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Interfacial Electronic Modulation of Dual-Monodispersed Pt–Ni_(3)S_(2) as Efficacious Bi-Functional Electrocatalysts for Concurrent H_(2) Evolution and Methanol Selective Oxidation

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Nano-Micro Letters 2024年第4期16卷 415-431页

作者： Qianqian Zhao Bin Zhao Xin Long Renfei Feng mohsen Shakouri Alisa Paterson Qunfeng Xiao Yu Zhang Xian‑Zhu Fu Jing‑Li Luo Shenzhen Key Laboratory of Energy Electrocatalytic Materials Shenzhen Key Laboratory of Polymer Science and TechnologyGuangdong Research Center for Interfacial Engineering of Functional MaterialsCollege of Materials Science and EngineeringShenzhen UniversityShenzhen 518060People’s Republic of China Canadian Light Source Inc. SaskatoonSK S7N 0X4Canada Instrumental Analysis Center of Shenzhen University(Lihu Campus) Shenzhen UniversityShenzhen 518055People’s Republic of China

Constructing the efficacious and applicable bifunctional electrocatalysts and establishing out the mechanisms of organic electro-oxidation by replacing anodic oxygen evolution reaction(OER) are critical to the development of electrochemicallydriven technologies for efficient hydrogen production and avoid CO_(2) emission. Herein, the hetero-nanocrystals between monodispersed Pt(~ 2 nm) and Ni_(3)S_(2)(~ 9.6 nm) are constructed as active electrocatalysts through interfacial electronic modulation, which exhibit superior bi-functional activities for methanol selective oxidation and H_(2) generation. The experimental and theoretical studies reveal that the asymmetrical charge distribution at Pt–Ni_(3)S_(2) could be modulated by the electronic interaction at the interface of dual-monodispersed heterojunctions, which thus promote the adsorption/desorption of the chemical intermediates at the interface. As a result, the selective conversion from CH_(3)OH to formate is accomplished at very low potentials(1.45 V) to attain 100 m A cm^(-2) with high electronic utilization rate(~ 98%) and without CO_(2) emission. Meanwhile, the Pt–Ni_(3)S_(2) can simultaneously exhibit a broad potential window with outstanding stability and large current densities for hydrogen evolution reaction(HER) at the cathode. Further, the excellent bi-functional performance is also indicated in the coupled methanol oxidation reaction(MOR)//HER reactor by only requiring a cell voltage of 1.60 V to achieve a current density of 50 m A cm^(-2) with good reusability.

关键词： Dual-monodispersed heterostructure Electronic interactive modulation Reaction mechanism Methanol oxidation reaction Hydrogen generation

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Impact of umbelliprenin-containing niosome nanoparticles on VEGF-A and CTGF genes expression in retinal pigment epithelium cells

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International Journal of Ophthalmology(English edition) 2024年第1期17卷 7-15页

作者： Farzad Dastaviz Akram Vahidi Teymoor Khosravi Ayyoob Khosravi Mehdi Sheikh Arabi Abouzar Bagheri mohsen Rashidi Morteza Oladnabi Stem Cell Research Center Golestan University of Medical SciencesGorgan ***Iran Department of Medical Genetics School of Advanced Technologies in MedicineGolestan University of Medical SciencesGorgan ***Iran Student Research Committee Golestan University of Medical SciencesGorgan ***Iran Department of Molecular Medicine Faculty of Advanced Medical TechnologiesGolestan University of Medical SciencesGorgan ***Iran Department of Medical Nanotechnology Faculty of Advanced Medical TechnologiesGolestan University of Medical SciencesGorgan ***Iran Department of Clinical Biochemistry and Genetics Faculty of MedicineMazandaran University of Medical SciencesSari ***Iran Department Pharmacology Faculty of MedicineMazandaran University of Medical SciencesSari ***Iran Gorgan Congenital Malformations Research Center Golestan University of Medical SciencesGorgan ***Iran

