检索结果-南通市图书馆

Post-streptococcal acute glomerulonephritis in children:Association between proteinuria levels and renal outcomes

World Journal of Clinical Pediatrics 2025年第1期14卷 119-126页

作者： Randula Ranawaka Kavinda Dayasiri Udara Sandakelum Dulani Nelson Manoji Gamage Department of Paediatrics Faculty of MedicineUniversity of ColomboColombo 0094Sri Lanka University Paediatric Unit Lady Ridgeway Hospital for ChildrenColombo 0094WesternSri Lanka Department of Paediatrics Faculty of MedicineUniversity of KelaniyaRagama 0094Sri Lanka University Pediatric Unit Lady Ridgeway Hospital for ChildrenColombo 0094WesternSri Lanka Nutrition Division Ministry of HealthColombo 0094Sri Lanka

BACKGROUND Post-streptococcal acute glomerular nephritis(PSAGN)is mostly a benign *** usual sequelae of PSAGN include hypertension,its complications,and acute kidney *** PSAGN is associated with significant long-term morbidity,and histological abnormalities such as crescentic glomerulonephritis are infrequently *** has also been linked to late-onset chronic kidney disease in some populations due to high levels of *** This prospective observational study was conducted at Lady Ridgeway Hospital(Colombo,Sri Lanka)over 15 *** with PSAGN were enrolled based on clinical and laboratory *** proteinuria≥2+for 2 weeks and serum creatinine>100μmol/L warranted renal biopsy,assessed via light microscopy and *** of complement 3(C3)within 6 to 8 weeks was required for *** on clinical features,urine protein levels,and renal function were collected from patient records,and potential associations were analysed using Statistical Package for the Social Sciences and R language for statistical *** approval was obtained from the Ethical Review Committee,Lady Ridgeway Hospital for Children(Ref No:LRH/ERC/2021/60).RESULTS Forty-four patients were *** were 27(61.4%)male patients and 17(38.6%)female ***-seven(84%)of them were above 5 years of ***(45%)patients had a history of skin sepsis,and eighteen(41%)had a history of throat *** patients with proteinuria≥2+,53%had serum creatinine>100µmol/L,while among those with proteinuria100µmol/*** association of high-degree proteinuria with elevated serum creatinine was significant(χ²=7.8,P=0.005)in *** odds ratio of the logistic regression model was 1.049(95%confidence interval:1.003-1.098),indicating a positive direction with statistically significant association(P=0.037).There was no significant association between proteinuria and the degree of

关键词： proteinuria Post-streptococcal acute glomerulonephritis Renal outcome Renal biopsy Crescents Serum creatinine

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

proteinuria in paediatric patients with human immunodefi ciency virus infection

引用

World Journal of Clinical Cases 2013年第1期1卷 13-18页

作者： Vania Giacomet Paola Erba Francesca Di Nello Sonia Coletto Alessandra Viganò Gian Vincenzo Zuccotti Department of Paediatrics L Sacco Hospital University of Milan 20157 Milan Italy

In human immunodef iciency virus(HIV)-infected people kidney disease is as an important cause of morbidity and mortality. Clinical features of kidney damage in HIV-infected patients range from asymptomatic microalbuminuria to nephrotic syndrome. The lack of specif ic clinical features despite the presence of heavy proteinuria may mask the renal involvement. Indeed, it is important in HIV patients to monitor renal function to early discover a possible kidney injury. After the introduction of antiretroviral therapy, mortality and morbidity associated to HIV-infection have shown a substantial reduction, although a variety of side effects for longterm use of highly active antiretroviral therapy, including renal toxicity, has emerged. Among more than 20 currently available antiretroviral agents, many of them can occasionally cause reversible or irreversible nephrotoxicity. At now, three antiretroviral agents, i.e., indinavir, atazanavir and tenofovir disoproxil fumarate have a well established association with direct nephrotoxicity. This review focuses on major causes of proteinuria and other pathological f indings related to kidney disease in HIV-infected children and adolescents.

