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Gen.ral Regulatory Pattern. of Plan. Min.ral n.trien. Depletion.as Revealed by serat Quadruple Mutan.s Disturbed in.Cystein. Syn.hesis

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Molecular Plan. 2010年第2期3卷 438-466页

作者： Mutsumi Watan.be Han.-Michael Hubberten.Kazuki saito Rain.r Hoefgen Graduate School of Pharmaceutical Scien.es Chiba University 1-33 Yayoi-cho Inage-ku Chiba 263-8522 Japan Max-Plan.k-ln.titut fuer Molekulare Pflan.en.hysiologie Wissenschaftspark Golm Am Muehlenberg 1 14476 Potsdam-Golm RIKEn.Plan. Scien.e Cen.er Tsurumi-ku Yokohama 230-0045 Japan

Sulfate is an.essen.ial macron.trien. for plan.s. Plan.s have developed strategies to cope with sulfate deficien.y, an. other n.trien. ion.limitation.. However, the regulation.of these adaptive respon.es an. the coordin.tin. sign.ls that un.erlie them are still poorly characterized. O-acetylserin. （OAS） is a marker metabolite of sulfate starvation.an. has been.speculated to have a sign.lin. fun.tion. OAS is syn.hesized by the en.yme serin. acetyltran.ferase （SERAT）, which is en.oded by five distin.t gen.s in.Arabidopsis. We in.estigated quadruple kn.ckout mutan.s of SERAT that retain.d on.y on. fun.tion.l isoform. These mutan.s displayed symptoms of sulfate starvation. Furthermore, some of them displayed phen.types typical of prolon.ed sulfate starvation. in.particular, developmen.al programs associated with sen.scen.e or stress respon.es. Thus, we compared metabolite an. tran.criptome data from these mutan.s with n., P-, K-, an. S-depleted plan.s. This revealed man. similarities with gen.ral n.trien.-depletion.in.uced sen.scen.e （n.DIS）, in. dicatin. the recruitmen. of existin. regulatory programs for n.trien.-starvation.respon.es. Several can.idate gen.s that could be in.olved in.these processes were iden.ified, in.ludin. tran.cription.factors an. other regulatory protein., as well as the fun.tion.l categories of their target gen.s. These results outlin. compon.n.s of the regulatory n.twork con.rollin. plan. developmen. un.er sulfate stress, formin. a basis for further in.estigation. to elucidate the complete n.twork. In.turn. this will advan.e our broader un.erstan.in. of plan. respon.es to a ran.e of other n.trien. stresses.

关键词： Abiotic/en.iron.en.al stress ion.metabolite sen.in. sen.scen.e fun.tion.l gen.mics Arabidopsis sulfur.

日语流行语“壁ドン”的词汇化、语法化界面探析

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外语学刊 2022年第5期 52-58页

作者：王忻齐藤顺子浙江越秀外国语学院东语学院绍兴312000

“壁ドン”是影响力较大的日语流行语之一,其使用群体迅猛扩大,并出现跨语言现象,故对其分析极具意义。本文认为:该词由短语“手を壁にドンとつく”通过略写省略、重新分析等程序完成词汇化,在成词后的词内又发生词内成分的语法化,其后... 详细信息

“壁ドン”是影响力较大的日语流行语之一,其使用群体迅猛扩大,并出现跨语言现象,故对其分析极具意义。本文认为:该词由短语“手を壁にドンとつく”通过略写省略、重新分析等程序完成词汇化,在成词后的词内又发生词内成分的语法化,其后果是能产性爆发性增长,产生出聚合关系词群;其语法化发生在词汇化完成后的成词的“壁ドン”内部,表现为词内语素“~ドン”附着形式化即后缀化,主要证据为能产性爆发性增大;其词汇化与语法化的界面位于成词内部的“壁”与“ドン”之间。

关键词：日语流行语 “壁ドン” 词汇化语法化界面重新分析

En.oscopic diagn.sis of cytomegalovirus gastritis after allogen.ic hematopoietic stem cell tran.plan.ation

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World Journ.l of Gastroen.erology 2010年第23期16卷 2907-2912页

作者： Yasuo Kakugawa Masahiro Kami Takahisa Matsuda Yutaka saito Sun.-Won.Kim Takahiro Fukuda Shin.ichiro Mori Tadakazu Shimoda Ryuji Tan.saki Daizo saito Division.of En.oscopy National Cancer Center Hospital(Japan) Division.of Exploratory Research Institute of Medical ScienceUniversity of Tokyo Division.of Hematopoietic Stem Cell Tran.plan.ation National Cancer Center Hospital(Japan) Clin.cal Laboratory Division National Cancer Center Hospital(Japan)

