Zinc oxide nanoparticles accelerate the healing of methicillin-resistant Staphylococcus aureus(MRSA)-infected wounds in rabbits

作     者：Muhammad Asif Ayesha Safdar Chaudhry Ambreen Ashar Hamad Bin Rashid Muhammad Hassan Saleem Hassaan Bin Aslam Abdul Aziz Muhammad Asif;Ayesha Safdar Chaudhry;Ambreen Ashar;Hamad Bin Rashid;Muhammad Hassan Saleem;Hassaan Bin Aslam;Abdul Aziz

作者机构：Department of Veterinary SurgeryUniversity of Veterinary and Animal SciencesLahorePunjabPakistan TECS DepartmentWilson College of TextilesNC State UniversityRaleigh 27606USA Department of Veterinary MedicineUniversity of Veterinary and Animal SciencesLahorePunjabPakistan Institute of MicrobiologyUniversity of Veterinary and Animal SciencesLahorePunjabPakistan Department of Veterinary Clinical SciencesUniversity of PoonchRawalakot 12350Pakistan 

出 版 物：《Asian Pacific Journal of Tropical Biomedicine》 (亚太热带生物医学杂志（英文版）)

年 卷 期：2023年第13卷第11期

页      面：488-496,I0002页

核心收录：

学科分类：1007[医学-药学(可授医学、理学学位)] 100705[医学-微生物与生化药学] 1001[医学-基础医学(可授医学、理学学位)] 100103[医学-病原生物学] 10[医学] 

主　　题：MRSA Wound healing ZnO Nanoparticles Ointment 

摘      要：Objective:To synthesize zinc oxide nanoparticles(ZnONPs)and evaluate their antibacterial and wound healing effects against wounds infected with methicillin-resistant Staphylococcus aureus(MRSA).Methods:ZnONPs were prepared by sol-gel method and characterized by X-ray diffraction(XRD)analysis and scanning electron microscopy(SEM).A total of 18 rabbits were divided into three groups:the ZnONPs group,the gentamicin group and the control group.A wound of 3 cm^(2) was inflicted on each rabbit and contaminated with MRSA *** was started from the fourth day *** healing,microbiological analysis,and histopathological analysis were performed to assess the efficacy of ZnONPs ***:XRD analysis confirmed the hexagonal wurtzite structure of the ZnONPs with an average crystallite size of 29.23 *** revealed discoid-shaped ZnONPs with a rough surface and an average size of 48.36 ***-dispersive X-ray analysis confirmed the purity of ***,the particle size ranged from 100-700 nm with a high agglomeration *** with ZnONPs promoted MRSA-infected wound *** addition,ZnONPs showed a good antibacterial effect as evidenced by a dose-dependent increase in the zone of ***:ZnONPs accelerate the healing of MRSA-infected ***,it can be explored for the treatment of MRSA infection.