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The Influence of Different Solar System Planetary Ephemerides on Pulsar Timing

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Research in Astronomy and Astrophysics 2024年第8期24卷 87-101页

作者： Jian-Peng Dai Wei han na Wang School of Physical Science and Technology Xinjiang University Xinjiang Astronomical Observatory Chinese Academy of Sciences University of Chinese Academy of Sciences Xinjiang Key Laboratory of radio Astrophysics

Pulsar timing offers a comprehensive avenue for exploring diverse topics in physics and *** solar system planetary ephemeris is crucial for pulsar timing as it provides the positions and velocities of solar system planets including the ***,it is inevitable that inherent inconsistencies exist in these *** between various ephemerides can significantly impact pulsar timing and parameter ***,pulsar timing highly depends on the JPL DE ephemeris,for instance,the Pulsar Timing Array data analysis predominantly utilizes *** this study,we examine inconsistencies across various ephemeris series,including JPL DE,EPM,and ***,discrepancies emerge particularly between the current ephemeris DE436 and the earliest released ephemeris DE200,as well as the most recent ephemerides,e.g.,DE440,INPOP21A,and *** detailed analysis of the effects of ephemeris on geometric correction procedures for the conversion of measured topocentric times of arrival is presented in this *** researches reveal that variations in the Roemer delays across different ephemerides lead to distinct *** timing residuals and the fact that these discrepancies can be readily incorporated into the subsequent pulsar parameters,leading to inconsistent fitting estimates,suggest that the influence of errors in the ephemeris on the timing process might currently be underappreciated.

关键词： (stars:) pulsars: general ephemerides Planetary Systems time

Emerging clinical relevance of microbiome in cancer:promising biomarkers and therapeutic targets

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Protein & Cell 2024年第4期15卷 239-260页

作者： Jia-Hao Dai Xi-Rong Tan han Qiao na Liu State Key Laboratory of Oncology in South China Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and TherapyGuangdong Provincial Clinical Research Center for CancerSun Yat-sen University Cancer CenterGuangzhou 510050China

The profound influence of microbiota in cancer initiation and progression has been under the spotlight for years,leading to numerous researches on cancer microbiome entering clinical *** promising biomarkers and therapeutic targets,the critical involvement of microbiota in cancer clinical practice has been increasingly ***,recent progress in this field is *** describe the potential of tumor-associated microbiota as effective diagnostic and prognostic biomarkers,*** addition,we highlight the relationship between microbiota and the therapeutic efficacy,toxicity,or side effects of commonly utilized treatments for cancer,including chemotherapy,radiotherapy,and *** that microbial factors influence the cancer treatment outcome,we further summarize some dominating microbial interventions and discuss the hidden risks of these *** review aims to provide an overview of the applications and advancements of microbes in cancer clinical relevance.

关键词： microbiome cancer diagnosis prognosis therapy

Neutrophil peptide 1 accelerates the clearance of degenerative axons during Wallerian degeneration by activating macrophages after peripheral nerve crush injury

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Neural Regeneration Research 2024年第8期19卷 1822-1827页

作者： Yuhui Kou Yusong Yuan Qicheng Li Wenyong Xie Hailin Xu na han Department of Trauma and Orthopedics Peking University People’s HospitalBeijingChina national Center for Trauma Medicine BeijingChina Key Laboratory of Trauma and Neural Regeneration(Peking University) Ministry of EducationBeijingChina Department of Orthopedics China-Japan Friendship HospitalBeijingChina Department of Central Laboratory and Institute of Clinical Molecular Biology Peking University People’s HospitalBeijingChina

Macrophages play an important role in peripheral nerve regeneration,but the specific mechanism of regeneration is still *** preliminary findings indicated that neutrophil peptide 1 is an innate immune peptide closely involved in peripheral nerve ***,the mechanism by which neutrophil peptide 1 enhances nerve regeneration remains *** study was designed to investigate the relationship between neutrophil peptide 1 and macrophages in vivo and in vitro in peripheral nerve crush *** functions of raW 264.7 cells we re elucidated by Cell Counting Kit-8 assay,flow cytometry,migration assays,phagocytosis assays,immunohistochemistry and enzyme-linked immunosorbent *** debris phagocytosis was observed using the CUBIC(Clear,Unobstructed Brain/Body Imaging Cocktails and Computational analysis)optical clearing technique during Wallerian *** inflammatory factor expression in different polarization states was detected using a protein *** results showed that neutrophil peptide 1 promoted the prolife ration,migration and phagocytosis of macrophages,and CD206 expression on the surfa ce of macrophages,indicating M2 *** axonal debris clearance rate during Wallerian degeneration was enhanced after neutrophil peptide 1 *** peptide 1 also downregulated inflammatory factors interleukin-1α,-6,-12,and tumor necrosis factor-αin invo and in ***,the results suggest that neutrophil peptide 1 activates macrophages and accelerates Wallerian degeneration,which may be one mechanism by which neutrophil peptide 1 enhances peripheral nerve regeneration.

