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基于一个大型随机试验预测稳定性心绞痛队列患者死亡、心肌梗死和卒中的危险评分

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英国医学杂志中文版 2006年第1期9卷 16-19页

作者： Tim C Clayton Stuart J Pocock Jacobus Lubsen Zoltán Vokó Bridget-Anne Kirwan Keith A A Fox Philip A Poole-wilson Department ofEpidemiology andPopulation Health London School of Hygiene andTropical MedicineLondon Department of Epidemiology and Biostatistics Erasmus Medical Centre 3000 DR Rotterdam Netherlandsprofessor School of Public Health University of Debrecen H-4028 Debrecen Hungary assistant professor SOCAR Research sa PO Box 2564 CH-1260 Nyon 2 Switzerland director Cardiovascular Research Unit EdinburghUniversityEdinburghEH16 4SBprofessor CardiovascularSciences NationalHeart and LungInstitute ImperialCollege LondonLondon SW3 6LYprofessor

目的对需要抗心绞痛治疗并且左心室功能代偿症状稳定的心绞痛患者建立预测全因死亡、心肌梗死和导致致残性卒中的复合危险评分。设计大型多中心临床试验数据的多变量Cox回归分析。背景西欧、以色列、加拿大、澳大利亚和新西兰的心脏专... 详细信息

目的对需要抗心绞痛治疗并且左心室功能代偿症状稳定的心绞痛患者建立预测全因死亡、心肌梗死和导致致残性卒中的复合危险评分。设计大型多中心临床试验数据的多变量Cox回归分析。背景西欧、以色列、加拿大、澳大利亚和新西兰的心脏专科门诊患者。入选者7311例具有全部需要资料的患者被入选。主要结局的测量指标平均随访4.9年时间内所有原因的死亡、心肌梗死或者致残性卒中。结果1063例患者发生任何原因死亡或者持久性心肌梗死或者致残性卒中。这些复合终点的5年危险性在危险性最低的十分位患者为4%,而在危险性最高的十分位患者为35%。危险评分结合16项临床常规变量的降序排序是:年龄、左心室射血分数、吸烟、白细胞计数、糖尿病、随机血糖浓度、肌酐浓度、既往卒中病史、1周至少1次心绞痛发作、冠状动脉造影发现(如果能够获得)、降脂治疗、QT间期、收缩期血压≥150mmHg、抗心绞痛药物数量、陈旧性心肌梗死以及性别。把这个模型分别应用于任何原因所致的死亡、心肌梗死和卒中进行预测评估,所得的结果相似。危险评分似乎不能预测事件性质(39%的死亡、46%心肌梗死以及15%致残性卒中)或者冠状动脉造影或血管重建率(占29%的患者)。结论该危险评分对客观地决定稳定性心绞痛患者进一步治疗措施以减少重要预后事件发生是有帮助的。该危险评分同样可以用于将来的计划性试验。

关键词：陈旧性心肌梗死心绞痛患者稳定性心绞痛冠状动脉造影危险评分随机试验血管重建治疗措施卒中预测

独立于心血管危险因素:中年男性较女性单核细胞致炎因子释放水平较高而糖皮质激素敏感性较低

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世界核心医学期刊文摘（心脏病学分册） 2005年第1期1卷 17-18页

作者： wirtz P.H. Von Knel R. Rohleder n. Fischer J.E. 张明娟 Institute of Behavioural Sciences Swiss Fed. Institute of Technology Turnerstrasse 1 C H-8092 Zurich SwitzerlandDr.

