Tumor microenvironment: an evil nexus promoting aggressive head and neck squamous cell carcinoma and avenue for targeted therapy

作     者：Ajaz A.Bhat Parvaiz Yousuf Nissar A.Wani Arshi Rizwan Shyam S.Chauhan Mushtaq A.Siddiqi Davide Bedognetti Wael EI-Rifai Michael P.Frenneaux Surinder K.Batra Mohammad Haris Muzafar A.Macha Ajaz A.Bhat;Parvaiz Yousuf;Nissar A.Wani;Arshi Rizwan;Shyam S.Chauhan;Mushtaq A.Siddiqi;Davide Bedognetti;Wael El-Rifai;Michael P.Frenneaux;Surinder K.Batra;Mohammad Haris;Muzafar A.Macha

作者机构：Functional and Molecular Imaging LaboratoryCancer Research DepartmentSidra MedicineDohaQatar Department of ZoologySchool of Life SciencesCentral University of KashmirGanderbalJammu&KashmirIndia Department of NephrologyAll India Institute of Medical SciencesNew DelhiIndia Department of BiochemistryAll India Institute of Medical SciencesNew DelhiIndia Watson-Crick Centre for Molecular MedicineIslamic University of Science and TechnologyAwantiporaJammu&KashmirIndia Laboratory of Cancer ImmunogenomicsCancer Research DepartmentSidra MedicineDohaQatar Department of SurgeryUniversity of MiamiMiamiFLUSA Academic Health SystemHamad Medical CorporationDohaQatar Department of Biochemisty and Molecular BiologyUniversity of Nebraska Medical CenterOmahaNEUSA Eppley Institute for Research in Cancer and Alied DiseasesUniversity of Nebraska Medical CenterOmahaNEUSA Buffet Cancer CenterUniversity of Nebraska Medical CenterOmahaNEUSA Laboratory Animal Research CenterQatar UniversityDohaQatar 

出 版 物：《Signal Transduction and Targeted Therapy》 (信号转导与靶向治疗（英文）)

年 卷 期：2021年第6卷第2期

页      面：324-338页

核心收录：

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

基　　金：This study was supported by Ramalingaswami Fellowship(Grant number:D.O.NO.BT/HRD/35/02/2006)from the Department of Biotechnology,Government of India,New Delhi to Muzafar A.Macha Mohammad Haris is funded by a grant(5071012001)from Sidra Medicine Doha,Qatar Ajaz A.Bhat is supported by Sidra Medicine internal grant(5011041002).We thank Dr.Vineeta Tanwar(Ohio State University,Columbus,Ohio,USA)for her professional assistance in editing the paper 

主　　题：targeted squamous thereby 

摘      要：Head and neck squamous cell carcinoma(HNSCC)is a very aggressive disease with a poor prognosis for advanced-stage *** clinical,genomic,and cellular studies have revealed the highly heterogeneous and immunosuppressive nature of *** signifcant advances in multimodal therapeutic interventions,failure to cure and recurrence are common and account for most *** is becoming increasingly apparent that tumor microenvironment(TME)plays a critical role in HNSCC tumorigenesis,promotes the evolution of aggressive tumors and resistance to therapy,and thereby adversely affects the prognosis.A complete understanding of the TME factors,together with the highly complex tumor-stromal interactions,can lead to new therapeutic interventions in ***,different molecular and immune landscapes between HPV^(+ve) and HPV^(-ve)(human papillomavirus)HNSCC tumors offer new opportunities for developing individualized,targeted chemoimmunotherapy(CIT)*** review highlights the current understanding of the complexity between HPV^(+ve) and HPV^(-ve) HNSCC TME and various tumor-stromal cross-talk modulating processes,including epithelial-mesenchymal transition(EMT),anoikis resistance,angiogenesis,immune surveillance,metastatic niche,therapeutic resistance,and development of an aggressive tumor ***,we summarize the recent developments and the rationale behind CIT strategies and their clinical applications in HPV^(+ve) and HPV^(-ve) HNSCC.