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Acta Pharmaceutica Sinica B 2012年第5期2卷 472-480页

作者： murali krishna matta Nageswara Rao Pilli Jaswanth Kumar Inamadugu Laxminarayana Burugula Seshagiri Rao JVLN College of Pharmaceutical Sciences Jawaharlal Nehru Technological UniversityKukatpallyHyderabad 500085India Analytical and Environmental Chemistry Division Department of ChemistrySri Venkateswara UniversityTirupati 517502India College of Pharmaceutical Sciences Andhra UniversityVisakhapatnam 530003India

A rapid and sensitive LC-MS/MS method for the simultaneous quantitation of lamivudine,zidovudine and nevirapine in human plasma using abacavir as internal standard has been developed and *** analytes and IS were extracted from plasma by solid phase extraction using Oasis HLB cartridges and separated on a Hypurity Advance C18 column using a mixture of acetonitrile:0.1% formic acid(76:24,v/v)at a flow rate of 0.8 mL/*** involved an API-4000 LC MS/MS with electrospray ionization in the positive ion mode and multiple-reaction monitoring for *** method was validated according to FDA guidelines and shown to provide intra-and inter-day precision and accuracy within acceptable limits in a run time of only 3.5 *** method was sucessfully applied to a pharmacokinetic study involving a single oral administration of a combination tablet to human male volunteers.

关键词： Lamivudine Zidovudine Nevirapine Solid phase extraction LC-MS/MS Pharmacokinetics

Hepatocellular carcinoma-time to take the ticket

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World Journal of Gastrointestinal Surgery 2019年第6期11卷 287-295页

作者： Anju Mullath murali krishna Department of Gastroenterology Lakeshore Hospital and Research CentreKochi 682040KeralaIndia Department of Surgery Military HospitalPalampur 176061Himachal PradeshIndia

Hepatocellular carcinoma is one of the leading malignancies *** detection of hepatocellular carcinoma and its management in the form of liver transplantation offers an attractive treatment *** Milan criteria,proposed by Mazzaferro et al,have been the standard for selecting patients with hepatocellular carcinoma for ***,several studies have shown that even patients selected outside the Milan criteria can undergo transplantation with a relatively good *** article examines the currently existing criteria other than the Milan criteria and also evaluates use of alpha-fetoprotein and positron emission tomography scans to predict the chance of recurrence.

关键词： Hepatocellular carcinoma Milan Alpha-fetoprotein Positron emission tomography

Dynamic properties and liquefaction behaviour of cohesive soil in northeast India under staged cyclic loading

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Journal of Rock Mechanics and Geotechnical Engineering 2018年第5期10卷 958-967页

作者： Shiv Shankar Kumar A.murali krishna Arindam Dey Department of Civil Engineering Indian Institute of Technology Guwahati

Estimation of strain-dependent dynamic soil properties, e.g. the shear modulus and damping ratio, along with the liquefaction potential parameters, is extremely important for the assessment and analysis of almost all geotechnical problems involving dynamic loading. This paper presents the dynamic properties and liquefaction behaviour of cohesive soil subjected to staged cyclic loading, which may be caused by main shocks of earthquakes preceded or followed by minor foreshocks or aftershocks, respectively. Cyclic triaxial tests were conducted on the specimens prepared at different dry densities （1.5 g/cm3 and 1.75 g/cm3） and different water contents ranging from 8% to 25%. The results indicated that the shear modulus reduction （G/Gmax） and damping ratio of the specimen remain unaffected due to the changes in the initial dry density and water content. Damping ratio is significantly affected by confining pressure, whereas G/Gmax is affected marginally. It was seen that the liquefaction criterion of cohesive soils based on single-amplitude shear strain （3.75% or the strain at which excess pore water pressure ratio becomes equal to 1, whichever is lower） depends on the initial state of soils and applied stresses. The dynamic model of the regional soil, obtained as an outcome of the cyclic triaxial tests, can be successfully used for ground response analysis of the region.

