RAMAN SPECTROSCOPIC STUDY ON PREDICTION OF TREATMENT RESPONSE IN CERVICAL CANCERS

作     者：S.RUBINA M.S.VIDYASAGAR C.MURALI KRISHNA 

作者机构：Chilakapati LaboratoryAdvanced Centre for TreatmentResearch and Education in CancerTata Memorial Centre Kharghar 410210India Department of Radiotherapy and Oncology Shirdi Sai Baba Cancer HospitalKasturba Medical College Manipal UniversityManipal 576104India 

出 版 物：《Journal of Innovative Optical Health Sciences》 (创新光学健康科学杂志（英文）)

年 卷 期：2013年第6卷第2期

页      面：63-70页

核心收录：

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

基　　金：DBT project  Department of Biotechnology  and Government of India [BT/PRI11282/MED/32/83/2008] 

主　　题：Concurrent chemoradiotherapy tumor response principal component linear discriminant analysis principal component analysis response evaluation criteria in solid tumors 

摘      要：Concurrent chemoradiotherapy(CCRT)is the choice of treatment for locally adv anced cervical cancers;however,tumors exhibit diverse response to *** prediction of tumor response leads to individualizing treatment *** evaluation criteria in solid tumors(RECIST),the current modality of tumor response assessment,is often subject ive and carried out at the first visit after treatment,which is about four ***,there is a need for better predictive tool for *** spectroscopic techniques,sensitive to molecular alteration,are being pursued as potential diagnostic *** pilot study ains to explore the fiber-optic-based Raman spectroscopy approach in prediction of tumor response to CCRT,before taking up extensive in vivo *** vivo Raman spectra were acquired from biopsies collected from 11 normal(148 spectra),16 tumor(201 spectra)and 13 complete response(151 CR spectra),one partial response(8 PR spectra)and one nonresponder(8 NR spectra)*** was analyzed using principal component linear discriminant analysis(PC-LDA)followed by leave-one-out cross-validation(LOO-CV).Findings suggest that normal tissues can be efficiently classified from both pre-and post-treated tumor biopsies,while there is an overlap between pre-and post-CCRT tumor *** of CR,PR and NR tissues were subjected to principal component analysis(PCA)and a tendency of classification was observed,corroborating previous ***,this study further supports the feasibility of Raman spectroscopy in prediction of tumor radioresponse and prospective noninvasive in vivo applications.