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Incidence of urinary incontinence following endoscopic laser enucleation of the prostate by en-bloc and non-en-bloc techniques:a multicenter,real-world experience of 5068 patients

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Asian Journal of Andrology 2024年第3期26卷 233-238页

作者： Daniele Castellani Vineet Gauhar Khi Yung Fong Mario Sofer Moisés Rodríguez Socarrás Azimdjon N Tursunkulov Lie Kwok Ying Sarvajit Biligere Ho Yee Tiong Dean Elterman Abhay Mahajan Mark Taratkin Sorokin Nikolai Ivanovich Tanuj pal Bhatia Dmitry Enikeev Nariman Gadzhiev Mohammed Taif Bendigeri Jeremy Yuen-Chun Teoh Marco Dellabella Fernando Gómez Sancha Bhaskar Kumar Somani Thomas Reinhard William Herrmann Urology Unit IRCCS INRCAAncona 60127Italy Urology Unit Marche University HospitalLe Marche Polytechnic UniversityAncona 60126Italy Department of Urology Ng Teng Fong General HospitalSingapore 609606Singapore Yong Loo Lin School of Medicine National University of SingaporeSingapore 117597Singapore Department of Urology Tel Aviv Sourasky Medical CenterAffiliated to the Sackler School of MedicineTel Aviv UniversityTel Aviv 6423906Israel Department of Urology and Robotic Surgery ICUA-Clínica CEMTROMadrid 28701Spain Urology Division Akfa Medline HospitalTashkent 100211Uzbekistan Advanced Urology Gleneagles HospitalSingapore 258499Singapore Department of Urology National University HospitalSingapore 119228Singapore Divisionof Urology Department of SurgeryUniversity of TorontoOntarioToronto M5G 2C4Canada Department of Urology Mahatma Gandhi Mission’s Medical College and HospitalAurangabad 431003India Institute for Urology and Reproductive Health Sechenov UniversityMoscow119435Russian Federation Department of Urologyand Andrology Lomonosov Moscow State UniversityMoscow 119992Russian Federation Department of Urology Sarvodaya Hospital and Research CentreFaridabadHaryana 121006India Department of Urology Medical University of ViennaVienna 1090Austria Department of Urology Saint-Petersburg State University HospitalSaint-Petersburg 199034Russian Federation Department of Urology Asian Institute of Nephrology and UrologyHyderabad 500082India S.H.Ho UrologyCentre Department of SurgeryFaculty of MedicineThe Chinese University of Hong KongHong Kong 96H2+Q9China Department of Urology University Hospitals Southampton NHS TrustSouthampton SO166YDUnited Kingdom Department of Urology Cantonal Hospital Thurgau AGFraunfeld 8500Switzerland

We aim to evaluate the incidence of incontinence following laser endoscopic enucleation of the prostate(EEP)comparing en-bloc(Group 1)versus 2-lobe/3-lobe techniques(Group 2).We performed a retrospective review of patients undergoing EEP for benign prostaticenlargement in 12 centers between January 2020 and January *** were presented as median and interquartile range(IQR).Univariable and multivariable logistic regression analysis was performed to evaluate factors associated with stress urinary incontinence(SUI)and mixed urinary incontinence(MUI).There were 1711 patients in Group 1 and 3357 patients in Group *** in Group 2were significantly younger(68[62–73]years vs 69[63–74]years,P=0.002).Median(interquartile range)prostate volume(PV)wassimilar between the groups(70[52–92]ml in Group 1 vs 70[54–90]ml in Group 2,P=0.774).There was no difference in preoperativeInternational Prostate Symptom Score,quality of life,or maximum flow ***,morcellation,and total surgical time weresignificantly shorter in Group *** 1 month,overall incontinence rate was 6.3%in Group 1 versus 5.3%in Group 2(P=0.12),and urge incontinence was significantly higher in Group 1(55.1%vs 37.3%in Group 2,P<0.001).After 3 months,the overall rate ofincontinence was 1.7%in Group 1 versus 2.3%in Group 2(P=0.06),and SUI was significantly higher in Group 2(55.6%vs 24.1%in Group 1,P=0.002).At multivariable analysis,PV and IPSS were factors significantly associated with higher odds of transient SUI/***,surgical time,and no early apical release technique were factors associated with higher odds of persistent SUI/MUI.

