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Combination of LC/MS and GC/MS based metabolomics to study the hepatotoxic effect of realgar nanoparticles in rats

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Chinese Journal of Natural Medicines 2017年第9期15卷 684-694页

作者： zhang mo-han CHEN Jia-Qing GUO Hui-Min LI Rui-Ting GAO Yi-Qiao TIAN Yuan zhang Zun-Jian HUANG Yin Key Laboratory of Drug Quality Control and Pharmacovigilance (Ministry of Education) China Pharmaceutical UniversityNanjing 210009 China State Key Laboratory of Natural Medicine China Pharmaceutical University Nanjing 210009 China

Realgar nanoparticles(NPs) are increasingly used as therapeutic agents for their enhanced anti-proliferation effect and cytotoxicity on cancer cells. However, the alteration of particle size may enhance biological reactivity as well as toxicity. A LC/MS and GC/MS based metabolomics approach was employed to explore the mechanism of realgar NPs-induced hepatotoxicity and identify potential biomarkers. Male Sprague-Dawley rats were administrated intragastrically with realgar or realgar NPs at a dose of 1.0 g·kg^(-1)·d^(-1) for 28 days and toxic effects of realgar NPs on liver tissues were examined by biochemical indicator analysis and histopathologic examination. Increased levels of serum enzymes and high hepatic steatosis were discovered in the realgar NPs treated group. Multivariate data analysis revealed that rats with realgar NPs-induced hepatotoxicity could be distinctively differentiated from the animals in the control and realgar treated groups. In addition, 21 and 32 endogenous metabolites were apparently changed in the serum and live extracts, respectively. Realgar NPs might induce free fatty acid and triglyceride accumulation, resulting in hepatotoxicity. In conclusion, the present study represents the first comprehensive LC/MS-and GC/MS-based metabolomics analysis of realgar NPs-induced hepatotoxicity, which may help further research of nanotoxicity.

关键词： Realgar nanoparticles Metabolomics Hepatotoxicity Liver extracts

Physiological and biochemical responses of Microcystis aeruginosa to phosphine(PH 3)under elevated CO2

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Journal of Environmental Sciences 2020年第8期32卷 171-178页

作者： Xiaojun Niu Dongqing zhang Runyuan zhang Qi Song Yankun Li mo Wang School of Environmental Science and Engineering Guangdong University of Petrochemical TechnologyMaoming 525000China School of Environment and Energy South China University of TechnologyGuangzhou 510006China State Key Laboratory of Pollution Control and Resource Reuse Nanjing 210093China Guangdong Provincial Key Laboratory of Atmospheric Environment and Pollution Control Guangzhou 510640China College of Architecture and Urban Planning Guangzhou UniversityGuangzhou 510006China

Phosphine(PH3)is an important factor driving the outbreak of cyanobacterial blooms that produce toxic microcystin threating human *** clarify the physiological and biochemical responses of cyanobacteria to PH3 under elevated CO2 concentration,Microcystis aeruginosa was used in the coupling treatment of 1000 ppmv CO2 and PH3 at different concentrations *** chlorophyll a(Chl-a),carotenoid,net photosynthetic rate and total protein of *** exhibited evidently increasing tendency under the coupling treatment of 1000 ppmv CO2 and PH 3 at different concentrations(7.51×10^−3,2.48×10^−2,7.51×10^−2 mg/L).The coupling treatments resulted in the higher concentrations of Chl-a and carotenoid of ***,compared to those in the control and the treatment with CO2 alone,and their enhancement increased with the increase in PH 3 *** total antioxidant capacity(T-AOC)in the coupling treatment with CO2 and PH3 of 2.48×10^−2 mg/L and 7.51×10^−3 mg/L showed increasing tendency,compared to the treatment with PH 3 ***,the coupling treatment with 1000 ppmv CO2 and PH3 also altered the pH and DO level in the culture *** this regard,the coupling treatment with CO2 and PH3 at an appropriate concentration can enhance the resistance of *** to PH3 toxicity and is beneficial to the reproduction of ***,presumably resulting in potential for the outbreak of cyanobacteria *** the concern about global warming and the increase in atmospheric CO2 level,our research laid a foundation for the scientific understanding of the correlation between PH3 and cyanobacteria blooms.

