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Effect of growth hormone,hyperbaric oxygen and combined therapy on the gastric serosa

World Journal of Gastroenterology 2013年第19期19卷 2904-2912页

作者： Gokhan Adas Mine Adas Soykan arikan Ahu Kemik Sarvan Akin Savas TokluDepartment of Underwater and Hyperbaric Medicine Istanbul Faculty of Medicine 34091 Istanbul Turkey Selva Mert Gul Barut Sedat Kamali Bora Koc Firat Tutal Department of Surgery Bakirkoy Dr.Sadi Konuk Training and Research Hospital34147 IstanbulTurkey Department of Endocrinology Okmeydani Training and Research Hospital34384 IstanbulTurkey Department of Surgery Istanbul Training and Research Hospital34098 IstanbulTurkey Department of Biochemistry Istanbul Faculty of Medicine34091 IstanbulTurkey Department of Underwater and Hyperbaric Medicine Istanbul Faculty of Medicine34091 IstanbulTurkey Department of Pathology Haseki Training and Research Hospital34096 IstanbulTurkey Department of Surgery Okmeydani training and Research Hospital34384 IstanbulTurkey

AIM:To investigate the role of growth hormone(GH),hyperbaric oxygen therapy(HBOT) and combined therapy on the intestinal neomucosa formation of the gastric ***:Forty-eight male Wistar-albino rats,weighing 250-280 g,were used in this *** rats were divided into four groups(n = 12):Group 1,control,gastric serosal patch;Group 2,gastric serosal patch + GH;Group 3,gastric serosal patch + HBOT;and Group 4,gastric serosal patch + GH + *** access was achieved through a midline incision,and after the 1-cm-long defect was created in the jejunum,a 1 cm × 1 cm patch of the gastric corpus was anastomosed to the jejunal *** blood samples were taken to determine the insulin-like growth factor 1(IGF-1) and insulin-like growth factor binding protein 3(IGFBP-3) basal *** was performed in Groups 3 and *** Groups 2 and 4,human GH was given subcutaneously at a dose of 2 mg per kg/d for 28 d,beginning on the operation *** animals were sacrificed 60 d after *** jejunal segment and the gastric anastomotic area were excised for histological *** inflammatory process,granulation,collagen deposition and fibroblast activity at the neomucosa formation were studied and ***,the villus density,villus height,and crypt depth were counted and *** measurements of villus height and crypt depth were calculated with an ocular *** vessel growth was determined by calculatingeach new vessel in a 1 mm 2 ***:In the histological comparison of groups,no significant differences were observed between the control group and Groups 2 and 3 with respect to epithelialization,granulation,fibroblastic activity and the inflammatory process,but significant differences were present between the control group and all others groups(Groups 2-4) with respect to angiogenesis(P < 0.01) and collagen deposition(P < 0.05,P < 0.01).Significant differences between the control group and Group 4 were also observed with respe

关键词： Growth hormone Hyperbaric oxygen Neomucosa Short bowel syndrome Hypoxia

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要和平不要战争

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大众科学 2017年第4期 64-64页

作者： Emrah arikan

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Evaluation of proximal tubule functions in children with COVID‑19:a prospective analytical study

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World Journal of Pediatrics 2022年第9期18卷 607-612页

作者： Fatma Devrim Elif Böncüoğlu Elif Kıymet ŞahikaŞahinkaya Ela Cem Mine Düzgöl Aybüke Akaslan Kara KamileÖtiken Arıkan AslıKantar Ebru Yılmaz Nida Dinçel Nuri Bayram İlker Devrim Department of Pediatric Nephrology University of Health Sciences Dr.Behçet Uz Child Disease and Pediatric Surgery Training and Research HospitalİzmirTurkey Department of Pediatric Infectious Diseases University of Health Sciences Dr.Behçet Uz Child Disease and Pediatric Surgery Training and Research HospitalİzmirTurkey

Background There are limited numbers of studies focusing on renal efects of coronavirus disease 2019(COVID-19)infection and proximal tubular dysfunction in children with COVID-19 *** purpose of this study was to evaluate the functions of the proximal tubule in hospitalized children with confrmed acute *** The children who were hospitalized for confrmed COVID-19 were included in this prospective descriptive *** presence of at least two of the following four abnormalities was used to diagnose proximal tubule injury:abnormal tubular reabsorption of phosphate,normoglycemic glycosuria,hyperuricosuria,and *** A total of 115 patients were included in the *** a third of the individuals had elevated blood creatinine levels or *** addition,abnormal renal tubular phosphate loss measured by renal tubular phosphate loss was found in 10(8.7%)patients,as was hyperuricosuria in 28.6%.As a result,total proximal tubular dysfunction was found in 24(20.9%)*** One in every fve children with acute COVID-19 infections had proximal tubular dysfunction,according to our ***,the rate of proximal tubular dysfunction was lower than in adults,it should be *** recovery of proximal tubular function in children with COVID-19 should be followed.