关键词： Cohesive soil Dynamic soil properties Liquefaction potential Cyclic triaxial tests Staged cyclic loading

Measuring nanoparticles in liquid with attogram resolution using a microfabricated glass suspended microchannel resonator

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Microsystems & Nanoengineering 2022年第4期8卷 261-270页

作者： Mehdi Mollaie Daryani Tomás Manzaneque Jia Wei murali krishna Ghatkesar Department of Precision and Microsystems Engineering Delft University of TechnologyDelftThe Netherlands Department of Microelectronics Delft University of TechnologyDelftThe Netherlands Present address:Department of Microelectronics Delft University of TechnologyDelftThe Netherlands

The use of nanoparticles has been growing in various industrial fields,and concerns about their effects on health and the environment have been ***,characterization techniques for nanoparticles are ***,we present a silicon dioxide microfabricated suspended microchannel resonator(SMR)to measure the mass and concentration of nanoparticles in a liquid as they *** measured the mass detection limits of the device using laser Doppler *** limit reached a minimum of 377 ag that correspond to a 34 nm diameter gold nanoparticle or a 243 nm diameter polystyrene particle,when sampled every 30 *** compared the fundamental limits of the measured data with an ideal noiseless measurement of the ***,we measured the buoyant mass of gold nanoparticles in real-time as they flowed through the SMR.

关键词： resonator suspended nanoparticles

Redundant Transmission Control Algorithm for Information-Centric Vehicular IoT Networks

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Computers, Materials & Continua 2023年第8期76卷 2217-2234页

作者： Abdur Rashid Sangi Satish Anamalamudi Mohammed SAlkatheiri murali krishna Enduri Anil Carie Mohammed AAlqarni Department of Computer Science College of Science and TechnologyWenzhou-Kean UniversityWenzhou325060China Department of Computer Science Engineering SRM University APAmaravati522502India Department of Cybersecurity College of Computer Science&EngineeringUniversity of JeddahJeddahSaudi Arabia Department of Software Engineering College of Computer Science&EngineeringUniversity of JeddahJeddahSaudi Arabia

Vehicular Adhoc Networks(VANETs)enable vehicles to act as mobile nodes that can fetch,share,and disseminate information about vehicle safety,emergency events,warning messages,and passenger ***,the continuous dissemination of information fromvehicles and their one-hop neighbor nodes,Road Side Units(RSUs),and VANET infrastructures can lead to performance degradation of VANETs in the existing hostcentric IP-based ***,Information Centric Networks(ICN)are being explored as an alternative architecture for vehicular communication to achieve robust content distribution in highly mobile,dynamic,and errorprone *** ICN-based Vehicular-IoT networks,consumer mobility is implicitly supported,but producer mobility may result in redundant data transmission and caching inefficiency at intermediate vehicular *** paper proposes an efficient redundant transmission control algorithm based on network coding to reduce data redundancy and accelerate the efficiency of information *** proposed protocol,called Network Cording Multiple Solutions Scheduling(NCMSS),is receiver-driven collaborative scheduling between requesters and information sources that uses a global parameter expectation deadline to effectively manage the transmission of encoded data packets and control the selection of information *** results for the proposed NCMSS protocol is demonstrated to analyze the performance of ICN-vehicular-IoT networks in terms of caching,data retrieval delay,and end-to-end application *** end-to-end throughput in proposed NCMSS is 22%higher(for 1024 byte data)than existing solutions whereas delay in NCMSS is reduced by 5%in comparison with existing solutions.

关键词： Caching data dissemination redundancy control ICN-vehicular IoT networks

Synthesis and characterization of AlCoCrCuFeZnx high-entropy alloy by mechanical alloying

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Progress in Natural Science:Materials International 2016年第4期26卷 380-384页

作者： M.murali S.P.Kumaresh Babu B.Jeevan krishna A.Vallimanalan Department of Metallurgical and Materials Engineering National Institute of Technology

Equi-atomic and non equi-atomic multi-component systems were synthesized through different routes to form high-entropy single solid solution. One such high-entropy alloy（HEA） with hexanary composition AlCoCrCuFeZnxwas synthesized using mechanical alloying. The effect of zinc variation on the crystal structure and phase formation was characterized using XRD, FESEM with EDS and TEM. The synthesis resulted in both equi-atomic and non equi-atomic nano crystalline AlCoCrCuFeZn with a crystallite size less than 10 nm.