关键词： benign prostatic hyperplasia en-bloc enucleation endoscopic enucleation of the prostate laser therapy stress urinaryincontinence urge urinary incontinence

Settling and spreading behaviour of particle clusters in quiescent liquids in confined vessels

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Particuology 2023年第12期83卷 91-100页

作者： Sayan pal Amol A.Kulkarni Chemical Engineering&Process Development Division CSIR-National Chemical LaboratoryPune411008India Academy of Scientific and Innovative Research(AcSIR) Ghaziabad 201002India University College London Torrington PlaceLondonWC1E 7JEUK

Here we report experiments on particle cluster settling at high Reynolds number in quiescent liquid contained in a *** particles were observed to spread at the vessel bottom surface in a near-circular annular shape after settling irrespective of the shape of the vessel cross-section and particle shape,size,and *** of different parameters such as mass,type and aspect ratio of the particles,height,and viscosity of liquid was investigated on spreading *** of the hemispherical bottom cap of the cluster that bounces upon hitting the vessel bottom surface was found to be responsible for the final circular annular shape of the settled *** leakage from the cluster was seen in the form of a *** the liquid having viscosity beyond 100 cP,cluster breakage was observed that resulted in hindered settling and asymmetric shapes of finally settled *** observations are useful to understand the overall area over which settling and spreading of such clusters can be observed.

关键词： Particle cluster Temporal evolution Settling Spreading

Machine Learning-based Electric Load Forecasting for Peak Demand Control in Smart Grid

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Computers, Materials & Continua 2023年第3期74卷 4785-4799页

作者： Manish Kumar Nitai pal Department of Electrical Engineering Indian Institute of Technology(ISM)Dhanbad826004India Department of Nuclear Science&Technology Pandit Deendayal Energy UniversityGandhinagarIndia

Increasing energy demands due to factors such as population,globalization,and industrialization has led to increased challenges for existing energy *** ways of energy generation and energy consumption like smart grids and smart homes are implemented to face these challenges with reliable,cheap,and easily available sources of *** integration of renewable energy and other clean distributed generation is increasing continuously to reduce carbon and other air pollutants *** the integration of distributed energy sources and increase in electric demand enhance instability in the ***-term electrical load forecasting reduces the grid fluctuation and enhances the robustness and power quality of the *** load forecasting in advance on the basic historical data modelling plays a crucial role in peak electrical demand control,reinforcement of the grid demand,and generation balancing with cost *** accurate forecasting of electrical data is a very challenging task due to the nonstationary and nonlinearly nature of the *** learning and artificial intelligence have recognized more accurate and reliable load forecastingmethods based on historical load *** purpose of this study is to model the electrical load of Jajpur,Orissa Grid for forecasting of load using regression type machine learning algorithms Gaussian process regression(GPR).The historical electrical data and whether data of Jajpur is taken for modelling and simulation and the data is decided in such a way that the model will be considered to learn the connection among past,current,and future dependent variables,factors,and the relationship among *** on this modelling of data the network will be able to forecast the peak load of the electric grid one day *** study is very helpful in grid stability and peak load control management.

关键词： Artificial intelligence electric load forecasting machine learning peak-load control renewable energy smart grids

Identification of high-dielectric constant compounds from statistical design

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npj Computational Materials 2022年第1期8卷 1396-1405页

作者： Abhijith Gopakumar Koushik pal Chris Wolverton Department of Materials Science and Engineering Northwestern University2220 Campus DriveEvanstonIL60208USA

The discovery of high-dielectric materials is crucial to increasing the efficiency of electronic devices and ***,we report three previously unexplored materials with very high dielectric constants(69<ϵ<101)and large b... 详细信息

关键词： dielectric high constant

Investigation of point defect evolution and Voronoi cluster analysis for magnesium during nanoindentation