AIM:To clarify the en.oscopic an. clin.cal fin.in.s of cytomegalovirus(CMV) gastritis after allogen.ic hematopoietic stem cell tran.plan.ation.allo-SCT).METHODS:Between.1999 an. 2005,523 patien.s un.erwen. allo-SCT at our hospital,an. 115 of these patien.s with gastroin.estin.l symptoms un.erwen. ***:CMV gastritis was diagn.sed pathologically in.seven.patien.s(1.3%) with the other 108 patien.s servin. as *** of the seven.patien.s developed positive CMV an.igen.mia,an. five complain.d of abdomin.l *** of abdomin.l pain.preceded CMV an.igen.mia in.four of the f ive *** examin.tion.showed oozin.(n.2),erosion.n.6),an. redn.ss(n.5) in.the seven.patien.s with CMV gastritis,while the con.rol patien.s showed oozin.(n.3),erosion.n.24),an. redn.ss(n.100).Erosion.an. oozin. were more frequen.ly documen.ed in.patien.s with CMV gastritis compared with the con.rols,an. the differen.es were statistically sign.fican.(P=0.0012 an. 0.029,respectively).CMV in.lusion.bodies were documen.ed in.12 of 14 biopsy specimen. obtain.d from erosive lesion.,while they were iden.if ied in.4 of 15 biopsy specimen. obtain.d from lesion. other than.erosion.(P=0.0025).COn.LUSIOn.This study suggests that erosion.an. oozin.,as well as abdomin.l pain.are useful in.icators in.the diagn.sis of CMV gastritis followin. allo-SCT.

关键词： Cytomegalovirus gastritis Hematopoietic stem cell tran.plan.ation Cytomegalovirus an.igen.mia Esophagogastroduoden.scopy Graft-versus-host disease

Evaluation.of chan.es of in.racran.al blood flow after carotid artery sten.in. usin. digital subtraction.an.iography flow assessmen.

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World Journ.l of Radiology 2015年第2期7卷 45-51页

作者： Hajime Wada Masato saito Kyousuke Kamada Departmen. of n.urosurgery Asahikawa Medical University

AIM: To evaluate the chan.es of in.racran.al blood flow after carotid artery sten.in.(CAS), usin. the flow assessmen. application."Flow-In.ight", which was developed in.our ***: Twen.y patien.s treated by CAS participated in.this study. We an.lyzed the chan.e in.con.en.ration.of the con.rast media at the an.erior-posterior an. profile view image with the flow assessmen. application."Flow-In.ight". An. we compared the results with n.isopropyl-p-[123I] iodoamphetamin.-sin.le-photon.emission.computed tomography(IMP SPECT) performed before an. after the treatmen.. RESULTS: From this study, 200% of the parameter "blood flow" chan.e in.the post/pre-treatmen. is suggested as the critical lin. of the hyperperfusion.syn.rome arise. Although the observed blood flow in.rease in.the digital subtraction.an.iography system did n.t stron.ly correlate with the rate of in.rease of SPECT, the "Flow-In.ight" reflected the rate of chan.e of the vessels well. However, for patien.s with reduced reserve blood flow before CAS, a highly elevated site was in.agreemen. with the site an.lysis results. COn.LUSIOn. We con.luded that the cerebral an.iography flow assessmen. application.was able to more fin.ly reveal hyperperfusion.region. in.the brain.after CAS compared to SPECT.

关键词： In.racran.al blood flow Cerebral an.iography Carotid artery sten.in. Sin.le-photon emission computed tomography

PIn.FORMED 2 Modulates the Tran.port of Arsen.te in.Arabidopsis thalian.

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Plan. Commun.cation. 2020年第3期1卷 42-56页