关键词： High-entropy alloy Mechanical alloying Crystallite size Lattice strain Selected area diffraction

RAMAN SPECTROSCOPIC STUDY ON PREDICTION OF TREATMENT RESPONSE IN CERVICAL CANCERS

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Journal of Innovative Optical Health Sciences 2013年第2期6卷 63-70页

作者： S.RUBINA M.S.VIDYASAGAR C.murali krishna Chilakapati Laboratory Advanced Centre for TreatmentResearch and Education in CancerTata Memorial Centre Kharghar 410210India Department of Radiotherapy and Oncology Shirdi Sai Baba Cancer Hospital Kasturba Medical College Manipal UniversityManipal 576104India

Concurrent chemoradiotherapy(CCRT)is the choice of treatment for locally adv anced cervical cancers;however,tumors exhibit diverse response to *** prediction of tumor response leads to individualizing treatment *** evaluation criteria in solid tumors(RECIST),the current modality of tumor response assessment,is often subject ive and carried out at the first visit after treatment,which is about four ***,there is a need for better predictive tool for *** spectroscopic techniques,sensitive to molecular alteration,are being pursued as potential diagnostic *** pilot study ains to explore the fiber-optic-based Raman spectroscopy approach in prediction of tumor response to CCRT,before taking up extensive in vivo *** vivo Raman spectra were acquired from biopsies collected from 11 normal(148 spectra),16 tumor(201 spectra)and 13 complete response(151 CR spectra),one partial response(8 PR spectra)and one nonresponder(8 NR spectra)*** was analyzed using principal component linear discriminant analysis(PC-LDA)followed by leave-one-out cross-validation(LOO-CV).Findings suggest that normal tissues can be efficiently classified from both pre-and post-treated tumor biopsies,while there is an overlap between pre-and post-CCRT tumor *** of CR,PR and NR tissues were subjected to principal component analysis(PCA)and a tendency of classification was observed,corroborating previous ***,this study further supports the feasibility of Raman spectroscopy in prediction of tumor radioresponse and prospective noninvasive in vivo applications.

关键词： Concurrent chemoradiotherapy tumor response principal component linear discriminant analysis principal component analysis response evaluation criteria in solid tumors

Investigating the effects of Pentoxifylline on human breast cancer cells using Raman spectroscopy

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Journal of Innovative Optical Health Sciences 2015年第2期8卷 26-36页

作者： Peeyush N.Goel S.P.Singh C.murali krishna R.P.Gude Gude Lab ACTRECTata Memorial Center KhargharNavi Mumbai 410210 India Chilakapati Lab ACTRECTata Memorial Center KhargharNavi Mumbai 410210 India

Breast cancer is one of the leading causes of cancer-related deaths in a global *** the present study,biochemical changes exerted upon Pentoxifylline(PTX)treatment had been ap-praised in human breast cancer cells using Raman *** are no clinically approved methods to monitor such therapeutic responses *** spectral profiling is suggestive of changes in DNA,protein and lipid contents showing a linear relationship with drug ***,multivariate analysis using principal component based linear-discriminant-analysis(PC-LDA)was employed for dlassifying the control and the PTX treated *** findings support the feasibility of Raman spectroscopy as an alternate/adjunct label-free,objective method for monitoring drug-induced modifications against breast cancer cells.