关键词： Phosphine M.aeruginosa CO2 Cyanobacteria bloom

From Liquid to Solid‑State Lithium Metal Batteries:Fundamental Issues and Recent Developments

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Nano-Micro Letters 2024年第2期16卷 68-125页

作者： Zhao zhang Wei‑Qiang han School of Materials Science and Engineering Zhejiang UniversityHangzhou 310027People’s Republic of China

The widespread adoption of lithium-ion batteries has been driven by the proliferation of portable electronic devices and electric vehicles,which have increasingly stringent energy density *** metal batteries(LMBs),with their ultralow reduction potential and high theoretical capacity,are widely regarded as the most promising technical pathway for achieving high energy density *** this review,we provide a comprehensive overview of fundamental issues related to high reactivity and migrated interfaces in ***,we propose improved strategies involving interface engineering,3D current collector design,electrolyte optimization,separator modification,application of alloyed anodes,and external field regulation to address these *** utilization of solid-state electrolytes can significantly enhance the safety of LMBs and represents the only viable approach for advancing *** review also encompasses the variation in fundamental issues and design strategies for the transition from liquid to solid *** noteworthy is that the introduction of SSEs will exacerbate differences in electrochemical and mechanical properties at the interface,leading to increased interface inhomogeneity—a critical factor contributing to failure in all-solidstate lithium metal *** on recent research works,this perspective highlights the current status of research on developing high-performance LMBs.

关键词： Lithium metal batteries All-solid-state lithium metal battery Li dendrite Solid electrolyte Interface

The　Structure　of　Sophoridine　N－oxide　from　Inner　mongolian　Sophora　Alopecuroides　L

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Chinese Chemical Letters 1996年第11期7卷 1013-1015页

作者： zhang, W mo, RG Xu, HZ INNER moNGOLIA UNIV DEPT CHEMHOHHOT 010021PEOPLES R CHINA

Sophoridine N -oxide (A) was isolated from the seeds of Inner mongolianSophora alopecuroides L. Its structure was characteraized. Deoxygenation of A gave sophoridine whereas N-oxidation of sophoridine gave two N-oxide... 详细信息

关键词： Inner oxide mongolian Sophoridine Structure Alopecuroides

绝经后骨质疏松症动物模型研究现状及趋势的文献计量可视化分析

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中国组织工程研究 2025年第14期29卷 3070-3080页

作者：章晓云李坤健莫坚柴源黄有荣广西中医药大学附属瑞康医院骨科广西壮族自治区南宁市530011 广西中医药大学广西壮族自治区南宁市530001

背景:近年来,绝经后骨质疏松症受到社会的广泛关注,随着动物模型研究的逐渐深入,动物模型已然成为现代中医药研究的重要手段以及实验基础,因此了解动物模型的研究现状、热点及发展趋势尤为重要。目的:分析国内外绝经后骨质疏松症动物模... 详细信息

背景:近年来,绝经后骨质疏松症受到社会的广泛关注,随着动物模型研究的逐渐深入,动物模型已然成为现代中医药研究的重要手段以及实验基础,因此了解动物模型的研究现状、热点及发展趋势尤为重要。目的:分析国内外绝经后骨质疏松症动物模型的研究现状、热点及发展趋势,为后续研究提供一定的理论基础及参考依据。方法:以“主题词=绝经后骨质疏松AND主题词=鼠+兔+犬+猪+羊+猴+鱼+实验动物+动物实验”为检索式,对1999-01-01/2023-10-01在中国知网、万方数据库中的文章进行主题词检索;同时以“TS=(Postmenopausal osteoporosis)AND TS=(mouse OR mice OR rat OR rabbit OR dog OR swine OR pig OR sheep OR monkey OR fish or flies OR“laboratory animal”OR“experiment animal”)”为检索式,对1999-01-01/2023-10-01在Web of Science核心合集数据库中的文章进行主题词检索。应用Citespace软件对文献作者、机构、国家、关键词以及文献共被引量进行可视化分析。结果与结论:①分析后筛选中国知网及万方数据库共纳入1238篇文献,Web of Science核心合集数据库共纳入3419篇文献。自1999年来,该领域发文量总体呈上升趋势,研究中心性最高的是美国,发文量最高的是中国,研究中心性最高的机构为美国加利福尼亚大学。②去除与文章主题直接相关的关键词,综合共现频率及中心性,“生物力学”“左归丸”“阿仑膦酸盐”“乳腺癌”“生化指标”处于该研究领域较为核心的地位。③通过文献共被引分析,被引频次前10位的文献中有5篇文献与绝经后骨质疏松症治疗措施与临床疗效有关。④综合关键词与共被引文献分析显示,探究成骨细胞的形成以及骨形成的机制、代谢组学的作用机制、中药复方的治疗、信号通路、甲状旁腺激素治疗及硬骨素抗体治疗等方面是当下的研究热点也是未来的研究趋势。

关键词：绝经后骨质疏松症动物模型文献计量学可视化分析 CiteSpace 成骨分化代谢组学中药复方研究热点

Case study of ionospheric fluctuation over mid-latitude region during one large magnetic storm

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Science China(Technological Sciences) 2012年第5期55卷 1198-1206页

