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Treatment preferences in men with erectile dysfunction： an open label study in Korean men switching from sildenafil citrate to tadalafil

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Asian Journal of Andrology 2007年第6期9卷 760-770页

作者： Tai Young Ahn Sung Won lee Sae-Woong Kim Dae Yul Yang Nam Cheol Park Kweon-Sik Min Kwangsung Park Jae-Seung Paick Yulia Dyachkova Trisha Dwight myung-sea luke lee Asan Medical Centre Seoul 138-736 Korea Samsung Medical Centre Seoul 135-710 Korea Youido St Marys Hospital Seoul 150-713 Korea Kang Dong Sacred Heart Hospital Seoul 134-701 Korea Pusan National University Hospital Pusan 602-739 Korea Pusan lnje University Paik Hospital Pusan 614-735 Korea Chonnam National University Hospital Gwangju 501-757 Korea Seoul National University Hospital Seoul 110-744 Korea Area Medical Centre Vienna Eli Lilly Austria Sydney A-1030 Australia Intercontinental Information Sciences Eli Lilly Australia Sydney 2113 Australia Eli Lilly Korea Seoul 135-280 Korea

To evaluate patient preferences for sildenafil citrate or tadalafil （PDE-5 inhibitors available for the treatment of erectile dysfunction [ED]） and assess potential reasons for these preferences. Methods： This open-label study was conducted on Korean men taking sildenafil, at least 6 weeks prior to study entry, for ED. Following screening, patients continued sildenafil treatment for 4 weeks, then after a 1-week washout period, switched to tadalafil for 8 weeks. Patients then continued with their treatment of choice during an extension phase. Psychosocial factors （time concern, spontaneity, sexual self-confidence） were evaluated using Psychological and Interpersonal Relation- ship Scales （PAIRS）, while timing of dose to sexual attempt patterns were assessed from patient diaries. Results： The present study enrolled 160 Korean men （mean age 55 years） with prior median sildenafil use of 585 days. During the extension phase, 73.7% of patients elected to take tadalafil, whereas 26.3% chose sildenafil （P 〈 0.001）. After switching from sildenafil to tadalafil, mean PAIRS time concern scores decreased from 2.54 to 2.42 （P = 0.002）, with no statistically significant differences observed between the sildenafil and tadalafil assessment phases in sexual spontaneity and self-confidence scores. Sexual attempts made 〉 4 h to 〈 36 h post-dose occurred in 4.5% of patients during the sildenafil assessment phase compared with 17.5% during the tadalafil assessment phase. Conclusion： After experiencing both sildenafil and tadalafil, the majority of patients exhibited a preference for tadalafil. This preference might be influenced by psychosocial factors, such as decreased time concerns, and a broader window of opportunity available for sexual activity.

关键词： erectile dysfunction tadalafil sildenafil citrate Psychological and Interpersonal Relationship Scales preference

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Microstructural tailoring,mechanical and thermal properties of SiC composites fabricated by selective laser sintering and reactive melt infiltration

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Journal of Advanced Ceramics 2023年第4期12卷 830-847页

作者： Xiao Chen Jie Yin Longzhi Huang sea-Hoon lee Xuejan Liu Zhengren Huang State Key Lab of High Performance Ceramics and Superfine Microstructures Shanghai Institute of CeramicsChinese Academy of SciencesShanghai 200050China College of Materials Science and Opto-Electronic Technology University of Chinese Academy of SciencesBeijing 100049China Extreme Materials Institute Korea Institute of Materials ScienceChangwon 51508Republic of Korea

