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Neural Regeneration Research 2025年第4期20卷 1079-1080页

作者： Victor V.Chizhikov Igor y.Iskusnykh Department of Anatomy and Neurobiology University of Tennessee Health Science CenterMemphisTNUSA

Development of the telencephalon relies upon several signaling centers-localized cellular populations that supply secreted factors to pattern the cortical *** such signaling center is the cortical hem,which arises during embryonic development at the telencephalic dorsal midline,adjacent to the choroid plexus and hippocampal primordium(Figure 1A).While the cortical hem has also been described in reptiles and birds,most of our knowledge about the developmental roles of the cortical hem is derived from the analysis in *** cortical hem produces several types of secreted molecules,including wingless-related integration site(Wnt)and bone morphogenetic(Bmp)*** cortical hem is particularly important for the development of the hippocampus,which is involved in learning and memory,and the neocortex,which is the most complex brain region that mediates multiple types of behavior and higher cognitive functions(Mangale et al.,2008;Dal-Valle-Anton and Borrell,2022).

关键词： epithelium Figure center

Exercise preconditioning alleviates ischemia-induced memory deficits by increasing circulating adiponectin

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Neural Regeneration Research 2025年第5期20卷 1445-1454页

作者： Meifeng Zheng Borui Zhang Sonata S y yau Kwok-Fai So Li Zhang Haining Ou Department of Rehabilitation Medicine Guangzhou Medical UniversityGuangzhouGuangdong ProvinceChina Department of Rehabilitation Medicine The Fifth Clinical College of Guangzhou Medical UniversityGuangzhouGuangdong ProvinceChina Key Laboratory of CNS Regeneration(Ministry of Education) Guangdong-Hong Kong-Macao Institute of CNS RegenerationJinan UniversityGuangzhouGuangdong ProvinceChina Department of Rehabilitation Sciences The Hong Kong Polytechnic UniversityHong Kong Special Administrative RegionChina State Key Laboratory of Brain and Cognitive Science Li Ka Shing Faculty of MedicineThe University of Hong KongHong Kong Special Administrative RegionChina Center for Exercise and Brain Science School of PsychologyShanghai University of SportShanghaiChina Neuroscience and Neurorehabilitation Institute University of Health and Rehabilitation SciencesQingdaoShandong ProvinceChina

Cerebral ischemia is a major health risk that requires preventive approaches in addition to drug *** exercise enhances neurogenesis and synaptogenesis,and has been widely used for functional rehabilitation after *** this study,we determined whether exercise training before disease onset can alleviate the severity of cerebral *** also examined the role of exercise-induced circulating factors in these *** mice were subjected to 14 days of treadmill exercise training before surgery for middle cerebral artery *** found that this exercise pre-conditioning strategy effectively attenuated brain infarct area,inhibited gliogenesis,protected synaptic proteins,and improved novel object and spatial memory *** analysis showed that circulating adiponectin plays a critical role in these preventive effects of *** activation of adiponectin receptors by Adipo Ron mimicked the effects of exercise,while inhibiting receptor activation abolished the exercise *** summary,our results suggest a crucial role of circulating adiponectin in the effects of exercise pre-conditioning in protecting against cerebral ischemia and supporting the health benefits of exercise.

关键词： adiponectin cerebral ischemia exercise pre-conditioning hippocampus memory function middle cerebral artery occlusion prefrontal cortex synaptic proteins treadmill exercise

Gene therapy for spinal muscular atrophy:perspectives on the possibility of optimizing SMN1 delivery to correct all neurological and systemic perturbations

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Neural Regeneration Research 2025年第7期20卷 2011-2012页

作者： Sharon J.Brown Rafael J.yáñez-Muñoz Heidi R.Fuller School of Pharmacy and Bioengineering Keele UniversityKeeleUK Wolfson Center for Inherited Neuromuscular Disease TORCH BuildingRJAH Orthopaedic HospitalOswestryUK *** Center of Gene and Cell TherapyDepartment of Biological SciencesSchool of Life Sciences and the EnvironmentRoyal Holloway University of LondonEghamUK

Spinal muscular atrophy(SMA)is a genetic condition that results in selective lower motor neuron loss with concomitant muscle weakness and *** genetic cause of SMA was understood in 1995 when loss or impairment of the survival motor neuron 1(SMN1)gene was identified as the main contributing factor(Lefebvre et al.,1995).This,in combination with the discovery that humans have a“back-up”gene,SMN2,which can produce low levels(approximately 10%)of the full-length functional SMN protein,has led to the generation of SMA-specific gene *** was traditionally classified according to age of symptom onset and developmental milestones achieved,with life expectancy and severity varying between ***,SMN2 copy number is used as a proxy for the prediction of disease severity,with higher SMN2 copy number typically being associated with reduced severity of SMA,although this relationship is not absolute:some individuals with low SMN2 copy number have less severe SMA phenotypes and vice ***,the etiology of SMA is further complicated by other factors,such as non-typical nucleotide variants and SMN2-independent modifiers of disease severity.

