Evaluation of proximal tubule functions in children with COVID‑19:a prospective analytical study
作者机构：Department of Pediatric NephrologyUniversity of Health Sciences Dr.Behçet Uz Child Disease and Pediatric Surgery Training and Research HospitalİzmirTurkey Department of Pediatric Infectious DiseasesUniversity of Health Sciences Dr.Behçet Uz Child Disease and Pediatric Surgery Training and Research HospitalİzmirTurkey
出 版 物：《World Journal of Pediatrics》 (世界儿科杂志（英文版）)
年 卷 期：2022年第18卷第9期
页 面：607-612页
核心收录：
主 题：Coronavirus disease 2019(COVID-19) Proteinuria Proximal tubular dysfunction Severe acute respiratory syndrome coronavirus 2(SARS-CoV-2) Tubular reabsorption of phosphate
摘 要：Background There are limited numbers of studies focusing on renal efects of coronavirus disease 2019(COVID-19)infection and proximal tubular dysfunction in children with COVID-19 infections.The purpose of this study was to evaluate the functions of the proximal tubule in hospitalized children with confrmed acute COVID-19.Methods The children who were hospitalized for confrmed COVID-19 were included in this prospective descriptive analysis.The presence of at least two of the following four abnormalities was used to diagnose proximal tubule injury:abnormal tubular reabsorption of phosphate,normoglycemic glycosuria,hyperuricosuria,and proteinuria.Results A total of 115 patients were included in the study.About a third of the individuals had elevated blood creatinine levels or proteinuria.In addition,abnormal renal tubular phosphate loss measured by renal tubular phosphate loss was found in 10(8.7%)patients,as was hyperuricosuria in 28.6%.As a result,total proximal tubular dysfunction was found in 24(20.9%)patients.Conclusions One in every fve children with acute COVID-19 infections had proximal tubular dysfunction,according to our data.Although,the rate of proximal tubular dysfunction was lower than in adults,it should be noted.The recovery of proximal tubular function in children with COVID-19 should be followed.
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