Poor flowability of printable powders and long preparation cycles are the main challenges in the selective laser sintering(SLS)of chopped carbon fiber(C_(f))reinforced silicon carbide(SiC)composites with complex *** this study,we develop an efficient and novel processing route in the fabrication of lightweight SiC composites via the SLS of phenolic resin(PR)and Cr powders with the addition of a-SiC particles combined with the one-step reactive melt infiltration(RMI).The effects of a-SiC addition on the microstructural evolution of the C_(f)/SiC/PR printed bodies,C_(f)/SiC/C green bodies,and derived SiC composites were *** results indicate that the added a-SiC particles play an important role in enhancing the flowability of raw powders,reducing the *** the reliability of the C/SiC/C green bodies,and contributing to improving the microstructure homogeneity and mechanical properties of the SiC *** maximum density,flexural strength,and fracture toughness(Kic)of the SiC composites are 2.749±0.006 g·cm^(3),266±5 MPa,and 3.30±0.06 MPa-m,*** coefficient of thermal expansion(CTE,a)of the SiC composites is approximately 4.29×10^(-6)K^(-1)from room temperature(RT)to 900℃,and the thermal conductivity(x)is in the range of 80.15-92.48 W·m^(-1)·K^(-1)at *** high-temperature strength of the SiC composites increase to 287±18 MPa up to 1200℃.This study provides a novel as well as feasible tactic for the preparation of high-quality printable powders as well as lightweight,high-strength,and high-x SiC composites with complex structures by the SLS and RMI.

关键词： chopped carbon fiber(C_(f)) microstructural tailoring selective laser sintering(SLS) mechanical properties thermal properties

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Bioinspired optical antennas: gold plant viruses

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Light(Science & Applications) 2015年第1期4卷 447-453页

作者： SoonGweon Hong Mi Yeon lee Andrew O Jackson luke P lee Department of Bioengineering University of California at BerkeleyBerkeleyCA 94720USA Berkeley Sensor and Actuator Center University of California at BerkeleyBerkeleyCA 94720USA Department of Plant&Microbial Biology University of California at BerkeleyBerkeleyCA 94720USA Department of Electrical Engineering and Computer Sciences University of California at BerkeleyBerkeleyCA 94720USA Biophysics Graduate Program University of California at BerkeleyBerkeleyCA 94720USA

The ability to capture the chemical signatures of biomolecules(i.e.,electron-transfer dynamics)in living cells will provide an entirely new perspective on biology and *** can be accomplished using nanoscale optical antennas that can collect,resonate and focus light from outside the cell and emit molecular ***,we describe biologically inspired nanoscale optical antennas that utilize the unique topologies of plant viruses(and thus,are called gold plant viruses)for molecular fingerprint *** electromagnetic calculations for these gold viruses indicate that capsid morphologies permit high amplification of optical scattering energy compared to a smooth *** experimental measurements of various gold viruses based on four different plant viruses,we observe highly enhanced optical cross-sections and the modulation of the resonance wavelength depending on the viral ***,in label-free molecular imaging,we successfully obtain higher sensitivity(by a factor of up to 10^(6))than can be achieved using similar-sized *** virtue of the inherent functionalities of capsids and the plasmonic characteristics of the gold layer,a gold virus-based antenna will enable cellular targeting,imaging and drug delivery.

关键词： molecular sensor nanophotonics optical antenna optical spectroscopy plant virus plasmonics plasmonic resonant energy transfer(PRET) surface enhanced Raman scattering(SERS)

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Cross-scale microstructure design of precursor-derived SiC-AlN nanoceramic composites hybrid with ex-situ ZrB_(2)

Advanced Powder Materials

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Advanced Powder Materials 2023年第1期2卷 35-42页

作者： Aidong Xia Buhao Zhang Jie Yin Xiao Chen sea-Hoon lee Xuejian Liu Zhengren Huang State Key Laboratory of High Performance Ceramics and Superfine Microstructures Shanghai Institute of CeramicsChinese Academy of SciencesShanghai 200050China Ningbo Institute of Materials Technology and Engineering Chinese Academy of SciencesNingbo 315201China College of Materials Science and Opto-Electronic Technology University of Chinese Academy of SciencesBeijing 100049China Ceramic Materials Division Korea Institute of Materials ScienceChangwon 51508Republic of Korea