Objective: To investigate whether stimulated monocyte cytokine release and its inhibition by glucocorticoids differs between men and women. Design: In vitro m onocyte interleukin 6 (IL-6) and tumour necrosis factor α(TnFα) release after lipopolysaccharide stimulation were assessed with and without co-incubation with increasing doses of dexamethasone and hyd rocortisone separately. glucocorticoid sensitivity was defined as the amount of a particular glucocorticoid required to inhibit lipopolysaccharide stimulated mo nocyte cytokine release by 50%. The established cardiovascular risk factors of age, body mass index, number of cigarettes smoked daily, low density cholesterol to high density cholesterol ratio, systolic and diastolic blood pressure, and h aemoglobin A1c were used as covariates. Setting: Aircraft manufacturing plant in southern germany. Patients: 269 middle aged male and 36 middle aged female empl oyees. Results: Release of monocyte IL-6 and TnFα(each p=0.001) was higher in samples from men than in those from women. Inhibition of lipopolysaccharide stim ulated IL-6 and TnFαrelease by either glucocorticoid was less pronounced in sa mples from men than in those from women (IL-6: dexamethasone p=0.033, hydrocort isone p=0.029; TnFα: dexamethasone pne p=0.089). Conclusio ns: The finding suggests that proinflammatory activity of circulating monocytes is higher in men than in women independent of cardiovascular risk factors, there by providing one explanation for the relatively greater coronary risk in men.

关键词：血管危险因素释放水平中年男性致炎因子糖皮质激素男性冠心病肿瘤坏死因子α 高密度脂蛋白因子分泌抑制作用

伴有黏液样变的原发性肝脏肿瘤:形态学罕见的肝脏腺瘤和肝细胞性肝癌

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临床与实验病理学杂志 2015年第6期31卷 606-606页

作者： salaria S n graham R P Aishima S 魏建国许春伟浙江省绍兴市人民医院病理科绍兴312000 解放军307医院病理科北京100071

sa1aria S n，graham R P，Aishima S，et al. Primary hepatic tumors with myxoid change：morpho1ogica11y unique hepatic ade-nomas and hepatoce11u1ar carcinomas. Am J Surg Patho1，2015，39（3）：318-24。原发性肝脏肿瘤中，如果有黏液产生被认为是向胆道分化最直接的证据。然而，作者观察到在良性和恶性的肝脏肿瘤中，均可有丰富的细胞外黏液产生，而这些肿瘤仅有向肝细胞分化的依据。为进一步描述这种不同寻常的发现，作者发现9例类似的病例并对其进行进一步的研究，其中4例为肝脏腺瘤，5例为肝细胞性肝癌。

关键词：肝细胞性肝癌肝脏肿瘤肝脏腺瘤黏液样原发性形态学肝细胞分化 graham

以肝脏大部切除术后剩余肝脏体积预测肝功能不全及感染的应用价值

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世界核心医学期刊文摘（胃肠病学分册） 2005年第6期1卷 47-48页

作者： Schindl M.J. Redhead D.n. Fearon K.C.H. S.J.wigmore 雒向宁 Dept. of Clin./Surg. Sci. (Surgery) Royal Infirmary Edinburgh 51 Little France Crescent Edinburgh EH16 4SA United Kingdom

Background and aims: major liver resection incurs a risk of postoperative liver dysfunction and infection and there is a lack of objective evidence relating residual liver volume to these complications. Patients and methods: Liver volumetry was performed on computer models derived from computed tomography (CT) angioportograms of 104 patients with normal synthetic liver function scheduled for liver resection. Relative residual liver volume (%RLV) was calculated as the relation of residual to total functional liver volume and related to postoperative hepatic dysfunction and infection. Receiver operator characteristic curve analysis was undertaken to determine the critical %RLV predicting severe hepatic dysfunction and infection. Univariate analysis and multivariate logistic regression analysis were performed to delineate perioperative predictors of severe hepatic dysfunction and infection. Results: The incidence of severe hepatic dysfunction and infection following liver resection increased significantly with smaller %RLV. A critical %RLV of 26.6%was identified as associated with severe hepatic dysfunction (pnally, body mass index (BMI), operating time, and intraoperative blood loss were significant prognostic indicators for severe hepatic dysfunction. It was not possible to predict the individual risk of postoperative infection precisely by %RLV. However, in patients undergoing major liver resection, infection was significantly more common in those who developed postoperative severe hepatic dysfunction compared with those who did not (p = 0.030). Conclusions: The likelihood of severe hepatic dysfunction following liver resection can be predicted by a small %RLV and a high BMI whereas postoperative infection is more related to liver dysfunction than precise residual liver volume. Understanding the relationship between liver volume and synthetic and immune function is the key to improving the safety of major liver resection.

