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Analysis of the trafficking system in blood-brain barrier models by high content screening microscopy

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Neural Regeneration Research 2018年第11期13卷 1883-1884页

作者： Andrea E.Toth morten S.Nielsen Department of Biomedicine Faculty of Health Aarhus University

The blood-brain barrier(BBB)and drug delivery:In our modern societies,the prevalence of nervous system disorders is increasing in relation to the aging *** overcome this problem,several interesting pharmacons and biom... 详细信息

关键词： Analysis of the trafficking system in blood-brain barrier models by high content screening microscopy

Inducible protein-10 as a predictive marker of antiviral hepatitis C treatment:A systematic review

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World Journal of Hepatology 2017年第14期9卷 677-688页

作者： Bastian Neesgaard morten Ruhwald Nina Weis Department of Infectious Diseases Copenhagen University Hospital Hvidovre Department of Infectious Disease Immu-nology Section of Human ImmunologyStatens Serum Institute Department of Clinical Medicine Faculty of Health and Medical SciencesUniversity of Copenhagen

To investigate interferon-γ-inducible protein-10’s (IP-10) potential to anticipate rapid (RVR)- and sustained virological responses (SVR) to chronic hepatitis C (CHC) treatment. METHODSWe included case series examining RVR or SVR in relation to 24 or 48 wk treatment for CHC, in patients treatment free for at least six months, with genotype 1 or 4, and in relation to 24 wk treatment for genotype 2 and 3, with pegylated interferon in combination with ribavirin. Patients had to have both a baseline IP-10 level as well as a hepatitis C virus (HCV)-RNA determination 4 wk after treatment initiation or 24 wk after end of treatment. Studies including patients with liver diseases other than CHC, human immunodeficiency virus-infection, treatment with immunosuppresents or cytostatica, alcohol dependency or active intravenous drug-use were excluded. We found 81 articles by searching the MEDLINE and EMBASE databases. Eight studies were eligible for inclusion. Their quality were assesed using an 18 point checklist for case series, developed using a modified Delphi technique. Information was extracted from the articles, and no raw data was requisitioned. The review protocol was registered at the International Prospective Register of Systematic Reviews (reg. number: CRD42014008736). RESULTSThree studies reported on baseline IP-10 level in association with RVR. A signigficant association was found for HCV genotype 1 infection by two studies. Only two studies reported on HCV genotype 4 infected and genotype 2 and 3 infected patients, respectively. A trend was seen for an association between RVR and baseline IP-10 for genotype 4, while no association was found for genotype 2 and 3. Seven studies provided information regarding baseline IP-10 and SVR. Following the pattern regarding rapid virological response all five studies examining SVR in relation to baseline IP-10 levels for HCV, genotype 1 infected patients showed a significant association. Likewise a significant association was s

关键词： Chronic hepatitis C Inducible protein-10’s Sustained virological response Interferon-γ-inducible protein-10 CXCL-10 Chemokine Genotype Pegylated interferon Ribavirin Rapid virological response

Induced pluripotent stem cells as suitable sensors for fibromyalgia and myalgic encephalomyelitis/chronic fatigue syndrome

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World Journal of Stem Cells 2021年第8期13卷 1134-1150页

作者： María B Monzón-Nomdedeu Karl J morten Elisa Oltra School of Biotechnology Universidad Católica de Valencia San Vicente MártirValencia 46001Spain Nuffield Department of Women's and Reproductive Health The Women CentreUniversity of OxfordOxford OX39DUUnited Kingdom Department of Pathology Universidad Católica de Valencia San Vicente MártirValencia 46001Spain Centro de Investigación Traslacional San Alberto Magno Universidad Católica de Valencia San Vicente MártirValencia 46001Spain

