biological *** personalized cancer treatment has become increasingly popular,the demand for more advanced imaging technologies has also significantly *** advantage of differences between the tumor microenvironment and normal tissue cells,tumor microenvironment-responsive or"turn-on"contrast agents have a higher signal-to-noise ratio and lower background interference compared with"turn-off"probes,which can remarkably improve the performance of tumor ***,tumor microenvironment-responsive contrast agents can not only detect changes in the tumor microenvironment,but also have important significance for tumor diagnosis,prediction of invasion potential,evaluation of treatment effectiveness,planning of therapeutic regimens,and tumor ***,this review focuses on recent research progress of tumor microenvironment-responsive intelligent probes,and highlights future research directions of tumor microenvironment-responsive contrast agents for precision diagnostics.

关键词： cancer imaging cancer treatment contrast agents diagnosis tumor microenvironment

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基于模糊控制的PHEV转矩管理策略

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甘肃科学学报 2015年第4期27卷 105-109页

作者：杨乃林中国石油长城钻探测井公司辽宁盘锦124011

针对并联型混合动力汽车提出了一种基于模糊逻辑控制方法的转矩管理策略,可对发动机和电动机的输出转矩进行实时分配,并保证在整个运行路段中电池电量的平衡。通过在Advisor软件的US06路段上进行仿真测试,结果表明设计的控制器可以在一... 详细信息

针对并联型混合动力汽车提出了一种基于模糊逻辑控制方法的转矩管理策略,可对发动机和电动机的输出转矩进行实时分配,并保证在整个运行路段中电池电量的平衡。通过在Advisor软件的US06路段上进行仿真测试,结果表明设计的控制器可以在一定程度上提高混合动力汽车的燃油经济性,同时降低各类污染物的排放量。

关键词：并联型混合动力汽车转矩分配策略电池荷电状态模糊逻辑控制

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腹腔巨淋巴结增生症1例

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胃肠病学 2009年第12期14卷 765-766页

作者：杨乃林霍砚淼吴志勇上海交通大学医学院附属仁济医院普外科 200127

病例：患者女，55岁，因“月经失调5个月，B超检查发现右附件占位性病变1d”入院。患者既往无慢性妇科疾病史．生育史1-0．1．1。平素月经规则，5-6d／30d，量少，无痛经史。2008年4月行经，经量稍多。末次月经（LMP）2008年7月6日．无... 详细信息

病例：患者女，55岁，因“月经失调5个月，B超检查发现右附件占位性病变1d”入院。患者既往无慢性妇科疾病史．生育史1-0．1．1。平素月经规则，5-6d／30d，量少，无痛经史。2008年4月行经，经量稍多。末次月经（LMP）2008年7月6日．无腹痛．无异常阴道流出液。2008年9月9日于我院行B超检查示有附件-37mm×43mm×48mm的不均质性占位，部分呈低回声。入院查体：一般情况可，心肺无异常。腹平软．无压痛、反跳痛、肌卫，未触及明显包块。

关键词：巨淋巴结增生腹腔月经失调浆细胞

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Pro-resolving lipid mediator reduces amyloid-β42–induced gene expression in human monocyte–derived microglia

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Neural Regeneration Research 2025年第3期20卷 873-886页

作者： Ying Wang Xiang Zhang Henrik Biverstål Nicolas GBazan Shuai Tan nailin Li Makiko Ohshima Marianne Schultzberg Xiaofei Li Department of Neurobiology Care Sciences&SocietyDivision of NeurogeriatricsKarolinska InstitutetStockholmSweden Department of Neurology Neuroscience CenterThe First Hospital of Jilin UniversityChangchunJilin ProvinceChina Department of Physiology and Pharmacology Karolinska InstitutetStockholmSweden Department of Biosciences and Nutrition Karolinska InstitutetHuddingeSweden Neuroscience Center of Excellence Louisiana State UniversityNew OrleansLAUSA Department of Medicine SolnaClinical Pharmacology GroupKarolinska University HospitalStockholmSweden

