Investigating the effects of Pentoxifylline on human breast cancer cells using Raman spectroscopy
作者机构：Gude LabACTRECTata Memorial Center KhargharNavi Mumbai 410210 India Chilakapati LabACTRECTata Memorial Center KhargharNavi Mumbai 410210 India
出 版 物：《Journal of Innovative Optical Health Sciences》 (创新光学健康科学杂志（英文）)
年 卷 期：2015年第8卷第2期
页 面：26-36页
核心收录：
学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学]
基 金：support from ACTREC,Tata Memorial Centre supported by CSIR-Senior Research fellowship supported by ACTREC Senior Research fellowship procured from DBT project BT/PRI11282/MED/32/83/2008,entitled\Development of in vivo laser Raman spectroscopy methods for diagnosis of oral precancerous and cancerous conditions,Department of Biotechnology,Government of India"
主 题：Pentoifylline MDA-MB-231 breast cancer cells Raman spectroscopy spectra multivariate analysis
摘 要：Breast cancer is one of the leading causes of cancer-related deaths in a global *** the present study,biochemical changes exerted upon Pentoxifylline(PTX)treatment had been ap-praised in human breast cancer cells using Raman *** are no clinically approved methods to monitor such therapeutic responses *** spectral profiling is suggestive of changes in DNA,protein and lipid contents showing a linear relationship with drug ***,multivariate analysis using principal component based linear-discriminant-analysis(PC-LDA)was employed for dlassifying the control and the PTX treated *** findings support the feasibility of Raman spectroscopy as an alternate/adjunct label-free,objective method for monitoring drug-induced modifications against breast cancer cells.
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