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Hepatocellular carcinoma national burden across different geographical regions in the United States between 2001 and 2020

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World Journal of Methodology 2024年第4期14卷 110-120页

作者： Yazan Abboud Raj Malhotra muhammad hassaan Arif Maan Anna Mathew Ibrahim Abboud Chun-Wei Pan Saqr Alsakarneh Fouad Jaber Islam Mohamed David Kim Nikolaos T Pyrsopoulos Department of Internal Medicine Rutgers New Jersey Medical SchoolNewarkNJ 07103United States University of California Riverside School of Medicine RiversideCA 92521United States Department of Internal Medicine John H Stroger Hospital of Cook CountyChicagoIL 60612United States Department of Internal Medicine University of Missouri-Kansas CityKansasMO 64108United States Division of Gastroenterology and Hepatology Rutgers New Jersey Medical SchoolNewarkNJ 07101United States

BACKGROUND While prior data showed an increasing incidence of hepatocellular carcinoma(HCC)in the United States,there are limited comprehensive and comparative data on the geographical variations of HCC trends in different demographicspecific *** To evaluate sex and age-specific incidence rates and time trends in different geographical regions in the United *** Age-adjusted HCC incidence rates were collected from the United States Cancer Statistics(USCS)database which covers approximately 98%of the population in the United *** rates were stratified by sex,age,and geographical *** percentage change(APC)and average APC(AAPC)were estimated using Joinpoint Regression.A pairwise comparison was conducted between sex-specific *** There were 467344 patients diagnosed with HCC in the United States in the USCS database between 2001 and *** rates and trends varied by geographical *** looking at the West region(115336 patients),incidence rates of HCC were overall increasing and also increasing in older ***,when evaluating younger adults,HCC incidence rates decreased in men but not in women with a sex-specific absolute AAPC-difference of 2.15(P=0.005).When evaluating the Midwest region(84612 patients),similar results were *** incidence rates were increasing in the overall population and in older adults as well,they were decreasing in younger men but not in women with a sex-specific absolute AAPC-difference of 1.61(P<0.001).For the Northeast region(87259 patients),the analysis showed similar results with decreasing HCC incidence rates in younger men but not counterpart women(Sex-specific AAPC-difference=3.26,P<0.001).Lastly,when evaluating the south(180137 patients),the results were also decreasing in younger men but not in women(Sex-specific AAPC-difference=2.55,P<0.001).CONCLUSION Nationwide analysis covering around 98%of the United States population shows an increasing incidence of HCC across all

关键词： Hepatocellular carcinoma Incidence Epidemiology Health disparity Geography

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Critical Success Factors of Infrastructure PPP Projects in Punjab,Pakistan

Critical Success Factors of Infrastructure PPP Projects in P...

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作者： muhammad hassaan 山东大学

学位级别：硕士

In many countries,the implementation of Public-private Partnership(PPP)concept has become increasingly more essential method of procuring infrastructure development ***,in Punjab the requirement and demand for infrastructure is huge while the resources are scarce and difficult to meet this *** are few projects implemented in Punjab under PPP concept,but the numbers of such projects are increasing and currently with more than25projects in pipeline,the Government of Punjab is interested to boost infrastructure development with the help of private investment,which is considered as vital source for the developing nations as well as for developed *** aim of this study is to explore the Punjab experience in implementing PPP projects focusing on the success factors considered as critical for *** operational projects were selected and semi-structured interview was carried out with the representative of potential stakeholders involved in these projects.A qualitative approach was applied to identify the Critical Success Factors(CSFs).Nine success factors were identified from literature and by holding discussion with experts and seeking their opinion,five success factors were considered as critical for the success of PPP project in *** to the findings,the CSFs in the context of Punjab are:appropriate risk allocation and sharing,favourable legal and regulatory framework,financial and economic viability,well-organized and committed public agency,and political support and *** is believed that the findings and suggestions presented in this study will assist both the private and public sectors to deliver PPP projects in Punjab more successfully.