AIM:To investigate the impact of niosome nanoparticles carrying umbelliprenin(UMB),an anti-angiogenic and anti-inflammatory plant compound,on the expression of vascular endothelial growth factor(VEGF-A)and connective tissue growth factor(CTGF)genes in a human retinal pigment epithelium(RPE)-like retina-derived cell ***:UMB-containing niosomes were created,optimized,and ***-like cells were treated with free UMB and UMB-containing *** IC_(50)values of the treatments were determined using an MTT *** expression of VEGF-A and CTGF was evaluated using real-time polymerase chain reaction after RNA extraction and cDNA ***’characteristics,including drug entrapment efficiency,size,dispersion index,and zeta potential were *** UMB had an IC_(50)of 96.2μg/mL,while UMB-containing niosomes had an IC_(50)of 25μg/***:Treatment with UMB-containing niosomes and free UMB resulted in a significant reduction in VEGF-A expression compared to control cells(P=0.001).Additionally,UMB-containing niosomes demonstrated a significant reduction in CTGF expression compared to control cells(P=0.05).However,there was no significant reduction in the expression of both genes in cells treated with free ***:Both free UMB and niosome-encapsulated UMB inhibits VEGF-A and CTGF genes ***,the latter demonstrates significantly greater efficacy,potentially due to the lower UMB dosage and gradual *** findings have implications for anti-angiogenesis therapeutic approaches targeting age-related macular degeneration.

关键词： umbelliprenin niosome age-related macular degeneration vascular endothelial growth factor-A connective tissue growth factor

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Optimization Algorithms for Sidelobes SSL Reduction: A Comparative Study

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Journal of Computer and Communications 2024年第7期12卷 120-132页

作者： mohsen Denden Aymen Alhamdan Department of Computer Science Higher Institute of Applied Sciences of Sousse Sousse University Sousse Tunisia Department of Electrical Computer Engineering Faculty of Engineering King Abdulaziz University Jeddah Saudi Arabia

The development of new technologies in smart cities is often hailed as it becomes a necessity to solve many problems like energy consumption and transportation. Wireless networks are part of these technologies but implementation of several antennas, using different frequency bandwidths for many applications might introduce a negative effect on human health security. In wireless networks, most antennas generate sidelobes SSL. SSL causes interference and can be an additional resource for RF power that can affect human being health. This paper aims to study algorithms that can reduce SSL. The study concerns typical uniform linear antenna arrays. Different optimum side lobe level reduction algorithms are presented. Genetic algorithm GA, Chebyshev, and Particle Swarm Optimization algorithm are used in the optimization process. A comparative study between the indicated algorithms in terms of stability, precision, and running time is shown. Results show that using these algorithms in optimizing antenna parameters can reduce SSL. A comparison of these algorithms is carried out and results show the difference between them in terms of running time and SSL reduction Level.

关键词： SSL Radio Wave Interference SAR Linear Antenna Arrays Genetic Algorithm Chebyshev Particle Swarm Optimization

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Soft multifunctional neurological electronic skin through intrinsically stretchable synaptic transistor

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Nano Research 2024年第7期17卷 6550-6559页

作者： Pengcheng Zhu Shuairong Mu Wenhao Huang Zeye Sun Yuyang Lin Ke Chen Zhifeng Pan mohsen Golbon Haghighi Roya Sedghi Junlei Wang Yanchao Mao Key Laboratory of Materials Physics of Ministry of Education School of Physics and MicroelectronicsZhengzhou UniversityZhengzhou 450001China School of Mechanical and Power Engineering Zhengzhou UniversityZhengzhou 450001China Department of Chemistry Shahid Beheshti UniversityTehran ***Iran