关键词： Human immunodeficiency virus-infection Nephropathy proteinuria Antiretroviral therapy Children

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

The Study on the Relationship between Serum Vascular Endothelial Growth Factor and proteinuria in Adriamycin induced Nephrotic Rats

引用

Journal of Huazhong University of Science and Technology(Medical Sciences) 2001年第4期21卷 301-303页

作者：朱忠华王玉梅汪宏波邓安国 Department of Nephrology Xiehe Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan 430030

To study the relationship between serum vascular endothelial growth factor (VEGF) and proteinuria in adriamycin induced nephrotic rats, a rat model of adriamycin induced nephrotitis was developed by injection of adriamycin into a tail vein in a rat. At different time points, 24 h urinary protein excretion was measured by using Coomassie brilliant blue method and the serum VEGF levels detected by using ELISA assay. The interventional effect of VEGF on this model was observed. The results showed that: (1) The adriamycin induced nephrotic syndrome rat model was developed successfully; (2) Serum VEGF levels and proteinuria were significantly increased at 7th day after intravenous injection of adriamycin. There was a positive correlation between serum VEGF levels and 24 h urinary protein excretion ( r=0.67, P proteinuria in adriamycin induced nephrotic rats.

关键词： adriamycin induced nephropathy vascular endothelial growth factor proteinuria

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Performance of microhaematuria and proteinuria as measured by urine reagent strips in estimating intensity and prevalence of Schistosoma haematobium infection in Nigeria

引用

Asian Pacific Journal of Tropical Medicine 2011年第12期4卷 997-1000页

作者： Houmsou RS Kela SL Suleiman MM Department of Biological Sciences Taraba State UniversityP.M.B 1167JalingoTaraba StateNigeria Biological Sciences Programme Abubakar Tafawa Balewa UniversityP.M.B 0248 BauchiBauchi StateNigeria

Objective:To assess if microhaematuria and proleinuria as measured by reagent strips could estimate intensity of Schistosoma haematobium(***) infection in endemic areas and evaluate their screening performance among children in Benue State,***:A lolal of 1124 urine samples were collected,screened for microhaematuria and proteinuria using reagent strips(Combi 9) and results were compared to filtration technique,the gold standard ***:A significant correlation was ohserved between microhaematuria(rho= 0.66. Pproteinuria(rho = 0.71.P<0.01) and intensity *** *** had sensitivity of 95.7%and specificity of 67.2%.while microhaematuria had sensitivity of 64.8%and specificity of 89.6%.The proportion of false positive diagnoses was higher in proleinuria(19.2%) than microliaematuria(6.0%).Conclusios:The findings suggest that use of urine reagent strips could potentially estimate intensity *** infection and their performance to screen urinary schistosomiasis agreed with previous observations.

关键词： Microhaematuria proteinuria False positive Benue Stale Nigeria

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

proteinuria in Children Living with HIV on Highly Active Antiretroviral Therapy (Haart)

引用

Open Journal of Pediatrics 2020年第2期10卷 255-262页

作者： Lucie Charlotte Ollandzobo Ikobo Roland Bienvenu Ossibi Ibara Neli Yvette Ngakengni Laren Babomi Gaston Ekouya Bowassa Linda Tchidjo Ngamo Steve Vassili Missambou Mandilou Sabrina Nadia Bouithy Evrard Romaric Nika Jean Robert Mabiala Babela Faculty of Health Sciences Marien Ngouabi University of Brazzaville Brazzaville Republic of Congo Pediatric Services Brazzaville University Hospital Brazzaville Republic of Congo Infectious Diseases Service Brazzaville University Hospital Brazzaville Republic of Congo Department of Neonatology Brazzaville University Hospital Brazzaville Republic of Congo Department of Internal Medicine and Cardiology Talangai Hospital Brazzaville Republic of Congo

