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Noninvasive Parameters and hepatic fibrosis scores in children with nonalcoholic fatty liver disease

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World Journal of Gastroenterology 2012年第13期18卷 1525-1530页

作者： Hye Ran Yang Hae Ryoung kim myung jin kim Jae Sung Ko Jeong Kee Seo Department of Pediatrics Seoul National University College of MedicineSeoul 110-744South Korea Department of Pediatrics Seoul National University Bundang HospitalSeongnam-siGyonggi-do 463-707South Korea Department of Pathology Seoul National University Bundang HospitalSeongnam-siGyonggi-do 464-894 South Korea

AIM:To evaluate the noninvasive parameters and hepatic fibrosis scores in obese children with nonalcoholic fatty liver disease(NAFLD).METHODS:A total of 77 children diagnosed with NAFLD via liver biopsy were included and divided into 2 subgroups according to the histopathologic staging of hepatic fibrosis:mild(stage 0-1)vs significant fibrosis(stage 2-4).Clinical and laboratory parameters were evaluated in each *** aspartate aminotransferase(AST)/alanine aminotransferase(ALT)ratio,AST/platelet ratio index(APRI),PGA index,Forns index,FIB-4,NAFLD fibrosis score,and pediatric NAFLD fibrosis index(PNFI)were ***:No clinical or biochemical parameter exhibited a significant difference between patients with mild and significant *** noninvasive hepatic fibrosis scores,only APRI and FIB4 revealed a significant difference between patients with mild and significant fibrosis(APRI:0.67±0.54 vs 0.78±0.38,P=0.032 and FIB4:0.24±0.12 vs 0.31±0.21,P=0.010).The area under the receiving operating characteristic curve of FIB4 was 0.81,followed by Forns index(0.73),APRI(0.70),NAFLD fibrosis score(0.58),AST/ALT ratio(0.53),PGA score(0.45),and PNFI(0.41).CONCLUSION:APRI and FIB4 might be useful noninvasive hepatic fibrosis scores for predicting hepatic fibrosis in children with NAFLD.

关键词： Fatty liver Hepatic fibrosis Noninvasive Obesity Child

Human periodontal ligament stem cells repair mental nerve injury

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Neural Regeneration Research 2013年第30期8卷 2827-2837页

作者： Bohan Li Hun-Jong Jung Soung-Min kim myung-jin kim Jeong Won Jahng Jong-Ho Lee Department of Oral and Maxillofacial Surgery School of Dentistry Binzhou Medical College Department of Occupation and Environment Konkuk Postgraduate Medical School Department of Oral and Maxillofacial Surgery School of Dentistry Seoul National University Dental Research Institute Seoul National University

Human periodontal ligament stem cells are easily accessible and can differentiate into Schwann cells. We hypothesized that human periodontal ligament stem cells can be used as an alternative source for the autologous Schwann cells in promoting the regeneration of injured peripheral nerve. To validate this hypothesis, human periodontal ligament stem cells （1 × 106） were injected into the crush-injured left mental nerve in rats. Simultaneously, autologous Schwann cells （1 × 106） and PBS were also injected as controls. Real-time reverse transcriptase polymerase chain reaction showed that at 5 days after injection, mRNA expression of low affinity nerve growth factor receptor was sig-nificantaly increased in the left trigeminal ganglion of rats with mental nerve injury. Sensory tests, histomorphometric evaluation and retrograde labeling demonstrated that at 2 and 4 weeks after in-jection, sensory function was significantly improved, the numbers of retrograde labeled sensory neurons and myelinated axons were significantly increased, and human periodontal ligament stem cells and autologous Schwann cells exhibited similar therapeutic effects. These findings suggest that transplantation of human periodontal ligament stem cells show a potential value in repair of mental nerve injury.