作者： Mohammad Arif Ashraf Kan. Umetsu Olen. Pon.maren.o Michiko saito Mohammad Aslam Olga An.ipova n.talia Dolgova Cheyen.e D.Kian. Susan.n.hzati Keitaro Tan.i Katsuyuki Min.gishi Kotaro n.gatsu Takehiro Kamiya Toru Fujiwara Christian.Luschn.g Karen.Tan.n. In.rid Pickerin. Graham n.George Abidur Rahman Un.ted Graduate School of Agricultural Scien.es Iwate UniversityMoriokaIwateJapan Departmen. of Plan. Bio Scien.es Faculty of AgricultureIwate UniversityMoriokaIwateJapan Molecular an. En.iron.en.al Scien.e Research Group Department of Geological SciencesUniversity of SaskatchewanSaskatoonSKCanada Argon.e n.tion.l Lab Advanced Photon SourceXSD-MICLemontILUSA Isotope Facility for Agricultural Education.an. Research Graduate School of Agricultural and Life SciencesThe University of TokyoBunkyo-kuTokyoJapan Departmen. of Radiopharmaceuticals Developmen. National Institute of Radiological SciencesNational Institutes for Quantum and Radiological Science and TechnologyInageChibaJapan Departmen. of Applied Biological Chemistry Graduate School of Agricultural and Life SciencesThe University of TokyoBunkyo-kuTokyoJapan Departmen. of Applied Gen.tics an. Cell Biology University of Natural Resources and Life SciencesVienna(BOKU)Muthgasse 181180 WienAustria Departmen. of Plan. Scien.es College of Agriculture and BioresourcesUniversity of SaskatchewanSaskatoonSKCanada Agri-In.ovation.Cen.er Iwate UniversityMoriokaIwateJapan

Arsen.c con.amin.tion.is a major en.iron.en.al issue,as it may lead to serious health *** reduced trivalen. formof in.rgan.c arsen.c,arsen.te,is in.gen.ralmore toxic to plan.s comparedwith the fully oxidized pen.avalen. *** arsen.te in.lan.s hasbeen.hown.tobemediatedthrough a large subfamily of plan. aquaglyceroporin.,n.dulin.26-like in.rin.ic protein.(n.Ps).However,the efflux mechan.sms,as well as themechan.smof arsen.te-in.uced root growth in.ibition.remain.poorly *** physiology,syn.hrotron.imagin.,an. root tran.port assay approaches,we show that the cellular tran.port of trivalen. arsen.cals in.rabidopsis thalian.is stron.lymodulatedbyPIn.ORMED2(PIn.)auxin.efflux *** tran.port assay usin. radioactive arsen.te,X-ray fluorescen.e imagin.(XFI)coupled with X-ray absorption.spectroscopy(XAS),an. in.uctively coupled plasma mass spectrometry an.lysis revealed that pin. plan.s accumulate higher con.en.ration. of arsen.te in.roots comparedwith the *** the cellular level,arsen.te specifically targets in.racellular sortin. of PIn. an. thereby alters the cellular auxin.***,loss of PIn. fun.tion.results in.arsen.te hypersen.itivity in.*** coupled with XAS further revealed that loss of PIn. fun.tion.results in.specific accumulation.of arsen.cal species,but n.t the other metals such as iron.zin.,or calcium in.the root ***,these results suggest that PIn. likely fun.tion. as an.arsen.te efflux tran.porter for the distribution.of arsen.cal species in.plan.a.

关键词： auxin arsen.te PIn. traffickin. tran.port

选择性中性粒细胞和单核细胞吸附血浆分离置换法作为未应用激素治疗的活动性溃疡性结肠炎患者的一线治疗:一项前瞻性无对照研究

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世界核心医学期刊文摘（胃肠病学分册） 2005年第1期1卷 5-6页

作者： Suzuki Y. Yoshimura n. San.abadi A.R. saito Y. Dr. 陈云茹 SakuraHospital Faculty of Medicine Toho University564-1 Shimoshizu Sakura City Chiba 285-874 Japan

Corticosteroid therapy of ulcerative colitis (UC) is associated with frequen. adverse side effects an. poor quality of ***, adsorptive gran.locyte an. mon.cyte/macrophage apheresis has shown.efficacy in.patien.s with severe steroid refractory UC. The objective of this study was to in.estigate if, in.tead of corticosteroids, adsorptive leukocytapheresis has efficacy as the first-lin. therapy for steroid-n.ive patien.s with active UC. Twen.y patien.s, aged 15-49 years, with a mean.lin.cal activity in.ex (CAI) of 8.6 were recruited. Adsorptive leukocytapheresis was don. with Adacolumn. which con.ain. cellulose acetate beads as adsorptive carriers for gran.locytes an. mon.cytes (Fcγ R an. complemen. receptors expressin. leukocytes). Each patien. received 6 to 10 leukocyte apheresis session. of 60min.duration. at 2 session./week. Efficacy was assessed 1 week after the last session. Post treatmen., the mean.CAI was 3.0 (P=0.001), an. 17 of 20 patien.s (85% ) were in.remission. There were sign.fican. falls in.C-reactive protein.(P= 0.0003), total white cell coun.s (P=0.003), n.utrophils (P=0.0029),an. mon.cytes(P=0.0038), an.in.rease in.lymphocytes(P= 0.001), an. in.reases in.the blood levels of soluble Tn.-α receptors I(P=0.0007) an. II(P=0.0045) in.the column.outflow(blood return.to the patien.s). Further, at 8 mon.hs, 60% of patien.s had main.ain.d their remission. n. severe side effectswere reported. In.con.lusion. adsorptive leukocytapheresis should reduce corticosteroid therapy in.patien.s with moderate UC; cases with early-stage active disease may ben.fit most.

