检索结果-南通市图书馆

Gastrointestinal neuroendocrine tumors in 2020

World Journal of Gastrointestinal Oncology 2020年第8期12卷 791-807页

作者： monjur ahmed Division of Gastroenterology and Hepatology Department of Internal MedicineThomas Jefferson UniversityPhiladelphiaPA 19107United States

Gastrointestinal neuroendocrine tumors are rare slow-growing tumors with distinct histological,biological,and clinical characteristics that have increased in incidence and prevalence within the last few *** contain chromogranin A,synaptophysin and neuron-specific enolase which are necessary for making a diagnosis of neuroendocrine ***-67 index and mitotic index correlate with cellular *** chromogranin A is the most commonly used biomarker to assess the bulk of disease and monitor treatment and is raised in both functioning and non-functioning neuroendocrine *** of the gastrointestinal neuroendocrine tumors are *** Health Organization updated the classification of neuroendocrine tumors in 2017 and renamed mixed adenoneuroendocrine carcinoma into mixed neuroendocrine *** neuroendocrine tumors arise from enterochromaffin like *** are classified into 4 *** type I and type II are gastrin *** intestinal neuroendocrine tumor is the most common small bowel *** than two-third of them occur in the terminal ileum within 60 cm of ileocecal *** with small intestinal neuroendrocrine tumors frequently show clinical symptoms and develop distant metastases more often than those with neuroendocrine tumors of other *** and jejunoileal neuroendocrine tumors are distinct biologically and *** syndrome generally occurs when jejuno-ileal neuroendocrine tumors metastasize to the *** neuroendocrine tumors are generally detected after *** neuroendocrine tumors generally present as a large tumor with local or distant metastasis at the time of *** neuroendocrine tumors are increasingly being diagnosed since the implementation of screening colonoscopy in *** neuroendocrine tumors are diagnosed and staged by endoscopy with biopsy,endoscopic ultrasound,serology of biomarkers,imaging studies an

关键词： Gastrointestinal neuroendocrine tumors Gastric neuroendocrine tumors Small intestinal neuroendocrine tumors Colonic neuroendocrine tumors Rectal neuroendocrine tumors Carcinoid syndrome

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Ischemic bowel disease in 2021

引用

World Journal of Gastroenterology 2021年第29期27卷 4746-4762页

作者： monjur ahmed Department of Medicine Division of Gastroenterology and HepatologyThomas Jefferson UniversityPhiladelphiaPA 19107United States

Ischemic bowel disease(ISBODI)includes colon ischemia,acute mesenteric ischemia(AMI)and chronic mesenteric ischemia(CMI).Epidemiologically,colon ischemia is the most common type followed by AMI and *** are various risk factors for the development of *** pain is the common presenting symptom of each *** clinical suspicion is essential in ordering appropriate *** studies and colonoscopy with biopsy are the main diagnostic *** varies from conservative measures to surgical resection and *** of multidisciplinary team is essential in managing *** open surgery with revascularization plays an important role,recently there is an increasing interest in percutaneous endovascular treatment.

关键词： Colon ischemia Ischemic colitis Acute mesenteric ischemia Chronic mesenteric ischemia Endovascular treatment of acute and chronic mesenteric ischemia

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Recent advances in the management of gastrointestinal stromal tumor

引用

World Journal of Clinical Cases 2020年第15期8卷 3142-3155页

作者： monjur ahmed Division of Gastroenterology and Hepatology Department of Internal MedicineThomas Jefferson UniversityPhiladelphiaPA 19107United States

