The combination of eddy thermal effect of biodegradable magnesium with immune checkpoint blockade shows enhanced efficacy against osteosarcoma

作     者：Jun Ge Nailin Yang Yuqi Yang Hao Yu Xiaoyuan Yang Yingjie Wang Tianyi Wang Shuning Cheng Yuanjie Wang Zhihui Han Yun Teng Jun Zou Huilin Yang Liang Cheng 

作者机构：Department of Orthopedic SurgeryThe First Affiliated Hospital of Soochow UniversitySuzhouJiangsuChina Institute of Functional Nano&Soft Materials(FUNSOM)Jiangsu Key Laboratory for Carbon-Based Functional Materials&DevicesSoochow UniversitySuzhouJiangsuChina Department of NeurosurgeryThe First Affiliated Hospital of Soochow UniversitySuzhouJiangsuChina 

出 版 物：《Bioactive Materials》 (生物活性材料（英文）)

年 卷 期：2023年第25卷第7期

页      面：73-85页

核心收录：

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

基　　金：This article was partially supported by the National Natural Science Foundation of China(U20A20254,52072253,82172506,82030068) Collaborative Innovation Center of Suzhou Nano Science and Technology,the 111 Project,Joint International Research Laboratory of Carbon-Based Functional Materials and Devices,a Jiangsu Social Development Project(BE2019658) a Jiangsu Natural Science Fund for Distinguished Young Scholars(BK20211544) Suzhou Key Laboratory of Nanotechnology and Biomedicine.L.Cheng was supported by the Tang Scholarship of Soochow University 

主　　题：Osteosarcoma Eddy thermal effect Magnesium rods(MgR) Osteosarcoma therapy Tumor microenvironment(TME) immunotherapy 

摘      要：Osteosarcoma(OS)patients have a poor prognosis due to its high degree of heterogeneity and high rate of *** hyperthermia therapy(MHT)combined with immunotherapy is an effective strategy to treat solid and metastatic ***,we combined biodegradable magnesium(Mg)macroscale rods,which acted as an eddy thermo-magnetic agent under a low external alternating magnetic field,and immunotherapy to achieve a radical cure for *** eddy thermal effect(ETE)of the Mg rods(MgR)showed outstanding cytotoxic effects and enhanced the maturation of dendritic cells(DCs),and the mild MHT induced the immunogenic cell death(ICD)in the OS *** with immune checkpoint blockade(ICB)therapy,we obtained an excellent curative effect against OS,and a further evaluation demonstrated that the local MHT induced by the MgR increased T cells infiltration and the polarization of M1 ***,the biodegradable MgR also promoted bone *** work highlighted the uneven ETE mediated by the biodegradable MgR induced a comprehensive immunologic activation in the OS tumor microenvironment(TME),which would inspire the application of MHT for the effective treatment of OS.