Specialized pro-resolving lipid mediators including maresin 1 mediate resolution but the levels of these are reduced in Alzheimer's disease brain, suggesting that they constitute a novel target for the treatment of Alzheimer's disease to prevent/stop inflammation and combat disease pathology. Therefore, it is important to clarify whether they counteract the expression of genes and proteins induced by amyloid-β. With this objective, we analyzed the relevance of human monocyte–derived microglia for in vitro modeling of neuroinflammation and its resolution in the context of Alzheimer's disease and investigated the pro-resolving bioactivity of maresin 1 on amyloid-β42–induced Alzheimer's disease–like inflammation. Analysis of RNA-sequencing data and secreted proteins in supernatants from the monocyte-derived microglia showed that the monocyte-derived microglia resembled Alzheimer's disease–like neuroinflammation in human brain microglia after incubation with amyloid-β42. Maresin 1 restored homeostasis by down-regulating inflammatory pathway related gene expression induced by amyloid-β42 in monocyte-derived microglia, protection of maresin 1 against the effects of amyloid-β42 is mediated by a re-balancing of inflammatory transcriptional networks in which modulation of gene transcription in the nuclear factor-kappa B pathway plays a major part. We pinpointed molecular targets that are associated with both neuroinflammation in Alzheimer's disease and therapeutic targets by maresin 1. In conclusion, monocyte-derived microglia represent a relevant in vitro microglial model for studies on Alzheimer's disease-like inflammation and drug response for individual patients. Maresin 1 ameliorates amyloid-β42–induced changes in several genes of importance in Alzheimer's disease, highlighting its potential as a therapeutic target for Alzheimer's disease.

关键词： Alzheimer's disease amyloid-β maresin microglia monocyte neuroinflammation resolution RNA-sequencing specialized pro-resolving lipid mediator

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具有涡流热效应的液态金属微球用于磁热增强的癌症栓塞-免疫联合治疗

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Science Bulletin 2023年第16期68卷 1772-1783,M0004页

作者：杨乃霖孙兴伟周杨楷杨笑远尤嘉熙虞泽鹏葛隽巩飞肖志晟靳勇刘庄程亮 Institute of Functional Nano&Soft Materials(FUNSOM) Jiangsu Key Laboratory for Carbon-Based Functional Materials and DevicesSoochow UniversitySuzhou 215123China Department of Intervention The Second Affiliated Hospital of Soochow UniversitySuzhou 215004China Nuclear Medicine Department The Second Affiliated Hospital of Soochow UniversitySuzhou 215004China Center for Medical Ultrasound Suzhou Municipal HospitalThe Affiliated Suzhou Hospital of Nanjing Medical UniversitySuzhou 215001China Department of Orthopaedic Surgery The First Affiliated Hospital of Soochow UniversitySuzhou 215006China

肝细胞癌患者由于肝癌的高转移性和高复发率表现出预后差的特征.本文提出了一种通过磁热疗法(MHT)增强癌症免疫治疗联合经导管动脉栓塞(TAE)治疗肝癌肿瘤的有效策略.通过微流控技术制备的尺寸均匀液态金属微球(LM MSs),由于在交变磁场... 详细信息

肝细胞癌患者由于肝癌的高转移性和高复发率表现出预后差的特征.本文提出了一种通过磁热疗法(MHT)增强癌症免疫治疗联合经导管动脉栓塞(TAE)治疗肝癌肿瘤的有效策略.通过微流控技术制备的尺寸均匀液态金属微球(LM MSs),由于在交变磁场下的涡流热效应表现出显著的磁感应加热能力,可同时作为MHT和TAE两种癌症治疗策略的有效药物.一方面,LM MSs优异的涡流磁热效应表现出高效的MHT治疗疗效.另一方面,LM MSs引发的MHT可以显著增强免疫系统激活,促进免疫细胞的浸润;与免疫检查点阻断(ICB)治疗联合后可以进一步刺激强大的免疫应答,从而抑制远端肿瘤的生长.此外,LM MSs-碘油栓塞剂在兔子原位肝癌模型中表现出优异的栓塞-磁热联合治疗效果.总之,该工作不仅证明了LM MSs可以作为有效的MHT试剂实现MHT-免疫联合治疗,而且还展示了TAE与MHT联合治疗在原位大型肝肿瘤治疗中的重要应用前景.

关键词：癌症治疗高复发率 TAE 微流控技术液态金属免疫细胞免疫应答交变磁场

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永磁无刷直流电机在MATLAB中的仿真研究

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湖南理工学院学报（自然科学版） 2016年第4期29卷 53-57页

作者：陶跃进邓斌余丹羊乃淋湖南理工学院计算机学院湖南岳阳414006

介绍了永磁无刷直流电机的工作原理,建立了其数学模型,然后在MATLAB/Simulink中建立了其转速单闭环PI控制的调速系统的仿真模型,最后对其仿真结果进行了分析.仿真结果表明,电机在空载和带载情况下,具有较好的动静态特性.

关键词：无刷直流电机数学模型单闭环建模和仿真

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