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Mechanical suppression of breast cancer cell invasion and paracrine signaling to osteoclasts requires nucleo-cytoskeletal connectivity

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Bone Research 2020年第4期8卷 393-405页

作者： Xin Yi Laura E.Wright Gabriel M.Pagnotti Gunes Uzer Katherine M.Powell Joseph M.Wallace Uma Sankar Clinton T.Rubin Khalid mohammad Theresa A.Guise William R.Thompson Department of Physical Therapy School of Health and Rehabilitation SciencesIndiana UniversityIndianapolisIN 46202USA Department of Medicine Division of EndocrinologySchool of MedicineIndiana UniversityIndianapolisIN 46202USA Department of Mechanical and Biomedical Engineering Boise State UniversityBoiseID 83725USA Department of Biomedical Engineering Purdue School of Engineering and TechnologyPurdue UniversityIndianapolisIN 46202USA Department of Anatomy&Cell Biology Indiana UniversityIndianapolisIN 46202USA Department of Biomedical Engineering Stony Brook UniversityStony BrookNY 11794USA

Exercise benefits the musculoskeletal system and reduces the effects of *** effects of exercise are multifactorial,where metabolic changes and tissue adaptation influence *** signals,a principal component of exercise,are anabolic to the musculoskeletal system and restrict cancer *** examined the mechanisms through which cancer cells sense and respond to low-magnitude mechanical signals introduced in the form of ***-magnitude,high-frequency vibration was applied to human breast cancer cells in the form of low-intensity vibration(LIV).LIV decreased matrix invasion and impaired secretion of osteolytic factors PTHLH,IL-11,and ***,paracrine signals from mechanically stimulated cancer cells,reduced osteoclast differentiation and resorptive *** the nucleus by knockdown of SUN1 and SUN2 impaired LIV-mediated suppression of invasion and osteolytic factor *** increased cell stiffness;an effect dependent on the LINC *** data show that mechanical vibration reduces the metastatic potential of human breast cancer cells,where the nucleus serves as a mechanosensory apparatus to alter cell structure and intercellular signaling.

关键词： invasion impaired skeletal

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Severe progression of autoimmune hepatitis in a young COVID-19 adult patient: A case report

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Journal of Acute Disease 2022年第4期11卷 161-164页

作者： Neeraj Kumar Sushant Satyapriya Shaik mohammad Tahaseen Kunal Singh Abhyuday Kumar Department of Trauma&Emergency AIIMS PatnaBiharIndia801505 Department of Anaesthesiology AIIMS PatnaBiharIndia801505 Department of Medicine AIIMS PatnaBiharIndia801505

Rationale:The impact of COVID-19 in patients with autoimmune liver disease treated with immunosuppressive therapy has not been described so *** case report describes the clinical course of a patient with autoimmune hepatitis(AIH)who developed COVID-19 and the features of cytokine syndrome leading to its deterioration in our intensive care ***’s Concern:A 28-year-old male presented with generalized anasarca for two weeks and chronic liver disease for 8 ***:AIH and Covid-19 with features of cytokine storm ***:Intravenous furosemide,mannitol,syrup lactulose,steroids(prednisolone 40 mg),azathioprine 1 mg/kg body weight,rifaximin,vitamin K,and blood ***:The patient had hepatic encephalopathy and AIH and died on the 10th day after admission despite ventilatory support,sustained low-efficiency hemodialysis,and ***:The dramatic release of cytokines and the inflammatory‐immune responses not only alter the pathophysiology but also affects the onset and severity of disease progression in patients with AIH.