BACKGROUND Fibromyalgia(FM)and myalgic encephalomyelitis/chronic fatigue syndrome(ME/CFS)are devastating metabolic neuroimmune diseases that are difficult to diagnose because of the presence of numerous symptoms and a lack of specific *** patient heterogeneity linked to patient subgroups and variation in disease severity,anomalies are found in the blood and plasma of these patients when compared with healthy control *** seeming specificity of these“plasma factors”,as recently reported by Ron Davis and his group at Stanford University,CA,United States,and observations by our group,have led to the proposal that induced pluripotent stem cells(iPSCs)may be used as metabolic sensors for FM and ME/CFS,a hypothesis that is the basis for this indepth *** To identify metabolic signatures in FM and/or ME/CFS supporting the existence of disease-associated plasma factors to be sensed by *** A PRISMA(Preferred Reported Items for Systematic Reviews and Meta-analysis)-based systematic review of the literature was used to select original studies evaluating the metabolite profiles of FM and ME/CFS body *** MeSH terms“metabolomic”or“metabolites”in combination with FM and ME/CFS disease terms were screened against the PubMed *** original studies applying omics technologies,published in English,were *** data obtained were tabulated according to the disease and type of body fluid *** across studies were searched and P-values reported by the original studies were gathered to document significant differences found in the disease *** Eighteen previous studies show that some metabolites are commonly altered in ME/CFS and FM body *** vitro cell-based assays have the potential to be developed as screening platforms,providing evidence for the existence of factors in patient body fluids capable of altering morphology,differentiation state and/or growth ***,they can be further develo

关键词： Myalgic encephalomyelitis/chronic fatigue syndrome Fibromyalgia Induced pluripotent stem cells Plasma factor Conditioned medium Sensor system

Injection of gas-liquid jets into gas-solid fluidized beds:A review

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Particuology 2023年第5期76卷 63-85页

作者： Frederik Zafiryadis Anker Degn Jensen Weigang Lin Elisabeth Akoh Hove morten Boberg Larsen Hao Wu Department of Chemical and Biochemical Engineering Technical University of Denmark2800 Kongens LyngbyDenmark Topsoe 2800Kongens LyngbyDenmark

Injection of gas-liquid sprays into gas-solid fluidized beds finds application in many *** mixing and distribution of liquid feed and solid bed material is paramount to ensure an efficient and profitable *** its long-term use,the mechanism of liquid injection into gas-solid fluidized beds continues to raise questions and is only partially *** paper provides a thorough and up-to-date review of experimental and numerical investigations of gas-liquid sprays into gas-solid fluidized beds conducted over the past *** on the surveyed literature,a phenomenological description of the prevalent mechanisms of gas-liquid injection under different operating conditions is *** review identifies suitable computational fluid dynamic models for simulating the mechanisms involved in gas-liquid-solid interactions along with recommendations for future numer-ical and experimental work.

关键词： Gas-liquid jet Gas-solid fluidized bed Atomization Fluid catalytic cracking Fluid coking

On Pattern Selection in Three-Dimensional Benard-Marangoni Flows

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Communications in Computational Physics 2012年第3期11卷 893-924页

作者： Arne morten Kvarving Tormod Bjøntegaard Einar M.Rønquist Department of Mathematical Sciences Norwegian University of Science and Technology(NTNU)Norway

In this paper we study B´enard-Marangoni convection in confined containers where a thin fluid layer is heated from *** consider containers with circular,square and hexagonal *** Marangoni numbers close to the critical Marangoni number,the flow patterns are dominated by the appearance of the wellknown hexagonal convection *** main purpose of this computational study is to explore the possible patterns the systemmay end up in for a given set of *** a series of numerical experiments,the coupled fluid-thermal system is started with a zero initial condition for the velocity and a random initial condition for the *** a given set of parameters we demonstrate that the system can end up in more than one *** example,the final state of the system may be dominated by a steady convection pattern with a fixed number of cells,however,the same system may occasionally end up in a steady pattern involving a slightly different number of cells,or it may end up in a state where most of the cells are stationary,while one or more cells end up in an oscillatory *** larger aspect ratio containers,we are also able to reproduce dislocations in the convection pattern,which have also been observed *** has been conjectured that such imperfections(e.g.,a localized star-like pattern)are due to small irregularities in the experimental setup(e.g.,the geometry of the container).However,we show,through controlled numerical experiments,that such phenomena may appear under otherwise ideal *** repeating the numerical experiments for the same non-dimensional numbers,using a different random initial condition for the temperature in each case,we are able to get an indication of how rare such events ***,we study the effect of symmetrizing the initial ***,we study the effect of selected geometry deformations on the resulting convection patterns.