Gastrointestinal stromal tumor(GIST)is a rare but an important clinical entity seen in our clinical *** is the most common mesenchymal tumor of the gastrointestinal tract and most common malignancy of the small *** the exact prevalence of GIST is not known,the incidence of GIST has been *** arise from interstitial cells of *** of the GISTs occur due to mutation in c-kit gene or platelet derived growth factor receptor alpha gene.15%of GISTs do not have these mutations and they are called wildtype *** all GISTs express KIT receptor tyrosine ***,GISTs look like spindle cell tumors most of the time but they can be epitheloid or mixed *** median size of GISTs varies from 2.7 cm to 8.9 ***,patients with small GISTs remain asymptomatic but as the GIST size increases,patients present with various symptoms depending on the location of the *** of GISTs are located in the stomach or small *** is suspected on imaging and endoscopic studies,and confirmed by tissue acquisition with immunohistochemical *** aggressiveness of GISTs depends on the size,mitotic index and *** resection is the treatment of *** various endoscopic modalities of resection are increasingly being *** kinase inhibitors are extremely useful in the management of large GISTs,unresectable GISTs and metastatic *** options for metastatic GISTs also include radiotherapy,chemotherapy,hepatic artery embolization,chemoembolization and radiofrequency ablation.

关键词： Gastrointestinal stromal tumor Mesenchymal tumor of gastrointestinal tract Gastrointestinal subepithelial tumors Management of gastrointestinal stromal tumor Familial gastrointestinal stromal tumor Risk stratification

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Checkpoint inhibitors: What gastroenterologists need to know

引用

World Journal of Gastroenterology 2018年第48期24卷 5433-5438页

作者： monjur ahmed Division of Gastroenterology and Hepatology Department of Internal MedicineThomas Jefferson University

Checkpoint inhibitors are increasingly being used in clinical practice. They can cause various gastrointestinal,hepatic and pancreatic side effects. As these side effects can be serious, appropriate management is essential. The different checkpoint inhibitors with their mechanisms of action and indications, as well as evaluation and management of gastrointestinal, hepatic and pancreatic side effects, are discussed in this article.

关键词： Checkpoint inhibitors Immunotherapy Gastrointestinal management Hepatic and pancreatic side effects

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Non-alcoholic fatty liver disease in 2015

引用

World Journal of Hepatology 2015年第11期7卷 1450-1459页

作者： monjur ahmed Division of Gastroenterology and Hepatology Department of Internal Medicine Thomas Jefferson University

There is worldwide epidemic of non-alcoholic fatty liver disease(NAFLD). NAFLD is a clinical entity related to metabolic syndrome. Majority of the patients are obese but the disease can affect non-obese individuals as well. Metabolic factors and genetics play important roles in the pathogenesis of this disorder. The spectrum of disorders included in NAFLD are benign macrovesicular hepatic steatosis, non-alcoholic steatohepatitis, hepatic fibrosis, cirrhosis of liver and hepatocellular carcinoma. Although the disease remains asymptomatic most of the time, it can slowly progress to end stage liver disease. It will be the most common indication of liver transplantation in the future. It is diagnosed by abnormal liver chemistry, imaging studies and liver biopsy. As there are risks of potential complications during liver biopsy, many patients do not opt for liver biopsy. There are some noninvasive scoring systems to find out whether patients have advanced hepatic fibrosis. At the present time, there are limited treatment options which include lifestyle modification to loose weight, vitamin E and thioglitazones. Different therapeutic agents are being investigated for optimal management of this entity. There are some studies done on incretin based therapies in patients with NAFLD. Other potential agents will be silent information regulator protein Sirtuin and antifibrotic monoclonal antibody Simtuzumab against lysyl oxidase like molecule 2. But they are still in the investigational phase.

关键词： Fatty liver Hepatic steatosis Non-alcoholicfatty liver disease Non-alcoholic steatohepatitis

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Myeloid-derived suppressor cells in gastrointestinal cancers:A systemic review

引用

World Journal of Gastrointestinal Oncology 2021年第1期13卷 1-11页

作者： Maham Farshidpour monjur ahmed Shilpa Junna Juanita L Merchant Inpatient Medicine Banner University of Medical CenterTucsonAZ 85724United States Division of Gastroenterology and Hepatology Department of Internal MedicineThomas Jefferson UniversityPhiladelphiaPA 19107United States Division of Gastroenterology and Hepatology Banner University of Medical CenterTucsonAZ 85724United States

Gastrointestinal(GI)cancers are one of the most common malignancies worldwide,with high rates of morbidity and ***-derived suppressor cells(MDSCs)are major components of the tumor microenvironment(TME).MDSCs facilitate the transformation of premalignant cells and play roles in tumor growth and ***,in patients with GI malignancies,MDSCs can lead to the suppression of T cells and natural killer ***,a better understanding of the role and mechanism of action of MDSCs in the TME will aid in the development of novel immune-targeted therapies.