关键词： axonal debris inflammatory factors macrophages neutrophil peptide 1 peripheral nerve injury peripheral nerve regeneration raW 264.7 cells sciatic nerve Wallerian degeneration

Effect of dexamethasone injection into Zusanli(ST 36) acupoint on ovalbumin-induced allergic rhinitis

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Journal of Traditional Chinese Medicine 2019年第3期39卷 307-314页

作者： na-ra han Seung-Jun han Phil-Dong Moon Sungwei Hong Hyeongjin Kim Yanhua Li Hyung-Min Kim Hyun-Ja Jeong Department of Pharmacology College of Korean Medicine Kyung Hee University Seoul 02447 Republic of Korea Department of Korean Medicine Graduate School of Wonkwang University Iksan 54538 Republic of Korea Department of Pharmacology Graduate School Kyung Hee University Seoul 02447Republic of Korea Department of Clinical Korean Medicine Graduate School Kyung Hee University Seoul 02447 Republic of Korea Department of Food Science & Technology and Research Institute for Basic Science Hoseo UniversityChungnam 31499 Republic of Korea

OBJECTIVE:To investigate the effects of acupunc ture with dexamethasone(***)on allergic rhini tis(AR)by injecting dexamethasone into the Zusan li(ST 36)***:Thirty 6-week-old female BALB/c mice were sensitized on days 1,5,and 14 by intraperitoneal injection of 100 pg of ovalbumin(OVA).The mice were then randomly divided into six groups(n =5 in each group).Five groups were sensitized intranasally with 2μL of 1.5 mg of OVA for 10 consecutive days,while one group was sensitized intranasally with PBS in a similar manner as a negative control *** hour before each administration of intranasal OVA,two groups were orally administered either a control vehicle(distilled water;AR control group)or 200 pg/kg Dex(*** group),while three groups received *** at Zusanli(ST36)with Dex concentrations of 2,20,and 200μg/kg for each group,*** symptoms were evaluated by measuring the rubbing score,which comprised the number of nose,ear,and eye rubs that occurred in the initial 10 min after OVA intranasal provocation on the 10 th *** isolated spleen,serum,and nasal mucosal tissue after measuring the rubbing *** weight was measured using an electronic *** levels of IgE,thymic stromal lymphopoietin,tumor necrosis factor-a,intercellular adhesion molecule-1,and macrophage-inflammatory protein-2 in serum or nasal mucosal tissue were measured using enzyme-linked immunosorbent *** serum histamine levels of OVA-sensitized AR mice were measured using O-phthaldialdehyde *** blot analysis was performed on nasal mucosal tissue ***:*** significantly reduced the rubbing score,spleen weight,serum IgE,and serum histamine in OVA-sensitized *** significantly decreased the serum levels of inflammatory cytokines(thymic stromal lymphopoietin and tumor necrosis factor-a)in OVA-sensitized *** significantly reduced the nasal mucosal levels of inflammatory markers(intercellular adhesion molecule-l

关键词： Dexamethasone Point ST36 (Zusanli) Pharmaceutical research Acupuncture Rhinitis,allergic Ovalbumin Thymic stromal lymphopoietin

Efficacy and safety of electroacupuncture for insomnia:A systematic review and meta-analysis

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Journal of Integrative Medicine 2024年第4期22卷 459-472页

作者： han-yu Xu Lin-na Wu Yuan Zhang Te Ba Xiao-feng Zhao Acupuncture and Moxibustion Department First Teaching Hospital of Tianjin University of Traditional Chinese MedicineTianjin 300193China national Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion Tianjin 300193China