关键词： B´enard-Marangoni spectral elements pattern formation

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英力士集团创始人:能源巨头的能量人生

企业家信息 2024年第2期 31-32页

作者：莫顿·班纳德森布莱恩·亨利艾鲁(翻译) 哥本哈根大学欧洲工商管理学院和哥本哈根大学不详

已满70岁的詹姆斯·“吉姆爵士”·拉特克利夫(James"SirJim"Ratcliffe)出生于英国曼彻斯特的一个工人家庭,2023年5月位列英国富豪榜第二位。《星期日泰唔士报》“富豪榜”显示,他目前的财富约有296.88亿英镑。而根据《福布斯》的报道,... 详细信息

已满70岁的詹姆斯·“吉姆爵士”·拉特克利夫(James"SirJim"Ratcliffe)出生于英国曼彻斯特的一个工人家庭,2023年5月位列英国富豪榜第二位。《星期日泰唔士报》“富豪榜”显示,他目前的财富约有296.88亿英镑。而根据《福布斯》的报道,拉特克利夫在全球富豪榜上的排名也一直在稳步攀升,目前排名第67位,石化产业是他巨额财富的主要来源。

关键词：全球富豪榜石化产业英国曼彻斯特巨额财富能源巨头拉特《福布斯》

Characterization of TGFβ-specific CD4+T cells through the modulation of TGFβexpression in malignant myeloid cells

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Cellular & Molecular Immunology 2021年第11期18卷 2575-2577页

作者： Rasmus Erik Johansson mortensen morten Orebo Holmström Mads Hald Andersen National Center for Cancer Immune Therapy Department of OncologyCopenhagen University HospitalHerlevDenmark Institute for Immunology and Microbiology Copenhagen UniversityCopenhagenDenmark

Transforming growth factor beta(TGFβ)is a pleiotropic cytokine with functions related to angiogenesis,tumor suppression,and immune tolerance[1].TGFβis involved in tumor immune escape and is a target for cancer immune therapy[1].We have reported that healthy donors and cancer patients harbor CD8^(+)cytotoxic T lymphocytes(CTLs)that are specific to TGFβ-derived epitopes and that these CD8^(+)CTLs kill malignant myeloid cells in a TGFβ-dependent manner[2].

关键词： TGFβ malignant myeloid

When nets meet environmental DNA metabarcoding:integrative approach to unveil invertebrate community patterns of hypersaline lakes

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Journal of Oceanology and Limnology 2023年第4期41卷 1331-1340页

作者： Matthew A.CAMPBELL Alex LAINI Nicole E.WHITE morten E.ALLENTOFT Mattia SACCÒ Trace and Environmental DNA(TrEnD)Laboratory School of Molecular and Life SciencesCurtin UniversityPerth 6102WAAustralia Department of Life Sciences and Systems Biology University of TurinTurin 10124Italy Subterranean Research and Groundwater Ecology(SuRGE)Group Trace and Environmental DNA(TrEnD)LaboratorySchool of Molecular and Life SciencesCurtin UniversityPerth 6102WAAustralia Lundbeck Foundation GeoGenetics Centre Globe InstituteUniversity of CopenhagenCopenhagen 1353Denmark