关键词： Public-private partnership Critical success factors Punjab Pakistan

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Primary esophageal tuberculosis mimicking esophageal carcinoma on computed tomography: A case report

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World Journal of Gastrointestinal Surgery 2019年第9期11卷 373-380页

作者： muhammad Salman Khan muhammad hassaan Arif Maan Amir Humza Sohail Wasim Ahmed Memon Department of Radiology Aga Khan UniversityKarachi 74800Pakistan Medical College Aga Khan UniversityKarachi 74800Pakistan Department of Surgery New York University Winthrop HospitalNew YorkNY 11501United States

BACKGROUND Tuberculosis(TB)has a rare extrapulmonary manifestation known as esophageal tuberculosis,accounting for 0.2%of total TB *** TB typically presents with dysphagia,with retrosternal pain or odynophagia,but generalized symptoms such as low-grade fever,decreased appetite,and weight loss are also *** carcinoma and Crohn’s disease of the esophagus are important differential diagnoses with similar *** SUMMARY We present a case of a 25-year-old male,who presented with esophageal TB mimicking an esophageal *** work-up,Mantoux test,and chest X-ray were ***-swallow examination showed moderate dilatation of distal esophagus with a nodular and irregular *** tomography showed significant thickening of thoracic and distal esophagus with infiltration into the lesser omentum and large,centrally necrotic lymph nodes on gastro-hepatic ligament suggestive of a possible *** was performed and a biopsy of mural thickening was performed and sent for histopathological *** histopathology report and TB-polymerase chain reaction confirmed the diagnosis of esophageal *** patient was started on antituberculous therapy(ATT),and complete resolution of symptoms and disease was achieved in 6 *** Esophageal TB is an extremely rare,yet important differential diagnosis in a patient presenting with *** TB can mimic esophageal carcinoma on computed tomography *** patient responded well to a complete course of ATT.

关键词： Case report Esophageal tuberculosis Esophageal carcinoma Computed tomography

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Deep Learning Based Classification of Wrist Cracks from X-ray Imaging

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Computers, Materials & Continua 2022年第10期73卷 1827-1844页

作者： Jahangir Jabbar Muzammil Hussain hassaan Malik Abdullah Gani Ali Haider Khan muhammad Shiraz Department of Computer Science National College of Business Administration&Economics LahoreMultan60000Pakistan Department of Computer Science School of Systems and TechnologyUniversity of Management and TechnologyLahore54000Pakistan Faculty of Computing and Informatics University of Malaysia SabahJalan UMSKota Kinabalu88400SabahMalaysia Department of Computer Science Federal Urdu University of ArtsScience and TechnologyIslamabadPakistan

Wrist cracks are the most common sort of cracks with an excessive occurrence *** the routine detection of wrist cracks,conventional radiography(X-ray medical imaging)is used but periodically issues are presented by crack *** cracks often appear in the human arbitrary bone due to accidental injuries such as ***,many hospitals lack experienced clinicians to diagnose wrist ***,an automated system is required to reduce the burden on clinicians and identify *** this study,we have designed a novel residual network-based convolutional neural network(CNN)for the crack detection of the *** the classification of wrist cracks medical imaging,the diagnostics accuracy of the RN-21CNN model is compared with four well-known transfer learning(TL)models such as Inception V3,Vgg16,ResNet-50,and Vgg19,to assist the medical imaging technologist in identifying the cracks that occur due to wrist *** RN-21CNN model achieved an accuracy of 0.97 which is much better than its competitor`s *** results reveal that implementing a correct generalization that a computer-aided recognition system precisely designed for the assistance of clinician would limit the number of incorrect diagnoses and also saves a lot of time.

关键词： Wrist cracks fracture deep learning X-rays CNN

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Numerical investigation of modal and fatigue performance of a horizontal axis tidal current turbine using fluid-structure interaction

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Journal of Ocean Engineering and Science 2019年第4期4卷 328-337页

作者： Habib Ullah Muzamil Hussain Naseem Abbas hassaan Ahmad Mohammed Amer muhammad Noman Faculty of Engineering and Technology University of LahoreLahore 54000Pakistan Department of Mechanical Engineering NFC Institute of Engineering and TechnologyMultan 60000Pakistan School of Mechanical Engineering Chung-Ang UniversitySeoul 06974Republic of Korea Department of Mechanical Engineering National Chiao Tung UniversityHsinchuTaiwan

The tidal power has the potential to play a vital role in a sustainable energy *** main objective of this paper is to investigate the performance and fatigue life of tidal current turbine(TCT)using fluid structure interaction(FSI)*** performance of TCT was predicted using Ansys *** performance curve,pressure distribution on the blade,and velocity streamline were visualized for eight repetitive analyses at different tip speed *** hydrodynamic load calculated from CFD analysis was transferred to FEA model for investigation of the structural response of *** analysis was performed to examine the mode shapes and natural frequencies of *** fatigue analysis were performed and number of cycles and safety factor at different equivalent alternating stresses were *** results of the simulation confirm that the turbine has a maximum value of the coefficient of performance atλ=5,the turbine operating frequency is not close to its natural frequency,and it is safe under the applied fatigue loads with a high factor of safety.

