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Cellular & Molecular Immunology 2018年第12期15卷 1074-1076页

作者： mohan s.maddur srini V.Kaveri Jagadeesh Bayry Institut National de la santéet de la Recherche Médicale Paris F-75006France Centre de Recherche des Cordeliers EquipeImmunopathologie et Immunointervention ThérapeutiqueParis F-75006France sorbonne Université Paris F-75006France UniversitéParis Descartes Sorbonne Paris CitéParis F-75006France Present address:Pfizer Inc.Pearl RiverNew YorkNYUSA

Dendritic cells(DCs)are the master regulators of the immune response and engage in constant cross-talk with other immune cells to initiate an appropriate immune *** outcome of cross-talk with various immune cells towards DC functions has been shown to be dependent on the particular subset of cells and their activation *** we show that for human B cells to induce maturation of DCs with an enhanced T-cell stimulatory capacity,B-cell receptor(BCR)signaling is sufficient for memory B-cells,whereas additional CD40 signaling is required for naïve B cells to induce complete activation of DCs.

关键词： activation immune maturation

Intravenous immunoglobulin-mediated expansion of regulatory T cells in autoimmune patients is associated with increased prostaglandin E2 levels in the circulation

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Cellular & Molecular Immunology 2015年第5期12卷 650-652页

作者： mohan s maddur Jamma Trinath Magalie Rabin Francis Bolgert Moneger Guy Jean-Michel Vallat Laurent Magy Kithiganahalli N Balaji srini V Kaveri Jagadeesh Bayry Institut National de la sante et de la Recherche Medicale Paris France Centre de Recherche des Cordeliers Equipe - Immunopathology and Therapeutic Immunointervention Paris France sorbonne Universites - UPMC Univ Paris 6 Paris France Universite Paris Descartes Paris France Department of Microbiology and Cell Biology Indian Institute of Science Bangalore India Centre de Reference 'Neuropathies Peripheriques Rares' et service de Neurologie Hopital Universitaire Limoges Limoges France Reanimation Neurologique Neurologie 1 Hopital de la Pitie-Salpetriere Paris France International Associated Laboratory IMPACT (Institut National de la sante et de la Recherche Medicale France -Indian Council of Medical Research India) National Institute of Immunohaematology Mumbai India

CD4＋FoxP3＋ regulatory T cells （Tregs） are immunosuppressive cells that are critical for immune tolerance. several studies have demonstrated that one of the anti-inflammatory mechanisms of action of intravenous immunoglobulin （Wig） involves the expansion of Tregs. Recently, we demonstrated that IVIgmediated Treg expansion involves the cyclooxygenase-2 （COX-2）-dependent induction of prostaglandin E2 （PGE2） in human dendritic cells （DCs）. However, the validity of these findings in autoimmune patients is lacking.

关键词： associated increased prostaglandin

Combining stochastic density functional theory with deep potential molecular dynamics to study warm dense matter

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Matter and Radiation at Extremes 2024年第1期9卷 44-57页

作者： Tao Chen Qianrui Liu Yu Liu Liang sun mohan Chen HEDPs CAPTCollege of Engineering and School of PhysicsPeking UniversityBeijing 100871People’s Republic of China

In traditional finite-temperature Kohn–sham density functional theory(KsDFT),the partial occupation of a large number of high-energy Ks eigenstates restricts the use of first-principles molecular dynamics methods at extremely high ***,stochastic density functional theory(sDFT)can overcome this ***,sDFT and the related mixed stochastic–deterministic density functional theory,based on a plane-wave basis set,have been implemented in the first-principles electronic structure software ABACUs[*** and ***,***.B 106,125132(2022)].In this study,we combine sDFT with the Born–Oppenheimer molecular dynamics method to investigate systems with temperatures ranging from a few tens of eV to 1000 ***,we train machine-learning-based interatomic models using the sDFT data and employ these deep potential models to simulate large-scale systems with long ***,we compute and analyze the structural properties,dynamic properties,and transport coefficients of warm dense matter.

