Loiasis in sub-Saharan migrants living in Spain with emphasis of cases from Equatorial Guinea

作     者：Sabino Puente German Ramírez-Olivencia Mar Lago Mercedes Subirats Francisco Bru Eugenio Pérez-Blazquez Marta Arsuaga Concepción Ladron de Guevara Fernando de la Calle-Prieto Belén Vicente Montserrat Alonso-Sardón Moncef Belhassen-Garcia Antonio Muro Puente Sabino;Ramírez-Olivencia German;Lago Mar;Subirats Mercedes;Bru Francisco;Pérez-Blazquez Eugenio;Arsuaga Marta;de Guevara Concepción Ladron;de la Calle-Prieto Fernando;Vicente Belén;Alonso-Sardón Montserrat;Belhassen-Garcia Moncef;Muro Antonio

作者机构：Unidad de Medicina Tropical.Servicio de Medicina Interna.Hospital La Paz-Carlos IIIMadridSpain Unidad de Aislamiento de Alto Nivel.Sección de Enfermedades Infecciosas.Servicio de Medicina Interna.Hospital Central de la Defensa Gómez UllaMadridSpain Microbiología.Hospital La Paz-Carlos IIIMadridSpain DermatologíaMadridSpain Servicio de Oftalmología.Hospital Universitario 12 de OctubreUniversidad Complutense de MadridMadridSpain Laboratorio de Inmunología Parasitaria y Molecular.CIETUS.IBSALFacultad de FarmaciaUniversidad de SalamancaAvenida Donantes de Sangre s/n37007 SalamancaSpain Área de Medicina Preventiva y Salud PúblicaIBSALCIETUSUniversidad de SalamancaSalamancaSpain Servicio de Medicina Interna.Sección de Enfermedades Infecciosas.CAUSA.IBSAL.CIETUSUniversidad de SalamancaPaseo San Vicente 58-18237007 SalamancaSpain 

出 版 物：《Infectious Diseases of Poverty》 (贫困所致传染病（英文）)

年 卷 期：2020年第9卷第1期

页      面：82-89页

核心收录：

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

基　　金：the National Key Research and Development Program of China(Grant 2016YFC1202000) the National Natural Science Foundation of China(Grant 81973108) 

主　　题：Loa loa Loiasis Tropical medicine Clinical study Immigrant Imported disease Spain 

摘      要：Background:Loiasis is an uncommon and poorly understood parasitic disease outside endemic areas of *** aim of this study was to describe the clinical and biological patterns and treatment of imported loiasis by sub-Saharan migrants diagnosed in Madrid,***:A retrospective study was conducted with sub-Saharan immigrants seen at the Tropical Medicine Unit of the Carlos III Hospital in Madrid,Spain,a reference center,over 19 *** variables were expressed as frequency counts and *** variables were expressed as the mean and standard deviation(SD)or median and interquartile range(IQR:Q3–Q1).Chi-square tests were used to assess the association between categorical *** measured outcomes were expressed as the odds ratio(OR)with a 95%confidential *** variables were compared by Student’s t-tests or Mann-Whitney U *** logistic regression models were used.P0.05 was considered a statistically significant ***:One hundred thirty-one migrants from tropical and subtropical areas with loiasis were ***-nine patients were male(37.4%).The migrants’mean age(±SD)was 42.3±17.3 years,and 124(94.7%)were from Equatorial *** median time(IQR)between arrival in Spain and the first consultation was 2(1–7)*** hundred fifteen migrants had eosinophilia,and one hundred thirteen had hyper-IgE ***-seven patients had pruritus(43.5%),and thirty patients had Calabar swelling(22.9%).Seventy-three patients had coinfections with other filarial nematodes(54.2%),and 58 migrants had only Loa loa infections(45.8%).One hundred two patients(77.9%)were treated;45.1%(46/102)patients were treated with one drug,and 54.9%(56/102)patients were treated with combined *** reactions were described in 14(10.7%)***:Our patients presented early clinical manifestations and few atypical ***,physicians should systematically consider loiasis in migrants with a