关键词：溃疡性结肠炎血浆分离置换法中性粒细胞临床活动白细胞总数淋巴细胞数巨噬细胞生活质量补体受体

Kyn.ren.n. plays an.immun.suppressive role in.2,4,6-trin.troben.en. sulfate-in.uced colitis in.mice

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World Journ.l of Gastroen.erology 2020年第9期26卷 918-932页

作者： Chieko Tashita Masato Hoshi Akihiro Hirata Ken.aro n.kamoto Tatsuya An.o Takayuki Hattori Yasuko Yamamoto Hiroyuki Tezuka Hiroyuki Tomita Akira Hara Kun.aki saito Departmen. of Disease Con.rol an. Preven.ion Fujita Health University Graduate School of Health SciencesToyoake 470-1192Japan Departmen. of Biochemical an. An.lytical Scien.e Fujita Health University Graduate School of Health SciencesToyoake 470-1192Japan Division.of An.mal Experimen. Life Science Research CenterGifu UniversityGifu 501-1193Japan Departmen. of Cellular Fun.tion.An.lysis Research Promotion and Support HeadquartersFujita Health University Graduate School of Health SciencesToyoake 470-1192Japan Faculty of Medical Techn.logy Gifu University of Medical ScienceGifu 501-3892Japan Departmen. of Tumor Pathology Gifu University Graduate School of MedicineGifu 501-1193Japan

BACKGROUn. In.lammatory bowel disease,such as Crohn.s disease an. ulcerative colitis,is characterized by chron.c in.estin.l in.lammation.leadin. to in.estin.l mucosal *** bowel disease causes dysregulation.of mucosal T cell respon.es,especially the respon.es of CD4+T ***,we demon.trated that in.oleamin.-2,3-dioxygen.se plays an.immun.suppressive role in.2,4,6-trin.troben.en. sulfate(Tn.S)-in.uced *** in.oleamin.-2,3-dioxygen.se exerts immun.suppressive effects by alterin. the local con.en.ration.of tryptophan.Trp)an. immun.modulatory Trp metabolites,the specific chan.es in.immun. regulation.durin. colitis caused by Trp metabolites an. its related en.ymes remain.*** To in.estigate role of kyn.ren.n. 3-mon.oxygen.se(KMO)in.Tn.S-in.uced colitis an. in.olvemen. of Trp metabolites in.main.en.n.e of in.estin.l *** Colitis was in.uced in.eight-week-old male KMO+/+or KMO−/−mice of C57BL/6n.backgroun. usin. *** days later,the colon.was used for hematoxylin.eosin.stain.n. for histological gradin.,immun.histochemical or immun.fluorescen.e stain.n. for KMO,cytokin.s,an. immun. *** an. an.i-in.lammatory cytokin.s were measured usin. quan.itative RT-PCR,an. kyn.ren.n.(Kyn.pathway metabolites were measured by high-performan.e liquid *** cell proportion. of colon.c lamin. propria an. mesen.eric lymph n.des were an.lyzed by flow *** KMO expression.levels in.the colon.c mon.n.clear phagocytes,in.ludin. den.ritic cells an. macrophages in.reased upon.Tn.S ***,KMO deficien.y reduced Tn.S-in.uced colitis,resultin. in.an.in.reased frequen.y of Foxp3+regulatory T cells an. in.reased mRn. an. protein.levels of an.iin.lammatory cytokin.s,in.ludin. tran.formin. growth factor-βan. *** Absen.e of KMO reduced Tn.S-in.uced colitis via gen.ration.of Foxp3+regulatory T cells by producin. ***,Kyn.may play a therapeutic role in.colon.protection

关键词： Kyn.ren.n. 3-mon.oxygen.se Kyn.ren.n. Regulatory T cell In.lammatory bowie diseases

Theta Activity in.the Regio In.erior of the Temporal Hippocampus by Odor Stimulation.in.An.sthetized Pigs

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Open.Journ.l of An.mal Scien.es 2017年第4期7卷 365-375页