关键词： atrophy traditionally absolute

Capillary method for measuring near-infrared spectra of microlitre volume liquids

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2007年第2期8卷 171-175页

作者： yUAN Bo murayama Koichi Department of Information Science and Optoelectronic Engineering State Key Laboratory of Modern Optical Instrumentation CNERC for Optical Instrument Zhejiang University Hangzhou 310027 China Department of Biochemistry and Biophysics Gifu University School of Medicine Gifu 500-8705 Japan

The present study theoretically explored the feasibility of the capillary method for measuring near-infrared (NIR) spectra of liquid or solution samples with microlitre volume, which was proposed in our previous studies. Lambert-Beer absorb- ance rule was applied to establish a model for the integral absorbance of capillary, which was then implemented in numerical analyses of the effects of capillary on various spectral features and dynamic range of absorption measurement. The theoretical speculations indicated that the capillary method might be used in NIR spectroscopy, which was further supported by the empirical data collected from our experiments by comparison between capillary NIR spectra of several organic solvents and cuvette cell NIR spectra.

关键词： Near-infrared (NIR) spectroscopy Capillary Cuvette cell Numerical analysis

A comparative study of land price estimation and mapping using regression kriging and machine learning algorithms across Fukushima prefecture,Japan

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Journal of Geographical Sciences 2020年第5期30卷 794-822页

作者： DERDOURI Ahmed murayama yuji Division of Spatial Information Science Graduate School of Life and Environmental SciencesUniversity of TsukubaTennodaiTsukubaIbarakiJapan Faculty of Life and Environmental Sciences University of TsukubaTennodaiTsukubaIbarakiJapan

Finding accurate methods for estimating and mapping land prices at the macro-scale based on publicly accessible and low-cost spatial data is an essential step in producing a meaningful reference for regional *** asset would assist them in making economically justified decisions in favor of key investors for development projects and post-disaster recovery *** 2005,the Ministry of Land,Infrastructure,and Transport of Japan has made land price data open to the public in the form of observations at dispersed *** this data is useful,it does not provide complete information at every site for all market ***,estimating and mapping land prices based on sound statistical theories is *** paper presents a comparative study of spatial prediction of land prices in 2015 in Fukushima prefecture based on geostatistical methods and machine learning *** use,elevation,and socioeconomic factors,including population density and distance to railway stations,were used for *** show the superiority of the random forest ***,land prices are distributed unevenly across the prefecture with the most expensive land located in the western region characterized by flat topography and the availability of well-connected and highly dense economic hotspots.

关键词： land price spatial estimation kriging machine learning Fukushima prefecture,Japan

Grain size altering yielding mechanisms in ultrafine grained high-Mn austenitic steel:Advanced TEM investigations

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Journal of Materials Science & Technology 2021年第27期86卷 192-203页

作者： Chang-yu Hung yu Bai Nobuhiro Tsuji Mitsuhiro murayama Department of Materials Science and Engineering Virginia TechBlacksburgVA24061USA Department of Materials Science and Engineering Kyoto UniversityYoshida-honmachiSakyo-kuKyoto606-8501Japan Elements Strategy Initiative for Structural Materials Kyoto UniversityYoshida-honmachiSakyo-kuKyoto606-8501Japan Institute for Materials Chemistry and Engineering Kyushu UniversityKasugaFukuoka8168580Japan

The underlying mechanism of discontinuous yielding behavior in an ultrafine-grained(UFG)Fe-31 Mn-3 Al-3 Si(wt.%)austenitic TWIP steel was investigated by the use of advanced TEM technique with taking the plastic deformation mechanisms and their correlation with grains size near the macroscopic yield point into *** yield drop mechanisms such as the dislocation locking by the Cottrell atmosphere due to the presence of interstitial impurities cannot explain the origin of this phenomenon in the UFG high-Mn austenitic TWIP ***,we experimentally revealed that the plastic deformation mechanisms in the early stage of deformation,around the macroscopic yield point,show an obvious association with grain *** specifically,the main mechanism shifts from the conventional slip in grain interior to twinning nucleated from grain boundaries with decreasing the grain size down to less than 1μ*** observation indicates that the grain size dependent deformation mechanisms transition is also deeply associated with the discontinuous yielding behavior as it could govern the changes in the grain interior dislocation density of mobile dislocations around the macroscopic yield point.