ZrB_(2)/SiC–AlN nanoceramic composites were densified at 1950℃ by hot pressing using an organic-precursorderived SiC and commercially available AlN and ZrB_(2).A cross-scale microstructure was constructed by distributing the ZrB_(2) secondary phase(~421 nm)within the SiC–AlN solid solution *** substructure of the SiC–AlN matrix was agglomerated by nanograins with an average size of only 62 ***_(2) connected around the majority of pores within the SiC–AlN matrix and contributed to the formation of numerous weak interfacial bonding,resulting in improved strength and *** highest flexural strength and fracture toughness of 579±52 MPa and 6.7±0.1 MPa m^(1/2) were obtained from a 10 wt%-ZrB2/SiC–AlN sample,*** high concentration of grain boundaries of the ZrB2/SiC–AlN nanoceramic composites resulted in heat insulation *** thermal diffusivity and conductivity were 3.6 mm^(2)·s^(-1) and 14.3 W⋅(m·K)^(-1) at 1400℃,respectively,while the electrical resistivity was 3.9×10^(3)Ω·cm for the 10 wt%-ZrB_(2)/SiC–AlN sample.

关键词： Nanoceramic composites Precursor-derived ceramics SiC-AlN solid Solution Mechanical properties Thermal and electrical properties

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Below-ground growth characteristics of 13-year-old Pinus densiflora on different contour conditions in a post-fire plantation in Samcheuk,Korea

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Journal of Forestry Research 2017年第5期28卷 1007-1018页

作者： Do-Hyun Kim Sung-Jun Na sea-Hyun Kim Ewane Basil Ewane Dae-Bong Kang Do-Hyung lee Department of Forest Resources Yeungnam University Department of Forest Genetic Resources National Institute of Forest Science

We estimated the growth volume of artificially reforested Pinus densiflora in a post-fire area on three different contour conditions by comparing and analyzing the vertical and horizontal distributions of below-ground roots on each contour. The main roots at the south-facing slope (SS) developed in a long and straight form, and those on the north-facing slope (NS) in a twisted form. The side roots developed more than the main roots on the Ridge. The depth of taproots decreased in the following order: SS > NS > Ridge. The roots on the SS developed in a pile-form root structure whereas those in the Ridge and NS developed concentrically near the root collar. The amount of root development decreased in the following order: SS > NS > Ridge. The ratio of fine roots from the whole-root development decreased in the following order: Ridge > SS > NS. These results can guide considerations of growth differences according to the planting contour conditions for future establishment of P. densiflora artificial plantations.

关键词： Pinus densiflora Growth characteristics Contour conditions Post-fire plantation Wildfire Restoration Soil depth

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Plasmonic bacteria on a nanoporous mirror via hydrodynamic trapping for rapid identification of waterborne pathogens

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Light(Science & Applications) 2018年第1期7卷 359-367页

作者： Keumrai Whang Jong-Hwan lee Yonghee Shin Wooju lee Young Wan Kim Dongchoul Kim luke P.lee Taewook Kang Department of Chemical and Biomolecular Engineering Sogang UniversitySeoul 04107Korea Berkeley Sensor and Actuator Center Departments of BioengineeringElectrical Engineering and Computer ScienceBiophysics Graduate ProgramUniversity of CaliforniaBerkeleyBerkeleyCA 94720USA Department of Mechanical Engineering Sogang UniversitySeoul 04107Korea

A rapid,precise method for identifying waterborne pathogens is critically needed for effective disinfection and better ***,conventional methods,such as culture-based counting,generally suffer from slow detection times and low ***,we developed a rapid detection method for tracing waterborne pathogens by an innovative optofluidic platform,a plasmonic bacteria on a nanoporous mirror,that allows effective hydrodynamic cell trapping,enrichment of pathogens,and optical signal *** designed and simulated the integrated optofluidic platform to maximize the enrichment of the bacteria and to align bacteria on the nanopores and plasmonic mirror via hydrodynamic cell *** nanoparticles are self-assembled to form antenna arrays on the surface of bacteria,such as Escherichia coli and Pseudomonas aeruginosa,by replacing citrate with hydroxylamine hydrochloride in order to amplify the signal of the plasmonic optical *** to the synergistic contributions of focused light via the nanopore geometry,self-assembled nanoplasmonic optical antennas on the surface of bacteria,and plasmonic mirror,we obtain a sensitivity of detecting *** as low as 102 cells/ml via surface-enhanced Raman *** believe that our label-free strategy via an integrated optofluidic platform will pave the way for the rapid,precise identification of various pathogens.

