检索结果-南通市图书馆

High Power Laser Science and Engineering 2015年第3期3卷 59-65页

作者： t.nagayama R.C.Mancini D.Mayes R.tommasini R.Florido Physics Department University of Nevada Lawrence Livermore National Laboratory Departamento de Física Universidad de Las Palmas de Gran Canaria

temperature and density asymmetry diagnosis is critical to advance inertial confinement fusion(ICF) science. A multimonochromatic x-ray imager, MMI, records the spectral signature from an ICF implosion core with time resolution, 2D spatial resolution and spectral resolution. While narrow-band images and 2D space-resolved spectra from the MMI data constrain the temperature and the density spatial structure of the core, the accuracy of the images and the spectra highly depends on the quality of the MMI data and the processing tools. Here, we synthetically investigate the criterion for reliable MMI diagnostics and its effects on the accuracy of the reconstructed images. the pinhole array tilt determines the object spatial sampling efficiency and the minimum reconstruction width, w. When the spectral width associated with w is significantly narrower than the spectral linewidth, the line images reconstructed from the MMI data become reliable. the MMI setup has to be optimized for every application to meet this criterion for reliable ICF diagnostics.

关键词： high power laser inertial confinement fusion monochromatic imager x-ray diagnostics

Giant Brunner's gland hyperplasia of the duodenum successfully resected en bloc by endoscopic mucosal resection: A case report

在线全文

学校读者我要写书评

暂无评论

World Journal of Gastrointestinal Endoscopy 2024年第6期16卷 368-375页

作者： Makomo Makazu Akiko Sasaki Chikamasa Ichita Chihiro Sumida takashi Nishino Miki nagayama Shinichi teshima Gastroenterology Medicine Center Shonan Kamakura General HospitalKamakura 247-8533Japan Department of Gastroenterology Shonan Kamakura General HospitalKanagawa 247-8533Japan Department of Pathology Shonan Kamakura General HospitalKamakura 247-8533Japan

BACKGROUND Duodenal Brunner's gland hyperplasia(BGH)is a therapeutic target when complications such as bleeding or gastrointestinal obstruction occur or when malignancy cannot be ruled ***,we present a case of large BGH treated with endoscopic mucosal resection(EMR).CASE SUMMARY An 83-year-old woman presented at our hospital with *** tests revealed severe anemia,esophagogastroduodenoscopy showed a 6.5 cm lesion protruding from the anterior wall of the duodenal bulb,and biopsy revealed the presence of glandular *** ultrasonography(EUS)demonstr-ated relatively high echogenicity with a cystic *** muscularis propria was slightly elevated at the base of the *** was performed without *** formalin-fixed lesion size was 6 cm×3.5 cm×3 cm,showing nodular proliferation of non-dysplastic Brunner's glands compartmentalized by fibrous septa,confirming the diagnosis of *** of EMR or hot snare polypectomy are rare for duodenal BGH>6 *** this case,the choice of EMR was made by obtaining information on the base of the lesion as well as on the internal characteristics through *** Large duodenal lesions with good endoscopic maneuverability and no evident muscular layer involvement on EUS may be resectable via EMR.

关键词： Duodenum Brunner’s gland hyperplasia Brunner’s gland hamartoma Brunner’s gland adenoma Endoscopic mucosal resection Case report

阻断大脑血管紧张素Ⅱ1型受体抑制高血压大鼠心房颤动的发生

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

中华高血压杂志 2015年第10期23卷 998-998页

作者： nagayama t Hirooka Y Kishi t Mukai Y Inoue S takase S takemoto M Chishaki A Sunagawa K

高血压是心房颤动的一个强危险因素。高血压相关的心房颤动的病理生理与交感神经兴奋或肾素血管紧张素系统相关。然而，目前的治疗尚不足以抑制其发生。研究者之前发现阻断脑血管紧张素Ⅱ1型受体（angiotensin Ⅱ type1receptor，At1R... 详细信息