关键词： neural regeneration peripheral nerve injury stem cells periodontal ligament stem cells mentalnerve Schwann cells cell transplantation sensory nerve neurotrophic factor neuroregeneration

Peripheral nerve regeneration with cotransplantation of umbilical cord mesenchymal stem cells and Schwann cells in rat sciatic nerve defect

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Neural Regeneration Research 2011年第7期6卷 485-493页

作者： jin-Yong Lee Hun-Jong Jung Mohammad S. Alrashdan Bohan Li Mi-Ae sung Sang BaeYoo Soung-Min kim myung-jin kim Jeong Won Jahng Jong-Ho Lee Department of Oral and Maxillofacial Surgery School of Dentistry Seoul National University Seoul Korea Department of Occupation and Environment Konkuk Postgraduate Medical School Choong-Ju Korea Department of Craniofacial Structure and Functional Biology School of Dentistry Seoul National University Seoul Korea Dental Research Institute School of Dentistry Seoul National University Seoul Korea

Previous research has demonstrated that cotransplantation of umbilical cord mesenchymal stem cells （UCMSCs） and Schwann cells （SCs） can repair spinal nerve injury, but few studies have investigated their use in peripheral nerve regeneration. In the present study, we cotransplanted UCMSCs and SCs to repair 5-mm left sciatic nerve defects in rats, and compared the effects of UCMSCs ＋ SCs transplantation with UCMSCs or SCs transplantation alone. After UCMSCs ＋ SCs transplantation, nerve conduction velocity of the left sciatic nerve and gait were both improved. Retrograde tracing analysis demonstrated that the mean count of fluorogold-labeled neurons, as well as the mean axon count and axon density, were significantly greater in the left sciatic nerve after UCMSCs ＋ SCs transplantation, compared with UCMSCs or SCs transplantation alone. Improvements in conduction velocity and increased sheath thickness in the left sciatic nerve were similar after UCMSCs transplantation and UCMSCs ＋ SCs transplantation. These findings suggest that UCMSCs transplantation can promote the repair of sciatic nerve defects to some extent, but that combined UCMSCs ＋ SCs transplantation has a significantly greater regenerative effect.

关键词： Schwann cells human umbilical cord mesenchymal stem cells peripheral nerve re-generation axotomy

Anti-Cancer Effects of Cordycepin on Oral Squamous Cell Carcinoma Proliferation and Apoptosis in Vitro

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Journal of Cancer Therapy 2011年第2期2卷 224-234页

作者： Ju-Hyon Lee Soon-Min Hong Jun-Yong Yun Hoon Myoung myung-jin kim Department of Oral & Maxillofacial Surgery College of Dentistry Seoul National University Republic of Korea 2Department of Oral and Maxillofacial Surgery KangDong Sacred Heart Hospital College of Medicine Hallym University Republic of Korea.

Cordycepin is an active component of parasitic fungus, Cordyceps militaris, and investigated for its pharmacologic efficacy. Increasing evidence supports the anti-tumoral effects of Cordycepin in various types of human solid tumors. We sought to determine the effects of Cordycepin on oral squamous cell carcinoma in vitro and in vivo. Two oral squamous cell carcinoma cell lines, KB and HSC3, were used in this study. Cells were treated with Cordycepin or diluent, followed by determinations of proliferation by sulforhodamine method and apoptosis by TUNEL assay in vitro. For in vivo experiments, tumor cells were transplanted into nude mice, followed by treatment with Cordycepin or control diluent. In addition, cells were examined for expression of adenosine receptor isotypes, and tested whether cordycepin-induced effects were mediated through adenosine receptors by combinatorial treatment of cordycepin and antagonists specific to each isotype of adenosine receptors. Two cell lines expressed protein of all types of adenosine receptors stronger than normal oral keratinocytes. Cordycepin showed anti-proliferating effect and apoptotic effect on both cell lines in vitro in a dose dependent manner. However, any adenosine receptors did not reverse the effect of cordycepin. In our in vivo experiments, cordycepin failed to decrease the tumor volume significantly, and failed to induce more apoptosis of tumor cells. Cordycepin has anti-proliferating effect and induces apoptosis not mediated by adenosine receptor on oral squamous cell carcinoma cells in vitro. However, in vivo results suggest that cordycepin in itself has a limited value as a novel chemotherapeutic agent for oral squamous cell carcinoma.

