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Using a skillful statistical model to predict September sea ice covering Arctic shipping routes

Acta Oceanologica Sinica 2020年第5期39卷 11-25页

作者： Sha Li muyin wang Wenyu Huang Shiming Xu Bin wang Yuqi Bai Ministry of Education Key Laboratory for Earth System Modeling Department of Earth System ScienceTsinghua UniversityBeijing 100084China Joint Institute for the Study of the Atmosphere and Ocean University of WashingtonSeattle WA98195USA Pacific Marine Environmental Laboratory National Oceanic and Atmospheric AdministrationSeattle WA98115USA State Key Laboratory of Numerical Modeling for Atmospheric Sciences and Geophysical Fluid Dynamics(LASG) Institute of Atmospheric PhysicsChinese Academy of SciencesBeijing 100029China

The rapid decrease in Arctic sea ice cover and thickness not only has a linkage with extreme weather in the midlatitudes but also brings more opportunities for Arctic shipping routes and polar resource exploration,both of which motivate us to further understand causes of sea-ice variations and to obtain more accurate estimates of seaice cover in the ***,a novel data-driven method,the causal effect networks algorithm,is applied to identify the direct precursors of September sea-ice extent covering the Northern Sea Route and Transpolar Sea Route at different lead times so that statistical models can be constructed for sea-ice *** whole study area was also divided into two parts:the northern region covered by multiyear ice and the southern region covered by seasonal *** forecast models of September sea-ice extent in the whole study area(TSIE)and southern region(SSIE)at lead times of 1–4 months can explain over 65%and 79%of the variances,respectively,but the forecast skill of sea-ice extent in the northern region(NSIE)is limited at a lead time of 1 *** lead times of 1–4 months,local sea-ice concentration and sea-ice thickness have a larger influence on September TSIE and SSIE than other teleconnection *** the lead time is more than 4 months,the surface meridional wind anomaly from northern Europe in the preceding autumn or early winter is dominant for September TSIE variations but is comparable to thermodynamic factors for NSIE and *** suggest that this study provides a complementary approach for predicting regional sea ice and is helpful in evaluating and improving climate models.

关键词： regional sea ice Arctic shipping routes machine learning statistical model predictions

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Recent Increased Warming of the Alaskan Marine Arctic Due to Midlatitude Linkages

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Advances in Atmospheric Sciences 2018年第1期35卷 75-84页

作者： James E.OVERLAND muyin wang Thomas J.BALLINGER NOAA/Pacific Marine Environmental Laboratory Seattle WA 98115USA Joint Institute for the Study of Atmosphere and Oceans University of Washington Seattle WA 98115USA Department of Geography Texas State UniversitySan Marcos TX 78666USA

Alaskan Arctic waters have participated in hemispheric-wide Arctic warming over the last two decades at over two times the rate of global warming. During 2008–13, this relative warming occurred only north of the Bering Strait and the atmospheric Arctic front that forms a north–south thermal barrier. This front separates the southeastern Bering Sea temperatures from Arctic air masses. Model projections show that future temperatures in the Chukchi and Beaufort seas continue to warm at a rate greater than the global rate, reaching a change of +4℃ by 2040 relative to the 1981–2010 mean. Offshore at 74°N, climate models project the open water duration season to increase from a current average of three months to five months by 2040. These rates are occasionally enhanced by midlatitude connections. Beginning in August 2014, additional Arctic warming was initiated due to increased SST anomalies in the North Pacific and associated shifts to southerly winds over Alaska, especially in winter 2015–16. While global warming and equatorial teleconnections are implicated in North Pacific SSTs, the ending of the 2014–16 North Pacific warm event demonstrates the importance of internal, chaotic atmospheric natural variability on weather conditions in any given year. Impacts from global warming on Alaskan Arctic temperature increases and sea-ice and snow loss, with occasional North Pacific support, are projected to continue to propagate through the marine ecosystem in the foreseeable future. The ecological and societal consequences of such changes show a radical departure from the current Arctic environment.

