Recent advances in the management of gastrointestinal stromal tumor

作     者：Monjur Ahmed 

作者机构：Division of Gastroenterology and HepatologyDepartment of Internal MedicineThomas Jefferson UniversityPhiladelphiaPA 19107United States 

出 版 物：《World Journal of Clinical Cases》 (世界临床病例杂志)

年 卷 期：2020年第8卷第15期

页      面：3142-3155页

核心收录：

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

主　　题：Gastrointestinal stromal tumor Mesenchymal tumor of gastrointestinal tract Gastrointestinal subepithelial tumors Management of gastrointestinal stromal tumor Familial gastrointestinal stromal tumor Risk stratification 

摘      要：Gastrointestinal stromal tumor(GIST)is a rare but an important clinical entity seen in our clinical *** is the most common mesenchymal tumor of the gastrointestinal tract and most common malignancy of the small *** the exact prevalence of GIST is not known,the incidence of GIST has been *** arise from interstitial cells of *** of the GISTs occur due to mutation in c-kit gene or platelet derived growth factor receptor alpha gene.15%of GISTs do not have these mutations and they are called wildtype *** all GISTs express KIT receptor tyrosine ***,GISTs look like spindle cell tumors most of the time but they can be epitheloid or mixed *** median size of GISTs varies from 2.7 cm to 8.9 ***,patients with small GISTs remain asymptomatic but as the GIST size increases,patients present with various symptoms depending on the location of the *** of GISTs are located in the stomach or small *** is suspected on imaging and endoscopic studies,and confirmed by tissue acquisition with immunohistochemical *** aggressiveness of GISTs depends on the size,mitotic index and *** resection is the treatment of *** various endoscopic modalities of resection are increasingly being *** kinase inhibitors are extremely useful in the management of large GISTs,unresectable GISTs and metastatic *** options for metastatic GISTs also include radiotherapy,chemotherapy,hepatic artery embolization,chemoembolization and radiofrequency ablation.