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Journal of Magnesium and Alloys 2023年第3期11卷 1029-1042页

作者： Pragyan Goswami Snehanshu pal Manoj Gupta Department of Metallurgical and Materials Engineering National Institute of TechnologyRourkelaOdisha 769008India Department of Mechanical Engineering National University of SingaporeSingapore 117575Singapore

The present study investigates the effect of nanoindentation on single-crystal magnesium specimens using the embedded-atom method potential in molecular dynamics *** are done under dynamic loading where the load-bearing capacity and change in the structural configuration are studied on the basal(Z-direction)and two prismatic planes(X-and Y-directions)with varying indenter *** investigation of structural evolution is done using atomic displacement analyses to measure the net magnitude of displacement,atomic strain analyses to evaluate the shear strain developed in the process,and Wigner-Seitz defect analyses to calculate the total vacancies at varied ***,Voronoi analyses are done when indented on the basal plane to identify the cluster distribution at different planar depths of the *** the analyses,it has been observed that the load-bearing capacity of the specimen varies with the indentation velocity and the direction of indentation on the ***,it is seen that the observed shear and total atomic displacement in the Z-direction is the least in comparison to the other two *** partial dislocation 1/3is seen to be majorly present and the population of dislocation loops is more abundant for lower indenter ***,clustersandare the major indices developed during nanoindentation on the basal plane where they exhibit symmetrical distribution as observed from the Z-direction.

关键词： Magnesium Molecular dynamics Nanoindentation Voronoi analysis Wigner-Seitz defect analysis

NMR relaxation and diffusion studies to probe the motional dynamics of risperidone within PLGA microsphere

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Magnetic Resonance Letters 2023年第2期3卷 197-205,I0005页

作者： Deepak Kumar Samanwita pal Department of Chemistry Indian Institute of Technology JodhpurRajasthan342037.India Central Ayurveda Research Institute Kolkata CCRASBidhannagarKolkata700091India

The present study aims to investigate the motional dynamics of risperidone within polylactic co-glycolic acid(PLGA)microsphere by employing solution state'H and 19F nuclear magnetic resonance(NMR)***,a second-generation fluorinated antipsychotic drug used for the treatment of schizophrenia is commercially marketed as PLGA microsphere formulation resulting in prolonged release of the drug in *** the current trend in the pharmaceutical market is to develop drug formulation with long-acting release(LAR)products,complete physicochemical characterization of such formulations are *** the effects of microsphere encapsulation on the motional properties and diffusion behavior of the drugs are not discussed adequately in any of the earlier *** therefore,have employed NMR relaxation and diffusion measurements to decipher the interaction of PLGA cavity water with risperidone.A detailed analysis of NMR relaxation rates confirmed the event of encapsulation and the presence of local motion in the non-fluorinated end of ***,the relaxation data indicated a significant alteration in 19F chemical shift anisotropy(CSA)and CSA/dipole-dipole(DD)cross-correlated relaxation mechanism and decreased effect of solvent relaxation pointing out reduced water concentration within the microsphere cavity.'H and 19F diffusion coefficients of risperidone led to the information about hydrodynamic radius of risperidone in free and encapsulated *** of hydrodynamic radius supported the presence of limited water in PLGA cavity allowing higher translational mobility of risperidone after the encapsulation.

关键词： Polylactic co-glycolic acid(PLGA)microsphere Motional dynamics 1H and 19F NMR Diffusion Hydrodynamic radius Cross-correlated relaxation

Impact of binary blends of biodiesels on fuel quality,engine performance and emission characteristics

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Clean Energy 2023年第2期7卷 417-425页

作者： Sandeep Gupta Mahendra pal Sharma Department of Hydro and Renewable Energy Indian Institute of Technology RoorkeeUttarakhand(247667)India