关键词： Alaska North Pacific Arctic warm advection polar vortex

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Preface to the Special Issue:Towards Improving Understanding and Prediction of Arctic Change and its Linkage with Eurasian Mid-latitude Weather and Climate

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Advances in Atmospheric Sciences 2018年第1期35卷 1-4页

作者： Xiangdong ZHANG Thomas JUNG muyin wang Yong LUO Tido SEMMLER Andrew ORR International Arctic Research Center University of Alaska FairbanksFairbanks AK 99775USA Alfred Wegener Institute Helmholtz Centre for Polar and Marine ResearchBremerhaven 27570Germany joint Institute for the Study of the Atmosphere and Ocean University of WashingtonSeattleWA 98115USA Center for Earth System Science Tsinghua UniversityBeijing 100084China British Antarctic Survey Cambridge CB3 0ETUK

The dramatic changes in the Arctic climate system during recent decades are one of the most prominent features of global climate *** most striking and fundamental characteristics are the amplified near-surface warming at a rate twice the global average since the mid 20th century(e.g.,Blunden and Arndt,2012;Huang et al.,2017),and the rapid

关键词： Preface to the Special Issue:Towards Improving Understanding and Prediction of Arctic Change and Its Linkage with Eurasian Mid-latitude Weather and Climate

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Extreme Cold Events from East Asia to North America in Winter 2020/21:Comparisons,Causes,and Future Implications

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Advances in Atmospheric Sciences 2022年第4期39卷 553-565页

作者： Xiangdong ZHANG Yunfei FU Zhe HAN James E.OVERLAND Annette RINKE Han TANG Timo VIHMA muyin wang Univeristy of Alaska Fairbanks FairbanksAK 99775USA University of Science and Technology of China Hefei 230026China Institute of Atmospheric Physics Chinese Academy of SciencesBeijing 100029China NOAA/Pacific Marine Environmental Laboratory SeattleWA 98115USA Alfred Wegener Institute Helmholtz Center for Polar and Marine Research14401 PotsdamGermany Finnish Meteorological Institute FI-00101 HelsinkiFinland University of Washington SeattleWA 98105USA

Three striking and impactful extreme cold weather events successively occurred across East Asia and North America during the mid-winter of 2020/*** events open a new window to detect possible underlying physical *** analysis here indicates that the occurrences of the three events resulted from integrated effects of a concurrence of anomalous thermal conditions in three oceans and interactive Arctic-lower latitude atmospheric circulation processes,which were linked and influenced by one major sudden stratospheric warming(SSW).The North Atlantic warm blob initiated an increased poleward transient eddy heat flux,reducing the Barents-Kara seas sea ice over a warmed ocean and disrupting the stratospheric polar vortex(SPV)to induce the major *** Rossby wave trains excited by the North Atlantic warm blob and the tropical Pacific La Nina interacted with the Arctic tropospheric circulation anomalies or the tropospheric polar vortex to provide dynamic settings,steering cold polar air *** long memory of the retreated sea ice with the underlying warm ocean and the amplified tropospheric blocking highs from the midlatitudes to the Arctic intermittently fueled the increased transient eddy heat flux to sustain the SSW over a long time *** displaced or split SPV centers associated with the SSW played crucial roles in substantially intensifying the tropospheric circulation anomalies and moving the jet stream to the far south to cause cold air outbreaks to a rarely observed extreme *** results have significant implications for increasing prediction skill and improving policy decision making to enhance resilience in“One Health,One Future”.

关键词： extreme weather events sea surface temperature Arctic sea ice Arctic amplification sudden stratospheric warming stratospheric polar vortex

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Preface to the Special Issue on Changing Arctic Climate and Low/Mid-latitudes Connections

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Advances in Atmospheric Sciences 2023年第12期40卷 2135-2137页

