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<i>Angiostrongylus costaricensis</i>: Systematic Review of Case Reports

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Advances in Infectious Diseases 2014年第1期4卷 36-41页

作者： Angela Romero-Alegría moncef belhassen-garcía Virginia Velasco-Tirado Ana garcia-Mingo Lucia Alvela-Suárez Javier Pardo-Lledias Miguel Cordero Sánchez Department of Internal Medicine CAUSA IBSAL Salamanca Spain Department of Internal Medicine CAUSA IBSAL Salamanca Spain CIETUS University of Salamanca Salamanca Spain Department of Internal Medicine General Hospital of Palencia “Río Carrión” Palencia Spain

Introduction: Abdominal angiostrongyliasis is an infrequently diagnosed disease because it is little known and is usually well tolerated. Methods: We carried out a systematic review with PubMed as a search engine for the MedLine database, and we analysed the clinical, epidemiological and analytical parameters of this disease. Results: In total, reports of 27 case have been found, together with a series of 116 patients, which were later augmented up to 194 patients. In the results, we have observed a predominance of male patients, and Costa Rica, Brazil and the United States as the main countries of origin. Typical symptoms include abdominal pain on the right iliac fossa, with leukocytosis and eosinophilia. Discussion: There are some serological diagnostic methods, although lack of standardization leads to most of the diagnoses being reached via pathology. Surgery is the usual treatment approach. Although there are medical options, this is a controversial subject because of the low number of cases published in the literature, which implies an absence of solid studies.

关键词： Angiostrongylus costaricensis Abdominal Angiostrongyliasis Acute Abdomen Eosinophilia

Molecular diagnosis of Chagas disease:a systematic review and meta-analysis

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Infectious Diseases of Poverty 2023年第5期12卷 93-93页

作者： Guillermo Pascual-Vázquez Montserrat Alonso-Sardón Beatriz Rodríguez-Alonso Javier Pardo-Lledías Angela Romero Alegría Pedro Fernández-Soto Juan Luis Muñoz Bellido Antonio Muro moncef belhassen-garcía Infectious and Tropical Diseases Group (E-INTRO) Biomedical Research Institute of Salamanca (IBSAL) Tropical Diseases Research Center of the University of Salamanca (CIETUS) Faculty of Pharmacy University of Salamanca Salamanca Spain Area of Preventive Medicine Epidemiology and Public Health Department of Biomedical and Diagnostic Sciences Faculty of Medicine E-INTRO IBSAL CIETUS University of Salamanca Salamanca Spain Internal Medicine Service University Health Care Complex of Salamanca (CAUSA) E-INTRO IBSAL CIETUS Salamanca Spain Internal Medicine Department Hospital Marqués de Valdecilla University of Cantabria IDIVAL (Valdecilla Research Institute) Santander Spain Internal Medicine Service CAUSA. E-INTRO IBSAL CIETUS Salamanca Spain Infectious and Tropical Diseases Group (E-INTRO) IBSAL. CIETUS. Faculty of Pharmacy University of Salamanca Salamanca Spain Microbiology and Parasitology Service CAUSA IBSAL CIETUS CSIC Department of Biomedical and Diagnostic Sciences University of Salamanca Salamanca Spain Internal Medicine Service. Infectious Diseases Section CAUSA IBSAL CIETUS University of Salamanca Salamanca Spain

