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The evolution of pneumococcal vaccine on children in Malaysia:the efficacy and outcome

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Infectious Diseases Research 2021年第4期2卷 11-21页

作者： Semiat Opeyemi Yusuff Siti Norbaya Masri Nurul Diana Dzaraly Niazlin mohd Taib mohd nasir mohd Desa Department of Medical Microbiology and Parasitology Faculty of Medicine and Health SciencesUniversiti Putra MalaysiaSelangor43400 UPMSerdangMalaysia Department of Biomedical Sciences Faculty of Medicine and Health SciencesUniversiti Putra Malaysia43400 UPMSerdangSelangorMalaysia

With pathogenic bacterium,numerous studies have been conducted in developing new vaccines,and available pneumococcal vaccines have been implemented for the prevention of related ***,Streptococcus pneumoniae is known to have developed resistance to many of the proposed preventive *** a result,contemporary research,including our study,has reviewed how Streptococcus pneumoniae has become resistant to vaccines and to further determine how to prevent the negative effect of the non-vaccine serotype on vaccine serotype *** have been known as one of the bacteria that has highest preventive strength of vaccination provided to humans,where children’s immunity requires the vital of it,based on immunization schedule to boost their immune system against the diseases of high mortality and *** pneumococcal vaccines are derived from its strains called serotypes,and further research is being conducted to determine more potent vaccines from other pneumococcal virulence *** impose and implement the pneumococcal vaccine,the serotype distribution needs to be *** deal with this verification,clinical or carriage samples are required for the determination and differentiation of vaccine serotypes from non-vaccine *** Malaysia,the carriage rates are often limited to the clinical epidemiology of Streptococcus *** samples are more needed in tracking the vaccine efficacy for pre-and post-immunization to prevent and reduce pneumococcal diseases before they manifest into clinical ***,in this review article,we explore the mentioned highlights for sufficient discussion,discovery,and knowledgeable implementation of pneumococcal vaccine.

关键词： Streptococcus pneumoniae Serotype Vaccine Children Carriage Malaysia

A study on the effectiveness of intravenous tramadol in the management of severe traumatic pain in emergency department

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海南医学院学报 2010年第7期16卷 838-841,846页

作者： Rashidi Ahmad mohd Ghazali Abd Rashid nasir Mohamad Kamarul Aryffin Baharuddin mohd Ismail Ibrahim Department of Emergency Medicine Department of Community Medicine School of Medical SciencesHealth campus of University Sains Malaysia

Introduction:Patients with pain contribute to 60%-70% of emergency department(ED)attendance and the tramadol is among analgesic of choice in ***,the use of intravenous tramadol is limited to moderate pain intensity because of its weak opiod agonist *** conducted a study to examine the effectiveness of intravenous tramadol among patients who suffer from severe traumatic ***:In this prospective study,eligible patients received a loading dose of intravenous tramadol(2mg/kg).If visual analogue score(VAS)more than 30 mm after the loading dose,intermittent bolus intravenous tramadol 20mg will be administered every 10 *** 30 minutes of study,rescue medication(*** or pethidine)will be provided to those patients with VAS more than 30 *** score,vital signs and side effects were recorded for every 10 minutesResults:Forty-seven patients who suffered from fracture and soft tissue injury were *** median VAS score on presentation and at 30 minutes was 90 mm 20 mm *** median total dose of IV tramadol received by the patients at 30 minutes was 150 mg(IQR=34.0).There was a significant change in medium pain score at 10,20 and 30 minutes treatment(P<0.001).Vital signs were within normal range throughout the study *** 66.1% of them had side effects of *** common side effects were sleepiness(75.0%)and dizziness(56.3%).Conclusion:The intravenous tramadol is a safe and effective analgesia in severe traumatic patients if an initial and intermittent dose is given adequately.