关键词： Cordycepin Adenosine Receptor Oral Squamous Cell Carcinoma

High mobility group box 1 in the central nervous system:regeneration hidden beneath inflammation

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Neural Regeneration Research 2025年第1期20卷 107-115页

作者： Hanki kim Bum Jun kim Seungyon Koh Hyo jin Cho Xuelian jin Byung Gon kim Jun Young Choi Department of Brain Science Ajou University School of MedicineSuwonSouth Korea Department of Biomedical Sciences Ajou University Graduate School of MedicineSuwonSouth Korea Department of Neurology Ajou University School of MedicineSuwonSouth Korea Department of Geriatrics The Affiliated Suqian First People’s Hospital of Nanjing Medical UniversitySuqianJiangsu ProvinceChina

High-mobility group box 1 was first discovered in the calf thymus as a DNA-binding nuclear protein and has been widely studied in diverse fields,including neurology and ***-mobility group box 1 in the extracellular space functions as a pro-inflammatory damage-associated molecular pattern,which has been proven to play an important role in a wide variety of central nervous system disorders such as ischemic stroke,Alzheimer’s disease,frontotemporal dementia,Parkinson’s disease,multiple sclerosis,epilepsy,and traumatic brain *** drugs that inhibit high-mobility group box 1 as a damage-associated molecular pattern,such as glycyrrhizin,ethyl pyruvate,and neutralizing anti-high-mobility group box 1 antibodies,are commonly used to target high-mobility group box 1 activity in central nervous system *** it is commonly known for its detrimental inflammatory effect,high-mobility group box 1 has also been shown to have beneficial pro-regenerative roles in central nervous system *** this narrative review,we provide a brief summary of the history of high-mobility group box 1 research and its characterization as a damage-associated molecular pattern,its downstream receptors,and intracellular signaling pathways,how high-mobility group box 1 exerts the repair-favoring roles in general and in the central nervous system,and clues on how to differentiate the pro-regenerative from the pro-inflammatory *** targeting high-mobility group box 1 in the central nervous system may benefit from differentiating between the two functions rather than overall suppression of high-mobility group box 1.

关键词： central nervous system damage-associated molecular pattern ethyl pyruvate glycyrhizzin high mobility group box 1 inflammation neural stem cells neurodevelopment oligodendrocyte progenitor cells redox status regeneration

Transplantation of mesenchymal stem cells from human umbilical cord versus human umbilical cord blood for peripheral nerve regeneration

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Neural Regeneration Research 2010年第11期5卷 838-845页

作者： Kang-Mi Pang Mi-Ae Sung Mohammad S.Alrashdan Sang Bae Yoo Samir Jabaiti Soung-Min kim Sung-June kim myung-jin kim Jeong Won Jahng Jong-Ho Lee Department of Oral Maxillofacial Surgery Seoul National University Seoul 110-768 Korea Department of Craniofacial Structure & Functional Biology Seoul National University Seoul 110-768 Korea Dental Research Institute School of Dentistry Seoul National University Seoul 110-768 Korea Department of Plastic and Reconstructive Surgery Faculty of Medicine Jordan University Hospital Amman 11942 Jordan Department of Electrical Engineering School of Electrical and Computer Science Seoul National University Seoul 110-768 Korea