关键词： Coronavirus disease 2019(COVID-19) Proteinuria Proximal tubular dysfunction Severe acute respiratory syndrome coronavirus 2(SARS-CoV-2) Tubular reabsorption of phosphate

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容量超负荷与重症儿童氧合障碍及病死率增高相关

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中国小儿急救医学 2012年第3期 244-244页

作者： arikan AA Zappitelli M Goldstein SL 杨明北京和睦家医院

目的重症儿童容量超负荷(fluid overload,FO)很常见,可能是导致机体氧合功能衰竭和病死率增高的原因之一。病情越重,抢救时输液往往越多,本研究旨在通过儿童Logistic脏器功能障碍(PELOD)评分进行对照,探讨FO与氧合的关系,进一步明确FO... 详细信息

目的重症儿童容量超负荷(fluid overload,FO)很常见,可能是导致机体氧合功能衰竭和病死率增高的原因之一。病情越重,抢救时输液往往越多,本研究旨在通过儿童Logistic脏器功能障碍(PELOD)评分进行对照,探讨FO与氧合的关系,进一步明确FO是反映疾病严重程度的表现还是导致病死率增高的原因之一。设计回顾性病历资料研究。场所三级儿童医院。对象和方法通过病历共采集80例呼吸衰竭患儿,平均年龄(58.7±73.0)个月,收集氧合指数(OI)、容量负荷比(FO%)和每日PELOD评分等数据。对FO%与住院时间和机械通气时间的独立相关性进行单因素和多因素研究。干预无。主要结果FO%峰值增高可预测OI峰值增高,与年龄、性别和PELOD评分无关(P=0.009)。以年龄、性别和PELOD评分作为对照后,发现任一住院日FO%≥15%均与当日OI独立相关(P<0.05),且FO%峰值和FO%重度增高(≥15%)均分别与机械通气时间延长(P=0.004,P=0.01)和PICU住院时间延长(P=0.008,P=0.01)以及总住院时间延长(P=0.02,P=0.04)独立相关。结论此研究首次报道了未接受肾替代治疗的PICU重症患儿FO程度与病程转归负相关。及时的液体治疗在挽救生命的同时,也会因血流动力学稳定后的正液平衡影响脏器功能并影响重症患儿的预后。

关键词：呼吸衰竭儿童重症输液管理

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利用液体超负荷及肾损伤评分对危重症患者肾疾病负担进行多维实时评估

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中国小儿急救医学 2017年第4期24卷 259-259页

作者： Akcan-arikan A Gebhard DJ Arnold MA 方伯梁首都医科大学附属北京儿童医院

目的据报道, 对间歇急性肾损伤(acute kidney injury, AKI)进行预警可降低成人AKI相关病死率。危重症儿童AKI风险因子较多;尽管已通过标准化定义提高了对此病的认识, 血清肌酐微小变化增加了AKI识别难度。年龄及体型的可变性导致肌酐阈... 详细信息

目的据报道, 对间歇急性肾损伤(acute kidney injury, AKI)进行预警可降低成人AKI相关病死率。危重症儿童AKI风险因子较多;尽管已通过标准化定义提高了对此病的认识, 血清肌酐微小变化增加了AKI识别难度。年龄及体型的可变性导致肌酐阈值不统一, 肾毒性药物暴露很常见, 但并未列入肾损伤评分。现有疾病危重度测量法并不包括液体超负荷(fluid overload, FO), 而其为一项描述良好的病死率风险因子。本研究假定在维持或改善不良预后相关度测量时, 相比于传统AKI分期, 多维肾脏情况测量可更好描述疾病的肾脏受累严重度。对象及场所一家独立儿童医院四级PICU 18个月收治的所有患儿。设计新制定一项联合AKI, FO≥15%及肾毒性暴露情况的实时多维肾脏情况测量法, 即液体超负荷肾损伤评分(fluid overload kidney injury score, FOKIS)且前瞻性用于所有患儿。出院或病死前FOKIS峰值被用于评估预后相关性。干预措施无结果 2 830例PICU患儿(中位年龄5.5年, IQR 1.3～12.9, 男性55%)FOKIS峰值波动于0～14分, 66%患儿FOKIS≥1分。控制年龄、儿童病死率风险评分-3(pediatric risk of mortality-3, PRISM-3)、呼吸机、升压药及肾替代治疗后, FOKIS与PICU病死率及PICU/总住院时长独立相关(P=0.047)。FOKIS由0到8+, 病死率由1.5%升至40%。除外尿量因素后, FOKIS与病死率相关性强于FO或AKI。结论该肾脏疾病负担多维评分与PICU不良预后显著相关。进一步研究将评估FOKIS能否作为一项预警及决策支持工具影响以患者为中心的预后。

关键词：急性肾损伤肾毒性液体超负荷肾替代治疗

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双眼脉络膜受累的全身非霍奇金淋巴瘤患者的吲哚青绿血管造影特征

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世界核心医学期刊文摘(眼科学分册) 2006年第11期 40-40页

作者： Saatci A.O. arikan G. Ozcan M.A. 曹绪胜 Mustafa Kemal Sahil Bulvan No:73Narlidere35320IzmirTurkey Dr.

A 35-year-old man with systemic non-Hodgkin's lymphoma and bilateral choroidal involvement is *** green angiography depicts choroidal involvement much better than fluorescein angiography and seems to be superior in di... 详细信息

关键词：吲哚青绿血管造影非霍奇金淋巴瘤眼脉络膜全身患者

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肾移植患者伴红色发癣菌合并播散性诺卡菌感染引起的深部皮肤真菌病1例

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世界核心医学期刊文摘（皮肤病学分册） 2005年第3期1卷 22-22页

作者： Sec.kin D. arikan S. Haberal M. 田中伟

Deep dermatophytosis and nocardiosis are uncommon infections. This ar ticle de scribes a patient who was immunosuppressed with deep dermatophytosis caused by T richophyton rubrum and concurrent disseminated nocardiosis. The infections occur red 16 years after the patient underwent renal transplantation, and may have bee n related to tacrolimus therapy.

关键词：红色发癣菌皮肤真菌病诺卡菌播散性免疫抑制剂

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