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中西医结合治疗重症急性胰腺炎的难点与展望

中国普外基础与临床杂志 2024年第2期31卷 129-133页

作者：夏庆邓力珲杜丹胡诚石娜四川大学华西医院中西医结合中心胰腺炎中心成都610041

尽管重症急性胰腺炎(severe acute pancreatitis,SAP)的治疗已取得一些进展,仍然存在阻碍疗效再提高的因素:缺乏准确易行的早期严重程度预测体系,多学科协作机制有待进一步优化,尚无中医药临床疗效评价体系,中医药治疗靶点不清、效应物... 详细信息

尽管重症急性胰腺炎(severe acute pancreatitis,SAP)的治疗已取得一些进展,仍然存在阻碍疗效再提高的因素:缺乏准确易行的早期严重程度预测体系,多学科协作机制有待进一步优化,尚无中医药临床疗效评价体系,中医药治疗靶点不清、效应物质不明、新药研发困难。为进一步降低SAP病死率、实现疗效再提高的目标,应加强中西医融合、多学科协作,进一步提高诊疗水平,以临床价值为导向开展基础与临床研究,“说明白”中医药的疗效,“讲清楚”其机制,将研究成果转化为SAP诊疗产品。针对SAP这一重大疑难疾病,应坚持守正创新、中西医协同、优势互补,推进中西医结合治疗SAP的创新发展,进一步降低病死率,减轻疾病负担。

关键词：急性胰腺炎中医药多学科诊治中西医结合治疗

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心房颤动射频消融术后复发的分阶段诊疗思路

中国中医急症 2024年第9期33卷 1566-1568,1585页

作者：时娜杨建飞王贺周亚滨黑龙江中医药大学黑龙江哈尔滨150040 黑龙江中医药大学附属第一医院黑龙江哈尔滨150040

本文认为,心房颤动射频消融术后近期复发患者多以“瘀结正虚”为特点,术后远期复发患者多以“瘀与邪结”为特点。故治疗时应重视辨析术后病机的动态演变,抓病机本质,针对术后近期与远期的病机特点,分阶段辨证论治。在术后近期应化瘀与... 详细信息

本文认为,心房颤动射频消融术后近期复发患者多以“瘀结正虚”为特点,术后远期复发患者多以“瘀与邪结”为特点。故治疗时应重视辨析术后病机的动态演变,抓病机本质,针对术后近期与远期的病机特点,分阶段辨证论治。在术后近期应化瘀与补虚并重,予益气活血、养心安神之法;术后远期应重点关注瘀血与气滞、痰浊、火邪、水饮等实性病邪,将活血化瘀贯穿治疗全程,分别予以理气、豁痰、降火和化饮之法,并关注患者的基础疾病、生活方式和精神心理,从多方位防治射频消融术后房颤复发。

关键词：心房颤动射频消融术分阶段诊疗

Research advance in regulation of fruit quality characteristics by microRnas

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Food Quality and Safety 2020年第1期4卷 1-7页

作者： Li Ma Yan-na shi Don Grierson Kun-song Chen Zhejiang Provincial Key Laboratory of Horticultural Plant Integrative Biology Zhejiang UniversityZijingang CampusHangzhou The State Agriculture Ministry Laboratory of Horticultural Plant Growth Development and Quality ImprovementZhejiang UniversityZijingang CampusHangzhouPR China School of Biosciences University of NottinghamSutton Bonington CampusLoughborough LE125RDUK

MicroRnas(miRnas)are short(19-24 nucleotides in length)noncoding Rnas that have a profound effect on gene *** completely or almost perfectly base-pairing with their individual target mRnas they cause mRna cleavage or repression of *** important regulators,miRnas plays an important role in the regulation of fruit *** studies have been reported in fruits,however current studies are mostly focused on the identification of miRnas and the prediction and validation of target *** review summarizes research progress on the role of miRnas in regulating fruit ripening and senescence and quality characteristics,such as coloration,flavor metabolism,and texture for providing information for future research.

关键词： miRna fruit quality regulation.

浅析我国婴幼儿配方液态奶政策法规和监管要求

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中国乳业 2024年第9期 61-67页

作者：郑跃耿健强姜洁郭蕊周密史娜北京市食品检验研究院(北京市食品安全监控和风险评估中心) 国家市场监管重点实验室(食品安全重大综合保障关键技术)北京100094

婴幼儿配方液态奶在我国刚兴起,相比婴幼儿配方乳粉尚处在萌芽阶段,婴幼儿配方液态奶市场总体发展基本空白。《中华人民共和国食品安全法(修正草案征求意见稿)》和《婴幼儿配方液态奶生产许可审查细则(征求意见稿)》使婴幼儿配方液态奶... 详细信息