关键词： COVID-19 Autoimmune hepatitis Cytokine storm syndrome Immunosuppressant drugs Liver dysfunction

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Forecasting COVID-19 situation in Bangladesh

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Biosafety and Health 2022年第1期4卷 6-10页

作者： Mossamet Kamrun Nesa Md.Rashed Babu mohammad Tareq Mamun Khan Department of Statistics Shahjalal University of Science and TechnologySylhet 3114Bangladesh Moulvibazar Government Women College Moulvibazar 3203Bangladesh

Forecasting the COVID‐19 confirmed cases,deaths,and recoveries demands time to know the severity of the novel *** research aims to predict all types of COVID‐19 cases(verified people,deaths,and recoveries)from the deadliest 3rd wave data of the COVID‐19 pandemic in *** used the official website of the Directorate General of Health Services as our data *** identify and predict the upcoming trends of the COVID‐19 situation of Bangladesh,we fit the Auto‐Regressive Integrated Moving Average(ARIMA)model on the data from Mar.01,2021 to Jul.31,*** finding of the ARIMA model(forecast model)reveals that infected,deaths,and recoveries number will have experienced exponential growth in Bangladesh to October *** model reports that confirmed cases and deaths will escalate by four times,and the recoveries will improve by five times at a later point in October 2021 if the trend of the three scenarios of COVID‐19 from March to July *** prediction of the COVID‐19 scenario for the next three months is very frightening in Bangladesh,so the strategic planner and field‐level personnel need to search for suitable policies and strategies and adopt these for controlling the mass transmission of the virus.

关键词： COVID‐19 ARIMA model Forecast Confirmed cases Deaths Recoveries

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Calculation of dpa rate in graphite box of Tehran Research Reactor(TRR)

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Nuclear Science and Techniques 2019年第6期30卷 44-56页

作者： Mohamad Amin Amirkhani Mohsen Asadi Asadabad Mostafa Hassanzadeh Seyed mohammad Mirvakili Ali mohammadi Reactor and Nuclear Safety Research School Nuclear Science and Technology Research Institute Tehran Iran Department of Physics Arak University Arak Iran

Radiation damage is an important factor that must be considered while designing nuclear facilities and nuclear materials. In this study, radiation damage is investigated in graphite, which is used as a neutron reflector in the Tehran Research Reactor (TRR) core. Radiation damage is shown by displacement per atom (dpa) unit. A cross section of the material was created by using the SPECOMP code. The concentration of impurities present in the non-irradiated graphite was measured by using the ICP-AES method. In the present study the MCNPX code had identified the most sensitive location for radiation damage inside the reactor core. Subsequently, the radiation damage (spectral-averaged dpa values) in the aforementioned location was calculated by using the SPECTER, SRIM Monte Carlo codes, and Norgett, Robinson and Torrens (NRT) model. The results of “Ion Distribution and Quick Calculation of Damage”(QD) method groups had a minor difference with the results of the SPECTER code and NRT model. The maximum radiation damage rate calculated for the graphite present in the TRR core was 1.567 9 10^-8 dpa/s. Finally, hydrogen retention was calculated as a function of the irradiation time.

关键词： Radiation damage Graphite SPECTER SRIM MCNPX Tehran Research Reactor

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Effect of injection angle,density ratio,and viscosity on droplet formation in a microfluidic T-junction

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Theoretical & Applied Mechanics Letters 2017年第4期7卷 243-251页

作者： mohammad Yaghoub Abdollahzadeh Jamalabadi mohammadreza Daqiq Shirazi Ali Kosar Mostafa Safdari Shadloo Department of Mechanical Robotics and Energy Engineering Dongguk University Seou104620 Republic of Korea School of Mechanical Engineering College of Engineering University of Tehran Tehran Iran Mechatronics Engineering Program Faculty of Engineering and Natural Sciences Sabanci University Tuzla Istanbu134956 Turkey CORIA-UMR 6614 Normandie University CNRS-University and INSA of Rouen 76000 Rouen France

The T-junction microchannel device makes available a sharp edge to form micro-droplets from biomaterial solutions. This article investigates the effects of injection angle, flow rate ratio, density ratio,viscosity ratio, contact angle, and slip length in the process of formation of uniform droplets in microfluidic T-junctions. The governing equations were solved by the commercial software. The results show that contact angle, slip length, and injection angles near the perpendicular and parallel conditions have an increasing effect on the diameter of generated droplets, while flow rate, density and viscosity ratios, and other injection angles had a decreasing effect on the diameter.

