Kainate receptor channel opening and gating mechanism

作     者：Shanti Pal Gangwar 

作者机构：不详 

出 版 物：《四川生理科学杂志》 (Sichuan Journal of Physiological Sciences)

年 卷 期：2024年第46卷第5期

页      面：1137-1137页

学科分类：1002[医学-临床医学] 100204[医学-神经病学] 10[医学] 

主　　题：epilepsy diseases mechanism 

摘      要：Kainate receptors,a subclass of ionotropic glutamate receptors,are tetrameric ligand-gated ion channels that mediate excitatory *** receptors modulate neuronal circuits and synaptic plasticity during the development and function of the central nervous system and are implicated in various neurological and psychiatric diseases,including epilepsy,depression,schizophrenia,anxiety and *** structures of kainate receptor domains and subunit assemblies are available12-18,the mechanism of kainate receptor gating remains poorly *** we present cryo-electron microscopy structures of the kainate receptor GluK2 in the presence of the agonist glutamate and the positive allosteric modulators lectin concanavalin A and BPAM344.