Background:Electroacupuncture is often used to treat ***:To evaluate the efficacy and safety of electroacupuncture for *** strategy:Databases including PubMed,Cochrane Library,Embase,Web of Science,Chinese Biomedical Literature Database,China national Knowledge Infrastructure,Wanfang Data and VIP Fulltext e-Journals Database were searched up to January 15,*** criteria:randomized clinical trials were included if they compared the clinical efficacy and safety of electroacupuncture with sham acupuncture,no treatment or usual care (UC) and general *** extraction and analysis:The full texts of the studies were reviewed to remove ineligible *** extracted data included authors,publication year,diagnostic criteria,sample size,population characteristics,interventions and *** above steps were performed independently by two reviewers and the data were cross ***15.0 software was used to analyze the extracted outcome *** continuous data (Pittsburgh Sleep Quality Index[PSQI]score and Insomnia Severity Index score),weighted mean difference (WMD) was calculated and 95% confidence interval (CI) was reported when the same scale was *** dichotomous variables (clinical response rate and adverse events),a meta-analysis was performed using risk ratio (RR) as the effect ***:Thirty-one trials with 2226 subjects were *** meta-analysis suggested that electroacupuncture was more effective in improving insomnia compared with the control group (sham acupuncture,no treatment,UC and general acupuncture)(RR=1.21;95 CI:[1.16,1.27]),significantly reducing the PSQI score in insomnia patients after treatment and at follow-up (WMD=-3.23;95%CI:[-4.29,-2.17];P<0.001).There was no significant difference in the incidence of adverse events between the EA and control groups (sham acupuncture and no treatment or ***=1.48;95%CI:[0.91,2.40];P=0.117).In addition,the regression results revealed t

关键词： Electroacupuncture Insomnia Systematic review Meta-analysis

Investigation on taste characteristics and sensory perception of soft-boiled chicken during oral processing based on electronic tongue and electronic nose

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Food Science and Human Wellness 2024年第1期13卷 313-326页

作者： na Xu Xianming Zeng Peng Wang Xing Chen Xinglian Xu Minyi han College of Food Science and Technology Nanjing Agricultural UniversityNanjing 210095China national Center of Meat Quality and Safety Control Nanjing Agricultural UniversityNanjing 210000China State Key Laboratory of Food Science and Technology Jiangnan UniversityWuxi 214122China Wens Foodstuff Co. Ltd.Yunfu 527400China

The sensory perception of food is a dynamic process,which is closely related to the release of flavor substances during oral ***’s not only affected by the food material,but also subjected to the individual oral *** explore the oral processing characteristics of soft-boiled chicken,the sensory properties,texture,particle size,viscosity,characteristic values of electronic nose and tongue of different chicken samples were *** correlation analysis showed that the physical characteristics especially the cohesiveness,springiness,resilience of the sample determined oral processing *** addition of chicken skin played a role in lubrication during oral *** particle size of the bolus was heightened at the early stage,and the fluidity was enhanced in the end,which reduced the chewing time to the swallowing point and raised the aromatic compounds signal of electronic *** the effect of chicken skin on chicken thigh with relatively high fat content,was opposite in electronic nose,which had a certain masking effect on the perception of umami and sweet *** conclusion,fat played a critical role in chicken oral processing and chicken thigh had obvious advantages in comprehensive evaluation of soft-boiled chicken,which was more popular among people.

关键词： Oral processing Chicken Electronic tongue Electronic nose

MdbHLH162 connects the gibberellin and jasmonic acid signals to regulate anthocyanin biosynthesis in apple

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Journal of Integrative Plant Biology 2024年第2期66卷 265-284页

作者： Jian-Ping An Rui-Rui Xu Xiao-na Wang Xiao-Wei Zhang Chun-Xiang You Yuepeng han Apple technology innovation center of Shandong Province College of Horticulture Science and EngineeringShandong Agricultural UniversityTai-An 271018China CAS Key Laboratory of Plant Germplasm Enhancement and Specialty Agriculture Wuhan Botanical GardenHubei Hongshan LaboratoryThe Innovative Academy of Seed Design of Chinese Academy of SciencesWuhan 430074China College of Biology and Oceanography Weifang UniversityWeifang 261061China

