Molecular diagnosis of Chagas disease:a systematic review and meta-analysis
作者机构：Infectious and Tropical Diseases Group (E-INTRO) Biomedical Research Institute of Salamanca (IBSAL) Tropical Diseases Research Center of the University of Salamanca (CIETUS) Faculty of Pharmacy University of Salamanca Salamanca Spain Area of Preventive Medicine Epidemiology and Public Health Department of Biomedical and Diagnostic Sciences Faculty of Medicine E-INTRO IBSAL CIETUS University of Salamanca Salamanca Spain Internal Medicine Service University Health Care Complex of Salamanca (CAUSA) E-INTRO IBSAL CIETUS Salamanca Spain Internal Medicine Department Hospital Marqués de Valdecilla University of Cantabria IDIVAL (Valdecilla Research Institute) Santander Spain Internal Medicine Service CAUSA. E-INTRO IBSAL CIETUS Salamanca Spain Infectious and Tropical Diseases Group (E-INTRO) IBSAL. CIETUS. Faculty of Pharmacy University of Salamanca Salamanca Spain Microbiology and Parasitology Service CAUSA IBSAL CIETUS CSIC Department of Biomedical and Diagnostic Sciences University of Salamanca Salamanca Spain Internal Medicine Service. Infectious Diseases Section CAUSA IBSAL CIETUS University of Salamanca Salamanca Spain
出 版 物：《Infectious Diseases of Poverty》 (贫困所致传染病（英文）)
年 卷 期：2023年第12卷第5期
页 面：93-93页
核心收录：
学科分类：12[管理学] 1204[管理学-公共管理] 120402[管理学-社会医学与卫生事业管理(可授管理学、医学学位)] 1004[医学-公共卫生与预防医学(可授医学、理学学位)] 10[医学]
基 金：Consejería de Sanidad, Junta de Castilla y Leon, (GRS 2555/A/22) Gerencia Regional de Salud de Castilla y Leon European Commission, EC Federación Española de Enfermedades Raras, FEDER Instituto de Salud Carlos III, ISCIII, (PI22/01721) European Regional Development Fund, ERDF
主 题：Chagas disease Trypanosoma cruzi Molecular diagnosis Polymerase chain reaction Loop-mediated isothermal amplification
摘 要：Background The complexity of the Chagas disease and its phases is impossible to have a unique test for both phases and a lot of different epidemiological ***,serology is the reference standard technique;occasionally,results are inconclusive,and a different diagnostic technique is *** guidelines recommend molecular testing.A systematic review and meta-analysis of available molecular tools/techniques for the diagnosis of Chagas disease was performed to measure their heterogeneity and efficacy in detecting Trypanosoma cruzi infection in blood *** A systematic review was conducted up to July 27,2022,including studies published in international *** and exclusion criteria were defined to select eligible *** were extracted and presented according to PRISMA 2020 *** quality was assessed using Quality Assessment of Diagnostic Accuracy Studies-2(QUADAS-2).A random-effects model was used to calculate pooled sensitivity,specificity,and diagnostic odds ratio(DOR).Forest plots and a summary of the receiving operating characteristics(SROC)curves displayed the *** was determined by I^(2)and Tau^(2)statistics and P *** plots and Deek s test were used to assess publication bias.A quantitative meta-analysis of the different outcomes in the two different clinical phases was *** We identified 858 records and selected 32 *** pertained to endemic countries and nonendemic areas with adult and paediatric *** sample sizes ranged from 17 to 708 *** were no concerns regarding the risk of bias and applicability of all included studies.A positive and nonsignificant correlation coefficient(S=0.020;P=0.992)was obtained in the set of studies that evaluated diagnostic tests in the acute phase population(ACD).A positive and significant correlation coefficient(S=0.597;P0.000)was obtained in the case of studies performed in the chronic phase population(
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