关键词：静脉注射患者软组织曲马多

Evaluation of antihepatotoxic potential of Solanum xanthocarpum fruit extract against antitubercular drugs induced hepatopathy in experimental rodents

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Asian Pacific Journal of Tropical Biomedicine 2012年第6期2卷 454-460页

作者： Talib Hussain Ramesh K Gupta Sweety K mohd Sajid Khan Md Sarfaraj Hussain Md arif Arshad Hussain Md Faiyazuddin Chandana Venkateswara Rao Pharmacognosy and Ethnopharmacology Division National Botanical Research Institute Department of Pharmacology and Toxicology Faculty of Pharmacy Integral University Department of Pharmacology Royal College of Pharmacy and Health Sciences Department of Biotechnology Integral University

Objective:To assess the hepatoprotective effect of Solanum xanthocarpum(S. xanthocarpum) fruit extract against antitubercular drug-induced liver toxicity in experimental ***:Ethanolic(50%) fruit extract ofS. xanthocarpum(100, 200 and 400 mg/kg bw) was administered daily for 35 days in experimental animals. Liver toxicity was induced by combination of three antitubercular drugs [isoniazid(I) 7.5 mg/kg, rifampicin(R) 10 mg/kg and pyrazinamide(P) 35 mg/kg] given orally as suspension for 35 days in rats. The hepatoprotective activity was assessed using various biochemical parameters like aspartate aminotransferase(AST), alanine aminotransferase(ALT), alkaline phosphatise(ALP), total bilirubin(TBL), albumin(ALB), total protein(TP), lactate dehydroginase(LDH), and serum cholesterol(CHL). Meanwhile,in vivoantioxidant activities as lipid peroxidation(LPO), reduced glutathione(GSH), superoxide dismutase(SOD) and catalase(CAT) were measured in rat liver homogenate. The biochemical observations were supplemented by histopathological ***:The results demonstrated that treatment ***(P<0.05-P<0.001) and dose-dependently prevented drug induced increase in serum levels of hepatic enzymes. Furthermore,S. xanthocarpumsignificantly(up toP<0.001) reduced the LPO in the liver tissue and restored activities of defence antioxidant enzymes GSH, SOD and CAT towards normal levels. Histopathology of the liver tissue showed that S. xanthocarpumattenuated the hepatocellular necrosis and led to reduction in inflammatory cells ***:The results of this study strongly indicate the protective effect of S. xanthocarpumagainst liver injury which may be attributed to its hepatoprotective activity, and thereby scientifically support its traditional use.

关键词： Solanum xanthocarpum Rifampicin Isoniazid Pyrazinamide Antioxidant Antihepatotoxicity Hepatoprotective effect Antitubercular drug Liver toxicity Liver injury Biochemical parameter Histopathology

Translation, Cross-Cultural Adaptation, Reliability and Validity of the Malay Version of Alcohol, Smoking and Substance Involvement Screening Test (ASSIST) V3.1

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Health 2018年第7期10卷 985-997页

作者： Nor Asiah Muhamad Omar Mihat Rushidi Ramly Aniza Abdul Aziz Rozanim Kamaruddin Wan Nor arifin Wan Mansor Noor Hashimah Abdullah mohd arif mohd Noor Rohaida Ismail Widya Astrina Wisman Noor Aliza Lodz muhammad Fadhli mohd Yusoff Institute for Public Health Ministry of Health Kuala Lumpur Malaysia Non Communicable Disease Section Ministry of Health Putrajaya Malaysia Universiti Sultan Zainal Abidin Terengganu Malaysia Lembah Pantai District Health Office Ministry of Health Kuala Lumpur Malaysia Hospital Universiti Sains Malaysia Kubang Kerian Malaysia Kelantan State Health Department Ministry of Health Kota Bharu Malaysia Hospital Raja Perempuan Zainab II Ministry of Health Kota Bharu Malaysia

Introduction: A psychoactive substance has become an overwhelming public health burden globally. It causes social problems for the user and surrounding people which may affect work or study and cause negative economic impact. Objective: This study aims to translate and culturally adapt the Alcohol, Smoking and Substance Involvement Screening Test (ASSIST) into Malay and to assess its reliability and validity. Methods: The Malay version of the ASSIST v 3.1 was developed after the translation and back-translation, which included the stages recommended by Beaton. The ASSIST v 3.1 was administered to 125 respondents. The Malay ASSIST v 3.1 was completed twice by each respondent 7 to 14-day intervals to assess test-retest reliability based on the intra-rater and interrater correlation coefficient. Results: Majority of the respondents were male, Malay and currently employed. The intra-rater reliability is 0.84 and the test-retest reliability (ICC = 0.97) were excellent. Conclusion: Malay ASSIST v3.1 was a valid and reliable tool to screen substances abuse at varying degree. Nonetheless, further studies are needed to assess its responsiveness.

