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Plant peroxisomal solute transporter proteins

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Journal of Integrative Plant Biology 2019年第7期61卷 817-835页

作者： Lennart Charton Anastasija Plett nicole Linka Institute for Plant Biochemistry and Cluster of Excellence on Plant Sciences (CEPLAS) Heinrich Heine University

Plant peroxisomes are unique subcellular organelles which play an indispensable role in several key metabolic pathways, including fatty acid b-oxidation,photorespiration, and degradation of reactive oxygen species. The compartmentalization of metabolic pathways into peroxisomes is a strategy for organizing the metabolic network and improving pathway efficiency. An important prerequisite, however, is the exchange of metabolites between peroxisomes and other cell compartments. Since the first studies in the 1970s scientists contributed to understanding how solutes enter or leave this *** review gives an overview about our current knowledge of the solute permeability of peroxisomal membranes described in plants, yeast, mammals and other eukaryotes. In general, peroxisomes contain in their bilayer membrane specific transporters for hydrophobic fatty acids(ABC transporter) and large cofactor molecules(carrier for ATP, NAD and CoA). Smaller solutes with molecular masses below 300–400 Da, like the organic acids malate, oxaloacetate, and 2-oxoglutarate, are shuttled via non-selective channels across the peroxisomal *** comparison to yeast, human, mammals and other eukaryotes, the function of these known peroxisomal transporters and channels in plants are discussed in this review.

关键词： Plant peroxisomal solute transporter proteins

Exploring the link between brain topological resilience and cognitive performance in the context of aging and vascular risk factors:A cross-ethnicity population-based study

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Science Bulletin 2024年第17期69卷 2735-2744页

作者： Hao Liu Jing Jing Jiyang Jiang Wei Wen Wanlin Zhu Zixiao Li Yuesong Pan Xueli Cai Chang Liu Yijun Zhou Xia Meng Yilong Wang Hao Li Yong Jiang Huaguang Zheng Suying Wang Haijun Niu nicole Kochan Henry Brodaty Tiemin Wei Perminder S.Sachdev Yubo Fan Tao Liu Yongjun Wang Beijing Advanced Innovation Center for Biomedical Engineering School of Biological Science and Medical EngineeringBeihang UniversityBeijing 100191China China National Clinical Research Center for Neurological Diseases Beijing 100070China Department of Neurology Beijing Tiantan HospitalCapital Medical UniversityBeijing 100070China Neuropsychiatric Institute Prince of Wales HospitalSydney NSW 2031Australia Centre for Healthy Brain Ageing(CHeBA) Discipline of Psychiatry and Mental HealthSchool of Clinical MedicineUNSW MedicineSydney NSW 2052Australia Department of Neurology Lishui HospitalZhejiang University School of MedicineLishui 323000China Cerebrovascular Research Lab Lishui HospitalZhejiang University School of MedicineLishui 323000China Department of Cardiology Lishui HospitalZhejiang University School of MedicineLishui 323000China

Brain aging is typically associated with a significant decline in cognitive *** risk factors(VRF)and subsequent atherosclerosis(AS)play a major role in this *** resilience reflects the brain’s ability to withstand external perturbations,but the relationship of brain resilience with cognition during the aging process remains ***,we investigated how brain topological resilience(BTR)is associated with cognitive performance in the face of aging and vascular risk *** used data from two cross-ethnicity community cohorts,PolyvasculaR Evaluation for Cognitive Impairment and Vascular Events(PRECISE,n=2220)and Sydney Memory and Ageing Study(MAS,n=246).We conducted an attack simulation on brain structural networks based on k-shell decomposition and node degree *** was defined based on changes in the size of the largest subgroup of the network during the simulation ***,we explored the negative correlations of BTR with age,VRF,and AS,and its positive correlation with cognitive ***,using structural equation modeling(SEM),we constructed path models to analyze the directional dependencies among these variables,demonstrating that aging,AS,and VRF affect cognition by disrupting *** results also indicated the specificity of this metric,independent of brain ***,these findings underscore the supportive role of BTR on cognition during aging and highlight its potential application as an imaging marker for objective assessment of brain cognitive performance.