Neurological electronic skin(E-skin)can process and transmit information in a distributed manner that achieves effective stimuli perception,holding great promise in neuroprosthetics and soft *** E-skin with multifunctional perception abilities can enable robots to precisely interact with the complex surrounding ***,current neurological E-skins that possess tactile,thermal,and visual perception abilities are usually prepared with rigid materials,bringing difficulties in realizing biologically synapse-like ***,we report a soft multifunctional neurological E-skin(SMNE)comprised of a poly(3-hexylthiophene)(P3HT)nanofiber polymer semiconductor-based stretchable synaptic transistor and multiple soft artificial sensory receptors,which is capable of effectively perceiving force,thermal,and light *** stretchable synaptic transistor can convert electrical signals into transient channel currents analogous to the biological excitatory postsynaptic *** it also possesses both short-term and long-term synaptic plasticity that mimics the human memory *** integrating a stretchable triboelectric nanogenerator,a soft thermoelectric device,and an elastic photodetector as artificial receptors,we further developed an SMNE that enables the robot to make precise actions in response to various surrounding *** with traditional neurological E-skin,our SMNE can maintain the softness and adaptability of biological synapses while perceiving multiple stimuli including force,temperature,and *** SMNE could promote the advancement of E-skins for intelligent robot applications.

关键词： electronic skin soft stretchable polymer semiconductor synaptic transistor multifunctional

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Comparative analysis of unipolar and bipolar plasma electrolytic oxidation coatings on Al-Mg laminated macro composites

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Transactions of Nonferrous Metals Society of China 2024年

作者： mohsen RASTEGARI Masoud ATAPOUR Aboozar TAHERIZADEH Amin HAKIMIZAD Maryam RAHMATI Department of Materials Engineering Isfahan University of Technology Yekta Mobaddel Pars Co. Science and Technology Campus Yazd University Dental Materials Research Center Dental Research Institute School of Dentistry Isfahan University of Medical Sciences

Al-Mg laminated macro composites （LMC） have garnered attention due to their excellent mechanical properties and low density. However， their weak corrosion resistance has limited their industrial applications. Plasma electrolytic oxidation （PEO） has been explored as a potential solution to this issue by producing hard and thick oxide coatings on the surface of Al-Mg LMCs manufactured through hot extrusion bonding. In this study， PEO coatings were prepared on Al-Mg LMCs using both unipolar and bipolar waveforms in an appropriate electrolyte for both aluminum and magnesium alloys. The techniques of FESEM/EDX， GIXRD， and electrochemical methods of Potentiodynamic polarization and EIS were carried out. The results revealed that the coatings produced using the bipolar waveform exhibited lower porosity and higher thickness than those produced using the unipolar one. The corrosion performance of the specimens' cut edge was investigated using electrochemical impedance spectroscopy （EIS） after 1， 8， and 12 hours of immersion in a 3.5%wt. NaCl solution. It was observed that the coating produced using the bipolar waveform demonstrated the highest corrosion resistance after 12 hours of immersion， with an estimated corrosion resistance of 41.87 kΩ.cm2， which was approximately three times higher than that of the unipolar coating. Notably， no signs of galvanic corrosion were observed in the LMC， and only minor corrosion attacks were observed on the magnesium layer in some areas.

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A Study on the Challenges of Human-Centric Cyber-Security and the Guarantee of Information Quality

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Journal of Information Security 2024年第2期15卷 218-231页

作者： Mohammed Hussein Kurdi mohsen Denden David Paul Department of Cyber-Security National Events Center Riyadh Saudi Arabia Department of Computer and Information Technologies Technical College of Telecommunication and Information Riyadh TCTI Technical and Vocational Training Corporation TVTC Riyadh Saudi Arabia Department of Computer Science Higher Institute of Applied Sciences of Sousse University of Sousse Sousse Tunisia School of Science & Technology University of New England Armidale Australia

Information security and quality management are often considered two different fields. However, organizations must be mindful of how software security may affect quality control. This paper examines and promotes methods through which secure software development processes can be integrated into the Systems Software Development Life-cycle (SDLC) to improve system quality. Cyber-security and quality assurance are both involved in reducing risk. Software security teams work to reduce security risks, whereas quality assurance teams work to decrease risks to quality. There is a need for clear standards, frameworks, processes, and procedures to be followed by organizations to ensure high-level quality while reducing security risks. This research uses a survey of industry professionals to help identify best practices for developing software with fewer defects from the early stages of the SDLC to improve both the quality and security of software. Results show that there is a need for better security awareness among all members of software development teams.