关键词：肝功能不全肝脏体积切除术术后肝功能术中失血量预测术手术安全性静脉血管造影围手术期单变量分析

电针对大鼠心肌缺血相关长链非编码RnA及mRnA表达谱的影响

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中国中医药现代远程教育 2017年第16期15卷 140-143页

作者：萨喆燕潘晓华黄倩茹万隆朱小香董亚琴许金森福建省中医药研究院.福建省经络感传重点实验室福建福州350003

目的探讨电针对心肌缺血大鼠心肌组织长链非编码RnA(long noncoding RnA,lnc RnA)表达的影响。方法 18只SD大鼠随机分为模型组、电针组、生理盐水对照组,每组6只。模型组、电针组大鼠经皮下多点位注射盐酸异丙肾上腺素(isoproterenol,I... 详细信息

目的探讨电针对心肌缺血大鼠心肌组织长链非编码RnA(long noncoding RnA,lnc RnA)表达的影响。方法 18只SD大鼠随机分为模型组、电针组、生理盐水对照组,每组6只。模型组、电针组大鼠经皮下多点位注射盐酸异丙肾上腺素(isoproterenol,ISO)制备心肌缺血模型,电针组电针内关穴5 d,比较各组心电图ECg偏移幅度;采用lnc R n A芯片检测电针组和模型组大鼠心肌组织lnc RnA和m RnA的表达差异,筛选出电针治疗心肌缺血相关的lnc RnA;实时荧光定量PCR验证3个随机挑选的lnc RnA。结果相较于模型组,电针组ECg偏移较小,差异表达的lnc RnA共547个,m RnA738个,PCR验证结果与芯片结果基本一致。结论与模型组比较,电针组大鼠lnc RnA表达谱变化显著,lnc RnA可能在电针治疗心肌缺血过程中发挥一定作用。

关键词：长链非编码RnA 心肌缺血电针

北京市某区1例人感染H7n9禽流感病毒的HA和nA基因特征分析

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实用预防医学 2020年第6期27卷 667-671页

作者：吴杨牛桓彩庄鹏李东迅刘重程李飒舒高林潘阳北京市昌平区疾病预防控制中心北京102200 北京市疾病预防控制中心北京100013

目的了解北京市某区1例人感染H7n9禽流感病毒基因特征,为禽流感病例的早期发现、疫情控制提供参考。方法提取病例临床样本病毒核酸,反转录扩增后进行病毒血凝素基因(hemagglutinin, HA)、神经氨酸酶基因(neuraminidase, nA)序列测定。... 详细信息

目的了解北京市某区1例人感染H7n9禽流感病毒基因特征,为禽流感病例的早期发现、疫情控制提供参考。方法提取病例临床样本病毒核酸,反转录扩增后进行病毒血凝素基因(hemagglutinin, HA)、神经氨酸酶基因(neuraminidase, nA)序列测定。获得的病毒序列与全球流感共享数据库中H7n9禽流感病毒株进行序列分析,比较该病毒与北京市既往发现株和其他省市毒株同源性,构建系统发育树,并对部分耐药位点和糖基化位点进行分析。结果北京市某区1例H7n9禽流感病毒为低致病性禽流感。HA、nA与北京既往发现的29株毒株氨基酸同源性为97.2%~100%和96.8%~100%,基于系统进化分析与之最为相近的疫苗株为A/Hunan/02650/2016。HA蛋白受体结合位点发生了g186V、Q226L突变,HA和nA的糖基化位点均未发生变化。结论该区出现的H7n9病毒与北京地区既往发现H7n9毒株具有高度同源性,部分氨基酸位点存在变异,但未发生耐药突变。

关键词： H7n9 禽流感序列分析

8-Hydroxyquinolylnitrones as multifunctional ligands for the therapy of neurodegenerative diseases