作者： zhang DongHe mo XiaoHua A Ercha HAO YongQiang Department of Geophysics Peking UniversityBeijing 100871China State Key Laboratory of Space Weather Chinese Academy of SciencesBeijing 100080China College of Physics and Electronic Engineering Guangxi University for NationalitiesNanning 530006China

From Nov. 6 to 10, 2004, a large number of solar events occurred, which triggered many solar flares and coronal mass ejections (CMEs). These CMEs caused two large geomagnetic storms and continuous energy proton events. During this period, one large positive ionospheric storm happened over the East-Asian region on Nov. 8, 2004. On Nov. 10, 2004, a strong spread-F was observed by the ionosonde located in the mid-latitude region of East China and Japan, and the ionospheric fluctuation over the ionosonde stations derived from GPS observation was also obvious. In this report, the characteristics of the spatial distribution of the ionosphere fluctuation and its temporal evolution are studied using the parameter of the rate of total electron content (ROT) derived from dual-frequency GPS measurement. Strong fluctuating activity of the ionosphere was found over the mid-latitude region in the southern and northern hemispheres between longitudes of 100°E and 180°E during the magnetic storm period on Nov. 10, 2004, and a regular movement of the disturbing region was observed. In the end, the reason of the ionospheric fluctuation during this magnetic storm is analyzed.

关键词： ionospheric irregularities ionospheric scintillation TEC GPS rate of TEC

Role ofthe IncRNA-p53 regulatory network in cancer

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Journal of molecular Cell Biology 2014年第3期8卷 181-191页

作者： Ali zhang Min Xu Yin-Yuan mo Division of Hematology/Oncology Northwestern University Feinberg School of Medicine Chicago IL USA Department of 6astroenterology.'Affiliated Hospital of Jiangsu University Zhenjiang 212001 China " Department of Pharmacology/Toxicology and Cancer Institute University of Mississippi Medical Center Jackson MS USA

Advances in functional genomics have led to discovery of a large group of previous uncharacterized long non-coding RNAs （IncRNAs）. Emerging evidence indicates that IncRNAs may serve as master gene regulators through various mechanisms. Dysregulation of IncRNAs is often associated with a variety of human diseases including cancer. Of significant interest, recent studies suggest that IncRNAs participate in the p53 tumor suppressor regulatory network. In this review, we discuss how IncRNAs serve as p53 regulators or p53 effectors. Further characterization of these p53-associated IncRNAs in cancer will provide a better understanding of lncRNA- mediated gene regulation in the p53 pathway. As a result, IncRNAs may prove to be valuable biomarkers for cancer diagnosis or poten- tial targets for cancer therapy.

关键词： p53 IncRNA gene regulation tumor suppressor oncogenes

The study of fuzzy chaotic neural network based on chaotic method

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哈尔滨工程大学学报 2006年第B7期27卷 64-70页

作者： WANG Ke-jun TANG mo zhang Yan College of Automation Harbin Engineering University Harbin 150001 China

This paper proposes a type of Fuzzy Chaotic Neural Network (FCNN). Firstly, the model of recurrent fuzzy neural network (RFNN) is considered, which adds a feedback in the second layer to realize dynamic map. Then, the Logistic map is introduced into the recurrent fuzzy neural network, so as to build a Fuzzy Chaotic Neural Network (FCNN). Its chaotic character is analyzed, and then the training algorithm and associate memory ability are studied subsequently. And then, a chaotic system is approximated using FCNN;the simulation results indicate that FCNN could approach dynamic system preferably. And owing to the introducing of chaotic map, the chaotic recollect capacity of FCNN is increased.

关键词：模糊混沌神经网络数理逻辑图递归模糊神经网络混沌方法

Mechanosensitive Piezo1 channel regulation of microglial cell function and implications to neurodegenerative diseases and neuroinflammation

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Neural Regeneration Research 2023年第11期18卷 2385-2386页

作者： mo zhang Philippa Malko Lin-Hua Jiang Department of Physiology and Pathophysiology and Sino-UK Joint Laboratory of Brain Function and Injury of Henan ProvinceXinxiang Medical UniversityXinxiangHenan ProvinceChina School of Biomedical Sciences Faculty of Biological SciencesUniversity of LeedsLeedsUK A4245-Transplantation Immunology and InflammationFaculty of MedicineUniversity of ToursToursFrance

Microglial cells are the key immunocompetent cells in the central nervous system (CNS) and play a crucial role in CNS health and disease (Paolicelli et al.,2022).Under the homeostatic conditions,microglial cells assume diverse and dynamic states,depending upon interactions with neighboring cells and structures in local contextual settings,continuously patrol brain parenchyma utilizing their highly mobile fine processes,phagocytize protein aggregates,unwanted synapses and cells to maintain CNS health,and secrete neurotrophic factors to support neuronal function (Colonna and Butovsky,2017;Paolicelli et al.,2022).

关键词： inflammation diseases function