高血压是心房颤动的一个强危险因素。高血压相关的心房颤动的病理生理与交感神经兴奋或肾素血管紧张素系统相关。然而，目前的治疗尚不足以抑制其发生。研究者之前发现阻断脑血管紧张素Ⅱ1型受体（angiotensin Ⅱ type1receptor，At1R）可通过交感神经抑制产生降压作用。因此，研究者评估脑At1R在高血压大鼠心房颤动发生中是否起作用。

关键词：血管紧张素Ⅱ1型受体高血压大鼠心房颤动大脑肾素血管紧张素系统交感神经兴奋危险因素病理生理

Autophagy and thyroid cancer

在线全文

学校读者我要写书评

暂无评论

Journal of Cancer Metastasis and treatment 2021年第1期7卷 81-96页

作者： Yuji nagayama Department of Molecular Medicine Atomic Bomb Disease InstituteNagasaki UniversityNagasaki 852-8523 Japan

this review provides the up-to-date physiological,pathophysiological,and carcinogenic roles of autophagy in the *** data on its physiological roles are mainly obtained with genetically engineered mice,demonstrating the importance of autophagy for the maintenance of cell homeostasis and survival as well as provision of building blocks for sufficient synthesis of proteins such as *** and negative controls of autophagic activity by thyrotropin and thyroid hormone,respectively,are now *** thyroid cancer,there is no published study on the role for autophagy in the initiation/development of thyroid cancer,and there exist many inconsistent data regarding its role in established thyroid cancer *** example,definitive conclusions remain to be elucidated regarding the level of autophagic activity in thyroid cancer cells and the effect of autophagy inducers/inhibitors on cancer cell survival/***,when autophagy is targeted in novel cancer therapeutics,some studies show its pro-survival,but others its anti-survival or context-dependent,effects on thyroid cancer *** studies are in the future necessary to further elucidate the potential of autophagy as a therapeutic target for thyroid cancer.

关键词： thyroid cancer autophagy pro-survival anti-survival

Hydraulic model tests for propagation of flow and sediment in floods due to breaking of a natural landslide dam during a mountainous torrent

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

International Journal of Sediment Research 2018年第2期33卷 107-116页

作者： takahiro Itoh Akihiko Ikeda takahiko nagayama takahisa Mizuyama Research and Development Center Nippon Koei Co. Ltd Saboε Landslide technical Center Hokuriku office Nippon Koei Co. Ltd National Graduate Institute for Policy Studies (GRIPS)

During mountain torrents, large-magnitude floods may result from heavy rainfall and cause the breakage of landslide dams naturally formed by heavy rainfall, earthquakes, and so on. the characteristics of longitudinal spreading of clear water discharge and changes in flow depth must be clarified because the changes in peak depth have not yet been examined in steep-slope torrents and because there are few data on spreading of flash floods and related sedimentation in mountainous torrents. In the present study, experimental data were collected through hydraulic model tests over a rigid bed, and the spreading of water, fine sediment, bed load, and large boulders due to flooding are discussed assuming that flash flooding/debris flows occur in the upstream reach. the effects of changes in flow width, such as expansions and contractions in the flow width, as well as changes in meandering channels, sediment transportation, and spreading flow depth resulting from bores are examined using flume data for a steepslope torrent. the data obtained in the present study reveal that fine sediment components are transported to the downstream reach if large-magnitude floods occur and that the spreading rate and peak lags of the fine sediment and water level indicate the occurrence of a flood in the upstream reach.

关键词： Propagation of water and sediment Debris flow Flash flood Hydraulic model tests Flow width

Research and Implementations of Structural Monitoring for Bridges and Buildings in Japan

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Engineering 2019年第6期5卷 1093-1119页

