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Chinese Journal of Chemistry 2021年第5期39卷 1093-1103页

作者： Jie Wang Narsaiah Battini mohammad fawad ansari Cheng-He Zhou Institute of Bioorgonic&Medicinal Chemistry Key Laboratory of Luminescence Analysis and Molecular Sensing(Southwest University)Ministry of EducationSchool of Chemistry and Chemical EngineeringSouthwest UniversityChongqing 400715China

Novel quinazolonthiazoles were designed and synthesized as new potential antimicrobial agents by facile multi-step procedure from o-aminobenzoic acids and 2-acetylthiazole.A series of biological evaluation showed that compound 7d was the most effective quinazolonethiazole with superior activity to reference drugs chloramphenicol and *** active molecule displayed unob-vious bacterial resistance against ***,the low toxicity to normal hepatocytes,suitable pharmacokinetics and *** preliminary biological interaction suggested that quinazolonethiazole 7d might induce bacterial death by disturbing the membrane permeability,whilst preventing bacteria from growth by integrating into DNA and binding with topoisomerase *** findings provided significant background for the further development of quinazolonethiazoles as new potential drugs in combating drug-resistant pathogens.

关键词： Thiazole Schiff bases Antimicrobial Drug design DNA

Design and Synthesis of Sulfanilamide Aminophosphonates as Novel Antibacterial Agents towards Escherichia coli

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Chinese Journal of Chemistry 2021年第8期39卷 2251-2263页

作者： Juan Wang mohammad fawad ansari Jian-Mei Lin Cheng-He Zhou Institute of Bioorganic&Medicinal Chemistry Key Laboratory of Luminescence Analysis and Molecular Sensing(Southwest University)Ministry of EducationSchool of Chemistry and Chemical EngineeringSouthwest UniversityChongqing 400715China School of Medicine University of Electronic Science and Technology of ChinaChengduSichuan 610072China

The limit ability of traditional antibiotics to treat drug resistant bacteria calls for new therapeutic alter natives.A class of unique sul-fanilamide aminophosphonates as new potential agents against microbes was syn... 详细信息

关键词： Sulfonamides Aminophosphonate Imidazole Membranes DNA

Design and Synthesis to Access Novel Antibacterial Hybrids of Berberine and Metronidazole

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Design and Synthesis to Access Novel Antibacterial Hybrids o...

萘酰亚胺三唑新骨架结构化合物的合成及其抗烟曲霉菌作用

中国化学会·第十六届全国有机合成化学学术研讨会

作者： mohammad fawad ansari Hang Sun Cheng-He Zhou 西南大学 Jamia Millia Islamia College of Chemistry and Chemical Engineering Southwest University

Natural products play an important role for the development of most of the biologically active compounds due to the presence of enormous structure and chemical diversity which cannot be matched by any synthetic libraries of small *** all the approved antibacterial drugs approximately 68% of them are natural products or their *** is a natural product with unique structure,a quaternary nitrogen and a large desirableπ-conjugated backbone enables berberinc-based derivatives to readily bind with biomolecules like deoxyribonucleic acid（DNA） or an enzyme via noncovalent forces such as π-π stacking and electronic interactions,thus exerting potent biological ***,we are interested to synthesize a series of hybrids of berberine and metronidazole as a novel class of antibacterial agents.

关键词： berberine thiazolyl Mannich base biological activity

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中国科学：化学 2021年第8期51卷 1094-1103页

作者：张鹏丽吕敬松 ansari mohammad fawad BATTINI Narsaiah 蔡桂鑫周成合西南大学化学化工学院发光分析与分子传感教育部重点实验室重庆400715

本文从萘二酸酐出发设计开发了一类结构独特的萘酰亚胺三唑新抗真菌分子.目标化合物结构经波谱证实.抗真菌活性研究表明该系列萘酰亚胺三唑化合物对烟曲霉菌的抑制活性远优于氟康唑,尤其是强活性化合物5j具有快速的抗真菌能力,且对正常... 详细信息

本文从萘二酸酐出发设计开发了一类结构独特的萘酰亚胺三唑新抗真菌分子.目标化合物结构经波谱证实.抗真菌活性研究表明该系列萘酰亚胺三唑化合物对烟曲霉菌的抑制活性远优于氟康唑,尤其是强活性化合物5j具有快速的抗真菌能力,且对正常细胞的毒性较低和无明显耐药性.进一步的研究表明,5j不仅可以通过嵌入DNA形成生物超分子络合物的方式来阻碍微生物DNA的复制,也能够损伤烟曲霉菌细胞膜和诱导活性氧的生成而影响菌株的存活.此外,其还可以通过四个氢键与烟曲霉菌中甾醇14-α去甲基酶(CYP51B)结合形成生物超分子而影响其酶的功能从而达到抗真菌目的.以上结果显示出该类化合物具备多靶向抗真菌潜力.该系列化合物的药物化学生物学研究揭示出此类萘酰亚胺三唑新骨架结构分子可望作为专门抗烟曲霉菌的特效药而被深入开发.