关键词： Cyber Security Development Methodology Information Quality Human-Centric SDLC Quality Assurance

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Rescue of p53 functions by in vitro-transcribed mRNA impedes the growth of high-grade serous ovarian cancer

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Cancer Communications 2024年第1期44卷 101-126页

作者： Monika Raab Izabela Kostova Samuel Peña-Llopis Daniela Fietz Monika Kressin Seyed mohsen Aberoumandi Evelyn Ullrich Sven Becker Mourad Sanhaji Klaus Strebhardt Department of Gynecology Medical SchoolGoethe-UniversityFrankfurt am MainGermany Translational Genomics in Solid Tumors West German Cancer CenterUniversity HospitalEssenGermany German Cancer Consortium(DKTK) EssenGermany German Cancer Research Center(DKFZ) HeidelbergGermany Histology and Embryology Institute for Veterinary AnatomyGiessenGermany Franfurt Cancer Institute(FCI) Goethe UniversityFrankfurt am MainGermany German Cancer Consortium(DKTK) Partner site Frankfurt/Mainza partnership between DKFZ and University Hospital FrankfurtFrankfurt am MainGermany Experimental Immunology Department for Children and Adolescents MedicineUniversity Hospital FrankfurtGoethe UniversityFrankfurt am MainGermany

Background:The cellular tumor protein p53(TP53)is a tumor suppressor gene that is frequently mutated in human *** various cancer types,the very aggressive high-grade serous ovarian carcinoma(HGSOC)exhibits the high-est prevalence of TP53 mutations,present in>96%of *** intensive efforts to reactivate p53,no clinical drug has been approved to rescue p53 *** this study,our primary objective was to administer in vitro-transcribed(IVT)wild-type(WT)p53-mRNA to HGSOC cell lines,primary cells,and ortho-topic mouse models,with the aim of exploring its impact on inhibiting tumor growth and dissemination,both in vitro and in ***:To restore the activity of p53,WT p53 was exogenously expressed in HGSOC cell lines using a mammalian vector ***,IVT WT p53 mRNA was delivered into different HGSOC model systems(primary cells and patient-derived organoids)using liposomes and studied for proliferation,cell cycle progression,apoptosis,colony formation,and chromosomal *** alterations induced by p53 mRNA were analyzed using RNA sequencing in OVCAR-8 and primary HGSOC cells,followed by ingenuity path-way *** vivo effects on tumor growth and metastasis were studied using orthotopic xenografts and metastatic intraperitoneal mouse ***:Reactivation of the TP53 tumor suppressor gene was explored in differ-ent HGSOC model systems using newly designed IVT mRNA-based *** introduction of WT p53 mRNA triggered dose-dependent apoptosis,cell cycle arrest,and potent long-lasting inhibition of HGSOC cell *** analysis of OVCAR-8 cells upon mRNA-based p53 reactivation revealed significant alterations in gene expression related to p53 signaling,such as apoptosis,cell cycle regulation,and DNA *** p53 function concurrently reduces chromosomal instability within the HGSOC cells,under-scoring its crucial contribution in safeguarding genomic integrity by moderating the baselin

关键词： apoptosis cell cycle chromosomal instability HGSOC metastatic intraperitoneal mouse model HGSOC orthotopic Xenograft model high-grade serous ovarian cancer in vitro-transcribed p53-mRNA liposomal IVT mRNA delivery system patient-derived organoid patient-derived primary cancer cell

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Spatial analysis of animal bites in Iran(2015-2020):A cross-sectional study

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Journal of Acute Disease 2024年第2期13卷 67-73页

作者： Hoda Amiri Khadijeh Yazdanparast mohsen Pourkhosravani Maryam Rastegar Department of Environmental Health Engineering School of HealthShiraz University of Medical SciencesShirazIran Department of Geography and Urban Planning Shahid Bahonar University of KermanIran Department of Biostatistics School of HealthMashhad University of Medical SciencesMashhadIran