Objective: To determine the prevalence of proteinuria in children living with HIV (CLHIV) and identify associated factors. Patients and methods: This was a cross-sectional, descriptive and analytical study carried out from April to August 2017 in the HIV care centres in Brazzaville and Pointe-Noire. The study included CLHIV with dipstick urinalysis test “Combur10 Test® M”. Results: Thirty seven CLHIV on HAART presented a proteinuria, 21.8%. Children were male gender in 21 cases (56.8%) and female gender in 16 cases (43.2%). Mean age was 10.9 ± 3.9 years. The children were infected with type 1 virus in 35 cases (94.6%), vertical transmission in all the cases (100%). Children were living with HIV for about 2 to 4 years of average n = 18 (48.6%) and they were WHO clinical stage 2 in 18 cases (48.6%). 13 children (35%) had CD4 level 3. All CLHIV (100%) were on HAART thus 20 (37.7%) on the combination of zidovudine (AZT), lamivudine (3TC) and nevirapine (NVP). This combination AZT, 3TC, NVP was a protective factor regarding the occurrence of proteinuria (OR: 0.43;IC (95%). Conclusion: Proteinuria

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

proteinuria in Hypertensive Nephropathy: A Review

引用

Open Journal of Nephrology 2014年第2期4卷 92-99页

作者： Rishi Sharma Surineni Kamalakar Ellen McCarthy Timothy A. Fields Kamal Gupta Rajat Barua Virginia Savin Kansas City VA Medical Center 4801 Linwood Boulevard Kansas City USA University of Kansas Medical Center 3901 Rainbow Boulevard Kansas City USA

Hypertension defined as a systolic blood pressure of ≥140 and a diastolic blood pressure ≥90 is anextremely prevalent condition;and it is responsible for significant mortality and morbidity. NHANESdata from 2005-2006 found that nearly 30% of adult US population has HTN;and nearly 8% of the population has undiagnosed HTN. HBP mortality in 2008 was 61,005. Any mentioned mortality in 2008 was 347,689 (NHLBI tabulation of NCHS mortality data). More than 20% of patients with systemic hypertension have chronic renal insufficiency (NHANES). Hypertensive nephropathy is a leading cause of end-stage renal disease (ESRD) requiring dialysis or transplantation or leading to death. The incidence of hypertension is high but only a subset of hypertensive patients progress to frank renal failure. A subset of hypertensive patients develop proteinuria during the course of disease and manifest nephrotic syndrome. This syndrome includes marked proteinuria, edema, and low serum albumin. Neither the incidence nor the clinical significance of proteinuria in hypertension without diabetes is known. Progression to chronic renal failure in some patients is preceded by proteinuria as indicated on “dip-stick” analyses of random urine samples. It appears that proteinuria is likely to increase both prior to and during evident loss of glomerular filtration, but this clinical observation has never been formally confirmed. There is a need for large studies to answer these questions. We also need to focus on the roles that genetic and environmental factors play in development and progression of renal disease in the setting of hypertension and proteinuria.

关键词： Hypertension Nephropathy proteinuria ESRD Genetics

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Artemisinin ameliorated proteinuria in rats with adriamycin-induced nephropathy through regulating nephrin and podocin expressions

引用

Journal of Traditional Chinese Medicine 2014年第1期34卷 63-68页

作者： Xili Wu Peng An Bingyu Ye Xingmin Shi Huimin Dang Rongguo Fu Chenglin Qiao Department of Integrated Chinese Traditional and Western Medicine Second Affiliated Hospital of Xi'an Jiaotong University School of Public Health of Xi'an Jiaotong University Department of Nephrology Second Affiliated Hospital of Xi'an Jiaotong University