作者： Xiangdong ZHANG Xianyao CHEN Andrew ORR James EOVERLAND Timo VIHMA muyin wang Qinghua YANG Renhe ZHANG North Carolina State University AshevilleNC 28801USA Frontier Science Center for Deep Ocean Multispheres and Earth System Key Laboratory of Physical OceanographyOcean University of ChinaQingdao 266100China British Antarctic Survey High CrossMadingley RoadCambridge CB30ETUK NOAA/Pacific Marine Environmental Laboratory SeattleWA 98115USA Finnish Meteorological Institute Helsinki FI-00560Finland University of Washington SeattleWA 98105USA School of Atmospheric Sciences Sun Yat-sen Universityand Southern Marine Science and Engineering Guangdong Laboratory(Zhuhai)Zhuhai 519082China Department of Atmospheric and Oceanic Sciences Fudan UniversityShanghai 200438China

The Arctic climate system has changed rapidly during recent decades with a two-four times faster warming rate than the global average subject to the uncertainties of analysis datasets and *** changes have apparently resulted in broader and sizeable impacts within the Arctic,in the low/mid-latitudes,and *** importance of these changes and impacts makes the Arctic stand out within the global climate systems,drawing great attention and interests from the climate research community,the general public,and the government *** of the persistent,leading-edge topics in climate stud-ies during recent decades has therefore been to improve understanding of the underlying driving mechanisms,evaluate socioe-conomic and ecological impacts,and enhance the ability of the prediction and projections of Arctic climate changes.

关键词： Arctic latitude warming

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放大器增益—带宽积的研究

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首都师范大学学报（自然科学版） 1997年第S1期18卷 112-117页

作者：王木印首都师范大学物理系

本文通过对几种放大电路的分析，阐述了放大器在电路和晶体管确定之后，“其增益与通频带的乘积基本上是个常数”这一重要概念．并指出了在设计宽带放大器时。

关键词：增益通频带放大器

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中频放大器产生自激振荡的原理

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北京师范学院学报（自然科学版） 1991年第2期12卷 69-73页

作者：王木印北京师范学院分院物理系

中频放大器在工作频率小于中频的情况下,有可能产生自激振荡,破坏其正常工作。本文运用晶体管等效电路、LC网络的阻抗频率特性、相量图、反馈等基础理论,对晶体管的内部反馈进行了具体分析,阐明了产生自激振荡的原理。

关键词：放大器自激振荡中频放大器

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In-depth urinary and exosome proteome profiling analysis identifies novel biomarkers for diabetic kidney disease

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Science China(Life Sciences) 2023年第11期66卷 2587-2603页

作者： Shichun Du Linhui Zhai Shu Ye Le wang muyin Liu Minjia Tan Department of Endocrinology Xin Hua Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghai 200092China State Key Laboratory of Drug Research Shanghai Institute of Materia MedicaChinese Academy of SciencesShanghai 201203China Zhongshan Institute for Drug Discovery Shanghai Institute of Materia MedicaChinese Academy of SciencesGuangdong 528400China Department of Cardiology Shanghai Institute of Cardiovascular DiseasesZhongshan HospitalFudan UniversityShanghai 200032China

Diabetic kidney disease(DKD)is a major microvascular complication of type 2 diabetes mellitus(T2DM).Monitoring the early diagnostic period and disease progression plays a crucial role in treating *** this study,to comprehensively elucidate the molecular characteristics of urinary proteins and urinary exosome proteins in type 2 DKD,we performed large-scale urinary proteomics(n=144)and urinary exosome proteomics(n=44)analyses on T2DM patients with albuminuria in varying *** dynamics analysis of the urinary and exosome proteomes in our study provides a valuable resource for discovering potential urinary biomarkers in patients with DKD.A series of potential biomarkers,such as SERPINA1 and transferrin(TF),were detected and validated to be used for DKD diagnosis or disease *** results of our study comprehensively elucidated the changes in the urinary proteome and revealed several potential biomarkers reflecting the progression of DKD,which provide a reference for DKD biomarker screening.