BACKGROUND： Mesenchymal stem cells （MSCs） appear to be a good alternative to Schwann cells in the treatment of peripheral nerve injury. Fetal stem cells, like umbilical cord blood （UCB） and umbilical cord （UC） stem cells, have several advantages over adult stem cells. OBJECTIVE： To assess the effects of UC-derived MSCs （UCMSCs） and UCB-derived MSCs （UCBMSCs） in repair of sciatic nerve defects. DESIGN, TIME AND SETTING： A randomized controlled animal experiment was performed at the laboratory of Department of Oral and Maxillofacial Surgery, Seoul National University Dental Hospital, from July to December 2009. MATERIALS： UCMSCs were provided by the Research Institute of Biotechnology, Dongguk University. UCBMSCs were provided by the Laboratory of Stem Cells and Tumor Biology, College of Veterinary Medicine, Seoul National University. Dulbecco＇s modified Eagle＇s medium （DMEM） was purchased from Gibco-BRL, USA. METHODS： Seven-week-old Sprague-Dawley rats were randomly and evenly divided into three groups： DMEM, UCBMSCs, and UCMSCs. A 10-mm defect in the left sciatic nerve was constructed in all rats. DMEM （15 μL） containing 1×10^6 UCBMSCs or UCMSCs was injected into the gap between nerve stumps, with the surrounding epineurium as a natural conduit. For the DMEM group, simple DMEM was injected. MAIN OUTCOME MEASURES： At 7 weeks after sciatic nerve dissection, dorsal root ganglia neurons were labeled by fluorogold retrograde labeling. At 8 weeks, electrophysiology and histomorphometry were performed. At 2, 4, 6, and 8 weeks after surgery, sciatic nerve function was evaluated using gait analysis. RESULTS： The UCBMSCs group and the UCMSCs group exhibited similar sciatic nerve function and electrophysiological indices, which were better than the DMEM group, as measured by gait analysis （P 〈 0.05）. Fluorogold retrograde labeling of sciatic nerve revealed that the UCBMSCs group demonstrated a higher number of labeled neurons; however, the differences were not significant. His

关键词： peripheral nerve regeneration umbilical cord mesenchymal stem cell umbilical cord blood mesenchymal stem cell axotomy defect stem cells

Enhancing micro-scale SiOx anode durability:Electro-mechanical strengthening of binder networks via anchoring carbon nanotubes with carboxymethyl cellulose

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Journal of Energy Chemistry 2025年第2期101卷 23-33页

作者： Chaeyeon Ha jin Kyo Koo Jun Myoung Sheem Young-Jun kim SKKU Advanced Institute of Nano Technology (SAINT) Sungkyunkwan University Department of Nano Science and Technology Sungkyunkwan University Advanced Center for Convergence Energy Storage System Sungkyunkwan University SKKU Institute of Energy Science and Technology (SIEST) Sungkyunkwan University

With the increasing prevalence of lithium-ion batteries（LIBs） applications,the demand for high-capacity next-generation materials has also *** currently considered a promising anode material due to its exceptionally high capacity for ***,the significant volumetric changes of SiOxduring cycling and its initial Coulombic efficiency（ICE） complicate its use,whether alone or in combination with graphite *** this study,a three-dimensional conductive binder network with high electronic conductivity and robust elasticity for graphite/SiOxblended anodes was proposed by chemically anchoring carbon nanotubes and carboxymethyl cellulose binders using tannic acid as a chemical *** addition,a dehydrogenation-based prelithiation strategy employing lithium hydride was utilized to enhance the ICE of *** combination of these two strategies increased the CE of SiOxfrom 74% to87% and effectively mitigated its volume expansion in the graphite/SiOxblended electrode,resulting in an efficient electron-conductive binder *** led to a remarkable capacity retention of 94% after30 cycles,even under challenging conditions,with a high capacity of 550 mA h g-1and a current density of 4 mA ***,to validate the feasibility of utilizing prelithiated SiOxanode materials and the conductive binder network in LIBs,a full cell incorporating these materials and a single-crystalline Ni-rich cathode was *** cell demonstrated a～27.3% increase in discharge capacity of the first cycle(～185.7 mA h g-1) and exhibited a cycling stability of 300 ***,this study reports a simple,feasible,and insightful method for designing high-performance LIB electrodes.

