Autophagy and thyroid cancer

作     者：Yuji Nagayama Yuji Nagayama

作者机构：Department of Molecular MedicineAtomic Bomb Disease InstituteNagasaki UniversityNagasaki 852-8523 Japan 

出 版 物：《Journal of Cancer Metastasis and Treatment》 (癌症转移与治疗（英文版）)

年 卷 期：2021年第7卷第1期

页      面：81-96页

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

基　　金：supported by the Japan Society for the Promotion of Science(KAKENHI Grant No.19K09028) 

主　　题：Thyroid cancer autophagy pro-survival anti-survival 

摘      要：This review provides the up-to-date physiological,pathophysiological,and carcinogenic roles of autophagy in the *** data on its physiological roles are mainly obtained with genetically engineered mice,demonstrating the importance of autophagy for the maintenance of cell homeostasis and survival as well as provision of building blocks for sufficient synthesis of proteins such as *** and negative controls of autophagic activity by thyrotropin and thyroid hormone,respectively,are now *** thyroid cancer,there is no published study on the role for autophagy in the initiation/development of thyroid cancer,and there exist many inconsistent data regarding its role in established thyroid cancer *** example,definitive conclusions remain to be elucidated regarding the level of autophagic activity in thyroid cancer cells and the effect of autophagy inducers/inhibitors on cancer cell survival/***,when autophagy is targeted in novel cancer therapeutics,some studies show its pro-survival,but others its anti-survival or context-dependent,effects on thyroid cancer *** studies are in the future necessary to further elucidate the potential of autophagy as a therapeutic target for thyroid cancer.