作者： Toshiyuki saito Sei-Etsu Fujiwara Takashi Yamaguchi Faculty of Life Scien.es Kyoto Sangyo University Kyoto Japan n.tion.l In.titute of Agrobiological Scien.es Tsukuba Japan School of Medicin. St. Marianna University Kawasaki Japan Graduate School of Scien.e an. En.in.erin. Yamagata University Yonezawa Japan

We examin.d theta activity in.the temporal hippocampus of ure-than.-chloralose-an.sthetized pigs by stimulation.with two chemical odors, beta-phen.l ethyl alcohol (PEA;rose-like odor) an. n.amyl acetate (ban.n.-like odor). n.ural activity was recorded in.the n.ural cell layer n.arby fimbria of the temporal hippocampus in.three of six an.mals. Odor stimulation.with PEA at a low con.en.ration.(10-4 w/w;100 ppm) sign.fican.ly in.reased power of the low-frequen.y theta ban. (type-2;4 - 6 Hz) for the middle 10 s (w (3, 6, 2.5%) >2.56). The PEA odor at a higher con.en.ration.(10-3 w/w;1000 ppm), however, showed a ten.en.y for gradual in.rease in.the low-frequen.y theta but the respon.e was in.ign.fican. compared with the con.rol. On.the other han., odor stimulation.with n.amyl acetate (10-4 w/w;100 ppm) caused n. apparen. in.rease or a ten.en.y for decrease in.power of the low-frequen.y theta. Thus, the type-2 theta respon.e in.the temporal hippocampus to the PEA odor con.rasted strikin.ly with that to the n.amylacetate in.the ure-than.-chloralose-an.sthetized pigs. The respon.e of the type-2 theta rhythm in.the temporal hippocampus may un.erlie the differen.e in.emotion.l sen.ation.an. cogn.tion.of PEA from n.amyl acetate in.the pig.

关键词： Fast Fourier Tran.form Rhythmic Oscillation. Sus scrofa domesticus

ICRF Heated Lon.-Pulse Plasma Discharges in.LHD

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Plasma Scien.e an. Techn.logy 2006年第1期8卷 28-32页

作者： R. KUMAZAWA T. SEKI T. MUTOH K. saito T. WATARI Y. n.KAMURA M. SAKAMOTO T. WATAn.BE S. KUBO T. SHIMOZUMA Y. YOSHIMURA H. IGAMI Y. TAKEIRI Y. OKA K. TSUMORI M. OSAKABE K. IKEDA K. n.GAOKA O. KAn.KO J. MIYAZAWA S. MORITA K. n.RIHARA M. SHOJI S. MASUZAKI M. GOTO T. MORISAKI B. J. PETERSOn.K. SATO T. TOKUZAWA n. ASHIKAWA K. n.SHIMURA H. FUn.BA H. CHIKARAISHI T. n.TAKE Y. TORII H. OKADA M. ICHIMURA H. HIGAKI Y. TAKASE H. KASAHARA F. SHIMPO G.n.MURA C.TAKAHASHI M.YOKOTA A. KATO 赵燕平 J. S. YOOn.J. G. KWAK H. YAMADA K. KAWAHATA n. OHYABU K. IDA Y. n.GAYAMA n. n.DA A. KOMORI S. SUDO O. MOTOJIMA n.tion.l In.titute for Fusion.Scien.e Toki Japan Kyusyu Un.versity Kasuga Japan n.goya Un.versity Faculty of Engineering Nagoya Japan Kyoto Un.versity Institute of Advanced Energy Uji Japan Tsukuba Un.versity Plasma Research Center Tsukuba Japan Tokyo Un.versity Graduate School of Frontier Sciences Tokyo Japan In.titute of Plasma Physics Chinese Academy of Sciences Hefei 230031 China KAERI 150 Deogjin-dong Yuseong-gu Daejeon Korea Rep.

A lon.-pulse plasma discharge for more than.30 min. was achieved on.the Large Helical Device （LHD）. A plasma of n. = 0.8 × 10^19 m^-3 an. T10 = 2.0 keV was sustain.d with PICH = 0.52 MW, PECH = 0.1 MW an. averaged Pn.I = 0.067 MW. Total in.ected heatin. en.rgy was 1.3 G J, which was a quarter of the prepared RF heatin. en.rgy. On. of the keys to the success of the experimen. was a dispersion.of the local plasma heat load to divertors, accomplished by shiftin. the magn.tic axis in.ard an. outward.

关键词： helical/stellarator con.iguration ICRF heatin. steady state operation