Background The complexity of the Chagas disease and its phases is impossible to have a unique test for both phases and a lot of different epidemiological ***,serology is the reference standard technique;occasionally,results are inconclusive,and a different diagnostic technique is *** guidelines recommend molecular testing.A systematic review and meta-analysis of available molecular tools/techniques for the diagnosis of Chagas disease was performed to measure their heterogeneity and efficacy in detecting Trypanosoma cruzi infection in blood *** A systematic review was conducted up to July 27,2022,including studies published in international *** and exclusion criteria were defined to select eligible *** were extracted and presented according to PRISMA 2020 *** quality was assessed using Quality Assessment of Diagnostic Accuracy Studies-2(QUADAS-2).A random-effects model was used to calculate pooled sensitivity,specificity,and diagnostic odds ratio(DOR).Forest plots and a summary of the receiving operating characteristics(SROC)curves displayed the *** was determined by I^(2)and Tau^(2)statistics and P *** plots and Deek's test were used to assess publication bias.A quantitative meta-analysis of the different outcomes in the two different clinical phases was *** We identified 858 records and selected 32 *** pertained to endemic countries and nonendemic areas with adult and paediatric *** sample sizes ranged from 17 to 708 *** were no concerns regarding the risk of bias and applicability of all included studies.A positive and nonsignificant correlation coefficient(S=0.020;P=0.992)was obtained in the set of studies that evaluated diagnostic tests in the acute phase population(ACD).A positive and significant correlation coefficient(S=0.597;P<0.000)was obtained in the case of studies performed in the chronic phase population(

关键词： Chagas disease Trypanosoma cruzi Molecular diagnosis Polymerase chain reaction Loop-mediated isothermal amplification

Imported Mansonella perstans infection in Spain

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Infectious Diseases of Poverty 2020年第4期9卷 158-158页

作者： Sabino Puente Mar Lago Mercedes Subirats Ismael Sanz-Esteban Marta Arsuaga Belén Vicente Montserrat Alonso-Sardon moncef belhassen-garcia Antonio Muro Unidad de Medicina Tropical Servicio de Medicina InternaHospital La Paz-Carlos IIIMadridSpain Microbiología Hospital La Paz-Carlos IIIMadridSpain Facultad de Fisioterapia Universidad Europea de MadridMadridSpain Laboratorio de Inmunología Parasitaria y Molecular CIETUSIBSALFacultad de FarmaciaUniversidad de Salamanca37007SalamancaSpain Área de Medicina Preventiva y Salud Pública IBSALCIETUSUniversidad de SalamancaSalamancaSpain Servicio de Medicina Interna Sección de Enfermedades InfecciosasCAUSAIBSALCIETUSUniversidad de SalamancaPaseo San Vicente 58-18237007SalamancaSpain

Background Mansonella perstans infection can be considered one of the most neglected tropical infectious *** few studies have reported on the clinical picture caused by infection with this ***,our study was aimed to describe the clinical patterns and treatment of imported *** infection by migrants from *** The present study evaluated a large cohort of migrants who have been diagnosed,examined and treated for imported *** infection at a Spanish reference center(Hospital Carlos III Tropical Medicine Unit,Madrid,Spain)over a 19-year *** patients voluntarily attend the emergency unit or are referred from primary care or general hospitals in ***-square test was used to compare the association between categorical *** continuous variables were compared by Student’s t-test or the Mann–Whitney *** corresponding regression models were used for multivariate *** Five hundred three cases of migrants from tropical and subtropical areas with *** infection were *** hundred sixty-four patients were female(52.5%).The mean age(±SD)was 44.6±18.2 years(range:16–93 years).The mean time(±SD)between the arrival in Spain and the first consultation was 8.6±18.0 *** major origin of the patients was Equatorial Guinea(97.6%).Regarding the clinical picture,257 patients were asymptomatic(54.7%)and 228 were symptomatic(45.3%);190 patients had pruritus(37.8%),50(9.9%)had arthralgia,18 patients had Calabar-like swelling(3.6%),and 15(3%)had abdominal *** hundred forty-two(87.9%)migrants had hyper-IgE,and 340(67.6%)had *** hundred ninety-five patients had coinfections with other filarial nematodes(38.8%),and 308 migrants had only *** infection(61.2%).Four hundred thirty-seven cases(86.9%)had been treated with anti-filarial drugs;292 cases were treated with one anti-filarial drug,and 145 cases were treated with combined anti-filarial ***,20(4%)