关键词： Pentoifylline MDA-MB-231 breast cancer cells Raman spectroscopy spectra multivariate analysis

Perturbations in Earth’s Atmosphere over An Indian Region during the Total Solar Eclipse on 22 July 2009

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Journal of Meteorological Research 2019年第4期33卷 784-796页

作者： S.B.Surendra PRASAD Vinay KUMAR K.krishna REDDY S.K.DHAKA Shristy MALIK M.Venkatarami REDDY U.murali krishna Semi-arid-zone Atmospheric Research Centre(SARC) Department of PhysicsYogi Vemana UniversityKadapaAndhra Pradesh 516003India Radio and Atmospheric Physics Lab Rajdhani CollegeUniversity of DelhiDelhi 110015India Department of Applied Physics Delhi Technical UniversityDelhi 110042India

During a total solar eclipse(TSE)on 22 July 2009,atmospheric perturbations were monitored from the surface to thermosphere to understand TSE’s impact on the meteorological(temperature,relative humidity,wind speed,and wind direction)and chemical(O3 and NOx)parameters around Kadapa(14.28°N,78.42°E),a tropical semi-arid region of *** this purpose,an experiment was conducted at Yogi Vemana University Campus,Kadapa,India,to measure the temperature,wind speed,wind direction,and concentrations of ozone(O3),NO,NO2,and NOx by using the automatic weather station(AWS)and O3 *** the eclipse day(22 July 2009),the surface observations at Kadapa showed a reduction in temperature(about 1.1℃)because of the solar *** of the thermal,dynamical(wind),and chemical parameters on the TSE day with control days[preceding(21 July 2009)and succeeding(23 July 2009)the TSE]illustrated the influence of solar *** the eclipse period,the O3 mixing ratio decreased,while NO2 and NOx increased;however,NO remained *** addition,radio occultation(RO)temperature profiles from Constellation Observing System for Meteorology,Ionosphere,and Climate(COSMIC)/Formosat Satellite Mission(FORMOSAT-3)and Thermosphere,Ionosphere,and Mesosphere Energetics and Dynamics(TIMED)satellites were utilized to understand the impact of TSE on dynamics of the middle and upper atmosphere from tropopause to the *** vertical resolution COSMIC observations revealed that during the solar eclipse,tropopause was cooler with twin peaks(double tropopause).The lower thermosphere between 110 and 130 km became warmer during the TSE,which might be caused by the dynamical response of the atmosphere in this region to the solar *** experimental data have provided very fine-scale variations of the atmospheric parameters both in time and height and also constituted a new set of results on TSE for further research.

关键词： total solar eclipse (TSE) atmospheric perturbations tropopause dynamics COSMIC/FORMOSAT-3satellite radio occultation (RO) observations

A Novel Approach Based on Hybrid Algorithm for Energy Efficient Cluster Head Identification in Wireless Sensor Networks

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Computer Systems Science & Engineering 2022年第10期43卷 259-273页

作者： C.Ram Kumar K.murali krishna Mohammad Shabbir Alam K.Vigneshwaran Sridharan Kannan C.Bharatiraja Department of Electronics and Communication Engineering Dr.N.G.P.Institute of TechnologyCoimbatore641048India Department of Electronics and Communication Engineering Vignan’s Institute of Information TechnologyDuvvadaVisakhapatnam530049India Department of Computer Science College of Computer Science and Information TechnologyJazan UniversityJizan45142Kingdom of Saudi Arabia Department of Electronics and Communication Engineering K.Ramakrishnan College of EngineeringTiruchirappalli621112India Department of Computer Science and Engineering JKK Munirajah College of TechnologyErode638506India Department of Electrical and Electronics Engineering SRM Institute of Science and TechnologyChennai603203India

The Wireless Sensor Networks(WSN)is a self-organizing network with random deployment of wireless nodes that connects each other for effective monitoring and data *** clustering technique employed to group the collection of nodes for data transmission and each node is assigned with a cluster *** major concern with the identification of the cluster head is the consideration of energy consumption and hence this paper proposes an hybrid model which forms an energy efficient cluster head in the Wireless Sensor *** proposed model is a hybridization of Glowworm Swarm Optimization(GSO)and Artificial Bee Colony(ABC)algorithm for the better identification of cluster *** performance of the proposed model is compared with the existing techniques and an energy analysis is performed and is proved to be more efficient than the existing model with normalized energy of 5.35%better value and reduction of time complexity upto 1.46%.Above all,the proposed model is 16%ahead of alive node count when compared with the existing methodologies.

关键词： Wireless sensor network cluster cluster head hybrid model glowworm swarm optimization artificial bee colony algorithm energy consumption