关键词： mirror trapping precise

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Pravastatin activates PPARα/PPARγexpression in the liver and gallbladder epithelium of hamsters

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Hepatobiliary & Pancreatic Diseases International 2011年第2期10卷 185-190页

作者： Seok Ho Dong Jin lee Dong Hee Koh Min Ho Choi Hyun Joo Jang sea Hyub Kae Division of Gastroenterology Department of Internal MedicineKyung Hee University College of Medicine Division of Gastroenterology Department of Internal MedicineHallym University College of Medicine

BACKGROUND:Our earlier study with cultured gallbladder epithelial cells demonstrated that statins(HMG-CoA reductase inhibitors)activate the expression of PPARαand PPARγ, consequently blocking the production of pro-inflmmatory *** present study used hamsters to investigate the effects of pavastatin on PPARα/PPARγexpression in the liver and gallbladder epithelium,and to determine whether pravastatin suppresses cholesterol crystal formation in the gallbladder. METHODS:A total of 40 Golden Syrian male hamsters(4 weeks old)were randomly assigned to four groups(basal diet control; basal diet+pavastatin;high cholesterol diet;high cholesterol diet+pravastatin).All hamsters were 11 weeks old at the end of the *** liver,gallbladder and bile were harvested. Immunohistochemical staining and Western blotting for PPARαand PPARγwere performed in the liver and gallbladder. A drop of fresh bile was examined for cholesterol crystals under a microscope. RESULTS:In the gallbladder and liver of the hamsters, pravastatin activated the PPARαand PPARγexpression of gallbladder epithelial cells and hepatocytes,and particularly the response of PPARγwas much stronger than that of PPARα. Pravastatin suppressed the formation of cholesterol gallstones or crystals in the gallbladder. CONCLUSION:Pravastatin is an effective medication to activate PPARs(especially PPARγ)in the liver and the gallbladder epithelium of hamsters,and contributes to the prevention of gallstone formation.

关键词： pravastatin PPARα PPARγ hamster gallstone

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Ultrafast photonic PCR

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Light(Science & Applications) 2015年第1期4卷 267-273页

作者： Jun Ho Son Byungrae Cho SoonGweon Hong Sang Hun lee Ori Hoxha Amanda J Haack luke P lee Department of Bioengineering University of CaliforniaBerkeleyCA 94720USA Berkeley Sensor and Actuator Center University of CaliforniaBerkeleyCA 94720USA Department of Electrical Engineering and Computer Sciences University of CaliforniaBerkeleyCA 94720USA Biophysics Graduate Program University of CaliforniaBerkeleyCA 94720USA

Nucleic acid amplification and quantification via polymerase chain reaction(PCR)is one of the most sensitive and powerful tools for clinical laboratories,precision medicine,personalized medicine,agricultural science,forensic science and environmental *** multiplex PCR,characterized by low power consumption,compact size and simple operation,is ideal for timely diagnosis at the point-of-care(POC).Although several fast/ultrafast PCR methods have been proposed,the use of a simple and robust PCR thermal cycler remains challenging for POC ***,we present an ultrafast photonic PCR method using plasmonic photothermal light-to-heat conversion via photon–electron–phonon *** demonstrate an efficient photonic heat converter using a thin gold(Au)film due to its plasmon-assisted high optical absorption(approximately 65%at 450 nm,the peak wavelength of heat source light-emitting diodes(LEDs)).The plasmon-excited Au film is capable of rapidly heating the surrounding solution to over 150℃ within 3 *** this method,ultrafast thermal cycling(30 cycles;heating and cooling rate of 12.7960.93℃ s^(-1) and 6.660.29℃ s^(-1),respectively)from 55℃(temperature of annealing)to 95℃(temperature of denaturation)is accomplished within 5 *** photonic PCR thermal cycles,we demonstrate here successful nucleic acid(λ-DNA)*** simple,robust and low cost approach to ultrafast PCR using an efficient photonic-based heating procedure could be generally integrated into a variety of devices or procedures,including on-chip thermal lysis and heating for isothermal amplifications.