关键词： Substance Use Translation Reliability Validity ASSIST

Potential therapeutic effects of thymoquinone on treatment of amphetamine abuse

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Asian Pacific Journal of Tropical Biomedicine 2018年第3期8卷 187-188页

作者： Nurul Farah Aina Md Fauzi Nor Hidayah Abu Bakar nasir Mohamad Khairi Che Mat Syed Hadzrullathfi Syed Omar mohd Shahril Othman Rohayah Husain Muhamad Zaid Ismail Faculty of Medicine University of Sultan Zainal Abidin Medical Campus Centre for Research in Addiction University of Sultan Zainal Abidin Gong Badak Campus Institute for Community Development & Quality of Life (iCODE) University of Sultan Zainal Abidin Gong Badak Campus Faculty of Contemporary Islamic Studies University of Sultan Zainal Abidin Gong Badak Campus Institute for Product Research and Civilization (INSPIRE) University of Sultan Zainal Abidin Gong Badak Campus

Dear Editor,The prevalence of drug abuse has diverted from traditional drugs such as opioid and cannabis to modern,synthetic and psychoactive drugs such as amphetamine groups,the amphetamine(AT)and methamphetamine[1].Amphetamine is used medically to treat several disorders such as attention deficit hyperactivity disorder,narcolepsy,depression and minor obesity[2].However,AT has also gained

关键词： Potential therapeutic effects of thymoquinone on treatment of amphetamine abuse AT

Pseudomonas aeruginosa USM-AR2 culture containing biosurfactant facilitates crude oil distillation process

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Pseudomonas aeruginosa USM-AR2 culture containing biosurfact...

Role of T cells in cancer immunotherapy:Opportunities and challenges

2011 International Conference on Biotechnology and Environment Management ( ICBEM 2011）

作者： Nur Asshifa Md Noh Salwa mohd Salleh Mohamad nasir Mohamad Ibrahim Ahmad Ramli mohd Yahya School of Biological Sciences Universiti Sains Malaysia 11800 Minden Penang Malaysia School of Chemical Sciences Universiti Sains Malaysia 11800 Minden Penang Malaysia

Petroleum supplies a large portion of the world’s energy, thereby driving industrial civilization. It remains an important factor in dictating market prices of diverse products and services. Distillation of crude oil is a common fractionation method of petroleum producing desirable products, such as automotive fuel and kerosene. Conventional distillation has been the current fractionation process for decades, producing distillates of interest and is conducted without any involvement of biological materials. The process involves tremendous amount of thermal energy and requiring a long time. This research offers an improved distillation performance and yield. A small amount of rhamnolipid produced from a microbial culture Pseudomonas aeruginosa USM-AR2, is added and mixed thoroughly with the crude oil prior to distillation. This results in a drastic reduction in distillation time without affecting or reducing the quality of the distillate. The pretreatment accelerates the emulsification and biodegradation process by decreasing surface tension and viscosity of oil, which in turn resulted in the shorter distillation times. Reducing the distillation times translates to energy and cost savings in producing petroleum products. Since oil prices affect many other industries, this discovery will have a great impact on the economy.