关键词： Ultrafine grains TWIP steel yield-drop phenomenon Deformation twin nucleation Structural defects Transmission electron microscopy

Novel CD9-targeted therapies in gastric cancer

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World Journal of Gastroenterology 2015年第11期21卷 3206-3213页

作者： yoko murayama Kenji Oritani Shusaku Tsutsui Department of Gastro-enterology and Hepatology Itami City Hospital Department of Hematology/Oncology Graduate School of MedicineOsaka University

There are 33 human tetraspanin proteins,emerging as key players in malignancy,the immune system,fertilization,cellular signaling,adhesion,morphology,motility,proliferation,and tumor ***9,a member of the tetraspanin family,associates with and influences a variety of cell-surface *** these interactions,CD9 modifies multiple cellular events,including adhesion,migration,proliferation,and ***9 is therefore considered to play a role in several stages during cancer *** CD9 expression is generally related to venous vessel invasion and metastasis as well as poor *** found that treatment of mice bearing human gastric cancer cells with anti-CD9 antibody successfully inhibited tumor progression via antiproliferative,proapoptotic,and antiangiogenic effects,strongly indicating that CD9 is a possible therapeutic target in patients with gastric ***,we describe the possibility of CD9 manipulation as a novel therapeutic strategy in gastric cancer,which still shows poor prognosis.

关键词： CD9 Tetraspanin Gastric cancer Tumo-rigenicity The

Structural Health Monitoring by Using Fiber-Optic Distributed Strain Sensors With High Spatial Resolution

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Photonic Sensors 2013年第4期3卷 355-376页

作者： Hideaki murayama Daichi WADA Hirotaka IGAWA School of Engineering The University of Tokyo 7-3-1 Hongo Bunkyo-ku Tokyo 113-8656 Japan Japan Aerospace Exploration Agency 6-13-10hsawa Mitaka Tokyo 181-0015 Japan

In this paper, we review our researches on the topics of the structural health monitoring （SHM） with the fiber-optic distributed strain sensor. Highly-dense information on strains in a structure can be useful to identify some kind of existing damages or applied loads in implementation of SHM. The fiber-optic distributed sensors developed by the authors have been applied to the damage detection of a single-lap joint and load identification of a beam simply supported. We confirmed that the applicability of the distributed sensor to SHM could be improved as making the spatial resolution higher. In addition, we showed that the simulation technique considering both structural and optical effects seamlessly in strain measurement could be powerful tools to evaluate the performance of a sensing system and design it for SHM. Finally, the technique for simultaneous distributed strain and temperature measurement using the PANDA-fiber Bragg grating （FBG） is shown in this paper, because problems caused by the cross-sensitivity toward strain and temperature would be always inevitable in strain measurement for SHM.

关键词： Structural health monitoring fiber-optic distributed sensor strain monitoring damage detection load identification

Pneumonia and seizures due to hypereosinophilic syndrome—organ damage and eosinophilia without synchronisation:A case report

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World Journal of Clinical Cases 2022年第18期10卷 6325-6332页

作者： Tetsuro Ishida Tomonori murayama Seiju Kobayashi Department of Psychiatry Hokujinkai Ishibashi HospitalOtaru 047-8585Japan Department of Psychiatry Kushiro Red Cross HospitalKushiro 085-8512Japan Department of Psychiatry Shinyukai Nakae HospitalSapporo 001-0022Japan

BACKGROUND Hypereosinophilic syndrome(HES)is a condition characterized by increased eosinophil proliferation in the bone marrow,as well as tissue eosinophilia,often causing organ *** cause of the disease is *** symptoms include fatigue,cough,shortness of breath,myalgia,angioedema,fever,and *** addition to the respiratory symptoms,damage to the central nervous system can lead to severe ***,we report a case with pneumonia and complex partial seizures secondary to *** SUMMARy A 94-year-old woman was admitted to our hospital for heart failure and bloody *** admission,she also showed symptoms of ***-contrast computed tomography of the chest showed pleural effusion and infiltrative *** gastrointestinal endoscopy showed multiple ulcers in the sigmoid *** analyses showed marked eosinophilia(eosinophils 1760/mm3,total leukocytes 6850/mm3).Initial treatment with furosemide 20 mg/d and prednisolone 25 mg/d relieved these ***,the patient subsequently experienced localised epileptic seizures characterized by bilateral eyelid twitching and eyes rolling upwards,without generalized convulsions,and respiratory arrest *** showed spikes and ***-contrast magnetic resonance imaging of the brain showed extensive periventricular *** administration of levetiracetam 1000 mg/d the epileptic seizures ***,the patient’s consciousness remained impaired,and her pneumonia worsened *** weeks later,she died of *** HES symptoms are variable and atypical,and the level and timing of eosinophilia and organ damage are often discordant.

关键词： Case report Hypereosinophilic syndrome Pneumonia Seizures Prednisolone Levetiracetam