关键词： Brain resilience Vascular risk factors Cognition decline K-shell decomposition Network attack simulation

Controlling Heat Transfer for the Manufacturing of High Molecular Weight Polyisobutylene via Formation of Micelles

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Chinese Journal of Polymer Science 2019年第9期37卷 898-902页

作者： Szilard Csihony nicole Janssen Klaus Mühlbach Advanced Materials & Systems

An alternative cationic polymerization method is developed to produce high molecular weight polyisobutylene (HM-PIB) with molecular weights above 5×10^5g/mol. The method involves micelle formation via functionalized low molecular weight polyisobutylene (LM-PIB) in non-polar solvent. One end of LM-PIB is modified with an imidazolium-containing ionic group, which together with the anion (eg. Al2Cl7) works as Lewis acid. While the monomer isobutylene dissolves readily in non-polar solvent, polymerization can occur only within the micelle, which affords stable HM-PIB particles. HM-PIB with a molecular weight (MW) close to 1 × 10^6 g/mol was produced successfully with the described method.

关键词： Cationic polymerization High molecular weight polyisobutylene Micelle

Telomeres:Linking stress and survival,ecology and evolution

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Current Zoology 2010年第6期56卷 714-727页

作者： Mark F.HAUSSMANN nicole M.MARCHETTO Department of Biology Bucknell University

Telomeres are protective structures at the ends of eukaryotic chromosomes. The loss of telomeres through cell division and oxidative stress is related to cellular aging, organismal growth and disease. In this way, telomeres link molecular and cellular mechanisms with organismal processes, and may explain variation in a number of important life-history traits. Here, we discuss how telomere biology relates to the study of physiological ecology and life history evolution. We emphasize current knowledge on how telomeres may relate to growth, survival and lifespan in natural populations. We finish by examining interest- ing new connections between telomeres and the glucocorticoid stress response. Glucocorticoids are often employed as indices of physiological condition, and there is evidence that the glucocorticoid stress response is adaptive. We suggest that one way that glucocorticoids impact organismal survival is through elevated oxidative stress and telomere loss. Future work needs to establish and explore the link between the glucocorticoid stress response and telomere shortening in natural populations. If a link is found, it provides an explanatory mechanism by which environmental perturbation impacts life history trajectories [Current Zoology 56 （6）： 714-727, 2010].

关键词： Corticosterone Stress Survival Telomeres

Evaluation of the Impact of Driver Behavior on Back of Queues Events in Work Zones Using the SHRP2 Naturalistic Driving Study Data

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Editorial:Industrial relevance of molybdenum in China

Journal of Transportation Technologies（交通科技期刊） 2024年第2期 179页

作者： Shauna Hallmark Guillermo Basulto-Elias nicole Oneyear Omar Smadi

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Advances in Manufacturing 2020年第1期8卷 35-39页

作者： Tim Outteridge nicole Kinsman Gaetano Ronchi Hardy Mohrbacher International Molybdenum Association LondonUK Department of Materials Engineering KU LeuvenLeuvenBelgium NiobelCon bvba SchildeBelgium

About 80%of all molybdenum mined in the world(not including units recovered via recycling)is used as an alloying element in iron and *** general,the intensity of molybdenum use in China is still lower than in more highly developed regions such as the USA and *** difference is manifest in both carbon steels and stainless steels,suggesting a significant opportunity for more widespread use of molybdenum in the future as China follows its self-reliance policy,calling for more sophisticated *** market development,as being pursued by the International Molybdenum Association(IMOA),is a key asset in that *** article summarizes some key facts on molybdenum mining,use and market development in China.