关键词： rhamnolipid distillation crude oil emulsification Pseudomonas aeruginosa

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Cancer Pathogenesis and Therapy 2023年第2期1卷 116-126页

作者： Hossain Ahmed Aar Rafi Mahmud mohd.Faijanur-Rob-Siddiquee Asif Shahriar Partha Biswas Ebrahim Khalil Shimul Shahlaa Zernaz Ahmed Tanzila Ismail Ema Nova Rahman arif Khan Furkanur Rahaman Mizan Talha Bin Emran Department of Biotechnology and Genetic Engineering University of Development Alternative(UODA)4/4BBlock ALalmatiaDhaka1209Bangladesh Department of Biochemistry and Molecular Biology Mawlana Bhashani Science and Technology UniversityTangail1902Bangladesh Department of Biochemistry and Molecular Biology Faculty of Biological ScienceUniversity of DhakaDhaka1000Bangladesh Department of Immunology and Microbiology School of MedicineUniversity of Texas Rio Grande ValleyMcAllenTX78504USA Department of Genetic Engineering and Biotechnology Faculty of Biological Science and TechnologyJashore University of Science and Technology(JUST)Jashore7408Bangladesh Department of Biochemistry and Microbiology North South UniversityDhaka1229Bangladesh Department of Biochemistry and Molecular Biology Jahangirnagar UniversitySavarDhaka1342Bangladesh Department of Food Science and Technology Chung-Ang UniversityAnseong17546Republic of Korea Department of Pharmacy BGC Trust University BangladeshChittagong4381Bangladesh Department of Pharmacy Faculty of Allied Health SciencesDaffodil International UniversityDhaka1207Bangladesh

Immunotherapies boosting the immune system's ability to target cancer cells are promising for the treatment of various tumor types,yet clinical responses differ among patients and ***,there has been increasing interest in novel cancer immunotherapy practices aimed at triggering T cell-mediated anti-tumor ***-directed cytotoxicity mediated by T lymphocytes has become a central focal point in the battle against cancer utilizing the immune *** molecular and cellular mechanisms involved in the actions of T lymphocytes have directed new therapeutic approaches in cancer immunotherapy,including checkpoint blockade,adoptive and chimeric antigen receptor(CAR)T cell therapy,and cancer *** review addresses all the strategies targeting tumor pathogenesis,including metabolic pathways,to evaluate the clinical significance of current and future immunotherapies for patients with cancer,which are further engaged in T cell activation,differentiation,and response against tumors.

关键词： Immunotherapy T cell Cancer Immune system Metabolic pathways

Gross Pollutants Study in Urban Areas under Tropical Climates

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Journal of Civil Engineering and Architecture 2014年第1期8卷 107-114页

作者： Lariyah mohd Sidek Hidayah Basri Mohamed Roseli Zainal Abidin Lira Chow Hock Md nasir Md Nor Nor Azazi Zakaria Centre for Sustainable Technology and Environment (CSTEN) College of Engineering Universiti Tenaga Nasional Kajang43000 Malaysia Drainage and Irrigation Department Humid Tropics Centre Kuala Lumpur Kuala Lumpur 50480 Malaysia Drainage and lrrigation Department River Basin & Coastal Zone Management Kuala Lumpur 50626 Malaysia River Engineering and Urban Drainage Centre (REDAC) Universiti Sains Malaysia Nibong Tebal 14300 Malaysia

Gross pollutants are the primary targeted pollutants in urban catchment management for urban water quality improvement as well as mitigation of flood. Apart from aesthetically unattractive because of its visibility, gross pollutants also contributes to degradation of river water quality and loss of aquatic habitat as it carries harmful pollutants such as oxygen demanding material, hydrocarbons and heavy metals. This study analyzed trend of gross pollutant generated from two urban residential areas located in Selangor, Malaysia. The median value of gross pollutant load obtained fi＇om the Amanah Apartment and Bandar Botanic are 347.41 kg/ha/year and 32.46 kg/ha/year, respectively. Relationship between gross pollutant wet load with rainfall depths was derived using regression equation. A significant trend of increasing gross pollutant wet load into drainage system with increasing rainfall depth was observed. The behavior of pollutant load is related to the one observed in Australia.

关键词： Gross pollutant load urban stormwater quality urban stormwater management.

Modeling of Antenna for Deep Target Hydrocarbon Exploration

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