Substrate and Functional Diversity of Protein Lysine Post-translational Modifica

作     者：Bingbing Hao Kaifeng Chen Linhui Zhai Muyin Liu Bin Liu Minjia Tan 

作者机构：State Key Laboratory of Drug ResearchShanghai Institute of Materia MedicaChinese Academy of SciencesShanghai 201203China University of Chinese Academy of SciencesBeijing 100049China Tianjian Laboratory of Advanced Biomedical SciencesInstitute of Advanced Biomedical SciencesZhengzhou UniversityZhengzhou 450001China Zhongshan Institute for Drug DiscoveryShanghai Institute of Materia MedicaChinese Academy of SciencesZhongshan 528400China State Key Laboratory of Pharmaceutical BiotechnologyNanjing UniversityNanjing 210023China Department of CardiologyShanghai Institute of Cardiovascular DiseasesZhongshan HospitalFudan UniversityShanghai 200032China Jiangsu Key Laboratory of Marine Pharmaceutical Compound ScreeningCollege of PharmacyJiangsu Ocean UniversityLianyungang 222005China 

出 版 物：《Genomics, Proteomics & Bioinformatics》 (基因组蛋白质组与生物信息学报（英文版）)

年 卷 期：2024年第22卷第1期

页      面：29-49页

核心收录：

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

基　　金：supported by grants from the Program of Shanghai Academic Research Leader(Grant No.22XD1420900) the National Natural Science Foundation of China(Grant Nos.22225702,32071432,32171434,and 81821005) the Youth Science and Technology Talents in Shanghai Sail Plan of China(Grant No.21YF1456000) the State Key Laboratory of Pharmaceutical Biotechnology,Nanjing University,China(Grant No.KF-202201) the Guangdong High-level New R&D Institute,China(Grant No.2019B090904008) the Guangdong High-level Innovative Research Institute,China(Grant No.2021B0909050003) 

主　　题：Protein lysine PTM Regulatory enzyme PTM crosstalk Drug target Acylation 

摘      要：Lysine post-translational modifications(PTMs)are widespread and versatile protein PTMs that are involved in diverse biological processes by regulating the fundamental functions of histone and non-histone *** of lysine PTMs is implicated in many diseases,and targeting lysine PTM regulatory factors,including writers,erasers,and readers,has become an effective strategy for disease *** continuing development of mass spectrometry(MS)technologies coupled with antibody-based affinity enrichment technologies greatly promotes the discovery and decoding of *** global characterization of lysine PTMs is crucial for deciphering the regulatory networks,molecular functions,and mechanisms of action of lysine *** this review,we focus on lysine PTMs,and provide a summary of the regulatory enzymes of diverse lysine PTMs and the proteomics advances in lysine PTMs by MS *** also discuss the types and biological functions of lysine PTM crosstalks on histone and non-histone proteins and current druggable targets of lysine PTM regulatory factors for disease therapy.