关键词：萘酰亚胺三唑超分子作用耐药性 DNA

Isopropanol-conjugated Aloe Emodin Carbazole as Artificial Probes for Enterococcus faecalis DNA

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Isopropanol-conjugated Aloe Emodin Carbazole as Artificial P...

Post processing of additive manufactured Mg alloys:Current status,challenges,and opportunities

中国化学会·第十六届全国有机合成化学学术研讨会

作者：梁馨元 mohammad fawad ansari Cheng-He Zhou 西南大学 School of Chemistry and Chemical Engineering Southwest University Jamia Millia Islamia

Structural characteristics of Aloe emodin endow natural superior resources with good interactions on DNA via multiple modes,thus Aloe emodin derivatives exhibit extensive potential in medicinal *** the basis of our previous work in carbazoles with a library of potent candidate probes for biomolecular processes,herein our interest is to combine aloe emodin scaffold with carbazole via isopropanol bridge to develop a series of new potential hybrid candidates of artificial probes for sensitive bacterial DNA in clinic.

关键词： aloe emodin carbazole antibacterial probe DNA

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Journal of Magnesium and Alloys 2024年第4期12卷 1283-1310页

作者： Nooruddin ansari Fatima Ghassan Alabtah mohammad I.Albakri Marwan Khraisheh Mechanical Engineering Program Texas A&M University at QatarP.O.Box 23874DohaQatar

Magnesium(Mg)and its alloys are emerging as a structural material for the aerospace,automobile,and electronics industries,driven by the imperative of weight *** are also drawing notable attention in the medical industries owing to their biodegradability and a lower elastic modulus comparable to *** ability to manufacture near-net shape products featuring intricate geometries has sparked huge interest in additive manufacturing(AM)of Mg alloys,reflecting a transformation in the manufacturing ***,AM of Mg alloys presents more formidable challenges due to inherent properties,particularly susceptibility to oxidation,gas trapping,high thermal expansion coefficient,and low solidification *** leads to defects such as porosity,lack of fusion,cracking,delamination,residual stresses,and inhomogeneity,ultimately influencing the mechanical,corrosion,and surface properties of AM Mg *** address these issues,post-processing of AM Mg alloys are often needed to make them suitable for *** present article reviews all post-processing techniques adapted for AM Mg alloys to date,including heat treatment,hot isostatic pressing,friction stir processing,and surface *** utilization of these methods within the hybrid AM process,employing interlayer post-processing,is also *** post-processing conditions are reported,and their influence on the microstructure,mechanical,and corrosion properties are ***,future prospects and research directions are proposed.

关键词： Magnesium alloy Additive manufacturing Post-processing Heat treatment HIP

Design and Synthesis of Emodin-derived Azoles as Novel Structural Type of Bacterial DNA Intercalators

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Design and Synthesis of Emodin-derived Azoles as Novel Struc...

A Review of Image Steganography Based on Multiple Hashing Algorithm

中国化学会·第十五届全国有机合成化学学术研讨会

作者： Xin-Yuan Liang Di Li mohammad fawad ansari Gui-Xin Cai 周成合 School of Chemistry and Chemical Engineering Southwest University Jamia Millia Islamia 西南大学

Aloe emodin was confirmed to exert antineoplastic efficacy incorporating an anthraquinone unit, which accounts for vital interactions with *** were proven to induce additional aromatic system and more interactive sites that facilitates most biological *** interest is to combine aloe emodin with azoles to develop a series of novel structural type of bacterial DNA intercalators.

