Mechanical suppression of breast cancer cell invasion and paracrine signaling to osteoclasts requires nucleo-cytoskeletal connectivity

作     者：Xin Yi Laura E.Wright Gabriel M.Pagnotti Gunes Uzer Katherine M.Powell Joseph M.Wallace Uma Sankar Clinton T.Rubin Khalid Mohammad Theresa A.Guise William R.Thompson Xin Yi;Laura E.Wright;Gabriel M.Pagnotti;Gunes Uzer;Katherine M.Powell;Joseph M.Wallace;Uma Sankar;Clinton T.Rubin;Khalid Mohammad;Theresa A.Guise;William R.Thompson

作者机构：Department of Physical TherapySchool of Health and Rehabilitation SciencesIndiana UniversityIndianapolisIN 46202USA Department of MedicineDivision of EndocrinologySchool of MedicineIndiana UniversityIndianapolisIN 46202USA Department of Mechanical and Biomedical EngineeringBoise State UniversityBoiseID 83725USA Department of Biomedical EngineeringPurdue School of Engineering and TechnologyPurdue UniversityIndianapolisIN 46202USA Department of Anatomy&Cell BiologyIndiana UniversityIndianapolisIN 46202USA Department of Biomedical EngineeringStony Brook UniversityStony BrookNY 11794USA 

出 版 物：《Bone Research》 (骨研究（英文版）)

年 卷 期：2020年第8卷第4期

页      面：393-405页

核心收录：

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

基　　金：Department of Defense BC150678P1(WRT) NIH AR069943-01(WRT) NIH AR068332(US) and Department of Defense BC150678(TAG) 

主　　题：invasion impaired skeletal 

摘      要：Exercise benefits the musculoskeletal system and reduces the effects of *** effects of exercise are multifactorial,where metabolic changes and tissue adaptation influence *** signals,a principal component of exercise,are anabolic to the musculoskeletal system and restrict cancer *** examined the mechanisms through which cancer cells sense and respond to low-magnitude mechanical signals introduced in the form of ***-magnitude,high-frequency vibration was applied to human breast cancer cells in the form of low-intensity vibration(LIV).LIV decreased matrix invasion and impaired secretion of osteolytic factors PTHLH,IL-11,and ***,paracrine signals from mechanically stimulated cancer cells,reduced osteoclast differentiation and resorptive *** the nucleus by knockdown of SUN1 and SUN2 impaired LIV-mediated suppression of invasion and osteolytic factor *** increased cell stiffness;an effect dependent on the LINC *** data show that mechanical vibration reduces the metastatic potential of human breast cancer cells,where the nucleus serves as a mechanosensory apparatus to alter cell structure and intercellular signaling.