关键词： Tidal current turbine Fluid-structure interaction Fatigue performance Computational Fluid Dynamic Blade element

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Zinc oxide nanoparticles accelerate the healing of methicillin-resistant Staphylococcus aureus(MRSA)-infected wounds in rabbits

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Asian Pacific Journal of Tropical Biomedicine 2023年第11期13卷 488-496,I0002页

作者： muhammad Asif Ayesha Safdar Chaudhry Ambreen Ashar Hamad Bin Rashid muhammad Hassan Saleem hassaan Bin Aslam Abdul Aziz Department of Veterinary Surgery University of Veterinary and Animal SciencesLahorePunjabPakistan TECS Department Wilson College of TextilesNC State UniversityRaleigh 27606USA Department of Veterinary Medicine University of Veterinary and Animal SciencesLahorePunjabPakistan Institute of Microbiology University of Veterinary and Animal SciencesLahorePunjabPakistan Department of Veterinary Clinical Sciences University of PoonchRawalakot 12350Pakistan

Objective:To synthesize zinc oxide nanoparticles(ZnONPs)and evaluate their antibacterial and wound healing effects against wounds infected with methicillin-resistant Staphylococcus aureus(MRSA).Methods:ZnONPs were prepared by sol-gel method and characterized by X-ray diffraction(XRD)analysis and scanning electron microscopy(SEM).A total of 18 rabbits were divided into three groups:the ZnONPs group,the gentamicin group and the control group.A wound of 3 cm^(2) was inflicted on each rabbit and contaminated with MRSA *** was started from the fourth day *** healing,microbiological analysis,and histopathological analysis were performed to assess the efficacy of ZnONPs ***:XRD analysis confirmed the hexagonal wurtzite structure of the ZnONPs with an average crystallite size of 29.23 *** revealed discoid-shaped ZnONPs with a rough surface and an average size of 48.36 ***-dispersive X-ray analysis confirmed the purity of ***,the particle size ranged from 100-700 nm with a high agglomeration *** with ZnONPs promoted MRSA-infected wound *** addition,ZnONPs showed a good antibacterial effect as evidenced by a dose-dependent increase in the zone of ***:ZnONPs accelerate the healing of MRSA-infected ***,it can be explored for the treatment of MRSA infection.

关键词： MRSA Wound healing ZnO Nanoparticles Ointment

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Primary hepatic leiomyosarcoma:A case report and literature review

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World Journal of Hepatology 2022年第9期14卷 1830-1839页

作者： Hassan Ahmed hassaan Bari Umer Nisar Sheikh muhammad Irfan Basheer Department of Surgical Oncology Shaukat Khanum Memorial Cancer Hospital and Research CentreLahore 54782Pakistan Department of Pathology Shaukat Khanum Memorial Cancer Hospital and Research CentreLahore 54782Pakistan

BACKGROUND Primary hepatic leiomyosarcoma(PHL)is a rare tumor with a very low incidence of about 0.2%.CASE SUMMARY A 48-year-old diabetic,hypertensive,and morbidly obese female patient presented with a history of abdominal pain and weight loss for 2 *** had no history of fever,jaundice,or other liver disease(s).Clinical examination revealed a palpable mass in the *** evaluation with a contrast-enhanced computed tomography(CT)scan of the abdomen and pelvis revealed an illdefined enhancing hyper vascular hepatic mass of 9.9 cm×7.8 cm occupying the left hepatic lobe with evidence of central necrosis,compression effect on the left hepatic vein,and partial wash-out on delayed *** further workup,the maximum standardized uptake value on positron emission computed tomography scan was 6.4,which was suggestive of *** remaining part of the liver was normal without any evidence of ***-guided biopsy of the mass showed smooth muscle neoplasm suggestive of *** optimization for co-morbidities,an extended left hepatectomy was planned in a multidisciplinary team *** intraoperative ultrasound,the left hepatic lobe was entirely replaced by a large tumor extending to the caudate lobe with a compression effect on the middle and left hepatic *** histopathology showed nodular and whorled white tumor comprised of spind-led/fascicular cells with moderate to severe pleomorphism and focal *** mitotic index was greater than 20 mitoses per 10 high-power *** resection margins were free of ***(IHC)depicted a desmin-positive/caldesmon-negative/discovered on gastrointestinal stromal tumor 1-negative/cluster of differentiation 117-negative profile,confirming the definitive diagnosis as *** This case report highlights the rare malignant mesenchymal hepatic *** confirm PHL diagnosis,one requires peculiar histopathological findings with ancillary IHC confirmation.M