婴幼儿配方液态奶在我国刚兴起,相比婴幼儿配方乳粉尚处在萌芽阶段,婴幼儿配方液态奶市场总体发展基本空白。《中华人民共和国食品安全法(修正草案征求意见稿)》和《婴幼儿配方液态奶生产许可审查细则(征求意见稿)》使婴幼儿配方液态奶迎来新进展,推动婴幼儿配方液态奶开发并逐渐成为高端产品,同时婴幼儿配方液态奶也为国内奶粉领域发展迎来利好。本文梳理了婴幼儿配方液态奶现阶段的监管要求和标准,分析拟加强婴幼儿配方液态奶注册及生产许可监管,为监管部门对婴幼儿配方液态奶开展监督管理提供借鉴。

关键词：婴幼儿配方液态奶注册管理生产许可政策法规标准要求

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亲水相互作用色谱-串联质谱法测定15种禽类及其制品中利巴韦林残留总量

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食品安全质量检测学报 2024年第16期15卷 203-210页

作者：史娜耿健强郑跃郭蕊周密姜洁北京市食品检验研究院(北京市食品安全监控和风险评估中心) 国家市场监督管理总局重点实验室(食品安全重大综合保障关键技术)北京100094

目的建立固相萃取-亲水相互作用色谱-串联质谱法测定禽类及其制品中利巴韦林残留总量的方法。方法均质后的样品经20 g/L三氯乙酸提取,酸性磷酸酯酶水解,苯硼酸型离子交换固相萃取柱净化后,由实心核颗粒HILIC色谱柱(100 mm×2.1 mm,1.6... 详细信息

目的建立固相萃取-亲水相互作用色谱-串联质谱法测定禽类及其制品中利巴韦林残留总量的方法。方法均质后的样品经20 g/L三氯乙酸提取,酸性磷酸酯酶水解,苯硼酸型离子交换固相萃取柱净化后,由实心核颗粒HILIC色谱柱(100 mm×2.1 mm,1.6μm)分离,流动相为5 mmol/L乙酸铵水溶液(含0.1%甲酸)-乙腈,梯度洗脱。在正离子扫描多反应监测模式下检测,内标峰面积法定量。结果在15种禽类及其制品基质中做加标曲线,在1~20μg/kg浓度范围内线性关系良好,相关系数为0.995~0.999。在1.0、2.0、10.0μg/kg 3个水平下加标回收率为90.7%~117.9%,相对标准偏差0.8%~9.4%。结论该方法稳定可靠,可适用于多种禽类及其制品中利巴韦林残留量的分析。

关键词：利巴韦林亲水相互作用色谱-串联质谱法禽类及其制品

Reactive Transport Process of Earthquake-induced Hydrochemical Changes in Guanding Thermal Spring,Western Sichuan,China

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Acta Geologica Sinica(English Edition) 2024年第1期98卷 241-249页

作者： na Jin JIANG Xue shi Zheming CHEN Yanmei Hubei Key Laboratory of Petroleum Geochemistry and Environment(Yangtze University) Wuhan 430100China School of Environmental Studies China University of GeosciencesWuhan 430074China School of Water Resources and Environment China University of GeosciencesBeijing 100083China State Key Laboratory of Water Resource Protection and Utilization in Coal Mining Beijing 100000China

Earthquake-related hydrochemical changes in thermal springs have been widely observed;however,quantitative modeling of the reactive transport process is *** the present study,we apply reactive transport simulation to capture the hydrochemical responses in a thermal spring following the Wenchuan Ms 8.0 and Lushan Ms 7.0 *** first constrain deep reservoir geothermal fluid compositions and temperature by multicomponent geothermometry,and then a reactive geochemical transport model is constructed to reproduce the hydrochemical evolution *** results show that the recharge from the shallow aquifer increases gradually until it reaches a peak because of the permeability enhancement caused by the Lushan earthquake,which may be the mechanism to explain the earthquake-related hydrochemical *** contrast to the postseismic effect of the Wenchuan earthquake,the chemical evolution can be considered as hydrochemical anomalies related to the Lushan *** study proves that the efficient simulation of reactive transport processes is useful for investigating earthquake-related signals in hydrochemical time series.

关键词： earthquake hydrochemical changes reactive geochemical transport model Kangding area

Effect of IL-10 on the expression of HSC growth factors in hepatic fibrosis rat

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World Journal of Gastroenterology 2005年第31期11卷 4788-4793页

作者： Mei-na shi Wei-Da Zheng Li-Juan Zhang Zhi-Xin Chen Xiao-Zhong Wang Department of Gastroenterology Union Hospital of Fujian Medical University Fuzhou 350001 Fujian Province China