关键词： genomics light-emitting diodes(LEDs) molecular diagnostics personalized medicine plasmonics point-of-care(POC)diagnostics polymerase chain reaction(PCR)

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Detection of coat protein gene of nervous necrosis virus using loopmediated isothermal amplification

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Asian Pacific Journal of Tropical Medicine 2016年第3期9卷 230-235页

作者： Jinik Hwang Sung-Suk Suh Mirye Park myung-Joo Oh Jong-Oh Kim Sukchan lee Taek-Kyun lee South sea Environment Research Department Korea Institute of ocean science & technology Korea University of Science and Technology Department of Aqualife Medicine Chonnam National University Department of Genetic Engineering Sungkyunkwan University

Objective:To establish a novel and highly specific loop-mediated isothermal amplification(LAMP) assay for the identification of nervous necrosis virus(NNV) ***:A set of synthesized primers was used to match the sequences of a specific region of the nnr gene from the National Center for Biotechnology Information database,not originating from NNV-infected fish,the efficiency and specificity of LAMP were measured dependent on the concentration of DNA polymerase and the reaction temperature and *** addition,to determine species-specific LAMP primers,cross reactivity testing was applied to the reaction between NVV and other virus families including viral hemorrhagic septicemia virus and marine ***:The optimized LAMP reaction carried out at 64 ℃ for 60 min,and above 4 U Bst DNA *** sensitivity of LAMP for the detection of nnv was thus about 10 times greater than the sensitivity of polymerase chain *** LAMP assay primers were specific for the detection NNV infection in Epinephelus ***:The development of LAMP primers based on genetic information from a public database,not virus-infected samples,may provide a very simple and convenient method to identify viral infection in aquatic organisms.

关键词： Nervous necrosis virus Nodaviridae Polymerase chain reaction Loop-mediated isothermal Amplification

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Pravastatin activates the expression of farnesoid X receptor and liver X receptor alpha in Hep3B cells

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Hepatobiliary & Pancreatic Diseases International 2014年第1期13卷 65-73页

作者： Hyun Woo Byun Eun Mi Hong Soo Hee Park Dong Hee Koh Min Ho Choi Hyun Joo Jang sea Hyub Kae Jin lee Division of Gastroenterology Department of Internal Medicine Hallym University College of Medicine Dongtan Sacred Heart Hospital

BACKGROUND: Statins are suggested to preserve gallbladder function by suppressing pro-inflammatory cytokines and preventing cholesterol accumulation in gallbladder epithelial cells. They also affect cross-talk among the nuclear hormone receptors that regulate cholesterol-bile acid metabolism in the nuclei of hepatocytes. However, there is controversy over whether or how statins change the expression of peroxisome proliferator-activated receptor(PPAR)α, PPARγ, liver X receptor α(LXRα), farnesoid X receptor(FXR), ABCG5, ABCG8, and 7α-hydroxylase(CYP7A1) which are directly involved in the cholesterol saturation index in bile. METHODS: Human Hep3B cells were cultured on dishes. MTT assays were performed to determine the appropriate concentrations of reagents to be used. The protein expression of PPARα and PPARγ was measured by Western blotting analysis, and the mRNA expression of LXRα, FXR, ABCG5, ABCG8 and CYP7A1 was estimated by RT-PCR. RESULTS: In cultured Hep3B cells, pravastatin activated PPARα and PPARγ protein expression, induced stronger expression of PPARγ than that of PPARα, increased LXRα mRNA expression, activated ABCG5 and ABCG8 mRNA expression mediated by FXR as well as LXRα, enhanced FXR mRNA expression, and increased CYP7A1 mRNA expression mediated by the PPARγ and LXRα pathways, together or independently. CONCLUSION: Our data suggested that pravastatin prevents cholesterol gallstone diseases via the increase of FXR, LXRαand CYP7A1 in human hepatocytes.

关键词： pravastatin PPARγ liver X receptor α farnesoid X receptor gallstone disease

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