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A Fuzzy Logic Based Power-Efficient Run-Time Reconfigurable Multicore System

Chinese Journal of Electronics 2018年第3期27卷 549-555页

作者： Shaheryar Najam muhammad yasir qadri Zohaib Najam Jameel Ahmed Nadia N.qadri Electrical Engineering Department Riphah International University School of Computer Science and Electronic Engineering University of Essex Electrical Engineering Department HITEC University Department of Electrical Engineering COMSATS Institute of Information Technology

Increasing demand for better throughput and performance has motivated designers to come up with more sophisticated processors with innovative designs. Such designs for multicore architectures offer large amount of parallelism which is often underutilized and thus becomes overhead and liability. Due to these advancements, there has been a exponential increase in power consumption and heat dissipation of computing devices. Under these circumstances, an ideal system would be a reconfigurable system that can switch off all underutilized resources and work with only required ones. There is a need of reconfigurable computing devices and processors that are smart enough to configure themselves dynamically on runtime to find balance between throughput and power-consumption. This paper proposes a novel fuzzy logic based Dynamic voltage and frequency scaling(DVFS)and power-gating enabled controller which is capable of reducing power-consumption without affecting throughput and overall performance of the system. The design is implemented on Intel processor using Ubuntu as an operating system. Implementation results show that proposed Fuzzy logic controller(FLC) reduces power-consumption upto 40% by reconfiguring the processor dynamically without compromising the throughput.

关键词： DVFS Fuzzy logic controller Energy Throughput

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Hepatitis C virus in Pakistan:A systematic review of prevalence,genotypes and risk factors

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World Journal of Gastroenterology 2009年第45期15卷 5647-5653页

作者： yasir Waheed Talha Shafi Sher Zaman Safi Ishtiaq qadri NUST Center of Virology and Immunology National University of Sciences & Technology

In Pakistan more than 10 million people are living with Hepatitis C virus (HCV), with high morbidity and mortality. This article reviews the prevalence, genotypes and factors associated with HCV infection in the Pakistani population. A literature search was performed by using the keywords; HCV prevalence, genotypes and risk factors in a Pakistani population, in Pubmed, PakMediNet and Google scholar. Ninetyone different studies dating from 1994 to May 2009 were included in this study, and weighted mean and standard error of each population group was calculated. Percentage prevalence of HCV was 4.95% ± 0.53% in the general adult population, 1.72% ± 0.24% in the pediatric population and 3.64% ± 0.31% in a young population applying for recruitment, whereas a very high 57% ± 17.7% prevalence was observed in injecting drug users and 48.67% ± 1.75% in a multi-transfused population. Most prevalent genotype of HCV was 3a. HCV prevalence was moderate in the general population but very high in injecting drug users and multi-transfused populations. This data suggests that the major contributing factors towards increased HCV prevalence include unchecked blood transfusions and reuse of injection syringes. Awareness programs are required to decrease the future burden of HCV in the Pakistani population.

关键词： Hepatitis C virus Prevalence Genotypes Blood transfusions Injections

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Notch signalling pathway in development of cholangiocarcinoma

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World Journal of Gastrointestinal Oncology 2020年第9期12卷 957-974页

作者： Bisma Rauff Arif Malik yasir Ali Bhatti Shafiq Ahmad Chudhary Ishtiaq qadri Shafquat Rafiq Institute of Molecular Biology and Biotechnology University of LahoreLahore 54000Pakistan Institute of Biomedical and Allied Health Sciences University of Health SciencesLahore 54000Pakistan Department of Biology Faculty of ScienceKing Abdulaziz University Jeddah Kingdom of Saudi Arabia Department of Gastrointestinal medicine Croydon University HospitalCroydon CR77YEUnited Kingdom

Cholangiocarcinoma(CCA)comprises of extra-hepatic cholangiocarcinoma and intrahepatic cholangiocarcinoma cancers as a result of inflammation of epithelium cell lining of the bile *** incidence rate is increasing dramatically worldwide with highest rates in Eastern and South Asian *** risk factors involve chronic damage and inflammation of bile duct epithelium from primary sclerosing cholangitis,chronic hepatitis virus infection,gallstones and liver fluke *** genetic variants have also been identified and as CCA develops on the background of biliary inflammation,diverse range of molecular mechanisms are involved in its *** these,the Notch signalling pathway acts as a major driver of cholangiocarcinogenesis and its components(receptors,ligands and downstream signalling molecules)represent a promising therapeutic ***-Secretase Inhibitors have been recognized in inhibiting the Notch pathway efficiently.A comprehensive knowledge of the molecular pathways activated by the Notch signalling cascade as well as its functional crosstalk with other signalling pathways provide better approach in developing innovative therapies against CCA.

关键词： Cholangicarcinoma Notch receptors Therapeutic targets Notch signalling pathway Gamma secretase inhibitor Cholangiocytes

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