关键词： stochastic theory functional

Nanoparticle delivery for central nervous system diseases and its clinical application

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Nano Research 2024年第7期17卷 6305-6322页

作者： Lin Tang Rui Zhang Yusi Wang mohan Liu Die Hu Yuanda Wang Li Yang Department of Biotherapy Cancer Center and State Key Laboratory of BiotherapyWest China HospitalSichuan UniversityChengdu 610041China

In the treatment of central nervous system(CNs)diseases such as glioma,Alzheimer's disease(AD)and Parkinson's disease(PD),drugs are expected to reach specific areas of the brain to achieve the desired *** a growing number of therapeutic targets have been identified in preclinical studies,the ones that can ultimately be used in the clinic are ***,the research process and clinical application of drugs for treating CNs diseases are still large *** barriers such as the blood‒brain barrier(BBB)act as selective permeable membranes,allowing only certain molecules to enter the brain;this barrier is the major obstacle restricting the arrival of most drugs to brain ***,nanoparticles,including lipid-based,cell-derived biomimetic,polymeric and inorganic nanoparticles,have gained increasing attention because of their ability to cross physiological barriers,and could play an important role as delivery carriers and ***,clinical applications of nanoparticles in CNs diseases are *** review focuses on the progress of current research on the use of nanoparticles for the treatment of CNs diseases to provide additional insight into the treatment of CNs diseases.

关键词： nanoparticles central nervous system(CNs)diseases clinical applications delivery carriers immunomodulators

Comparison of the Anatomy and Adaptability of Reconstructed Teeth with Natural Teeth:An Innovative Approach in Forensic Dentistry

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Journal of Forensic science and Medicine 2024年第1期10卷 47-54页

作者： supraja s P M Tejaswi Ravikanth Manyam mohan Kumar Pasupuleti swetha P Ramesh Kumar Budumuru Department of Oral and Maxillofacial Pathology Vishnu Dental CollegeBhimavaramAndhra PradeshIndia Vishnu Dental College BhimavaramAndhra PradeshIndia Department of Periodontics and Implantology Vishnu Dental CollegeBhimavaramAndhra PradeshIndia Department of Oral Medicine and Radiology Vishnu Dental CollegeBhimavaramAndhra PradeshIndia

Background:Forensic tooth reconstruction is the technique of reconstructing the morphology of a missing tooth from the intra-alveolar morphology of dental sockets from skeletal *** and Objectives:The aim and objective of the study are to compare and investigate whether the anatomy and adaptability of reconstructed teeth simulate with the natural tooth and to investigate whether the dental materials have potential in reconstruction of *** and Methods:An in vitro experimental study was undertaken on a human *** to the Fédération Dentaire Internationale,charting will be done based on the number of teeth *** entire study will be conducted in three phases using dental *** 1 comprised preparation for negative replica,where an impression will be taken,Phase 2 comprised preparation of a positive replica or cast,and Phase 3 comprised tooth reconstruction using the flowable ***:The specimen tooth(which had been taken from its socket)and the newly constructed tooth were compared,and when the length of the newly constructed root was measured using digital vernier calipers,there was a disparity of 0.5-1 *** cone-beam computed tomography radiographs demonstrated the necessary ***:The present study demonstrated that dental information can be obtained even when teeth are absent postmortem by making an attempt to recreate the teeth using dental materials while documenting the intra-alveolar anatomy of the dental root socket.

关键词： Adaptability anatomy reconstruction teeth

Determining the Checkpoint of Transition from Thin to Thick Periodontal Phenotypes in the Maxillary and Mandibular Anterior Regions of south Indian Population

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Journal of Forensic science and Medicine 2024年第1期10卷 55-61页

作者： mohan Kumar Pasupuleti Rasagna Chowdary G Gautami sPenmetsa Vivek Bypalli Ramesh s.V.Konathala sruthima N.V.s.Gottumukkala Department of Periodontics and Implantology Vishnu Dental CollegeBhimavaramAndhra PradeshIndia2Vishnu Dental CollegeBhimavaramAndhra PradeshIndia

