Myeloid-derived suppressor cells in gastrointestinal cancers:A systemic review

作     者：Maham Farshidpour Monjur Ahmed Shilpa Junna Juanita L Merchant 

作者机构：Inpatient MedicineBanner University of Medical CenterTucsonAZ 85724United States Division of Gastroenterology and HepatologyDepartment of Internal MedicineThomas Jefferson UniversityPhiladelphiaPA 19107United States Division of Gastroenterology and HepatologyBanner University of Medical CenterTucsonAZ 85724United States 

出 版 物：《World Journal of Gastrointestinal Oncology》 (世界胃肠肿瘤学杂志（英文版）（电子版）)

年 卷 期：2021年第13卷第1期

页      面：1-11页

核心收录：

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

主　　题：Myeloid-derived suppressor cells Gastrointestinal cancers Immune checkpoint inhibitors Tumor progression 

摘      要：Gastrointestinal(GI)cancers are one of the most common malignancies worldwide,with high rates of morbidity and ***-derived suppressor cells(MDSCs)are major components of the tumor microenvironment(TME).MDSCs facilitate the transformation of premalignant cells and play roles in tumor growth and ***,in patients with GI malignancies,MDSCs can lead to the suppression of T cells and natural killer ***,a better understanding of the role and mechanism of action of MDSCs in the TME will aid in the development of novel immune-targeted therapies.