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Acta Pharmaceutica Sinica B 2023年第5期13卷 2152-2175页

作者： Damijan Knez Daniel Diez-Iriepa Mourad Chioua Andrea gottinger Milica Denic Fabien Chantegreil Florian nachon Xavier Brazzolotto Anna Skrzypczak-wiercioch Ane Meden Anja Pilar Janko Kos Simon akelj Jure Stojan Kinga saat Julia Serrano Ana Patricia Fernández Aitana Sánchez-garcía Ricardo martínez-Murillo Claudia Binda Francisco López-Muoz Stanislav gobec Josémarco-Contelles University of Ljubljana Faculty of PharmacyLjubljana 1000Slovenia Laboratory of Medicinal Chemistry(Institute of Organic Chemistry CSIC)Madrid 28006Spain Departamento de Química Orgánicay Química Inorgánica Alcaláde HenaresMadrid 28871Spain Department of Biology and Biotechnology University of PaviaPavia 27100Italy Département de Toxicologie et Risques Chimiques Institut de Recherche Biomédicale des ArméesParis 91220France Department of Animal Anatomy and Preclinical Sciences University Centre of Veterinary Medicine JU-UAUniversity of Agriculture in KrakowKrakow 30-059Poland Institute of Biochemistry Faculty of MedicineUniversity of LjubljanaLjubljana 1000Slovenia Department of Pharmacodynamics Chair of PharmacodynamicsFaculty of PharmacyJagiellonian University Medical CollegeKrakow 30-688Poland Department of Translational neurobiology Neurovascular Research GroupCajal Institute(CSIC)Madrid 28002Spain Biotechnology and Vegetal Biology Department Escuela Técnica Superior de Ingeniería AgronómicaAlimentaria y de BiosistemasUniversidad Politécnica de MadridMadrid 28040Spain Faculty of Health Camilo JoséCela University of Madrid(UCJC)Neuropsychopharmacology Unit“Hospital 12 de Octubre”Research InstituteMadrid 28692Spain

we describe the development of quinolylnitrones(Qns)as multifunctional ligands inhibiting cholinesterases(ChEs:acetylcholinesterase and butyrylcholinesterase—h BChE)and monoamine oxidases(hmaO-A/B)for the therapy of neurodegenerative *** identified Qn 19,a simple,low molecular weight nitrone,that is readily synthesized from commercially available *** 19 has no typical pharmacophoric element to suggest ChE or maO inhibition,yet unexpectedly showed potent inhibition of h BChE(IC50=1.06±0.31 nmol/L)and h maO-B(IC_(50)=4.46±0.18μmol/L).The crystal structures of 19 with hBChE and hmaO-B provided the structural basis for potent binding,which was further studied by enzyme *** 19 acted as a free radical scavenger and biometal chelator,crossed the blood—brain barrier,was not cytotoxic,and showed neuroprotective properties in a 6-hydroxydopamine cell model of Parkinson's *** addition,in vivo studies showed the anti-amnesic effect of 19 in the scopolamine-induced mouse model of AD without adverse effects on motoric function and ***,chronic treatment of double transgenic APPswe-PS1δE9 mice with 19 reduced amyloid plaque load in the hippocampus and cortex of female mice,underscoring the disease-modifying effect of Qn 19.

关键词： Quinolylnitrone Butyrylcholinesterase Monoamine oxidase B Alzheimer's disease Multifunctional ligands 6-Hydroxydopamine model Passive avoidance task novel object recognition

动态增强磁共振成像对直肠癌术前新辅助治疗疗效的评价

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磁共振成像 2010年第2期1卷 103-109页

作者：周妮娜陈敏王文超赵伟峰杨正汉李飒英张晨卫生部北京医院放射科 100730

目的观察动态增强磁共振(DCE-MRI)能否在术前判断直肠癌新辅助治疗的疗效,比较常规T2wI与DCE-MRI对直肠癌术前T、n分期的准确性。方法收集术前或术后病理确诊的直肠癌患者40例。其中行术前新辅助治疗者22例,未进行术前新辅助治疗者18例... 详细信息