Aim:The aim of this study was to compare and investigate the tissue thickness at the maxillary and mandibular central incisors utilizing the probe visibility method and traditional way of measuring gingival thickness(GT)by endodontic ***:In 200 selected patients,the GT was measured at both the maxillary and mandibular anterior using an endodontic file after local infiltration at the mid-distance from the gingival margin to the mucogingival *** checkpoint of transition from thin to thick periodontal phenotype was determined by probe visibility method in the following age groups:Group A:21-30 years;Group B:31-40 years;Group C:41-50 years;and Group D:51-60 ***:GT varied from 0.3 to 1.9 *** translucency was observed up to the thickness of 0.7 *** 0.8 mm of GT,there was no probe ***:According to the present research,the gingiva appears transparent up to a thickness of around 0.7 *** checkpoint of transition between thin and thick periodontal phenotypes at both the maxillary and mandibular anterior was associated with a GT of 0.8 mm.

关键词： Gingiva periodontal phenotype probe visibility

Multiplexed fluorescence and scatter detection with single cell resolution using on-chip fiber optics for droplet microfluidic applications

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Microsystems & Nanoengineering 2024年第2期10卷 207-218页

作者： Preksha Gupta Ambili mohan Apurv Mishra Atindra Nair Neeladri Chowdhury Dhanush Balekai Kavyashree Rai Anil Prabhakar Taslimarif saiyed Discovery Innovation Accelerator Centre for Cellular and Molecular PlatformsBellary RoadBengaluru560065KarnatakaIndia Department of Electrical Engineering Indian Institute of Technology MadrasChennai600036Tamil NaduIndia

Droplet microfluidics has emerged as a critical component of several high-throughput single-cell analysis techniques in biomedical research and *** significant progress in the development of individual assays,multiparametric optical sensing of droplets and their encapsulated contents has been *** current approaches,most commonly involving microscopy-based high-speed imaging of droplets,are technically complex and require expensive instrumentation,limiting their widespread *** address these limitations,we developed the OptiDrop platform;this platform is a novel optofluidic setup that leverages the principles of flow *** platform enables on-chip detection of the scatter and multiple fluorescence signals from the microfluidic droplets and their contents using optical *** highly customizable on-chip optical fiber-based signal detection system enables simplified,miniaturized,low-cost,multiparametric sensing of optical signals with high sensitivity and single-cell resolution within each *** demonstrate the ability of the OptiDrop platform,we conducted a differential expression analysis of the major histocompatibility complex(MHC)protein in response to IFNγ*** results showed the platform’s ability to sensitively detect cell surface biomarkers using fluorescently labeled ***,the OptiDrop platform combines the versatility of flow cytometry with the power of droplet microfluidics to provide wide-ranging,scalable optical sensing solutions for research and diagnostics.

关键词： scatter enable resolution

Enhancing security in QR Code Technology Using AI: Exploration and Mitigation strategies

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International Journal of Intelligence science 2024年第2期14卷 49-57页

作者： saranya Vaithilingam santhosh Aradhya mohan shankar Department of Information Technology University of the Cumberlands Williamsburg KY USA

The widespread adoption of QR codes has revolutionized various industries, streamlined transactions and improved inventory management. However, this increased reliance on QR code technology also exposes it to potential security risks that malicious actors can exploit. QR code Phishing, or “Quishing”, is a type of phishing attack that leverages QR codes to deceive individuals into visiting malicious websites or downloading harmful software. These attacks can be particularly effective due to the growing popularity and trust in QR codes. This paper examines the importance of enhancing the security of QR codes through the utilization of artificial intelligence (AI). The abstract investigates the integration of AI methods for identifying and mitigating security threats associated with QR code usage. By assessing the current state of QR code security and evaluating the effectiveness of AI-driven solutions, this research aims to propose comprehensive strategies for strengthening QR code technology’s resilience. The study contributes to discussions on secure data encoding and retrieval, providing valuable insights into the evolving synergy between QR codes and AI for the advancement of secure digital communication.