作者： Yozo Fujino Dionysius MSiringoringo Yoshiki Ikeda tomonori nagayama tsukasa Mizutani Institute of Advanced Sciences Yokohama National UniversityYokohama 240-8501Japan Disaster Prevention Research Institute Kyoto UniversityKyoto 611-0011Japan Department of Civil Engineering The University of TokyoTokyo 113-8656Japan

this paper provides a review on the development of structural monitoring in Japan, with an emphasis on the type, strategy, and utilization of monitoring systems. the review focuses on bridge and building structures using vibration-based techniques. Structural monitoring systems in Japan historically started with the objective of evaluating structural responses against extreme events. In the development of structural monitoring, monitoring systems and collected data were used to verify design assumptions, update speci cations, and facilitate the ef cacy of vibration control systems. Strategies and case studies on monitoring for the design veri cation of long-span bridges and tall buildings, the performance of seismic isolation systems in building and bridges, the veri cation of structural retro t, the veri cation of structural control systems (passive, semi-active, and active), structural assessment, and damage detec- tion are described. More recently, the application of monitoring systems has been extended to facilitate ef cient operation and effective maintenance through the rationalization of risk and asset management using monitoring data. this paper also summarizes the lessons learned and feedback obtained from case studies on the structural monitoring of bridges and buildings in Japan.

关键词： Structural monitoring Long-span bridge High-rise building Seismic monitoring Wind-induced responses Pavement and slab monitoring Structural control monitoring Structural assessment

Associations of body mass index and hospital-acquired disability with post-discharge mortality in older patients with acute heart failure

在线全文

学校读者我要写书评

暂无评论

Journal of Geriatric Cardiology 2022年第3期19卷 209-217页

作者： Akihiro Sakuyama Masakazu Saitoh Kentaro Hori Yuichi Adachi Keigo Iwai Masatoshi nagayama Department of Physical therapy Faculty of Health ScienceJuntendo UniversityTokyoJapan Department of Rehabilitation Sakakibara Heart InstituteTokyoJapan Department of Cardiology Sakakibara Heart InstituteTokyoJapan

OBJECtIVES to investigate the effect of hospital-acquired disability(HAD)on all-cause mortality after discharge according to the body mass index(BMI)in older patients with acute decompensated heart *** We included 408 patients aged≥65 years who were hospitalized for acute decompensated heart failure and had undergone an acute phase of cardiac rehabilitation at the Sakakibara Heart Institute between April 2013 and September 2015(me-dian age:82 years,interquartile range(IQR):76-86;52%male).Patients were divided into three groups based on BMI at hospital admission:underweight(t(18.5 to 25 kg/m^(2)),and overweight(≥25 kg/m^(2)).HAD was defined as a decrease of at least five points at discharge compared to before hospitalization according to the Barthel *** the median follow-up period was 475(IQR:292-730)days,and all-cause mortality during the follow-up period was 84 deaths(21%).According to multivariate Cox regression analysis,being underweight(HR:1.941,95%CI:1.134−3.321,P=0.016)or overweight(HR:0.371,95%CI:0.171−0.803,P=0.012),with normal BMI as the reference,and HAD(HR:1.857,95%CI:1.062−3.250,P=0.030)were independently associated with all-cause *** with HAD exhibited a significantly lower cumulative survival rate in the underweight group(P=0.001)and tended to have a lower cumulative survival rate in the normal weight group(P=0.072).HAD was not significantly associated with cumulative survival in the overweight group(P=0.392).CONCLUSIONS BMI and HAD independently predicted all-cause mortality after discharge in older patients with acute de-compensated heart ***,HAD was significantly associated with higher all-cause mortality after discharge,espe-cially in the underweight group.

关键词： patients acute index

Interplay between epidermal stem cell dynamics and dermal deformation

在线全文

学校读者我要写书评

暂无评论

npj Computational Materials 2018年第1期4卷 280-288页

作者： Yasuaki Kobayashi Yusuke Yasugahira Hiroyuki Kitahata Mika Watanabe Ken Natsuga Masaharu nagayama Center for Simulation Sciences Ochanomizu UniversityTokyo 112-8620Japan Graduate School of Science Hokkaido UniversitySapporo 060-0810Japan Department of Physics Chiba UniversityChiba 263-8502Japan Department of Dermatology Graduate School of MedicineHokkaido UniversitySapporo 060-8638Japan Research Institute for Electronic Science Hokkaido UniversitySapporo 060-0812Japan