关键词： Mansonellosis Mansonella perstans Clinical study Immigrant Imported diseases Spain

Coverage rates for diphtheria,tetanus,poliomyelitis,and pertussis age-specific booster recommendations in France:2018 update of the real-world cohort analysis

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Infectious Medicine 2023年第1期2卷 51-56页

作者： Régis Verdier Clarisse Marchal Manon belhassen Marie Le Pannerer Nicole Guiso Robert Cohen Sanofi LyonFrance PELyon(Pharmaco Epidemiology Lyon) LyonFrance Independent Expert ParisFrance UniversitéParis Est IMRB-GRC GEMINICréteilFrance Clinical Research Center(CRC) Centre Hospitalier Intercommunal de CréteilCréteilFrance GPIP Pediatric Infectious Disease GroupFrance ACTIV Pediatric Clinical and Therapeutical Association of the Val de MarneSaint-Maur des FossésFrance UnitéCourt Séjour Petits NourrissonsService de NéonatologieCentre Hospitalier Intercommunal de CréteilCréteilFrance

The French National Immunization Program was updated in 2013 for vaccination against diphtheria,tetanus,per-tussis,and *** previous findings on the evolution of age-specific booster vaccination coverage rates(VCRs)up to 2017 suggested suboptimal vaccination coverages due to the pre-2013 recommendation-residual vaccination *** the current analysis,we evaluated all age-specific booster VCR and distribution of age at vaccination visits in *** this retrospective observational cohort study,the cumulative booster VCRs were updated at all vaccination visits up to 2018 among the people who were eligible for a booster vaccination,using a 1/97th random sample of French national healthcare reimbursement *** cumulative booster VCR for individuals from all age groups increased from 2017 to 2018,except for 85-years-old vaccination *** of the individuals from all age groups were vaccinated(boosted)with a vaccine containing the pertussis *** 2018,sharp peaks corresponding to the recommended ages for booster vaccination visits were observed for individuals aged 6,11 to 13,25,45,and 65 *** study reiterates suboptimal coverages in France and implies the need for booster vaccination throughout life for the protection of the population.

关键词： Booster vaccine DTaP-IPV France Pertussis National Immunisation Programme Vaccination coverage rate

Loiasis in sub-Saharan migrants living in Spain with emphasis of cases from Equatorial Guinea

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Infectious Diseases of Poverty 2020年第1期9卷 82-89页

作者： Sabino Puente German Ramírez-Olivencia Mar Lago Mercedes Subirats Francisco Bru Eugenio Pérez-Blazquez Marta Arsuaga Concepción Ladron de Guevara Fernando de la Calle-Prieto Belén Vicente Montserrat Alonso-Sardón moncef belhassen-garcia Antonio Muro Unidad de Medicina Tropical.Servicio de Medicina Interna.Hospital La Paz-Carlos III MadridSpain Unidad de Aislamiento de Alto Nivel.Sección de Enfermedades Infecciosas.Servicio de Medicina Interna.Hospital Central de la Defensa Gómez Ulla MadridSpain Microbiología.Hospital La Paz-Carlos III MadridSpain Dermatología MadridSpain Servicio de Oftalmología.Hospital Universitario 12 de Octubre Universidad Complutense de MadridMadridSpain Laboratorio de Inmunología Parasitaria y Molecular.CIETUS.IBSAL Facultad de FarmaciaUniversidad de SalamancaAvenida Donantes de Sangre s/n37007 SalamancaSpain Área de Medicina Preventiva y Salud Pública IBSALCIETUSUniversidad de SalamancaSalamancaSpain Servicio de Medicina Interna.Sección de Enfermedades Infecciosas.CAUSA.IBSAL.CIETUS Universidad de SalamancaPaseo San Vicente 58-18237007 SalamancaSpain