OBJECTIVE:To investigate the effects of artemisinin against proteinuria and glomerular filtration barrier damage in rats with adriamycin-induced nephropathy,and the potential mechanism underpinned the ***:Forty adriamycin rats were randomly divided into two groups with the ratio of 1︰3;the small-number group served as control group(n=10),and the rats in the large-number group were treated with adriamycin to induce nephropathy;then they were further randomly assigned into 3subgroups:benazepril group(n=10),artemisiningroup(n=10),and adriamycin group(n=10).The benazepril group and artemisinin group were treated with benazepril suspl(5.0 mg/kg daily)and artemisinin suspl(150 mg/kg daily)respectively after being modeled;those in the control group and adriamycin group were intragastrically administered an equivalent volume of distilled water every *** treatment after model establishment lasted for a total of 4 *** 24 h uric protein,blood biochemicals,renal pathological changes,renal ultrastrutural changes,Nephrin and Podocin proteins and gene expressions were measured by Coomassie brilliant blue assay,completely automatic biochemical analyzer,light microscope,electron microscopy,Western blot and reverse transcription polymerase chain reaction,***:The rats in adriamycin group showed a significant increase in 24 h uric protein excretion,serum total cholesterol(TC),triglyceride(TG),blood urea nitrogen(BUN),serum creatinine(Scr)and decrease in albumin(Alb)(P0.05).The renal pathological and ultrastrutural observation indicate that artemisinin could attenuate the severity of foot process effacement and fusion in the nephropathic

关键词： Artemisinin proteinuria Doxorubicin Kidney diseases Nephrin NPHS2 protein

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Helicobacter pylori Infection is Associated with Occurrence of proteinuria in Type 2 Diabetes Patients:A Systemic Review and Meta-Analysis

引用

Chinese Medical Journal 2018年第22期131卷 2734-2740页

作者： Yan Shi Jia-Yu Duan Dong-Wei Liu Ying-Jin Qiao Qiu-Xia Han Shao-Kang Pan Li Tang Guang-Yan Cai Xiang-Mei Chen Zhang-Suo Liu Han-Yu Zhu Department of Nephrology Chinese People's Liberation Army General HospitalChinese People's Liberation Army Institute of NephrologyState Key Laboratory of Kidney DiseasesNational Clinical Research Center for Kidney DiseasesBeijing 100853China Department of Nephrology Zhengzhou UniversityThe First Affiliated Hospital of Zhengzhou UniversityResearch Institute of NephrologyKey Laboratory of Accurate Diagnosis and Treatment of Chronic Kidney Diseases in Henan ProvinceCore Unit of National Kidney Disease Clinical Medical Research CenterZhengzhouHenan 450052China

Background:Type 2diabetes (T2DM)patients are susceptible to Helicobacterpylori (HP),and it has been reported that the occurrence of proteinuria is associated with HP infection in T2DM patients;however,this view remains *** meta-analysis aimed to explore the association between HP infection and the occurrence of proteinuria in T2DM *** addition,we hope to provide some recommendations to readers in clinical or related fields. Methods:Our meta-analysis was conducted with the methodology of the Cochrane *** strategies were formulated by relevant ***-control studies that compared the occurrence ofproteinuria in T2DM patients with and without HP infection were involved in our *** English or Chinese studies were searched on online databases before 2018,including PubMed,the Cochrane library,Medline,Google Scholar,the China National Infrastructure,and Wanfang *** search strategies were "diabetic proteinuria,diabetic microalbuminuria,diabetic albumainuria,diabetic kidney disease,diabetic renal dysfunction,diabetic renal disease,diabetic nephropathy,diabetic complications,and diabetic mellitus,combined with HP."The quality of these involved articles was separately assessed by two investigators using the Newcastle-Ottawa Scale (NOS).Odds ratios (ORs)and associated 95% confidence intervals (CIs)were extracted and pooled using fixed-effects models. Results:Seven studies involving 1029participants were *** quality of these seven articles was all above five stars as assessed by NOS,and there was no significant publication bias in our *** found that T2DM patients with HP infection had a 2.00 times higher risk of the occurrence of proteinuria than patients without HP infection (OR:2.00,95%CI:1.48-2.69). Conclusions:Our analysis showed that HP infection was associated with the occurrence of proteinuria in T2DM *** radical surgery might be a therapeutic option for protecting

关键词： Helicobacterpylori Kidney Meta-Analysis proteinuria Type 2 Diabetes

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Effect of Astragali and Angelica particle on proteinuria in Chinese patients with primary glomerulonephritis