关键词： Microfluidics Droplet formation Flow rate ratio Density ratio

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A review of guidelines,recommendations,and framework of men’s preconception care

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Reproductive and Developmental Medicine 2022年第4期6卷 254-259页

作者： Zeinab Rabiei mohammad Shariati Naser Mogharabian Rahim Tahmasebi Ashraf Ghiasi Zahra Motaghi Student Research Committee School of Nursing and MidwiferyShahroud University of Medical SciencesShahroudIran Department of Community Medicine Tehran University of Medical SciencesTehranIran Infertility Fellowship Sexual Health and Fertility Research CenterShahroud University of Medical SciencesShahroudIran Department of Biostatistics Bushehr University of Medical SciencesBushehrIran Department of Midwifery School of Nursing and MidwiferyBirjand University of Medical SciencesBirjandIran Department of Reproductive Health School of Nursing and MidwiferyShahroud University of Medical SciencesShahroudIran

The focus of men’s health is within the context of preconception health and primary care,which involves a new method of engaging men’s attention to their preconception and general *** aim of this review research is to offer health care practitioners a complete framework for men’s preconception *** 2000 to October 2021,researchers examined electronic databases such as Web of Science,PubMed,Scopus,ScienceDirect,ProQuest,Cochrane,SAGE,Springer,UpToDate,and Google Scholar for published papers on men’s preconception *** independent authors assessed the quality of the included studies using techniques suitable for this type of *** 14 of the 835 studies that were found in the original search matched the inclusion *** responsibility across the life span(evaluation of reproductive life plan,acquiring information about contraception)and risk assessment(age,medical and surgical history,medications,family history and genetic risks,social history,sexual health assessment,physical examination,laboratory testing,mental health,and intimate partner violence)are the two main topics of preconception care in men according to a review of *** findings clearly demonstrated the critical components of a comprehensive preconception care approach for ***,preconception care for men remains a developing *** research is required to develop standards for evaluating males during the preconception period.

关键词： Guidelines Men Preconception Care Recommendations

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Cerebral state index versus Glasgow coma scale as a predictor for in-hospital mortality in brain-injured patients

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Chinese Journal of Traumatology 2014年第4期17卷 220-224页

作者： Mehrdad Mahdian mohammad Reza Fazel Esmaeil Fakharian Hossein Akbari Soroush Mahdian Trauma Research Center Kashan University of Medical Sciences Kashan I.R.Iran Student Research Committee Arak University of Medical Sciences Arak I.R.Iran

Objective：To compare the value of Glasgow coma scale （GCS） and cerebral state index （CSI）on predicting hospital discharge status of acute braininjured ***：In 60 brain-injured patients who did not receive sedatives,GCS and CSI were measured daily during the first 10 days of *** outcome of prognostic cut-off points was calculated by GCS and CSI using receiver operating characteristic （ROC） curve regarding the time of admission and third day of ***,specificity and other predictive values for both indices were ***：Of the 60 assessed patients,14 patients had mild,13 patients had moderate and 33 patients had severe *** the course of the study,17 patients （28.3％） deteriorated in their situation and *** mean GCS and CSI in patients who deceased during hospitalization was significantly lower than those who were discharged from the ***＜4.5 and CSI＜64.5 at the time of admission was associated with higher mortality risk in traumatic brain injury patients and GCS was more sensitive than CSI to predict in-hospital death in these *** the first day of hospitalization,the area under ROC curve was 0.947 for GCS and 0.732 for ***：GCS score at ICU admission is a good predictor of in-hospital ***＜4.5 and CSI＜64.5 at the time of admission is associated with higher mortality risk in traumatic brain injury patients and GCS is more sensitive than CSI in predicting death in these patients.