Background:Loiasis is an uncommon and poorly understood parasitic disease outside endemic areas of *** aim of this study was to describe the clinical and biological patterns and treatment of imported loiasis by sub-Saharan migrants diagnosed in Madrid,***:A retrospective study was conducted with sub-Saharan immigrants seen at the Tropical Medicine Unit of the Carlos III Hospital in Madrid,Spain,a reference center,over 19 *** variables were expressed as frequency counts and *** variables were expressed as the mean and standard deviation(SD)or median and interquartile range(IQR:Q3–Q1).Chi-square tests were used to assess the association between categorical *** measured outcomes were expressed as the odds ratio(OR)with a 95%confidential *** variables were compared by Student’s t-tests or Mann-Whitney U *** logistic regression models were used.P<0.05 was considered a statistically significant ***:One hundred thirty-one migrants from tropical and subtropical areas with loiasis were ***-nine patients were male(37.4%).The migrants’mean age(±SD)was 42.3±17.3 years,and 124(94.7%)were from Equatorial *** median time(IQR)between arrival in Spain and the first consultation was 2(1–7)*** hundred fifteen migrants had eosinophilia,and one hundred thirteen had hyper-IgE ***-seven patients had pruritus(43.5%),and thirty patients had Calabar swelling(22.9%).Seventy-three patients had coinfections with other filarial nematodes(54.2%),and 58 migrants had only Loa loa infections(45.8%).One hundred two patients(77.9%)were treated;45.1%(46/102)patients were treated with one drug,and 54.9%(56/102)patients were treated with combined *** reactions were described in 14(10.7%)***:Our patients presented early clinical manifestations and few atypical ***,physicians should systematically consider loiasis in migrants with a

关键词： Loa loa Loiasis Tropical medicine Clinical study Immigrant Imported disease Spain

Molecular markers of nuclear restoration gene Rf1 in sunflower using bulked segregant analysis-RAPD

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Science China(Life Sciences) 1996年第5期39卷 551-560页

作者：季静王罡 E.belhassen H.Serieys A.Berville Laboratory of Paant Molecular Biology Changchun University of Agricultural and Animal Sciences. Changchun 130062 China INRA Station de Genetique et d'Amelioration des Plantes 2 Place de Viala Chinese de Phytotechnie34060 Nontpellier France

Restoration of cytoplasmic male sterility (CMS) in sunflower was demonstrated to be controlled by polygenes by analysing 982 effective crosses among 109 self-crossed lines and 16 CMS lines. Two self-crossed lines and one CMS line with distinct genotypes were applied to creation of segregating populations for DNA bulks of the target gene Rfl. Bulked DNA was prepared in order to investigate single gene Rfl and its gene marker among polygenic characters at the same genetic background. Using 80 10-mer operon primers, 620 RAPD reactions were carried out between fertile and sterile DNA bulks. In about 800 loci, primary results showed that 8 were related to the restoration genes. Furthermore. 2 were confirmed as RAPD markers for gene Rfl by examining 9 maintenance and 7 restoration lines. This method is the improvement for bulked segregant analysis[1] with which markers of single gene of target can be identified rapidly among polygenic characters.

关键词： sunflower cytoplasmic male sterility restoration gene bulked DNA RAPD marker.

向日葵细胞质雄性不育系线粒体基因组atpA位点的研究

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Acta Genetica Sinica 1998年第4期25卷 367-374页

作者：季静王罡 H.Serieys E.belhassen A.Bervillé 中国人民解放军农牧大学植物分子生物学研究室 INRA Station de Génétique et d' Amélioration des Plantes Domaine de Melgueil 34130 MAUGUIO FRANCE

对21种向日葵细胞质雄性不育(CMS)品系的线粒体基因组atpA基因位点处的DNA分子变异进行了分析和研究。首次通过基因组DNA及mtDNA与一含有部分atpA基因和orf H522的4.1kb探针Southern分子杂交分析及mtDNA限制性内切酶图谱分析证明,在atp... 详细信息

