Design and Synthesis to Access Novel Antibacterial Hybrids of Berberine and Metronidazole
作者单位：西南大学 Jamia Millia Islamia College of Chemistry and Chemical EngineeringSouthwest University
会议名称：《中国化学会·第十六届全国有机合成化学学术研讨会》
会议日期：2019年
学科分类：1007[医学-药学(可授医学、理学学位)] 10[医学]
关 键 词：berberine thiazolyl Mannich base biological activity
摘 要：Natural products play an important role for the development of most of the biologically active compounds due to the presence of enormous structure and chemical diversity which cannot be matched by any synthetic libraries of small *** all the approved antibacterial drugs approximately 68% of them are natural products or their *** is a natural product with unique structure,a quaternary nitrogen and a large desirableπ-conjugated backbone enables berberinc-based derivatives to readily bind with biomolecules like deoxyribonucleic acid（DNA） or an enzyme via noncovalent forces such as π-π stacking and electronic interactions,thus exerting potent biological ***,we are interested to synthesize a series of hybrids of berberine and metronidazole as a novel class of antibacterial agents.