Objective:To investigate the distribution pattern of animal bites in Mirjaveh,Iran from 2015 to ***:The data on animal bites were collected from the Department of Infectious Diseases,the provincial health *** climatic data on precipitation and temperature during the study period were also *** correlation between incidence and temperature,precipitation rate,land type,and altitude was also ***:The results showed that men were more affected by animal bites than women(76.4%,P<0.001),and the highest incidence rate occurred in the age group of 5-19 *** incidence rate of animal bites was found to be correlated with temperature and *** increase in temperature was associated with a rise in the incidence rate of animal *** number of animal bites increased until 2019,possibly due to an increase in the number of dogs in the ***:Targeted interventions should be implemented to reduce the incidence of animal bites,particularly among children,housewives,and *** access to appropriate treatments,increasing public awareness of the hazards of animal bites,and increasing the number of vaccinated dogs in the area are essential strategies to be considered.

关键词： Animal bites Epidemiology Zoonotic disease Iran

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Country-based modelling of COVID-19 case fatality rate:A multiple regression analysis

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World Journal of Virology 2024年第1期13卷 84-94页

作者： Soodeh Sagheb Ali Gholamrezanezhad Elizabeth Pavlovic mohsen Karami Mina Fakhrzadegan Department of Radiology Seattle Children's HospitalUniversity of WashingtonSeattleWA 98145United States Department of Radiology Keck School of MedicineUniversity of Southern CaliforniaLos AngelesCA 90033United States Department of Nursing University of New BrunswickNew Brunswick E3B 5A3Canada Department of Orthopedics Taleghani HospitalShahid Beheshti University of Medical SciencesTehran ***Iran

BACKGROUND The spread of the severe acute respiratory syndrome coronavirus 2 outbreak worldwide has caused concern regarding the mortality rate caused by the *** determinants of mortality on a global scale cannot be fully understood due to lack of *** To identify key factors that may explain the variability in case lethality across *** We identified 21 Potential risk factors for coronavirus disease 2019(COVID-19)case fatality rate for all the countries with available *** examined univariate relationships of each variable with case fatality rate(CFR),and all independent variables to identify candidate variables for our final multiple *** regression analysis technique was used to assess the strength of *** The mean of COVID-19 mortality was 1.52±1.72%.There was a statistically significant inverse correlation between health expenditure,and number of computed tomography scanners per 1 million with CFR,and significant direct correlation was found between literacy,and air pollution with *** final model can predict approximately 97%of the changes in *** The current study recommends some new predictors explaining affect mortality ***,it could help decision-makers develop health policies to fight COVID-19.

关键词： COVID-19 SARS-CoV-2 Case fatality rate Predictive model Multiple regression

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Parallel Inference for Real-Time Machine Learning Applications

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Journal of Computer and Communications 2024年第1期12卷 139-146页

作者： Sultan Al Bayyat Ammar Alomran mohsen Alshatti Ahmed Almousa Rayyan Almousa Yasir Alguwaifli College of Computer Science and Information Technology Imam Abdulrahman Bin Faisal University Dammam Saudi Arabia

Hyperparameter tuning is a key step in developing high-performing machine learning models, but searching large hyperparameter spaces requires extensive computation using standard sequential methods. This work analyzes the performance gains from parallel versus sequential hyperparameter optimization. Using scikit-learn’s Randomized SearchCV, this project tuned a Random Forest classifier for fake news detection via randomized grid search. Setting n_jobs to -1 enabled full parallelization across CPU cores. Results show the parallel implementation achieved over 5× faster CPU times and 3× faster total run times compared to sequential tuning. However, test accuracy slightly dropped from 99.26% sequentially to 99.15% with parallelism, indicating a trade-off between evaluation efficiency and model performance. Still, the significant computational gains allow more extensive hyperparameter exploration within reasonable timeframes, outweighing the small accuracy decrease. Further analysis could better quantify this trade-off across different models, tuning techniques, tasks, and hardware.

关键词： Machine Learning Models Computational Efficiency Parallel Computing Systems Random Forest Inference Hyperparameter Tuning Python Frameworks (TensorFlow PyTorch Scikit-Learn) High-Performance Computing

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