关键词： emodin azole antibacterial DNA HSA

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Computers, Materials & Continua 2024年第8期80卷 2463-2494页

作者： Abdullah Alenizi mohammad Sajid mohammadi Ahmad A.Al-Hajji Arshiya Sajid ansari Department of Information Technology College of Computer and Information SciencesMajmaah UniversityAl-Majmaah11952Saudi Arabia Department of Computer Science College of Engineering and Information TechnologyOnaizah CollegesQassim56312Saudi Arabia

Steganography is a technique for hiding secret messages while sending and receiving communications through a cover *** ancient times to the present,the security of secret or vital information has always been a significant *** development of secure communication methods that keep recipient-only data transmissions secret has always been an area of ***,several approaches,including steganography,have been developed by researchers over time to enable safe data *** this review,we have discussed image steganography based on Discrete Cosine Transform(DCT)algorithm,*** have also discussed image steganography based on multiple hashing algorithms like the Rivest–Shamir–Adleman(RSA)method,the Blowfish technique,and the hash-least significant bit(LSB)*** this review,a novel method of hiding information in images has been developed with minimal variance in image bits,making our method secure and effective.A cryptography mechanism was also used in this *** encoding the data and embedding it into a carry image,this review verifies that it has been ***,embedded text in photos conveys crucial signals about the *** review employs hash table encryption on the message before hiding it within the picture to provide a more secure method of data *** the message is ever intercepted by a third party,there are several ways to stop this operation.A second level of security process implementation involves encrypting and decrypting steganography images using different hashing algorithms.

关键词： Image steganography multiple hashing algorithms Hash-LSB approach RSA algorithm discrete cosine transform(DCT)algorithm blowfish algorithm

Experimental and Finite Element Analysis of Corroded High-Pressure Pipeline Repaired by Laminated Composite

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Computer Modeling in Engineering & Sciences 2024年第8期140卷 1783-1806页

作者： Seyed mohammad Reza Abtahi Saeid ansari Sadrabadi Gholam Hosein Rahimi Gaurav Singh Hamid Abyar Daniele Amato Luigi Federico Faculty of Mechanical Engineering Tarbiat Modares UniversityTehran***Iran A.Leon Linton Department of Mechanical Robotics and Industrial EngineeringLawrence Technological UniversitySouthfieldMI48075USA Department of Mechanical Engineering Faculty of EngineeringMeybod UniversityYazd***Iran Department of Industrial Engineering University of SalernoVia Giovanni PaoloⅡFiscianoItaly Italian Aerospace Research Center(C.I.R.A.) Via MaioriseCapuaCE81043Italy

Repairs of corroded high-pressure pipelines are essential for fluids transportation under high *** of the methods used in their repairs is the use of layered *** composite used must have the necessary ***,the experiments and analytical solutions presented in this paper are performed according to the relevant standards and codes,including ASME PCC-2,ASME B31.8S,ASME B31.4,ISO 24817 and ASME *** addition,the experimental tests are replicated numerically using the finite element *** the strain gauges at different distances from the defect location,can reduce the nonlinear effects,deformation,and fluctuations due to the high *** direct relationship between the depth of an axial defect and the stress concentration is observed at the inner side edges of the *** reparation reduces the non-linearities related to the sharp variation of the geometry and a more reliable numerical simulation could be performed.

关键词： High-pressure pipeline composite repair ASME PCC-2 ISO 24817

A Review on the Recent Trends of Image Steganography for VANET Applications

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Computers, Materials & Continua 2024年第3期78卷 2865-2892页

作者： Arshiya S.ansari Department of Information Technology College of Computer and Information SciencesMajmaah UniversityAl-Majmaah11952Saudi Arabia

Image steganography is a technique of concealing confidential information within an image without dramatically changing its outside *** vehicular ad hoc networks(VANETs),which enable vehicles to communicate with one another and with roadside infrastructure to enhance safety and traffic flow provide a range of value-added services,as they are an essential component of modern smart transportation *** steganography has been suggested by many authors for secure,reliable message transfer between terminal/hope to terminal/hope and also to secure it from attack for privacy *** paper aims to determine whether using steganography is possible to improve data security and secrecy in VANET applications and to analyze effective steganography techniques for incorporating data into images while minimizing visual quality *** to simulations in literature and real-world studies,Image steganography proved to be an effectivemethod for secure communication on VANETs,even in difficult network *** this research,we also explore a variety of steganography approaches for vehicular ad-hoc network transportation systems like vector embedding,statistics,spatial domain(SD),transform domain(TD),distortion,masking,and *** study possibly shall help researchers to improve vehicle networks’ability to communicate securely and lay the door for innovative steganography methods.

关键词： Steganography image steganography image steganography techniques information exchange data embedding and extracting vehicular ad hoc network(VANET) transportation system