关键词： Artificial Intelligence Cyber security QR Codes Quishing AI Framework Machine Learning AI-Enhanced security

Need for operational simplicity and timely disbursal of benefits—a qualitative exploration of the implementation of a direct benefit transfer scheme for persons with tuberculosis in India

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贫困所致传染病(英文) 2024年第3期13卷 1-15页

作者： mohan Malu Thangaraj Jeromie W. V. Pandey sumit Priya G. sri Lakshmi Arunachalam sivavallinathan sharma Rahul shewade Hemant Deepak Aishwarya B. Afeeq K. Khatoon Afsana Gokulvijay B. sireesha Gude Chandra Kavita Nandhakumar s. samuel Prince Viswanathan C. Nanditha shanmugasundaram Devika Rao Raghuram Murhekar Manoj V. Jeyashree Kathiresan Indian Council of Medical Research-National Institute of Epidemiology R-127 TNHB Ayapakkam Chennai Tamil Nadu India TB support Network WHO Country Office for India New Delhi India Central Tuberculosis Division Government of India New Delhi India

Background Ni-kshay Poshan Yojana (NPY) is a direct benefit transfer scheme of the Government of India introduced in 2018 to support the additional nutritional requirements of persons with TB (PwTB). Our recent nationwide evaluation of implementation and utilization of NPY using programmatic data of PwTB from nine randomly selected Indian states, reported a 70% coverage and high median delay in benefit credit. We undertook a qualitative study between January and July 2023, to understand the detailed implementation process of NPY and explore the enablers and barriers to effective implementation and utilization of the NPY *** We followed a grounded theory approach to inductively develop theoretical explanations for social phenomena through data generated from multiple sources. We conducted 36 in-depth interviews of national, district and field-level staff of the National Tuberculosis Elimination Programme (NTEP) and NPY beneficiaries from 30 districts across nine states of India, selected using theoretical sampling. An analytical framework developed through inductive coding of a set of six interviews, guided the coding of the subsequent interviews. Categories and themes emerged through constant comparison and the data collection continued until theoretical *** stakeholders perceived NPY as a beneficial initiative. strong political commitment from the state administration, mainstreaming of NTEP work with the district public healthcare delivery system, availability of good geographic and internet connectivity and state-specific grievance redressal mechanisms and innovations were identified as enablers of implementation. However, the complex, multi-level benefit approval process, difficulties in accessing banking services, perceived inadequacy of benefits and overworked human resources in the NTEP were identified as barriers to implementation and *** The optimal utilization of NPY is enabled by strong political commitment and

关键词： National Tuberculosis Elimination Programme Nutritional status Direct benefit transfer Ni-kshay Poshan Yojana Implementation Cash transfer scheme Grounded theory India

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碳化材料的烧蚀性能参数辨识方法

北京航空航天大学学报 2024年第4期50卷 1384-1391页

作者：程莫瀚李文光王志北京理工大学宇航学院北京100081

针对碳化材料烧蚀性能参数测量难度大的问题,对基于优化算法的烧蚀性能参数辨识方法进行了研究。根据一维连续模型描述碳化烧蚀材料的内部热响应情况,与公开试验数据进行对比验证,各测量点计算误差均小于15%。采用基函数表征法对材料碳... 详细信息

针对碳化材料烧蚀性能参数测量难度大的问题,对基于优化算法的烧蚀性能参数辨识方法进行了研究。根据一维连续模型描述碳化烧蚀材料的内部热响应情况,与公开试验数据进行对比验证,各测量点计算误差均小于15%。采用基函数表征法对材料碳化前后的比热容和导热率进行表征,基函数选取为切比雪夫多项式。根据PICA材料的温度测试试验数据,对材料的热解动力学参数和基函数的待定系数采用遗传算法进行辨识,将辨识得到的材料烧蚀性能参数代入一维连续模型中进行计算,与验证工况下的试验数据进行比对,计算得到的温度曲线平均相对误差小于10%。

关键词：热防护材料烧蚀性能参数辨识优化算法数值计算