目的观察动态增强磁共振(DCE-MRI)能否在术前判断直肠癌新辅助治疗的疗效,比较常规T2wI与DCE-MRI对直肠癌术前T、n分期的准确性。方法收集术前或术后病理确诊的直肠癌患者40例。其中行术前新辅助治疗者22例,未进行术前新辅助治疗者18例。所有患者均在gE1.5T Twinspeed HD MR扫描仪行盆腔动态增强扫描。扫描序列包括T2wI压脂、T1wI、DwI,快速三维容积T1加权脂肪抑制成像增强扫描(3DLAVA)。分析动态增强曲线的各项参数在新辅助治疗前后的变化,观察癌灶曲线上升速率。结果①对未进行术前治疗的直肠癌分期的准确性:DCE-MRI与常规T2wI对直肠癌T分期的准确性分别为83.3%和66.7%,对环周切缘阴性判断准确性为88.2%和70.6%。T2wI及DCE-MRI均能发现直径≥2mm的淋巴结。②对新辅助治疗后直肠癌再分期的准确性:DCE-MRI对T、n再分期的准确性可达86.4%和81.8%,对环周切缘情况判断准确性为100%。而T2wI进行T、n再分期较困难。③治疗前癌灶的曲线上升速率明显高于正常肠管;治疗后达病理完全缓解组原癌灶部略低于下段正常肠管,但是差异不明显;治疗后未达病理完全缓解组癌灶部仍高于下段正常肠管。结论DCE-MRI对术前直肠癌分期的准确性高,并能够准确判断新辅助治疗后癌周切缘情况。癌灶与参照肠管的上升速率比较有助于在术前判断疗效。

关键词：直肠肿瘤磁共振成像,动态增强肿瘤辅助疗法肿瘤分期

不同麻醉及镇痛方法对子宫肌瘤患者围术期凝血功能的影响

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宁夏医学杂志 2016年第11期38卷 1000-1002页

作者：孙建坤张永海田新利马汉祥宁夏吴忠市人民医院宁夏吴忠751100 宁夏医科大学总医院宁夏银川750004

目的比较蛛网膜下腔阻滞-硬膜外镇痛与全麻-静脉镇痛对行子宫肌瘤手术患者围术期凝血功能的影响。方法选择行开腹子宫肌瘤剔除手术或开腹全子宫切除手术患者60例,随机分为蛛网膜下腔阻滞-硬膜外镇痛组(sa组,n=30)与全麻-静脉镇痛组(gA组... 详细信息

目的比较蛛网膜下腔阻滞-硬膜外镇痛与全麻-静脉镇痛对行子宫肌瘤手术患者围术期凝血功能的影响。方法选择行开腹子宫肌瘤剔除手术或开腹全子宫切除手术患者60例,随机分为蛛网膜下腔阻滞-硬膜外镇痛组(sa组,n=30)与全麻-静脉镇痛组(gA组,n=30)。分别于麻醉前(T_1)、术毕即刻(T_2)和术后48h(T3)时间点,抽取患者静脉血检测凝血酶原时间(PT)、激活部分凝血活酶时间(APTT)、凝血酶时间(TT)和纤维蛋白原(FIB)。结果在全麻-静脉镇痛组,围术期期间T_1、T_2、T3时间点PT、APTT和TT变化差异无统计学意义(P>0.05);在蛛网膜下腔阻滞-硬膜外镇痛组,TT在围术期期间3个时间点无明显变化,PT、APTT在T_1、T_2时间点差异无统计学意义(P>0.05),而在术后T_3时间点与术前比较明显延长(PgA组明显高于sa组(P<0.05)。结论与全麻-术后静脉镇痛相比,蛛网膜下腔阻滞-硬膜外镇痛可有效预防子宫肌瘤手术患者围术期的高凝状态。

关键词：全身麻醉蛛网膜下腔阻滞镇痛凝血功能