关键词： Leiomyosarcoma Immunohistochemistry Hepatectomy Surgical resection Case Report

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Primate-specific Long Non-coding RNAs and MicroRNAs

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Genomics, Proteomics & Bioinformatics 2017年第3期15卷 187-195页

作者： hassaan Mehboob Awan Abdullah Shah Farooq Rashid Ge Shan CAS Key Laboratory of Innate Immunity and Chronic Disease CAS Center for Excellence in Molecular Cell ScienceSchool of Life SciencesUniversity of Science and Technology of ChinaHefei 230027China

Non-coding RNAs （ncRNAs） are critical regulators of gene expression in essentially all life forms. Long ncRNAs （IncRNAs） and microRNAs （miRNAs） are two important RNA classes possessing regulatory functions. Up to date, many primate-specific ncRNAs have been identified and investigated. Their expression specificity to primate lineage suggests primate-specific roles. It is thus critical to elucidate the biological significance of primate or even human-specific ncRNAs, and to develop potential ncRNA-based therapeutics. Here, we have summarized the studies regard- ing regulatory roles of some key primate-specific lncRNAs and miRNAs.

关键词： Non-coding RNAPrimate-specific LncRNA MicroRNA Evolution

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Planting design for urban parks： Space syntax as a landscape design assessment tool

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Frontiers of Architectural Research 2015年第1期4卷 35-45页

作者： Ayman hassaan Mahmoud Reham H. Omar Department of Architecture Faculty of Engineering Cairo University Giza 12211 Egypt The Canadian International College Egypt

Trees are a major factor in defining the spatial qualities of outdoor spaces. This study investigates the influence of spatial configuration produced by the proposed tree planting design on the visual fields of an urban park using space syntax theory. Space syntax theory assumes that an urban area can be represented as a matrix of connected spaces. The quantitative properties of this matrix in the form of syntactic measures can be measured using computer simulations. This research investigates how space syntax techniques can help assess the effect of tree configurations on the social structure of a small-scale garden in an urban park. Such techniques are assumed useful in predicting the social structure of the proposed space and in assessing design alternatives. An experimental study using three different planting design proposals for an urban park is conducted. Data are analyzed using space syntax techniques. Results reveal a significant effect of planting configurations on syntactic measures across the three proposals. This study suggests that space syntax techniques may have a significant value in the assessment of schematic planting design, especially at the pedestrian movement level.

关键词： Landscape desisn Space syntax Plantins Urban parks Cairo

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Role of artificial intelligence in hepatobiliary and pancreatic surgery

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World Journal of Gastrointestinal Surgery 2021年第1期13卷 7-18页

作者： hassaan Bari Sharan Wadhwani Bobby V M Dasari Department of HPB and Liver Transplantation Surgery Queen Elizabeth HospitalBirmingham B152THUnited Kingdom Department of Radiology Queen Elizabeth HospitalBirmingham B152THUnited Kingdom

Over the past decade,enhanced preoperative imaging and visualization,improved delineation of the complex anatomical structures of the liver and pancreas,and intra-operative technological advances have helped deliver the liver and pancreatic surgery with increased safety and better postoperative *** intelligence(AI)has a major role to play in 3D visualization,virtual simulation,augmented reality that helps in the training of surgeons and the future delivery of conventional,laparoscopic,and robotic hepatobiliary and pancreatic(HPB)surgery;artificial neural networks and machine learning has the potential to revolutionize individualized patient care during the preoperative imaging,and postoperative *** this paper,we reviewed the existing evidence and outlined the potential for applying AI in the perioperative care of patients undergoing HPB surgery.

关键词： Artificial intelligence Liver surgery Pancreatic surgery Augmented reality Virtual reality Intra-operative

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