Hepatocellular carcinoma national burden across different geographical regions in the United States between 2001 and 2020

作     者：Yazan Abboud Raj Malhotra Muhammad Hassaan Arif Maan Anna Mathew Ibrahim Abboud Chun-Wei Pan Saqr Alsakarneh Fouad Jaber Islam Mohamed David Kim Nikolaos T Pyrsopoulos 

作者机构：Department of Internal MedicineRutgers New Jersey Medical SchoolNewarkNJ 07103United States University of California Riverside School of MedicineRiversideCA 92521United States Department of Internal MedicineJohn H Stroger Hospital of Cook CountyChicagoIL 60612United States Department of Internal MedicineUniversity of Missouri-Kansas CityKansasMO 64108United States Division of Gastroenterology and HepatologyRutgers New Jersey Medical SchoolNewarkNJ 07101United States 

出 版 物：《World Journal of Methodology》 (世界方法学杂志)

年 卷 期：2024年第14卷第4期

页      面：110-120页

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

主　　题：Hepatocellular carcinoma Incidence Epidemiology Health disparity Geography 

摘      要：BACKGROUND While prior data showed an increasing incidence of hepatocellular carcinoma(HCC)in the United States,there are limited comprehensive and comparative data on the geographical variations of HCC trends in different demographicspecific *** To evaluate sex and age-specific incidence rates and time trends in different geographical regions in the United *** Age-adjusted HCC incidence rates were collected from the United States Cancer Statistics(USCS)database which covers approximately 98%of the population in the United *** rates were stratified by sex,age,and geographical *** percentage change(APC)and average APC(AAPC)were estimated using Joinpoint Regression.A pairwise comparison was conducted between sex-specific *** There were 467344 patients diagnosed with HCC in the United States in the USCS database between 2001 and *** rates and trends varied by geographical *** looking at the West region(115336 patients),incidence rates of HCC were overall increasing and also increasing in older ***,when evaluating younger adults,HCC incidence rates decreased in men but not in women with a sex-specific absolute AAPC-difference of 2.15(P=0.005).When evaluating the Midwest region(84612 patients),similar results were *** incidence rates were increasing in the overall population and in older adults as well,they were decreasing in younger men but not in women with a sex-specific absolute AAPC-difference of 1.61(P0.001).For the Northeast region(87259 patients),the analysis showed similar results with decreasing HCC incidence rates in younger men but not counterpart women(Sex-specific AAPC-difference=3.26,P0.001).Lastly,when evaluating the south(180137 patients),the results were also decreasing in younger men but not in women(Sex-specific AAPC-difference=2.55,P0.001).CONCLUSION Nationwide analysis covering around 98%of the United States population shows an increasing incidence of HCC across all