关键词： Myeloid-derived suppressor cells Gastrointestinal cancers Immune checkpoint inhibitors Tumor progression

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Acute cholangitis-an update

引用

World Journal of Gastrointestinal Pathophysiology 2018年第1期9卷 1-7页

作者： monjur ahmed Division of Gastroenterology and Hepatology Department of Internal Medicine Thomas Jefferson University

Acute cholangitis is bacterial infection of the extrahepatic biliary system. As it is caused by gallstones blocking the common bile duct in most of the cases, its prevalence is greater in ethnicities with high prevalence of gallstones. Biliary obstruction of any cause is the main predisposing factor. Diagnosis is established by the presence of clinical features, laboratory results and imaging studies. The treatment modalities include administration of intravenous fluid, antibiotics, and drainage of the bile duct. The outcome is good if the treatment is started early, otherwise it could be grave.

关键词： Acute cholangitis Ascending cholangitis Biliary infection Hepatic fever Infection of the bile duct

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Blood thinners and gastrointestinal endoscopy

引用

World Journal of Gastrointestinal Endoscopy 2016年第17期8卷 584-590页

作者： monjur ahmed Division of Gastroenterology and Hepatology Department of Internal Medicine Thomas Jefferson University

As the number of diagnostic and therapeutic gastrointestinal endoscopies is increasing, and there is an increase in number of patients taking blood thinners, we are seeing more and more patients on blood thinners prior to endoscopic procedures. Gastrointestinal bleeding or thromboembolism can occur in this category of patients in the periendoscopic period. To better manage these patients, endoscopists should have a clear concept about the various blood thinners in the market. Patients’ risk of thromboembolism off anticoagulation, and the risk of bleeding from endoscopic procedures should be assessed prior to endoscopy. The endoscopic procedure should be done when it is safe to do it.

关键词： Acute coronary syndrome Gastrointestinal bleeding and endoscopy Blood thinners Antiplatelet agents and endoscopy Gastrointestinal bleeding and endoscopy Anticoagulation bridge before endoscopy Anticoagulants and endoscopy

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Eosinophilic esophagitis in adults: An update

引用

World Journal of Gastrointestinal Pharmacology and Therapeutics 2016年第2期7卷 207-213页

作者： monjur ahmed Division of Gastroenterolgy and Hepatology Department of Internal Medicine Thomas Jefferson University

Eosinophilic esophagitis is a worldwide chronic allergic disease of the *** the last decade,there is an epidemic of this entity in the western *** seen in children and young adults,patients present with dysphagia or food impaction in the emergency *** endoscopic findings,esophageal eosinophilia and non-responsiveness to proton pump inhibitors help make the *** of foodallergens,administration of steroidal anti-inflammatory medications and dilation of the esophagus are the mainstays of *** are ongoing for mucosal healing and optimum maintenance treatment.

关键词： Eosinophilic esophagitis Dysphagia Food bolus impaction Esophageal eosinophilia Esophageal stricture

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Era of direct acting anti-viral agents for the treatment of hepatitis C

引用

World Journal of Hepatology 2018年第10期10卷 670-684页

作者： monjur ahmed Division of Gastroenterology and Hepatology Department of Internal Medicine Thomas Jefferson University

Hepatitis C infection is universal and the most common indication of liver transplantation in the United States. The period of less effective interferon therapy with intolerable side effects has gone. Now we have stepped into the era of direct acting anti-viral agents(DAAs) against hepatitis C virus. Treatment of hepatitis C is now extremely effective, tolerable and requires a short duration of intake of oral agents. Less monitoring is required with the current therapy and drug-drug interactions are less than the previous regimen. The current treatment options of chronic hepatitis C with various DAAs are discussed in this article.

关键词： Direct acting anti-viral agents Hepatitis C virus infection Post-liver transplant Hepatitis C virus/human immunodeficiency virus co-infection

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：