AIM： To study the effect of IL-10 on the expression of growth factors - transforming growth factor-β1 （TGF-β1）, epidermal growth factor （EGF）, hepatocyte growth factor （HGF）and platelet-derived growth factor （PDGF） of hepatic stellate cells （HSCs） of hepatic fibrosis rat and the anti-fibrogenic role of exogenous IL-10. METHODS： Hepatic fibrosis was induced by CCI4 administration intra-peritoneally. Sixty clean male Sprague-Dawley （SD） rats were randomly divided into three groups： normal control group （GN, 8 rats）, hepatic fibrosis model group （GC, 28 rats） and IL-10 treated group （GI, 24 rats）. At the beginning of the 7^th and 11^th wk, rats in each group were routinely perfused with pronase E and type IV collagenase through a portal vein catheter and the suspension obtained from the liver was spun by centrifugation with 11% Nycodenz density gradient to isolate HSCs. Histological examination was used to determine the degree of hepatic fibrosis. RT-PCR was employed to analyze mRna expression from freshly isolated cells. Immunocytochemistry was performed to detect protein expression in primary cultured HSCs. RESULTS： Rat hepatic fibrosis was developed with the increase of injection frequency of CCl4, and HSCs were successfully isolated. At the 7^th and 11^th wk, TGF-β1, EGF, and HGF mRna in GC increased obviously compared with GN （P = 0.001/0.042, 0.001/0.001, 0.001/0.001） and GI （P= 0.001/0.007, 0.002/0.001, 0.001/0.001）. For TGF-β1, no difference was observed between GI and GN. For EGF, mRna level in GI increased compared with GN during the 7^th wk （P= 0.005） and 11^th wk （P= 0.049）. For HGF, mRna level in GI decreased compared with GN at the 7^th wk （P = 0.001） and 11^th wk （P= 0.021）. Between these two time points, TGF-β1 expression at the 7^th wk was higher than that of the 11^th wk （P = 0.049）, but for EGF, the former was lower than the latter （P = 0.022）. As for PDGF mRna, there was no significant difference between thesegroups, but difference seemed to exist i

关键词： Hepatic fibrosis Hepatic stellate cells Interleukin-10 Transforming growth factor-131 Epidermal growth factor Hepatocyte growth factor Platelet-derived growth factor

Evaluation of the safety and efficacy of therapeutic bandage contact lenses on post-cataract surgery patients

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International Journal of Ophthalmology(English edition) 2018年第2期11卷 230-234页

作者： Dan-na shi Hang Song Tong Ding Wei-Qiang Qiu Wei Wang Department of Ophthalmology Peking University Third Hospital

AIM： To evaluate the safety of therapeutic bandage contact lens for post-cataract surgery patients and to illustrate its efficacy on post-operative comfort and tear-film stability. METHODS： A total of 40 participants were recruited and randomly divided into two groups. Group one was instructed to wear bandage contact lenses for a week and use antibiotic eye drops for a month since the first day after surgery. Group two received sub-conjunctival injection of tobramycin and was asked to wear eye pads on the first day after surgery and then were instructed to use antibiotic eye drops as the first group did. Ocular surface disease index（OSDI） questionnaire, slit-lamp microscope examination of tear break-up time（TBUT）, corneal fluorescein score（CFS）, tear meniscus height（TMH） together with anterior segment optical coherence tomography（AS-OCT） and corneal topography were evaluated preoperatively and postoperatively. RESULTS： The subjective feeling（P=0.004）, TBUT（P〈0.001） and TMH（P=0.02） post-surgery had improved in patients who used bandage contact lenses compared with those who did not at 1wk post-surgery. Until three month postoperatively, the comfort degree（P=0.004） and TMH（P=0.01） of group two were still worse than group one. Moreover, TBUT（P〈0.001） and CFS（P=0.004） of the group with eye pads got worse than the results before, whereas the group with bandage contact lenses recovered to normal. None of these patients had infections or other complications. CONCLUSION： Wearing therapeutic bandage contact lens after cataract surgery, compared with traditional eye-pads, is a safe method to improve tear-film stability and reduce post-operative discomfort without hindering corneal incision recovery.

关键词： bandage contact lens cataract surgery tearfilm stability comfort

2020—2022年全国食品安全监督抽检数据分析

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质量安全与检验检测 2024年第4期34卷 58-62页

对2020—2022年我国食品安全整体情况和食品安全抽检过程中发现的食品安全问题进行分析,通过对不合格食品的种类、不合格指标、以及抽样环节等进行分析,有助于为食品监管部门的日常监管进一步实施“监检联动”,助推食品安全监管工作提... 详细信息

对2020—2022年我国食品安全整体情况和食品安全抽检过程中发现的食品安全问题进行分析,通过对不合格食品的种类、不合格指标、以及抽样环节等进行分析,有助于为食品监管部门的日常监管进一步实施“监检联动”,助推食品安全监管工作提质增效。收集汇总2020—2022年全国食品安全监督抽检结果,从整体情况、食品大类不合格情况、项目类别主要问题分布情况等方面进行分析。结果显示,2020—2022年全国完成食品安全监督抽检共计1990.5192万批次,检出不合格样品52.2661万批次,总体不合格率为2.63%。监督抽检样品涉及34个食品大类,检出不合格率最高的是餐饮食品、食用农产品、蔬菜制品等。农兽药残留超标、微生物污染、超范围超限量使用食品添加剂是造成食品安全抽检不合格的主要原因。2020—2022年我国食品安全总体形势良好,食品安全问题应得到持续关注。

关键词：食品安全监督抽检农药和兽药微生物食品添加剂