关键词： Brain injuries Glasgow coma scale Outcome assessment

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Tumor microenvironment: an evil nexus promoting aggressive head and neck squamous cell carcinoma and avenue for targeted therapy

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Signal Transduction and Targeted Therapy 2021年第2期6卷 324-338页

作者： Ajaz A.Bhat Parvaiz Yousuf Nissar A.Wani Arshi Rizwan Shyam S.Chauhan Mushtaq A.Siddiqi Davide Bedognetti Wael EI-Rifai Michael P.Frenneaux Surinder K.Batra mohammad Haris Muzafar A.Macha Functional and Molecular Imaging Laboratory Cancer Research DepartmentSidra MedicineDohaQatar Department of Zoology School of Life SciencesCentral University of KashmirGanderbalJammu&KashmirIndia Department of Nephrology All India Institute of Medical SciencesNew DelhiIndia Department of Biochemistry All India Institute of Medical SciencesNew DelhiIndia Watson-Crick Centre for Molecular Medicine Islamic University of Science and TechnologyAwantiporaJammu&KashmirIndia Laboratory of Cancer Immunogenomics Cancer Research DepartmentSidra MedicineDohaQatar Department of Surgery University of MiamiMiamiFLUSA Academic Health System Hamad Medical CorporationDohaQatar Department of Biochemisty and Molecular Biology University of Nebraska Medical CenterOmahaNEUSA Eppley Institute for Research in Cancer and Alied Diseases University of Nebraska Medical CenterOmahaNEUSA Buffet Cancer Center University of Nebraska Medical CenterOmahaNEUSA Laboratory Animal Research Center Qatar UniversityDohaQatar

Head and neck squamous cell carcinoma(HNSCC)is a very aggressive disease with a poor prognosis for advanced-stage *** clinical,genomic,and cellular studies have revealed the highly heterogeneous and immunosuppressive nature of *** signifcant advances in multimodal therapeutic interventions,failure to cure and recurrence are common and account for most *** is becoming increasingly apparent that tumor microenvironment(TME)plays a critical role in HNSCC tumorigenesis,promotes the evolution of aggressive tumors and resistance to therapy,and thereby adversely affects the prognosis.A complete understanding of the TME factors,together with the highly complex tumor-stromal interactions,can lead to new therapeutic interventions in ***,different molecular and immune landscapes between HPV^(+ve) and HPV^(-ve)(human papillomavirus)HNSCC tumors offer new opportunities for developing individualized,targeted chemoimmunotherapy(CIT)*** review highlights the current understanding of the complexity between HPV^(+ve) and HPV^(-ve) HNSCC TME and various tumor-stromal cross-talk modulating processes,including epithelial-mesenchymal transition(EMT),anoikis resistance,angiogenesis,immune surveillance,metastatic niche,therapeutic resistance,and development of an aggressive tumor ***,we summarize the recent developments and the rationale behind CIT strategies and their clinical applications in HPV^(+ve) and HPV^(-ve) HNSCC.

关键词： targeted squamous thereby

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Breast Cancer Detection in Saudi Arabian Women Using Hybrid Machine Learning on Mammographic Images

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Computers, Materials & Continua 2022年第9期72卷 4833-4851页