关键词： diabetic kidney disease type 2 diabetes mellitus urinary proteome urinary exosome proteome biomarkers

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Substrate and Functional Diversity of Protein Lysine Post-translational Modifica

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Genomics, Proteomics & Bioinformatics 2024年第1期22卷 29-49页

作者： Bingbing Hao Kaifeng Chen Linhui Zhai muyin Liu Bin Liu Minjia Tan State Key Laboratory of Drug Research Shanghai Institute of Materia MedicaChinese Academy of SciencesShanghai 201203China University of Chinese Academy of Sciences Beijing 100049China Tianjian Laboratory of Advanced Biomedical Sciences Institute of Advanced Biomedical SciencesZhengzhou UniversityZhengzhou 450001China Zhongshan Institute for Drug Discovery Shanghai Institute of Materia MedicaChinese Academy of SciencesZhongshan 528400China State Key Laboratory of Pharmaceutical Biotechnology Nanjing UniversityNanjing 210023China Department of Cardiology Shanghai Institute of Cardiovascular DiseasesZhongshan HospitalFudan UniversityShanghai 200032China Jiangsu Key Laboratory of Marine Pharmaceutical Compound Screening College of PharmacyJiangsu Ocean UniversityLianyungang 222005China

Lysine post-translational modifications(PTMs)are widespread and versatile protein PTMs that are involved in diverse biological processes by regulating the fundamental functions of histone and non-histone *** of lysine PTMs is implicated in many diseases,and targeting lysine PTM regulatory factors,including writers,erasers,and readers,has become an effective strategy for disease *** continuing development of mass spectrometry(MS)technologies coupled with antibody-based affinity enrichment technologies greatly promotes the discovery and decoding of *** global characterization of lysine PTMs is crucial for deciphering the regulatory networks,molecular functions,and mechanisms of action of lysine *** this review,we focus on lysine PTMs,and provide a summary of the regulatory enzymes of diverse lysine PTMs and the proteomics advances in lysine PTMs by MS *** also discuss the types and biological functions of lysine PTM crosstalks on histone and non-histone proteins and current druggable targets of lysine PTM regulatory factors for disease therapy.

关键词： Protein lysine PTM Regulatory enzyme PTM crosstalk Drug target Acylation

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A pilot study on Paxlovid therapy for hemodialysis patients with severe acute respiratory syndrome coronavirus 2 infections

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Frontiers of Medicine 2024年第1期18卷 169-179页

作者： Xu Hao Zhiyao Bao Ranran Dai Xiaojing Wu Xin Li muyin Zhang Hao Li Lili Xu Panpan Qiao Xuefei Liu Weiting Hu Ze Zhang Jie Fang Min Zhou Weiming wang Jieming Qu Department of Nephrology Ruijin HospitalShanghai Jiao Tong University School of MedicineShanghai200025China Department of Pulmonary and Critical Care Medicine Ruijin HospitalShanghai Jiao Tong University School of MedicineShanghai200025China Institute of Respiratory Diseases Shanghai Jiao Tong University School of MedicineShanghai200025China Department of Pharmacy Ruijin HospitalShanghai Jiao Tong University School of MedicineShanghai200025China

We aimed to investigate the safety and efficacy of nirmatrelvir/ritonavir(Paxlovid)therapy for hemodialysis-dependent patients with severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)*** hemodialysis patients infected with the Omicron variant of SARS-CoV-2 from April 3 to May 30,2022,were *** parameters and chest CT(computed tomography)imaging were *** treatment group included six patients who received 150 mg/100 mg of Paxlovid orally once daily for 5 days,whereas the control group included seven patients who received basic *** serious adverse reactions or safety events were *** control patients progressed to moderate disease,and none in the treatment group showed progression of chest CT findings(P<0.05).Paxlovid therapy tended toward early viral clearance and low viral load on Day ***,83.3%of the patients in the treatment group and 57.1%of the patients in the control group turned negative within 22 *** the Paxlovid treatment group,we found significantly increased levels of lymphocytes(P=0.03)and eosinophils(P=0.02)and decreased levels of D-dimer on Day 8 compared with those on Day *** therapy showed a potential therapeutic effect with good tolerance in hemodialysis *** optimal dose and effectiveness evaluation must be further investigated in a largeer cohort.

关键词： Paxlovid hemodialysis SARS-CoV-2 viral load chest CT scan

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