tissue growth is a driving force of morphological changes in living *** the buckling instability is known to play a crutial role for initiating spatial pattern formations in such growing systems,little is known about the rationale for succeeding morphological changes beyond this *** mammalian skin,the dermis has many protrusions toward the epidermis,and the epidermal stem cells are typically found on the tips of these *** the initial instability may well be explained by the buckling involving the dermis and the basal layer,which contains proliferative cells,it does not dictate the direction of these protrusions,nor the spatial patterning of epidermal stem *** we introduce a particle-based model of self-replicating cells on a deformable substrate composed of the dermis and the basement membrane,and investigate the relationship between dermal deformation and epidermal stem cell pattering on *** show that our model reproduces the formation of dermal protrusions directing from the dermis to the epidermis,and preferential epidermal stem cell distributions on the tips of the dermal protrusions,which the basic buckling mechanism fails to *** argue that cell-type-dependent adhesion strengths of the cells to the basement membrane are crucial factors influencing these patterns.

关键词： buckling rational initiating

Development and installation of bedload monitoring systems with submerged load cells

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Mountain Science 2016年第2期13卷 369-376页

作者： Ken GOtO takahiro ItOH takahiko nagayama Rei UtSUNOMIYA Daizo tSUtSUMI takahisa MIZUYAMA Research and Development Center Nippon Koei Co.Ltd.2304 InariharaTsukubaIbaraki 300-1259Japan Nippon Koei Co. Ltd.4-2 Koji-machiChiyodaTokyo 102-0083Japan JFE Advantech Go. Ltd.3-48 Takahata-choNishinomiyaHyogo 663-8202Japan Disaster Prevention Research Institute Kyoto University436-13 NakaoOkuhidaonsengoTakayamaGifu 506-1422Japan Graduate School of Agriculture Kyoto UniversityKitashirakawa Oiwake-choSakyoKyoto 606-8502Japan

Bedload governs riverbed channel variations and morphology, it is necessary to determine bedload discharge through an arbitrary cross section in a mountain fiver. A new system with submerged load cells has been developed to directly measure bedload discharge. the system consists of：（1） an iron box which is 1 m long, 0.5 m wide and 0.1 m in depth, （2） two submerged load cells 0.7 m apart, （3） a pressure sensor and, （4） an electromagnetic velocity meter. this system has been designed to exclude the effect of the hydraulic pressure of water on direct measurements of bedload particle weight. Initial tests in a laboratory were conducted to examine the accuracy of measurements with the system under aerial conditions. the system has been installed in the supercritical flume in Ashi-arai-dani River of the Hodaka Sedimentation Observatory of the Disaster Prevention Research Institute （DPRI） of Kyoto University to obtain bedload discharge under natural conditions. Flume tests were conducted in this channel by artificial supply of uniform sediment particles of several grain sizes. the average velocity of the sediment particles near the bed was estimated using cross-correlation functions for weight waves obtained by the two load cells, Bedload discharge calculations were based on time integration of the product of sediment velocity and sediment weight obtained by the two load cells. this study clarifies the reasons why bedload measurements are difficult, and provides some solutions using the monitoring systems with submerged load cells through the field measurements. Additionally, the applicability of bedload measurement with the submerged load cells is explained based on experimental artificial sediment supply data.

关键词： Bedload Submerged load cell Flume tests

Single molecular DNA/RNA sequencing with microscopy

在线全文

学校读者我要写书评

暂无评论

Asian Journal of Pharmaceutical Sciences 2016年第1期11卷 83-84页

作者： Masanori Kataoka Kuniaki nagayama Hidehiro Oana Oceanography Section Science Research CenterKochi UniversityKochiJapan the Graduate University for Advanced Studies KanagawaJapan Department of Mechanical Engineering The University of TokyoTokyoJapan

Ultra high-throughput DNA sequencing has been a very hot topic beyond the field of genomic *** have been various approaches to this issue ranging from direct observation of individual DNA synthesis[1],amperometric/optical detection of bases using a nanopore[2,3]and direct sequencing with a high-resolution probe microscope[4].Recently,we have developed a technique to chemically modify all nucleobases in DNA[5],so that the bases A,t,G,C can be differentiated in the sequence by using high-resolution electron microscopy(EM).

关键词： Single molecular DNA/RNA sequencing Quantum dot complex