关键词： Lithium-ion batteries SiO x anode Blended anode Carbon nanotubes Carboxymethyl cellulose Conductive binder network

Unlocking Novel Functionality:Pseudocapacitive Sensing in MXene-Based Flexible Supercapacitors

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Nano-Micro Letters 2025年第4期17卷 212-229页

作者： Eunji kim Seongbeen kim Hyeong Min jin Gyungtae kim Hwi-Heon Ha Yunhui Choi Kyoungha Min Su-Ho Cho Hee Han Chi Won Ahn Jaewoo Roh Il-Kwon Oh jinwoo Lee Yonghee Lee Department of Chemical and Biomolecular Engineering Korea Advanced Institute of Science and Technology(KAIST)291 Daehak-RoYuseong-GuDaejeon 34141Republic of Korea National Nano Fab Center(NNFC) 291 Daehak-RoYuseong-GuDaejeon 34141Republic of Korea Department of Organic Materials Engineering Chungnam National University99 Daehak-RoYuseong-GuDaejeon 34134Republic of Korea Department of Materials Science and Engineering Chungnam National University99 Daehak-RoYuseong-GuDaejeon 34134Republic of Korea Department of Nano&Advanced Materials Science and Engineering Kyungpook National University2559Gyeongsang-DaeroSangju-SiGyeongsangbuk-Do 37224Republic of Korea Department of Mechanical Engineering Korea Advanced Institute of Science and Technology(KAIST)291 Daehak-RoYuseong-GuDaejeon 34141Republic of Korea

Extensively explored for their distinctive pseudocapacitance characteristics,MXenes,a distinguished group of 2D materials,have led to remarkable achievements,particularly in the realm of energy storage *** work presents an innovative Pseudocapacitive *** key lies in switching the energy storage kinetics from pseudocapacitor to electrical double layer capacitor by employing the change of local pH(-log[H^(+)])in MXene-based flexible supercapacitors during *** sensing is observed in acidic electrolyte but absent in neutral *** shearing during bending causes liquid-crystalline MXene sheets to increase in their degree of anisotropic *** blocking of H+mobility due to the higher diffusion barrier,local pH *** electrochemical energy storage kinetics transits from Faradaic chemical protonation(intercalation)to non-Faradaic physical *** utilize the phenomenon of capacitance change due to shifting energy storage kinetics for strain sensing *** developed highly sensitive Pseudocapacitive Sensors feature a remarkable gauge factor(GF)of approximately 1200,far surpassing conventional strain sensors(GF:~1 for dielectric-cap sensor).The introduction of the Pseudocapacitive Sensor represents a paradigm shift,expanding the application of pseudocapacitance from being solely confined to energy devices to the realm of multifunctional *** technological leap enriches our understanding of the pseudocapacitance mechanism of MXenes,and will drive innovation in cutting-edge technology areas,including advanced robotics,implantable biomedical devices,and health monitoring systems.

关键词： MXenes Supercapacitors Pseudocapacitive sensing Local pH Operando measurements

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中度牙周炎患者牙齿病理性移位的多学科治疗

中国口腔医学继续教育杂志 2012年第6期15卷 381-384页

作者： Yong-ll kim myung-jin kim Jeom-ll Choi Soo-Byung Park 林婷不详北京口腔种植培训中心北京市100043 北京吴城口腔诊所北京市100043

牙齿的生理位置是由牙周组织、殆、舌头及嘴唇的力量相互作用决定的。慢性牙周炎形成的骨破坏影响了这些因素之间的平衡，导致病理性牙齿移位，通常需要多学科治疗程序。这个病例展示了系统性的牙周-正畸-修复治疗来达到理想的结构，功... 详细信息

牙齿的生理位置是由牙周组织、殆、舌头及嘴唇的力量相互作用决定的。慢性牙周炎形成的骨破坏影响了这些因素之间的平衡，导致病理性牙齿移位，通常需要多学科治疗程序。这个病例展示了系统性的牙周-正畸-修复治疗来达到理想的结构，功能和美学效果。

关键词：病理性移位牙周炎患者牙齿移位多学科治疗慢性牙周炎牙周组织生理位置相互作用