Anthocyanins are secondary metabolites induced by environmental stimuli and developmental *** positive regulators of anthocyanin biosynthesis have been reported,whereas the anthocyanin repressors have been *** the signal transduction pathways of gibberellin(GA)and jasmonic acid(JA)and their regulation of anthocyanin biosynthesis have been investigated,the cross-talk between GA and JA and the antagonistic mechanism of regulating anthocyanin biosynthesis remain to be *** this study,we identified the anthocyanin repressor MdbHLH162 in apple and revealed its molecular mechanism of regulating anthocyanin biosynthesis by integrating the GA and JA ***162 exerted passive repression by interacting with MdbHLH3 and MdbHLH33,which are two recognized positive regulators of anthocyanin ***162 negatively regulated anthocyanin biosynthesis by disrupting the formation of the anthocyanin-activated MdMYB1-MdbHLH3/33complexes and weakening transcriptional activation of the anthocyanin biosynthetic genes MdDFR and MdUF3GT by MdbHLH3 and *** GA repressor MdRGL2a antagonized MdbHLH162-mediated inhibition of anthocyanins by sequestering MdbHLH162 from the MdbHLH162-MdbHLH3/33 *** JA repressors MdJAZ1 and MdJAZ2 interfered with the antagonistic regulation of MdbHLH162 by MdRGL2a by titrating the formation of the MdRGL2a-MdbHLH162 *** findings reveal that MdbHLH162 integrates the GA and JA signals to negatively regulate anthocyanin *** study provides new information for discovering more anthocyanin biosynthesis repressors and explores the cross-talk between hormone signals.

关键词： anthocyanin biosynthesis bHLH transcription factor gibberellin jasmonic acid regulatory network transcriptional regulation

TonEBP expression is essential in the IL-1β–induced migration and invasion of human A549 lung cancer cells

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Oncology Research 2024年第1期32卷 151-161页

作者： HEE JU SONG TAEHEE KIM han na CHOI SOO JIN KIM SANG DO LEE Department of Physiology School of MedicineChungnam National UniversityDaejeon35015Korea

Lung cancer has the highest mortality rate among all cancers,in part because it readily *** tumor microenvironment,comprising blood vessels,fibroblasts,immune cells,and macrophages[including tumor-associated macrophages(TAMs)],is closely related to cancer cell growth,migration,and *** secrete several cytokines,including interleukin(IL)-1β,which participate in cancer migration and invasion.p21-activated kinase 1(PAK1),an important signaling molecule,induces cell migration and invasion in several ***responsive enhancer-binding protein(TonEBP)is also known to participate in cancer cell growth,migration,and ***,the mechanisms by which it increases lung cancer migration remain ***,in this study,we aimed to elucidate the mechanisms by which IL-1βand TonEBP affect lung cancer cell migration and *** found that A549 cocultured-MΦ-secreted IL-1βinduced A549 cell migration and invasion via the PAK1 *** deficiency reduced A549 cell migration and invasion and increased responsiveness to IL-1β–induced migration and ***1 phosphorylation,which was promoted by IL-1β,was reduced when TonEBP was *** results suggest that TonEBP plays an important role in IL-1βinduction and invasiveness of A549 cells via the PAK1 *** findings could be valuable in identifying potential targets for lung cancer treatment.

关键词： Lung cancer TonEBP Tumor microenvironment Tumor-associated macrophage IL-1β

Ferroelectric perovskite PbTiO3for advanced photocatalysis

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rare Metals 2024年第9期43卷 4038-4055页

作者： Shuang Zhao Shi-Shi Shen Lu han Bo-Chao Tian na Li Wei Chen Xi-Bao Li School of Materials and Metallurgy University of Science andTechnology Liaoning School of Materials Science and Engineering Nanchang Hangkong University Department of Chemistry National University of Singapore

The ferroelectric semiconductor material PbTiO3exhibits remarkable spontaneous polarization and photoelectric properties, positioning it as a promising polar photocatalyst. The internal electric field of ferroelectrics can separate photocarriers and enhance the catalytic performance of photocatalysts. Moreover, when combined with other semiconductors, PbTiO3contributes to the construction of a depolarization field, extending the catalytic applications of PbTiO3catalysts. PbTiO3exhibits optical absorption, semiconductor, and piezoelectric properties. Its piezoelectric polarization field enhances charge separation, modulates band structure, surface charge conduction, and heterojunction interface charge conduction,thereby amplifying photocatalytic activity. This paper begins by examining the structure, properties, and preparation methods of PbTiO3. Subsequently, it delves into the optimization of PbTiO3's structure and performance,exploring applications in photocatalysis as a ferroelectric photocatalyst. Emphasis is placed on the detailed discussion of surface modification, heterostructure formation, and ferroelectric polarization of PbTiO3ferroelectrics. These aspects are thoroughly explored for their role in regulating activity and optimizing the performance of photocatalysis and photopiezoelectric catalysis. In conclusion, the paper addresses the current research status of PbTiO3ferroelectric materials and highlights the challenges that lie *** intention is to provide valuable references for the ongoing research in PbTiO3ferroelectric materials.

关键词： Polarization