Saline and hypersaline wetlands account for almost half of the volume of inland water *** provide pivotal habitat for a vast range of species,including crucial ecosystem services for humans such as carbon sink storage and extractive resource *** their importance,effective ecological assessment is in its infancy compared to current conventional surveys carried out in freshwater *** integration of environmental DNA(eDNA)analysis and traditional techniques has the potential to transform biomonitoring processes,particularly in remote and understudied saline *** this context,this preliminary study aims to explore the potential of eDNA coupled with conventional approaches by targeting five hypersaline lakes at Rottnest Island(Wadjemup)in Western *** focused on the invertebrate community,a widely accepted key ecological indicator to assess the conservational status in rivers and *** combination of metabarcoding with morphology-based taxonomic analysis described 16 taxa belonging to the orders Anostraca,Diptera,Isopoda,and ***-based diversity assessment revealed more taxa at higher taxonomic resolution than the morphology-based taxonomic ***,certain taxa(i.e.,Ephydridae,Stratyiomidae,Ceratopogonidae)were only identified via net ***,our results indicate that great potential resides in combining conventional net-based surveys with novel eDNA approaches in saline and hypersaline ***,urgent and effective conservational frameworks are required to contrast the enormous pressure that these ecosystems are increasingly *** investigations at larger spatial temporal scales will allow consolidation of robust,reliable,and affordable biomonitoring frameworks in the underexplored world of saline wetlands.

关键词： macroinvertebrate hypersaline e nvironmental DNA(eDNA) conservation ecological survey community composition

Patients with inflammatory bowel disease have increased risk of autoimmune and inflammatory diseases

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World Journal of Gastroenterology 2017年第33期23卷 6137-6146页

作者： morten L Halling Jens Kjeldsen Torben Knudsen Jan Nielsen Lars Koch Hansen Department of Gast-roenterology and Hepatology Hospital of Southwest Jutland Department of Medical Gastroenterology S Odense University Hospital Center for Clinical Epidemiology Odense Uni-versity Hospital

AIM To investigate whether immune mediated diseases(IMD) are more frequent in patients with inflammatory bowel disease(IBD).METHODS In this population based registry study,a total of 47325 patients with IBD were alive and registered in the Danish National Patient Registry on December 16,2013. Controls were randomly selected from the Danish Civil Registration System(CRS) and matched for sex,age,and municipality. We used ICD 10 codes to identify the diagnoses of the included patients. The IBD population was divided into three subgroups: Ulcerative colitis(UC),Crohn's disease(CD) and Both the latter referring to those registered with both diagnoses. Subsequently,odds-ratios(OR) and 95%CI were obtained separately for each group and their respective controls. The use of Bonferoni post-test correction adjusted the significance level to P < 0.00125. P-values were estimated using Fisher's exact *** There were significantly more women than men in the registry,and a greater percentage of comorbidity in the IBD groups(P < 0.05). Twenty different IMDs were all significantly more frequent in the IBD group. Sixteen were associated with UC versus twelve with CD. In both UC and CD ORs were significantly increased(P < 0.00125) for primary sclerosing cholangitis(PSC),celiac disease,type 1 diabetes(T1D),sarcoidosis,asthma,iridocyclitis,psoriasis,pyoderma gangrenosum,rheumatoid arthritis,and ankylosing spondylitis. Restricted to UC(P < 0.00125) were autoimmune hepatitis,primary biliary cholangitis,Grave's disease,polymyalgia rheumatica,temporal arteritis,and atrophic gastritis. Restricted to CD(P < 0.00125) were psoriatic arthritis and episcleritis. Restricted to women with UC(P < 0.00125) were atrophic gastritis,rheumatoid arthritis,temporal arteritis,and polymyalgia rheumatica. Restricted to women with CD were episcleritis,rheumatoid arthritis,and psoriatic arthritis. The only disease restricted to men(P < 0.00125) was sarcoidosis. CONCLUSION Immune mediated diseases were si

关键词： Immune mediated diseases Ulcerative colitis Risk Prevalence Registry Chronic inflammatory diseases Autoimmune diseases Inflammatory bowel disease Crohn’s disease extraintestinal manifestations