对21种向日葵细胞质雄性不育(CMS)品系的线粒体基因组atpA基因位点处的DNA分子变异进行了分析和研究。首次通过基因组DNA及mtDNA与一含有部分atpA基因和orf H522的4.1kb探针Southern分子杂交分析及mtDNA限制性内切酶图谱分析证明,在atpA基因位点区域有4种DNA序列存在于21种细胞质雄性不育品系中。首次指出在向日葵CMS品系中即使细胞质来源相同,不育基因却有多种存在形式,并通过实验结果推测了导致细胞质雄性不育的机理。

关键词：向日葵 CMS atpA基因位点 orfH522

运用Bulked DNA-RAPD方法寻找向日葵细胞质雄性不育核恢复基因Rf1探针研究

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中国科学（C辑） 1996年第4期26卷 377-384页

作者：季静王罡 E.belhassen H.Serieys A.Bervillé 解放军农牧大学 DINRA Station de Genetique et d’Amelioration des PlantesDmaine de Meigueil

通过109个自交系与16个细胞质雄性不育系的982个有效杂交分析研究,证明向日葵细胞质雄性不育育性的恢复是由多个恢复基因决定的.采用3个不同基因类型:2个自交系和1个不育系,创造目的基因的分离群体,制备混合DNA(BulkedDNA),使遗传背景... 详细信息

通过109个自交系与16个细胞质雄性不育系的982个有效杂交分析研究,证明向日葵细胞质雄性不育育性的恢复是由多个恢复基因决定的.采用3个不同基因类型:2个自交系和1个不育系,创造目的基因的分离群体,制备混合DNA(BulkedDNA),使遗传背景一样的情况下在多基因性状中研究其中1个基因(Rfl),来寻找多基因性状中的目的单基因探针.运用80个10mer operon引物对育性差异的混合DNA进行了620个RAPD放大筛选,在约80个位点中,初步筛选出8个位点与核恢复基因有关,进一步以9个保持系及7个恢复系进行验证,确定了两个与核恢复基因Rfl连锁的RAPD探针.并将Michelmore的Bulked Segregant Analysis方法进行了改进,能够迅速地从多基因所决定的性状中寻找出目的单基因探针.

关键词：向日葵细胞质雄性不育恢复基因 RAPD探针

Yolk Sac Tumor and Fanconi Anemia: Case Report

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Journal of Cancer Therapy 2021年第10期12卷 585-592页

作者： Chabchoub Imen Sboui Hiba Ammar Nouha Ben Abdeljalil Nouha Hochlef Makrem belhassen Samia Zrig Ahmed Zakhama Abdelfattah Chabchoub Elyes Ben Ahmed Slim Department of Medical Onocology Faculty of Medecine Sousse University Hospital Farhat Hached Sousse Tunisia Department of Anathomopathology Faculty of Medecine Monastir University Hospital Fatouma Bourguiba Monastir Tunisia Department of Pediatric Surgery Faculty of Medecine Monastir University Hospital Fatouma Bourguiba Monastir Tunisia Department of Radiology Faculty of Medecine Monastir University Hospital Fatouma Bourguiba Monastir Tunisia Department of Genetics Faculty of Medecine Sousse University Hospital Farhat Hached Sousse Tunisia

Yolk sac tumor (YST), which most frequently arises in the gonads as a type of germ cell tumor, is rare in children but is highly malignant. The common age group affected by yolk sac tumours is 11 to 24 years. In this study, we described a rare case of YST in terms of the clinical manifestation, imaging, and histopathology findings, diagnosis and treatment in a 12-year-old girl who was followed since birth for Fanconi-like syndrome. This is a rare clinical association that also limits chemotherapy.

关键词： Alpha-Fetoprotein Chemotherapy Yolk Sac Tumor Pediatric Surgery Fan-coni-Like Syndrome