Role ofthe IncRNA-p53 regulatory network in cancer

作     者：Ali Zhang Min Xu Yin-Yuan Mo 

作者机构：Division of Hematology/Oncology Northwestern University Feinberg School of Medicine Chicago IL USA Department of 6astroenterology.'Affiliated Hospital of Jiangsu University Zhenjiang 212001 China " Department of Pharmacology/Toxicology and Cancer Institute University of Mississippi Medical Center Jackson MS USA 

出 版 物：《Journal of Molecular Cell Biology》 (分子细胞生物学报（英文版）)

年 卷 期：2014年第8卷第3期

页      面：181-191页

核心收录：

学科分类：0710[理学-生物学] 083002[工学-环境工程] 0830[工学-环境科学与工程（可授工学、理学、农学学位）] 07[理学] 08[工学] 071009[理学-细胞生物学] 09[农学] 0903[农学-农业资源与环境] 0901[农学-作物学] 090102[农学-作物遗传育种] 0713[理学-生态学] 

基　　金：supported by NIH(Y.-Y.M.) 

主　　题：p53 IncRNA gene regulation tumor suppressor oncogenes 

摘      要：Advances in functional genomics have led to discovery of a large group of previous uncharacterized long non-coding RNAs （IncRNAs）. Emerging evidence indicates that IncRNAs may serve as master gene regulators through various mechanisms. Dysregulation of IncRNAs is often associated with a variety of human diseases including cancer. Of significant interest, recent studies suggest that IncRNAs participate in the p53 tumor suppressor regulatory network. In this review, we discuss how IncRNAs serve as p53 regulators or p53 effectors. Further characterization of these p53-associated IncRNAs in cancer will provide a better understanding of lncRNA- mediated gene regulation in the p53 pathway. As a result, IncRNAs may prove to be valuable biomarkers for cancer diagnosis or poten- tial targets for cancer therapy.