The incessant pressure of energy requirements by the growing global populace has led to the exploration of unconventional methods to produce renewable and sustainable *** these,biodiesel is most suited to the present needs of eco-friendly standards to keep the atmosphere free from residual *** fuel-modification methods were developed over a couple of decades to make biodiesel suitable for diesel *** the present research,Jatropha curcas biodiesel and waste-cooking-oil(WCO)biodiesel were used to craft a unique binary blend to obtain desirable fuel properties and operational suitability for the diesel *** blend with 80% WCO biodiesel and 20% *** biodiesel,which had the most suitable fuel properties,was tested on a four-stroke single-cylinder vertical diesel *** emissions and operational parameters were analysed and compared with *** results of the study indicated that engine emissions for binary blend,carbon monoxide and unburnt hydrocarbon emissions were highly reduced,and carbon dioxide and nitrogen oxide(NO_(x))emissions increased relative to *** full load,NO_(x) emission was found to be 51.32% higher than that from diesel and 3.8% lower than that from WCO *** performance showed that for the binary blend,at full load,the brake-specific fuel consumption was 396.82 g/kWh,which was 15.26% higher,and the brake thermal efficiency was 22.7%,which was 2.74% lower than regular diesel *** present study suggests that the binary blend of *** biodiesel and WCO biodiesel can be a promising approach towards advancements in the fuel properties of biodiesels.

关键词： binary blends waste-cooking-oil biodiesel Jatropha curcas biodiesel engine emission engine performance

ChemNODE: A neural ordinary differential equations framework for efficient chemical kinetic solvers

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能源与人工智能(英文) 2022年第1期7卷 142-148页

作者： Opeoluwa Owoyele Pinaki pal Energy Systems Division Argonne National Laboratory9700 S Cass AvenueLemontIL 60439United States

Solving for detailed chemical kinetics remains one of the major bottlenecks for computational fluid dynamics simulations of reacting flows using a finite-rate-chemistry *** has motivated the use of neural networks to predict stiff chemical source terms as functions of the thermochemical state of the combustion ***,due to the nonlinearities and multi-scale nature of combustion,the predicted solution often diverges from the true solution when these machine learning models are coupled with a computational fluid dynamics *** is because these approaches minimize the error during training without guaranteeing successful integration with ordinary differential equation *** the present work,a novel neural ordinary differential equations approach to modeling chemical kinetics,termed as ChemNODE,is *** this machine learning framework,the chemical source terms predicted by the neural networks are integrated during training,and by computing the required derivatives,the neural network weights are adjusted accordingly to minimize the difference between the predicted and ground-truth solution.A proof-of-concept study is performed with ChemNODE for homogeneous autoignition of hydrogen-air mixture over a range of composition and thermodynamic *** is shown that ChemNODE accurately captures the chemical kinetic behavior and reproduces the results obtained using the detailed kinetic mechanism at a fraction of the computational cost.

关键词： Machine learning Neural ordinary differential equations Artificial neural networks Deep learning Chemical kinetics Artificial neural network Chemistry solvers

Pichia as yeast cell factory for production of industrially important bio-products:Current trends,challenges,and future prospects

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生物质资源与工程(英文) 2023年第2期8卷 108-124页

作者： Akansha Shrivastava Mamta pal Rakesh Kumar Sharma Department of Biosciences Manipal University JaipurJaipur 303007India Sardar Swaran Singh National Institute of Bio-Energy Jalandhar 144601India

Yeast has been used as a cell factory for thousands of years to produce a wide variety of com-plex biofuels,bioproducts,biochemicals,food ingredients,and *** a variety of biotechnological production hosts,a few specific genera of yeast have proven *** developments in metabolic engineering and synthetic biology provide a workable long-term supply solution for these *** this review,we have covered recent advances in the design of yeast cell factories for the synthesis of terpenoids,alkaloids,phenylpropanoids,and other natural chemicals,primarily focusing on Pichia ***-edge solutions involving genetic and process engineering have also been ***,the review summarized recent advancements and challenges in synthetic and systems biology,as well as initiatives in metabolic engineering aimed at commercializing non-conventional yeasts like *** processes used in non-traditional yeasts to produce enzymes,therapeutic proteins,lipids,and metabolic products for industrial applications were thoroughly elaborated.

关键词： Natural product Pichia Non-conventional yeast Biosynthesis System biology Synthetic biology