关键词： China molybdenum industry Global molybdenum reserves Molybdenum applications Enduser markets Molybdenum alloying Market development

Forecasting the development of boreal paludified forests in response to climate change: a case study using Ontario ecosite classification

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Forest Ecosystems 2015年第1期2卷 45-55页

作者： Benoit Lafleur nicole J Fenton Yves Bergeron Institut de recherche sur les forêts Université du Québec en Abitibi-Témiscamingue 445 boul. de l’Université Rouyn-Noranda QC J9X 5E4 Canada Centre d’étude de la forêt Université du Québec à Montréal 141 Avenue du Président-Kennedy Montréal QC H2X 1Y4 Canada

Background：Successional paludification,a dynamic process that leads to the formation of peatlands,is influenced by climatic factors and site features such as surficial deposits and soil *** boreal regions,projected climate change and corresponding modifications in natural fire regimes are expected to influence the paludification process and forest *** objective of this study was to forecast the development of boreal paludified forests in northeastern North America in relation to climate change and modifications in the natural fire regime for the period 2011–***：A paludification index was built using static（*** deposits and soil texture）and dynamic（*** regime and soil organic layer thickness）stand scale factors available from forest *** index considered the effects of three temperature increase scenarios（i.e.＋1°C,＋3°C and＋6°C）and progressively decreasing fire cycle（from 300 years for 2011–2041,to 200 years for 2071–2100）on peat accumulation rate and soil organic layer（SOL）thickness at the stand level,and paludification at the landscape ***：Our index show that in the context where in the absence of fire the landscape continues to paludify,the negative effect of climate change on peat accumulation resulted in little modification to SOL thickness at the stand level,and no change in the paludification level of the study area between 2011 and ***,including decreasing fire cycle to the index resulted in declines in paludified ***,the index predicts a slight to moderate decrease in the area covered by paludified forests in 2100,with slower rates of ***：Slower paludification rates imply greater forest productivity and a greater potential for forest harvest,but also a gradual loss of open paludified stands,which could impact the carbon balance in paludified ***,as the thick Sphagnum layer typical of paludified forests may protect soil organic layer from dr

关键词： Boreal forest Canada Carbon sequestration Paludification Peat forests Forest harvest

The Nation in Utero： Translating the Science of Fetal Education in Republican China

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Frontiers of History in China 2012年第1期7卷 4-31页

作者： nicole Richardson Department of History University of California at Davis Davis CA 95616 USA

As Chinese nationalists grappled with the political and military weakness of the young Republic of China, some sought to strengthen the Chinese race by advocating a return to the ancient practice of fetal education. Fetal education held that every sight, sound, and flavor that a pregnant mother took in through her senses, as well as her emotions and demeanor, directly affected her fetus. This paper examines how the text Taijiao, Song Jiazhao＇s 1914 Chinese translation of Shimoda Jirr＇s Japanese work Taiky6, presents a modern reformulation of fetal education that draws upon both modern Western science and East Asian medicine. As the text uses modern biology and psychology to explain and demonstrate the efficacy of fetal education, it also narrows the scope of fetal education to focus almost exclusively on the mother＇s psychological state Similarly, as the text turns to instruct women on the practice of fetal education, it draws upon Edo and Qing gynecological principles to emphasise the importance of the pregnant mother＇s emotional self-control. Ultimately this text represents a neo-traditionalist response to modernity as it presents a Neo-Confucian vision of fetal education focused on a pregnant mother＇s moral self-cultivation and emotional self control.

关键词： fetal education (taijiao) gynecology fetus Western science,medicine Neo-Confucianism Republican Era

The role of cellular and molecular neuroimmune crosstalk in gut immunity

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Cellular & Molecular Immunology 2023年第11期20卷 1259-1269页

作者： Daping Yang nicole Almanzar Isaac M.Chiu Department of Immunology Harvard Medical SchoolBostonMA02115USA

The gastrointestinal tract is densely innervated by the peripheral nervous system and populated by the immune *** two systems critically coordinate the sensations of and adaptations to dietary,microbial,and damaging stimuli from the external and internal microenvironment during tissue homeostasis and *** brain receives and integrates ascending sensory signals from the gut and transduces descending signals back to the gut via autonomic *** regulate intestinal immune responses through the action of local axon reflexes or through neuronal circuits via the gut-brain *** neuroimmune crosstalk is critical for gut homeostatic maintenance and disease *** this review,we discuss the roles of distinct types of gut-innervating neurons in the modulation of intestinal mucosal *** will focus on the molecular mechanisms governing how different immune cells respond to neural signals in host defense and *** also discuss the therapeutic potential of strategies targeting neuroimmune crosstalk for intestinal diseases.

关键词： Neuroimmunology Neuroimmune Host defense Gut Sensory