引用

Journal of Traditional Chinese Medicine 2016年第3期36卷 299-306页

作者： Shen Peicheng Yang Xuejun He Liqun Department of Nephrology Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine

OBJECTIVE: To investigate the effect of the traditional Chinese herbs Astragali and Angelicae Sinensis(A & As) particle [contains Huangqi(Radix Astragali Mongolica), Danggui(Radix Angelicae Sinensis),Huzhanggeng(Rhizoma Polygoni Cuspidati) and Danshen(Radix Salviae Miltiorrhizae)] on proteinuria in glomerulonephritis patients with stage 2 chronic kidney ***: A prospective, multi-center, and randomized controlled clinical trial was performed for 24 weeks. From March 2011 to April 2012, 158 patients from nine hospitals in China *** were randomized into the A&As group(79 cases, A&As particle 15.2 g/day) and losartan group(79 cases, losartan 50 mg/day). At each follow-up visit, clinical data including blood pressure, urinalysis, 24-h-urinary protein excretion, serum albumin and serum creatinine were ***: All 158 patients completed the follow-up. proteinuria in the losartan group exhibited a biphasic time-dependent decline with a significant steady reduction from baseline to week 12(P = 0.0014), and a platform level during the remaining 12-week follow-up(P > 0.05). In contrast, there was a continual significant decrease of proteinuria in the A & As group(P proteinuria in the A & As group from week 16 to week 24 was significantly reduced(P proteinuria treatment.

关键词： Angelica sinensis Renal insufficiency chronic Glomerulonephritis proteinuria Medicine Chinese Traditional

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Qualitative Analysis of Diagnostic Value of 24-h proteinuria for Preeclampsia

引用

Chinese Medical Journal 2015年第22期128卷 2998-3002页

作者： Xu Zhuang Yun-Yan Chen Qiong Zhou Jian-Hua Lin Department of Obstetrics and Gynecology Renji Hospital School of Medicine Shanghai Jiao Tong University Shanghai 200127 China

Background： Preeclarnpsia （PE） is a serious idiopathic disease posing a threat to both mothers and fetuses＇ lives during pregnancy, whose main diagnostic criteria include hypertension with proteinuria. However, American College of Obstetricians and Gynecologists （ACOG） updated the diagnostic criteria for PE and redtlced the diagnostic value of proteinuria for patients with PE. Qualitative analysis of the diagnostic value of 24-h proteinuria for patients with PE in China was conducted to evaluate the diagnostic criteria value in the latest ACOG guideline. Methods： Complete clinical data of 65 patients with hypertensive disorder in pregnancy （HDP） were collected. All patients were delivered to and hospitalized in Renji Hospital. Adverse outcome was defined in case of the emergence of any serious complication for a mother or the fetus. A retrospective study was conducted according to ACOG guideline, to analyze the relationship between each diagnostic criteria of ACOG guideline and maternal and perinatal outcomes. Spearman correlation test was used to detect the association between each diagnostic criterion, its corresponding value, and the adverse pregnancy outcome. Logistic regression was performed to verily the result of Spearman correlation test. Results： Of 65 HDP patients, the percentage of adverse pregnancy outcome was 63.1%. Adverse pregnancy outcomes constitute diversification. There were 55 cases with 24-h proteinuria value ≥0.3 g, of which the adverse outcome rate was 74.5%. While adverse pregnancy outcomes did not appear in the rest 10 HDP patients with proteinuria 〈0.3 /24 h. The statistic difference was significant （P = 0.000）. However, no significant difference was tbund in other criteria groups （impaired liver function： P = 0.417; renal insufficiency： P = 0.194; thrombocytopenia： P - 0.079： and cerebral or visual symptoms： P = 0.296）. The correlation coefficient between 24-h proteinuria ≥0.3 g and adverse pregnancy outcomes was 0.557 （P 〈 0.005）. hnpaire

关键词： American College of Obstetricians and Gynecologists Guideline Hypertensive Disorders in Pregnancy Preeclampsia Pregnancy Outcomes proteinuria

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：