作者： Yassir Edrees Almalki Ahmad Shaf Tariq Ali Muhammad Aamir Sharifa Khalid Alduraibi Shoayea Mohessen Almutiri Muhammad Irfan mohammad Abd Alkhalik Basha Alaa Khalid Alduraibi Abdulrahman Manaa Alamri Muhammad Zeeshan Azam Khalaf Alshamrani Hassan A.Alshamrani Division of Radiology Department of MedicineMedical CollegeNajran UniversityNajran61441Kingdom of Saudi Arabia Department of Computer Science COMSATS University IslamabadSahiwal CampusSahiwal57000Pakistan Department of Radiology College of MedicineQassim UniversityBuraidah52571Kingdom of Saudi Arabia Department of Radiology King Fahad Specialist HospitalBuraydah52571Kingdom of Saudi Arabia Electrical Engineering Department College of EngineeringNajran UniversityNajran61441Kingdom of Saudi Arabia Radiology Department Human Medicine CollegeZagazig UniversityZagazig44631Egypt Department of Surgery College of MedicineNajran UniversityNajran61441Kingdom of Saudi Arabia Department of Computer Science Bahauddin Zakariya UniversityMultan66000Pakistan Radiological Sciences Department College of Applied Medical SciencesNajran UniversityNajran61441Kingdom of Saudi Arabia

Breast cancer(BC)is the most common cause of women’s deaths *** mammography technique is the most important modality for the detection of *** detect abnormalities in mammographic images,the Breast Imaging Reporting and Data System(BI-RADs)is used as a *** correct allocation of BI-RADs categories for mammographic images is always an interesting task,even for *** this work,to detect and classify the mammogram images in BI-RADs,a novel hybrid model is presented using a convolutional neural network(CNN)with the integration of a support vector machine(SVM).The dataset used in this research was collected from different hospitals in the Qassim health cluster of Saudi *** collection of all categories of BI-RADs is one of the major contributions of this *** significant contribution is the development of a hybrid approach through the integration of CNN and *** proposed hybrid approach uses three CNN models to obtain ensemble CNN model *** ensemble model saves the values to integrate them with *** proposed system achieved a classification accuracy,sensitivity,specificity,precision,and F1-score of 93.6%,94.8%,96.9%,96.6%,and 95.7%,*** proposed model achieved better performance compared to previously available methods.

关键词： Breast cancer CNN SVM BIRADS classification

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圆锥角膜患者基于角膜曲率验配硬性隐形眼镜的预测公式(英文)

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国际眼科杂志 2011年第11期11卷 1869-1872页

作者： mohammad Taher Rajabi Zahra Mohajernezhad-fard Seyede Khojaste Naseri Fahimeh Jafari Askar Doostdar Parviz Zarrinbakhsh mohammad Bagher Rajabi Sedighen Kohansal 伊朗德黑兰德黑兰大学医学科学院法拉比眼科医院眼科伊朗德黑兰德黑兰大学医学科学院视光系伊朗德黑兰德黑兰大学医学科学院Zarrinbakhsh诊所

目的:探讨隐形眼镜基线(BC)和角膜曲率结果(Krf)之间简单的数学相关性。方法:本回顾性研究包括350例400只圆锥角膜的眼睛,其先前五年在学院眼科中心验配硬性隐形眼镜。根据角膜曲率结果患者被分为五组,分别为Krf8,Krf-Krs(两个角膜曲率... 详细信息

目的:探讨隐形眼镜基线(BC)和角膜曲率结果(Krf)之间简单的数学相关性。方法:本回顾性研究包括350例400只圆锥角膜的眼睛,其先前五年在学院眼科中心验配硬性隐形眼镜。根据角膜曲率结果患者被分为五组,分别为Krf8,Krf-Krs(两个角膜曲率的差异;平坦和陡峭)=0.3-0.6,Krf-Krs>0.6mm1至5组,使用多元线性回归和蒙罗相关系数推测公式。结果:除了第3组患者,可以在所有组中发现线性相关。第1组,BC=0.211×5.904Krf。第2组,BC=0.456×Krf4.160。第4组,BC=0.321×5.219Krf。第5组,BC=0.337×Krf+5.090。结论:RGP验配新公式的发展,可增强眼科医生工作的信心,避免不必要的和频繁的眼镜试验。通常的隐形眼镜验配方法需要更换新的公式,从而帮助节省时间和费用。

关键词：圆锥角膜角膜曲率隐形眼镜验配

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